Phenotypic and genomic analyses of the probiotic SHAMU-QH-02.

The past few years have witnessed burgeoning interest in the potential beneficial role of probiotics in multiple fields. This study aimed to explore the probiotic properties and analyze the genomic information of the SHAMU-QH-02 strain, isolated from the human biliary tract. The SHAMU-QH-02 strain was identified using 16S rRNA gene and whole-genome sequencing.

Inhibition of ANXA1 Ameliorates Myocardial Ischemia/Reperfusion Injury by Targeting RAS/Raf/MAPK Axis-Mediated Ferroptosis.

Annexin-A1 (ANXA1) participates in regulating ferroptosis. Ferroptosis is involved in myocardial ischemia-reperfusion injury (MIRI). However, effect and mechanism of ANXA1 in ferroptosis after MIRI remain unclear.

[Research Progress on the Extraction, Qualitative, and Quantitative Methods of Microplastics in Biological Samples].

Microplastics （MPs）, which usually refer to plastic fragments, particles, or fibers with a diameter or length of less than 5 mm, are contaminants of emerging concern （CECs） that have a significant impact on the ecological system. MPs have been widely detected in the soil, surface water, ocean, and atmosphere. These MPs could accumulate in organisms via absorption and/or ingestion, transfer along the food chain, and ultimately pose a threat to the health of higher trophic organisms and even human beings.

Nickel-catalyzed sequential 1,2--migration/BCBs ring-opening to access spirocyclobutyl β-amino acid esters.

Hetero-atom migration strategy is a powerful tool to access complex molecules. Herein, we disclose a cascade radical 1,2--migration/ring-opening of -aryl bicyclobutyl amides (BCBs) with β-bromo α-amino acid esters by cooperative Ni/diboron catalysis, which afforded a wide array of spirocyclobutyl oxindoles tethering a β-amino acid motif under room temperature conditions. The method suppressed the typical intramolecular C(sp)-H cyclization of β-bromo amino acid esters after 1,2--migration, successfully incorporating β-amino acid moieties into the spirocyclobutyl oxindole scaffolds.

Prophylactic Effect of Prefrontal Alternating Current Stimulation on Postoperative Sleep Disturbance in Patients Undergoing Gynecological Laparoscope: A Randomized, Double-Blind, Sham-Controlled Trial.

Aims: Postoperative sleep disturbance (PSD) is a common complication following surgical procedures. We aimed to evaluate the effect of prefrontal transcranial alternating current stimulation (tACS) in preventing PSD among patients undergoing gynecological laparoscopic surgery.

Methods: A total of 176 eligible patients, aged 18-65 years, with ASA Class I to III, and scheduled for gynecological laparoscopic surgery, were randomly allocated to receive either a single 20-min session of prefrontal tACS (2 mA, 7 Hz) or sham stimulation immediately after extubation.

Titanium ions promote tomato growth and increase stress resistance.

Background: Titanium ions can significantly promote plant growth and increase crop yield, yet the underlying mechanism remains an enigma. This study investigated the effect of titanium ions on tomato (Solanum lycopersicum) by foliar spraying and root irrigation with titanium ion solution (8 mg/L) in both pot and field trials.

Results: Pot and field trials showed that exogenous titanium ions significantly stimulated plant growth and root system development, enhanced antioxidant capacity, alleviated Blossom end rot and saline-alkali stress.

Early Detection of Accelerated Hyperopia Reserve Depletion in Chinese Children with Poor Visual Habits: A Longitudinal Cohort Study.

Objective Or Purpose: This study aimed to identify early critical points of accelerated hyperopia reserve depletion in Chinese children with poor visual habits using Dynamic Network Landscape Entropy (DNLE). We hypothesized that DNLE could detect critical transitions in ocular parameter networks before myopia onset, enabling timely interventions.

Design: A prospective cohort study (Anyang Childhood Eye Study, 2012-2019) with 6 annual follow-ups.

Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation.

Cerebral amyloid angiopathy (CAA) and insomnia are age-related neurological disorders increasingly recognized as being closely associated. However, research on the shared genes and their biological mechanisms remains limited. This study aims to identify common genes between CAA and insomnia and explore their potential molecular mechanisms, offering new insights for diagnosis and treatment.

A novel splicing variant in TECTA associated with prelingual autosomal dominant nonsyndromic hearing loss via dominant-negative effect.

The TECTA gene encodes α-tectorin, the major non-collagenous glycoprotein of the tectorial membrane, and plays a critical role in intracochlear sound transmission. Unsurprisingly, mutations in TECTA underlie hearing loss in both mice and humans. Two forms of hearing loss are linked to TECTA mutations: DFNA8/12 (autosomal dominant) and DFNB21 (autosomal recessive).

Optimization and Hepatoprotective Potential of Sulfated Polysaccharide From Pleurotus ostreatus.

In this study, we explored an efficient method for synthesizing sulfated Pleurotus ostreatus polysaccharides (SPOP) with a higher degree of substitution. The structure conformation was characterized and confirmed by the Fourier transform infrared (FT-IR) spectroscopy analysis. A three-factor-three-level Box-Behnken design (BBD) was successfully applied to optimize the SPOP synthesis process.

Comprehending the mechanism of catechins against α-glucosidase by multispectral data and their antidiabetic effects in vivo.

Diabetes mellitus (DM) is a common metabolic disorder characterized by the elevated blood glucose levels. Catechins comprising four isomers, (+)-catechin [(+)CT], (-)-catechin [(-)CT], (+)-epicatechin [(+)ECT] and (-)-epicatechin [(-)ECT], are a family of flavanols widespread in natural sources. In this study, four catechins were extensively evaluated against diabetes-related enzymes, of which (+)CT (IC = 63.

Prolong cycle-life by interlayer doping and vacancy coupling engineering in Li-rich oxide cathodes.

Although Li-rich layered oxides (LLOs) are widely favored due to their high capacity derived from oxygen anionic redox, the rapid degradation of the initial lattice shortens their cycle-life. This is mainly attributed to internal strain and irreversible degradation of the oxygen redox environment, leading to layered structure damage, phase transformation and oxygen vacancies, which accumulate rapidly with cycling. Mechanism exploration and modification development targeting individual factors have established the principles and effectiveness of transition metal (TM) dopes in the Li layer and cation vacancies in the TM layer for inhibiting layered phase degradation and promoting anionic reversible reactions, thereby inspiring coupling defects engineering.

Asymmetric total synthesis of amovillosumins A and B and their hypoglycemic and anti-inflammatory activities.

Motivated by the significant bioactivities and therapeutic potential of 1,4-benzodioxan derivatives, we reported the asymmetric total synthesis of amovillosumins A (1) and B (2), two architecturally unique norlignans isolated from Amomum villosum. The target compounds were achieved in nine and seven steps, respectively, from commercially available materials, delivering exceptional overall yields (45-47 %) with excellent enantiopurity (91-95 % ee). The key synthesis strategies encompassed Williamson ether formation, stereocontrolled ketone reduction, and Ullmann coupling to establish the pivotal 1,4-dioxan scaffold.

Rational screening of covalent organic frameworks for solid-phase microextraction of advanced glycation end products from thermally processed foods.

Advanced glycation end products (AGEs) are increased by thermal processing in foods, raising the risk of chronic diseases. To efficiently monitor AGEs, density functional theory (DFT) was applied for predicting and screening the suitable adsorbent before synthesis. The binding energies between ten COFs and two representative AGEs were calculated.

[Effects of the photovoltaic-earthworm model and organic material application on soil quality].

We investigated the effects of earthworm and organic material application methods on soil quality on slopes where photovoltaic panels are installed, aiming to explore a new model for promoting sustainable development of photovoltaic agriculture and improving soil quality. We proposed the photovoltaic-earthworm model, which involves breeding with high medicinal value in the soil under photovoltaic panels. There were four treatments: surface application of cow manure between photovoltaic panels to breed earthworms (Out+S), surface application of cow manure under photovoltaic panels to breed earthworms (In+S), mixed application of cow manure between photovoltaic panels to breed earthworms (Out+M), and mixed application of cow manure under photovoltaic panels to breed earthworms (In+M), with the bare land as the control (CK).

Analysis of Factors Influencing Cardiovascular Events and Mortality in Patients on Dialysis after Parathyroidectomy.

Background: Renal secondary hyperparathyroidism (SHPT) represents a prevalent complication among dialysis patients, significantly impacting long-term prognosis. Parathyroidectomy (PTX) serves as a clinically effective therapeutic option for patients diagnosed with refractory secondary hyperparathyroidism.

Objective: This study aims to assess the impact of PTX on cardiovascular events (CVEs) and all-cause mortality in dialysis patients, as well as to analyze the incidence and potential determinants of postoperative cardiovascular events and all-cause mortality.

Antidiabetic diarylheptanoids from the leaves of Amomum tsao-ko and their inhibition mechanism against α-glucosidase.

Thirteen diarylheptanoids, including four undescribed ones (1-4), were isolated from the leaves of Amomum tsao-ko. Compounds 1 and 2 are two unusual diarylheptanoid-phenylpropanoid hybrids. Several of the isolates were tested for their biological activity in promoting GLP-1 secretion and inhibiting multiple type 2 diabetes-related enzymes.

Mitochondrial proteins and congenital birth defect risk: a mendelian randomization study.

Background: Mitochondrial dysfunction has been hypothesized to play a role in the etiology of congenital birth defects. However, evidence from observational studies is susceptible to bias and confounding. Mendelian randomization uses genetic variants as instrumental variables to investigate causal relationships.

Global, Regional, and National Epidemiology of Depression in Working-Age Individuals, 1990-2019.

Background: Depression is a disorder that can have a serious impact on functioning and quality of life. Understanding the global, regional, and national epidemiology of depression in working-age populations (15-49 years) is important for informing mental health policies and services. However, up-to-date data have been lacking, especially in developing regions.

BioMeta: modular reprogrammable metasurface for noninvasive human respiration monitoring.

Human vital-sign sensing using electromagnetic wave has emerged as a promising technology for the noninvasive monitoring of individuals' health status. Here, a modular reprogrammable metasurface system is presented to suppress noise in noninvasive human respiration sensing. The proposed reprogrammable Biological Metasurface () provides three-dimensional dynamic control over wavefront shaping and thus can reduce interference from human limb motions.

Application and Effectiveness of the Perioperative Position Management in Patients with Congenital Microtia.

Background: The reconstructed ear structure is fragile, necessitating strict avoidance of postoperative pressure to ensure surgical outcome. The study aimed to evaluate the clinical application and effectiveness of a perioperative position management program constructed for patients with congenital microtia.

Methods: A quasi-trial design with non-randomized grouping was adopted.

Urinary metal levels and their association with Parkinson's disease risk: insights from NHANES 2013-2020.

Background: Parkinson's disease (PD) poses a significant public health challenge worldwide, with both genetic predispositions and behavioral factors contributing to its onset and progression. While the precise mechanisms underlying PD remain uncertain, environmental influences are increasingly acknowledged as critical risk factors. This research focused on investigating the relationship between urinary metal levels and the likelihood of developing PD.

Retraction notice to "Non-negative matrix factorization model-based construction for molecular clustering and prognostic assessment of head and neck squamous carcinoma" [Heliyon 8 (2022) e10100].

[This retracts the article DOI: 10.1016/j.heliyon.

Transition-metal-free arene C-H functionalization for the synthesis of sulfoximines.

A transition-metal-free C-H functionalization method has been developed for the synthesis of aryl sulfoximines. This two-step protocol involves the 3,5-dimethyl-4-isoxazolyliodonium salt as an intermediate. The iodonium salt is obtained with high site selectivity from arenes C-H activation, and is then converted into sulfoximines through a ligand coupling at the hypervalent iodine center with sulfinamides.

Antidiabetic constituents of Kaempferiae rhizoma: Previously undescribed O-linked diarylheptanoid dimers promoting GLP-1 secretion via PKA-CREB pathway.

Glucagon-like peptide-1 (GLP-1) is a fascinating target for the treatment of diabetes to avoid hypoglycemia. Kaempferiae Rhizoma (KR), the dried rhizomes of Kaempferia galanga, is a famous pungent medicine used for activating Qi, warming interior, removing digestion and relieving pain in China. In order to characterize the antidiabetic effects of KR, 21 previously undescribed O-linked diarylheptanoid dimers, kaemgalangins A-A (1-4), B-B (5-17) and C-C (18-21), were isolated from the ethyl acetate fraction.