Publications by authors named "Meng-Yan Zhao"
Nickel-catalyzed sequential 1,2--migration/BCBs ring-opening to access spirocyclobutyl β-amino acid esters.
Chem Commun (Camb)
August 2025
Hetero-atom migration strategy is a powerful tool to access complex molecules. Herein, we disclose a cascade radical 1,2--migration/ring-opening of -aryl bicyclobutyl amides (BCBs) with β-bromo α-amino acid esters by cooperative Ni/diboron catalysis, which afforded a wide array of spirocyclobutyl oxindoles tethering a β-amino acid motif under room temperature conditions. The method suppressed the typical intramolecular C(sp)-H cyclization of β-bromo amino acid esters after 1,2--migration, successfully incorporating β-amino acid moieties into the spirocyclobutyl oxindole scaffolds.
View Article and Find Full Text PDFCerebral syphilitic gumma misdiagnosed as brain abscess: A case report.
World J Clin Cases
January 2024
Article Synopsis
- Cerebral syphilitic gumma is a rare condition often mistaken for brain tumors or abscesses due to its non-specific symptoms and similar imaging results.
- A reported case involved a patient initially misdiagnosed with a brain abscess, leading to unnecessary surgery until a correct diagnosis of syphilitic gumma was made post-operation.
- To improve diagnostic accuracy, it’s crucial for physicians to recognize the characteristics of neurosyphilis and combine multiple examination methods in their assessments.