Carbonylmetallated Palladium Nanoclusters for Visible-Light-Driven Carbonylation under 1 atm of CO.

Palladium nanoclusters (Pd NCs) hold great promise in organic synthesis; however their controlled synthesis via direct reduction remains challenging due to kinetically favored formation of nanoparticles. In this study, we employ carbonylmetallate ligands to regulate the reduction reaction kinetics and successfully achieve three [Co(CO)] terminated Pd NCs. Magnetic studies, in conjunction with quantum chemical calculations, suggest that the Pd cluster exhibits a quartet ground state and open-shell character with 1S configuration, representing the first open-shell palladium containing one free electron.

Selenolated Copper Hydride Clusters for Visible-Light Photocatalytic Iodofluoroalkylation of Alkynes.

The photocatalytic iodofluoroalkylation of unsaturated systems is of great interest, with significant potential in the synthesis of fluorinated compounds. Herein, we introduce a selenate-protected hydride cluster, [CuH(dppy)(PhCHSe)](PF) (dppy = diphenyl-2-pyridylphosphine, PhCHSe = benzylselenate), that enables visible light-mediated iodofluoroalkylative difunctionalization of alkynes. Single crystal X-ray structural analysis reveals that the cluster comprises a hydride-embedded hexagonal close-packed Cu kernel of the symmetry, coprotected by benzylselenate and dppy ligands.

Simultaneous determination of nine compounds from the roots of , and and their anti-tumor activities.

Langdu is generally considered as the roots of , and . However, whether these three plants can substitute for one another has always been a concern. This article aims to clarify the differences among the three Langdu species in chemical constituents and anti-tumor effects.

Significantly enhanced NIR emission of solid-state clusters based on CuPt triggered with volatile organic compounds.

Near-infrared (NIR) emitting metal clusters, recognized for their low toxicity, large Stokes shift, and exceptional photostability, hold considerable promise as stimuli-responsive luminescent materials for applications including organic vapor sensing, pollutant detection, and photoluminescent thermometers. However, their limited quantum yield (QY) for NIR emission poses a challenge, highlighting the need for developing light-up sensors with NIR emitting metal clusters to broaden the scope of applications. Herein, the carbazole-alkyne ligand-incorporated novel bimetallic cluster, CuPt(CZ-PrA)(dppy)(PF) (CZ-Cu4Pt2, CZ-PrAH = 9-(Prop-2-yn-1-yl)-9-carbazole; dppy = diphenyl-2-pyridylphosphine), was synthesized, which exhibits NIR emission centered at 740 nm in the solid state and shows a significant blue shift compared to the previously reported analogues.

Highly intense NIR emissive CuPt bimetallic clusters featuring Pt(i)-Cu-Pt(i) sandwich kernel.

Metal nanoclusters (NCs) capable of near-infrared (NIR) photoluminescence (PL) are gaining increasing interest for their potential applications in bioimaging, cell labelling, and phototherapy. However, the limited quantum yield (QY) of NIR emission in metal NCs, especially those emitting beyond 800 nm, hinders their widespread applications. Herein, we present a bright NIR luminescence (PLQY up to 36.

Simultaneous Determination of Thirteen Iridoid Glycosides in Crude and Processed Fructus Corni from Different Areas by UPLC-MS/MS Method.

Fructus Corni (F. Corni) is the dried mature pulp of Cornus officinalis Sieb. et Zucc.

Pharmacological activities and therapeutic potential of galangin, a promising natural flavone, in age-related diseases.

Background: The extension of average life expectancy and the aggravation of population aging have become the inevitable trend of human development. In an aging society, various problems related to medical care for the elderly have become increasingly prominent. However, most of the age-related diseases have the characteristics of multiple diseases at the same time, prone to complications, and atypical clinical manifestations, which bring great difficulties to its treatment.

[Effects of addition of leaf litter with different chemical properties on soil organic carbon mineralization and priming effect].

Litter inputs can affect the mineralization of soil organic carbon (SOC). However, it is yet unknown how the input of leaf litter with different chemical properties drives SOC mineralization and priming effect. In this study, C-labeled leaf litter of six tree species were added to soil cores (10 cm depth) collected from a natural secondary forest in subtropical region.

[Effects of addition of organic carbon with different chemical structure on the fate and accumulation of exogenous carbon in red and sandy soils].

Plant litter input has important influences on soil CO emission and soil organic carbon (SOC) formation in terrestrial ecosystem. However, it is not well known for the fate of carbon when exogenous organic matters with different chemical structures are added to soil with different textures. In this study, we added the uniformly C-labelled substrates of glucose, starch, and cellulose to red soil and sandy soil, and compared the net C accumulation and recovery and its proportions in soil releasing CO, SOC, dissolved organic carbon (DOC) and microbial biomass carbon (MBC) pools.

X-ray photochromism of chalcogenide frameworks linked with metal-amine chelates.

Reported here are two X-ray photochromic metal chalcogenide frameworks, which consist of tetrahedral clusters that are linked by transition-metal amine chelates. They have similar structures, but with different organic amine species, and they exhibit different coloration behavior. The photoinduced electron transfer from the metal chalcogenide clusters to the zinc amine chelates is a key point in accounting for their photochromism.

Ultrastable Anti-Acid "Shield" in Layered Silver Coordination Polymers.

Surface passivation technology provides noble-metal materials with limited chemical stability, especially under highly acidic condition. To design effective strategy to enhance stability of noble-metal particles, an understanding of their surface anticorrosion mechanism at the atomic level is desirable by using two-dimensional (2D) noble-metal coordination polymer (CP) as an ideal model for their interfacial region. With the protection of 2-thiobenzimidazole (TBI), we isolated two Ag-based 2D CPs, {Ag (TBI) X } (S-X, where S denotes sheet and X=Cl or Br).

A Pathogenic Missense Variant (c.1617G>A, p.Met539Ile) in Causing Infantile X-Linked Spinal Muscular Atrophy (SMAX2).

Infantile X-linked spinal muscular atrophy (SMAX2) is a rare type of spinal muscular atrophy associated with variants. Clinical imaging and neurophysiological tests were performed on a Chinese patient with SMAX2. Further, focused panel sequencing of was carried out on samples of both the proband and his maternal relatives.

Clinical Characteristics and Outcomes of Pediatric Cerebral Venous Sinus Thrombosis: An Analysis of 30 Cases in China.

Cerebral venous sinus thrombosis (CVST) in children is rare in a clinical setting. The aim of this study was to summarize the etiological, clinical, and imaging characteristics of CVST in children. We retrospectively analyzed the data of 30 patients with a diagnosis of CVST who were admitted to Children's Hospital of Fudan University from 2008 to 2018.

[Optimal design by customized plate on reconstruction of maxillary unilateral defect via free fibula flap].

Purpose: To optimize reconstruction of maxillary unilateral defect by free fibula flap rapidly through 3D printing technique.

Methods: 3D models of reconstruction of unilateral maxillary defect by free fibula flap was established via CAD/CAM, metal customized plates and resin osteotomy guides were designed and manufactured via 3D printing technique, simulating operation was performed on models in vitro, and reconstructive accuracy after surgical simulation was analyzed using SPSS 18.0 software package.

Prospective study of the efficacy of a ketogenic diet in 20 patients with Dravet syndrome.

Purpose: We evaluated the efficacy and tolerability of the ketogenic diet (KD) on generalised convulsions and status epilepticus (SE) in patients with Dravet syndrome (DS).

Methods: Patients with DS having ≥2 generalised convulsions/month despite drug treatment were included in this study and placed on a KD for 6 months. From 3 months before (baseline) to 6 months after KD initiation, caregivers recorded patients' seizure activity, antiepileptic drug use, and adverse events.

Quality of Life in Patients After Maxillectomy and Placement of Prosthetic Obturator.

Purpose: The aim of this study was to assess quality of life (QoL) and obturator functioning in patients having undergone a maxillectomy as a tumor ablative resection and rehabilitation with a prosthetic obturator.

Materials And Methods: The University of Washington Quality of Life scale version 4 (UW-QoLv4) and the Obturator Functioning Scale (OFS) were used to evaluate the self-reported QoL and obturator functioning. The effects of demographic and treatment variables on QoL were assessed using age, defect size, postoperative radiotherapy (RT), neck dissection, and dentition.

[Treatments of stage-Is testicular mixed germ cell tumors: A report of 3 cases].

Objective: To investigate different treatment methods for stage-Is testicular mixed germ cell tumors (TMGCTs).

Methods: We retrospectively analyzed the clinical data about 3'cases of stage-Is TMGCTs (aged 26-39 years) treated in the 175th Hospital of PLA, reviewed relevant literature, and explored the clinical characteristics of TMGCTs.

Results: Of the 3 patients, 1 was treated by radical orchiectomy, 1 by radical orchiectomy + retroperitoneal lymph node dissection + BEP chemotherapy scheme, and the other by radical orchiectomy + radiotherapy.

Six-month efficacy of the Ketogenic diet is predicted after 3 months and is unrelated to clinical variables.

Objective: The aim of this study was to evaluate the 6-month efficacy of a Ketogenic diet (KD) in children with drug-resistant epilepsy and to analyze the associated factors that affect the efficacy of a KD.

Methods: Eighty-seven pediatric patients with drug-resistant epilepsy who followed a KD for at least 6 months were included in this study. The efficacy of a KD was assessed based upon the seizure frequency, as recorded by parents and caregivers.

CHD2 myoclonic encephalopathy is frequently associated with self-induced seizures.

Objective: To delineate the phenotype of early childhood epileptic encephalopathy due to de novo mutations of CHD2, which encodes the chromodomain helicase DNA binding protein 2.

Methods: We analyzed the medical history, MRI, and video-EEG recordings of 9 individuals with de novo CHD2 mutations and one with a de novo 15q26 deletion encompassing CHD2.

Results: Seizures began at a mean of 26 months (12-42) with myoclonic seizures in all 10 cases.

Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma.

The purpose of this study was to investigate the potential of the blood levels of MIR-21 and PTEN as novel biomarkers for oral squamous cell carcinoma (OSCC). We initially detected MIR-21 and PTEN using real-time RT-PCR from 90 blood samples and then compared their results with expression in cancer tissues from 10 OSCC patients. Finally, we examined the relationship between these markers and clinical parameters.

Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis.

Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Here, we evaluated the expression of cold-inducible RNA-binding protein (CIRP) and toll-like receptors 4 (TLR4) in OSCC tissues with immunohistochemistry. Using biostatistical methods designed to assess the impact of the expression of CIRP and TLR4 on the prognosis of patients with OSCC and relate that expression to the clinicopathological characteristics of these patients.

Bcl-2 increases stroke-induced striatal neurogenesis in adult brains by inhibiting BMP-4 function via activation of β-catenin signaling.

Our previous experiments suggest that treatment with Bcl-2 increases proliferation and differentiation of neuronal progenitors induced by ischemic injury and ameliorates neurological functional deficits after stroke. However, in addition to its traditional anti-apoptotic effect, little is known about the concrete molecular modulation mechanism. In this study, Bcl-2-expressing plasmids were injected into the lateral ventricle of rat brains immediately following a 30-min occlusion of the middle cerebral artery to determine the role of Bcl-2 in adult neurogenesis.

Caspase inhibition attenuates accumulation of beta-amyloid by reducing beta-secretase production and activity in rat brains after stroke.

In this study, we tested if caspase-3 inhibition decreased ischemia-induced Abeta elevation by reducing beta-secretase (BACE1) activity. Changes in caspase-3, Abeta and BACE1 levels were detected in rat striatum on different days after middle cerebral artery occlusion using immunostaining. We found that the positive labeled cells of activated caspase-3, Abeta, and BACE1 were significantly and time-dependently increased in the ipsilateral striatum.

Beta-catenin siRNA inhibits ischemia-induced striatal neurogenesis in adult rat brain following a transient middle cerebral artery occlusion.

Beta-catenin, a protein that functions in both cell adhesion and Wnt signaling, plays vital roles in mammalian neural development. To investigate the roles of beta-catenin in stroke-induced neurogenesis, we injected beta-catenin siRNA into ipsilateral ischemic lateral ventricle. We found that inactivation of beta-catenin by siRNA caused the decline of beta-catenin in the ischemic striatum, enlarged stroke-induced infarct volume, reduced SVZ expansion, and inhibited striatal neurogenesis in adult rat brain following a transient middle cerebral artery occlusion (tMCAO).