Advances in stem cell-based therapeutics for acute high-altitude illness: research progress and prospects.

Acute high-altitude illness (AHAI), triggered by hypobaric hypoxia following rapid ascent to high elevations, induces complex pathophysiological responses that may be life-threatening. Recent advances in regenerative medicine have highlighted the therapeutic potential of stem cells in mitigating hypoxia-induced damage. Among them, Mesenchymal stem cells (MSCs), the most extensively investigated, exert therapeutic efficacy through immunomodulation, attenuation of oxidative stress, and enhancement of tissue repair mechanisms.

Hard-Soft-Acid-Base Management Enabled Bright and Stable Pure-Blue Perovskite Quantum Dot LEDs.

Light-emitting diodes (LEDs) based on perovskite quantum dots (QDs) have achieved external quantum efficiencies (EQEs) exceeding 20% at a practical luminance (>1000 cd m) for real-world applications in the green and red regions. However, the pure-blue perovskite QD LEDs still suffer from low efficiency at high luminance: the EQE of the reported best device at 600 cd m is below 7.0%.

Titanium ions promote tomato growth and increase stress resistance.

Background: Titanium ions can significantly promote plant growth and increase crop yield, yet the underlying mechanism remains an enigma. This study investigated the effect of titanium ions on tomato (Solanum lycopersicum) by foliar spraying and root irrigation with titanium ion solution (8 mg/L) in both pot and field trials.

Results: Pot and field trials showed that exogenous titanium ions significantly stimulated plant growth and root system development, enhanced antioxidant capacity, alleviated Blossom end rot and saline-alkali stress.

BCMA/GPRC5D bispecific CAR T-cell therapy for relapsed/refractory multiple myeloma with extramedullary disease: a single-center, single-arm, phase 1 trial.

Relapsed/refractory multiple myeloma (RRMM) with extramedullary disease (EMD) represents a challenging condition, with limited treatment options and poor prognosis. We conducted a phase 1 clinical trial to evaluate the safety and effectiveness of a novel bispecific chimeric antigen receptor (CAR) T-cell therapy targeting two antigens, B-cell maturation antigen and G protein-coupled receptor class C group 5 member D (BCMA/GPRC5D), in this high-risk population. A total of 12 patients were enrolled, of whom 3 were excluded due to disease progression or death before CAR T-cell infusion, despite meeting the inclusion criteria, leaving 9 for analysis.

Rapid development of acute monocytic leukemia (AML-M5b) with t(9;11)(p22;q23) after chemotherapy for T-cell lymphoblastic lymphoma: A case report.

Objective: To investigate the diagnosis and treatment of T lymphoblastic lymphoma (T-LBL) progressing into acute monocytic leukemia (AML-M5b) and explore possible pathogenic mechanisms.

Methods: Comprehensive diagnosis and evaluation of the patient's disease status were conducted through lymph node biopsy, bone marrow aspiration and biopsy, PET/CT, immunohistochemistry, flow cytometry, fusion gene detection, and whole-exome sequencing (WES) based on the clinical manifestations at different stages.

Results: The lymph node biopsy revealed Ki67 positivity at 80 % and expression of TDT, CD4, CD8, CD3, and CD5.

The mango bacterial black spot altered the endophyte community structure and diversity.

Mango bacterial black spot is a major disease limiting mango production, which is now causing increasingly severe economic losses. In this study, we analyzed the differences in the composition and structure of bacterial and fungal communities in the pulp and leaves between the healthy mangoes of variety Kate and those affected by bacterial black spot, and attempted to explore potential biocontrol microorganisms for mangoes. The results showed there existed significant differences in microbial communities, the bacterial Stenotrophomonas, Curtobacterium, Massilia and fungous Penicillium, Alternaria, Aureobasidiu showed great abundance both in pulps and leaves.

The biological function of m6A methyltransferase KIAA1429 and its role in human disease.

KIAA1429 is a major m6A methyltransferase, which plays important biological and pharmacological roles in both human cancer or non-cancer diseases. KIAA1429 produce a tumorigenic role in various cancers through regulating DAPK3, ID2, GATA3, SMC1A, CDK1, SIRT1 and other targets, promoting cell proliferation, migration, invasion, metastasis and tumor growth . At the same time, KIAA1429 is also effective in non-tumor diseases, such as reproductive system and cardiovascular system diseases.

[Effects of addition of organic carbon with different chemical structure on the fate and accumulation of exogenous carbon in red and sandy soils].

Plant litter input has important influences on soil CO emission and soil organic carbon (SOC) formation in terrestrial ecosystem. However, it is not well known for the fate of carbon when exogenous organic matters with different chemical structures are added to soil with different textures. In this study, we added the uniformly C-labelled substrates of glucose, starch, and cellulose to red soil and sandy soil, and compared the net C accumulation and recovery and its proportions in soil releasing CO, SOC, dissolved organic carbon (DOC) and microbial biomass carbon (MBC) pools.

Unexpected Cascade Dehydrogenation Triggered by Pd/Cu-Catalyzed C(sp)-H Arylation/Intramolecular C-N Coupling of Amides: Facile Access to 1,2-Dihydroquinolines.

In this work, we successfully explored an unexpected dehydrogenation triggered by Pd/Cu-catalyzed C(sp)-H arylation and intramolecular C-N coupling of amides to synthesize the bioactive 1,2-dihydroquinoline scaffold with good regioselectivity and good compatibility of functional groups. This strategy provides an alternative route to realize molecular complexity and diversity from simple and readily available molecules via multiple C-H bond activation. Preliminary mechanistic studies demonstrated that β,γ-dehydrogenation is triggered by the arylation of the C(sp)-H bond and the intramolecular C-N coupling.

Breviscapine remodels myocardial glucose and lipid metabolism by regulating serotonin to alleviate doxorubicin-induced cardiotoxicity.

The broad-spectrum anticancer drug doxorubicin (Dox) is associated with a high incidence of cardiotoxicity, which severely affects the clinical application of the drug and patients' quality of life. Here, we assess how Dox modulates myocardial energy and contractile function and this could aid the development of relevant protective drugs. Mice were subjected to doxorubicin and breviscapine treatment.

Targeting NAD+: is it a common strategy to delay heart aging?

Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numerous studies with NAD+ supplementations have suggested its use in anti-aging treatment. However, systematic reviews regarding the overall role of NAD+ in cardiac aging are scarce.

Nicotinic Acid Riboside Regulates Nrf-2/P62-Related Oxidative Stress and Autophagy to Attenuate Doxorubicin-Induced Cardiomyocyte Injury.

Doxorubicin (Dox) is an effective chemotherapeutic drug for the treatment of various cancers. Due to its potential fatal cardiotoxic side effects, the clinical application is often limited. Dexrazoxane (Dex) is the only drug approved by the Food and Drug Administration (FDA) for the prevention of Dox-induced cardiotoxicity but has side effects.

Effects of aboveground and belowground litter inputs on the balance of soil new and old organic carbon under the typical forests in subtropical region.

Litter is one of the most important factors controlling the accumulation, stabilization, and turnover of soil organic carbon (SOC) in forests. There is a knowledge gap of the impacts of aboveground and belowground litter inputs on the balance of new and old SOC under different forests in subtropical region. We examined the effects of aboveground and belowground litter inputs on SOC turnover using isotopic tracing technique, based on a 3-year C3 plants/C4 soil replacement experiment in natural forest (NF), Masson pine () plantation (PM) and Chinese fir () plantation (CL).

Diffuse large B-cell lymphoma with low F-fluorodeoxyglucose avidity features silent B-cell receptor signaling.

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of aggressive lymphomas exhibiting increased glucose uptake. However, some DLBCLs featuring relatively low F-fluorodeoxyglucose (F-FDG) uptake denoted by the maximum standardized uptake value (SUV) on PET/CT have been identified. The biologic correlates of such a heterogeneity have remained largely unknown.

[Relationship Between the VNTR Loci Polymorphism and MALDI-TOF MS Protein Profile Diversity in Complex].

Objective: To study the relationship between the copy numbers of repetitive units at variable number tandem repeat (VNTR) loci of complex (MTBC) with its diversity of protein profiles.

Methods: The MTBC strains were subjected to genotyping using multiple locus variable number tandem repeat analysis (MLVA). Also, the principal component analysis (PCA) was performed for bacterial protein profiles of MTBC using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).

[Triton X-100 Enhanced the Detection of Hodge Test and Carba NP Test for Carbapenemase-producing Complex].

Objective: To find out highly effective phenotypic methods to detect carbapenemase-producing complex) so as to support the epidemiological investigation and clinical application.

Methods: We included 113 complex and compared the detection performance of modified Hodge test, Carba NP test, Triton Hodge test, and the simplified Carba NP-direct test with Tritont X-100.

Results: We tested 83 carbapenemase-producing complex and 30 non-carbapenemase producers.

Optical Properties of Al-Doped ZnO Films in the Infrared Region and Their Absorption Applications.

The optical properties of aluminum-doped zinc oxide (AZO) thin films were calculated rapidly and accurately by point-by-point analysis from spectroscopic ellipsometry (SE) data. It was demonstrated that there were two different physical mechanisms, i.e.

A novel pretreatment method combining sealing technique with direct injection technique applied for improving biosafety.

Aim: People today have a stronger interest in the risk of biosafety in clinical bioanalysis. A safe, simple, effective method of preparation is needed urgently.

Methodology/results: To improve biosafety of clinical analysis, we used antiviral drugs of adefovir and tenofovir as model drugs and developed a safe pretreatment method combining sealing technique with direct injection technique.