Discovery of 8-hydroxy-tetrahydroquinoline ferroptosis inhibitors for the treatment of acute kidney injury.

Acute kidney injury (AKI) is a severe public health challenge, characterized by high incidence and mortality rates, alongside a lack of effective therapeutic interventions. Emerging evidence highlights kidney tubular ferroptosis as a key driver of AKI pathogenesis. While α-tocopherol, a natural lipid antioxidant, exhibits potent anti-ferroptotic activity, its therapeutic potential remains limited by a lack of structural optimization.

Multipath Bromine Capture by a Metal-Organic Framework and Its Applications.

Bromine and its compounds are of great importance in industrial and agricultural processes. Developing new methods for capturing and separating elemental bromine from brine or seawater is attractive and challenging. Here, we demonstrated that a highly stable Cd-MOF allows for reversible bromine uptake from either vapor or a brine phase at ambient temperature.

Rational screening of covalent organic frameworks for solid-phase microextraction of advanced glycation end products from thermally processed foods.

Advanced glycation end products (AGEs) are increased by thermal processing in foods, raising the risk of chronic diseases. To efficiently monitor AGEs, density functional theory (DFT) was applied for predicting and screening the suitable adsorbent before synthesis. The binding energies between ten COFs and two representative AGEs were calculated.

Au-Acyclic Diaminocarbene-Linked Porphyrin Covalent Organic Framework as a Cascade Catalyst for Photocatalytic Sulfide Oxidation and Intermolecular Nucleophilic Addition.

The design and synthesis of a multifunctional covalent organic framework (COF) for various applications have been considered a big challenge. Herein, we report the construction of a novel porphyrin-based Au-acyclic diaminocarbene (Au-ADC)-linked COF (abbreviated as ) via a metal-mediated nucleophilic addition reaction. The resultant multifunctional revealed an outstanding performance in a cascade catalyzing photocatalytic sulfide oxidation under visible-light irradiation and intermolecular nucleophilic addition.

Influence of Environmental Antecedents on Joint Developmental Trajectories of Self-esteem and Depression in Childhood.

Self-esteem and depression are variable and interrelated in children. However, it is unknown how they co-develop in the general child population and how their patterns of co-development may be related to environmental antecedents. The current study utilized a longitudinal dataset of 544 Chinese children ages 9-13 years to: (a) identify longitudinal associations and joint developmental trajectories of self-esteem and depression problems by CLPM, RI-CLPM, and parallel-process growth mixture models, and (b) investigate early environmental antecedents that might explain differentiated co-developmental patterns.

Large-pore covalent organic framework as solid phase extraction absorbentforefficientdetermination of polypeptide antibiotics in animal-derived foods.

The precise determination of polypeptide antibiotics (PPTs) in foods has been always challenging because of the interference of various endogenous peptides in complex matrix. Herin, a novel large-pore covalent organic framework (TABPT-SPDA-COF) with accessible pore size of 7.9 nm was synthesized as a solid phase extraction (SPE) absorbent for efficiently enriching four PPTs existed in foods originating from animals.

A new multifunctional phenanthroline-derived probe for colorimetric sensing of Fe2+ and fluorometric sensing of Zn2.

A new phenanthroline derivative bearing imidazole group, (2-(3,5-di(pyridin-4-yl)phenyl)-1-p-tolyl-1H-imidazo[4,5-f][1,10]phenanthroline) (1), has been devised. 1 can be used as a multifunctional probe exhibiting a highly sensitive colorimetric response to Fe2+ and a selectively ratiometric fluorescent response to Zn2+ in a buffer-ethanol solution. The absorption enhancement accompanied by a visual color change from colorless to red upon addition of Fe2+, makes 1 a suitable naked-eye sensor for Fe2+.

Discovery of Novel -Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activities.

The concept of ferroptosis inhibition has gained growing recognition as a promising therapeutic strategy for addressing a wide range of diseases. Here, we present the discovery of four series of -aminophenol derivatives as potential ferroptosis inhibitors beginning with the endogenous substance 3-hydroxyanthranilic acid (3-HA) by employing quantum chemistry techniques, in vitro and in vivo assays. Our findings reveal that these -aminophenol derivatives exhibit unique intra-H bond interactions, compelling -amines to achieve enhanced alignment with the aromatic π-system, thereby expanding their activity.

Design, synthesis, and biological evaluation of 2-amino-6-methyl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities.

The suppression of ferroptosis is emerging as a promising therapeutic strategy for effectively treating a wide range of diseases, including neurodegenerative disorders, organ ischemia-reperfusion injury, and inflammatory conditions. However, the clinical utility of ferroptosis inhibitors is significantly impeded by the limited availability of rational drug designs. In our previous study, we successfully unraveled the efficacy of ferrostatin-1 (Fer-1) attributed to the synergistic effect of its ortho-diamine (-NH) moiety.

Structural Change and Radical Generation of a Cadmium-Based Metal-Organic Framework Induced by an Electric Field.

Herein we report the structural change and radical generation of a cadmium-based metal-organic framework (Cd-MOF) induced by external electric fields. Under a weaker single electric field, different coordination modes of Cd-L lead to 3D → 2D structural change. Under stronger superposed electric fields, Cd-MOF was excited to produce a stable free radical.

Online risky behavior and sleep quality among Chinese college students: The chain mediating role of rumination and anxiety.

This study explored the chain mediating effects of rumination and anxiety in the relationship between online risky behavior and sleep quality among Chinese college students. A sample of 1039 Chinese college students (Mage = 19.49, SD = 1.

Monolayer Nanosheets Exfoliated from Cage-Based Cationic Metal-Organic Frameworks.

The rational design and preparation of monolayer metal-organic framework (MOF) nanosheets remain great challenges. Recently, we found that monolayer MOF nanosheets can be facially exfoliated on a large scale from pristine two-dimensional (2D) MOFs with substantially reduced interlaminar interaction. By employing cage-like bicyclocalix[2]arene[2]triazine tri-imidazole as the building block, a family of cationic two-dimensional metal-organic frameworks (2D MOFs) with steric layer were designed and prepared.

Cu-Based Conductive MOF Grown on Cu Foam as a Highly Selective and Stable Non-Enzymatic Glucose Sensor.

A non-enzymatic electrochemical sensor for glucose detection is executed by using a conductive metal-organic framework (MOF) Cu-MOF, which is built from the 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) ligand and copper acetate by hydrothermal reaction. The Cu-MOF demonstrates superior electrocatalytic activity for glucose oxidation under alkaline pH conditions. As an excellent non-enzymatic sensor, the Cu-MOF grown on Cu foam (Cu-MOF/CF) displays an ultra-low detection limit of 0.

Cd-MOF: specific adsorption selectivity for linear alkyne (propyne, 2-butyne and phenylacetylene) molecules.

The selective adsorption of APPT-Cd-MOF 1 for propyne, 2-butyne and phenylacetylene was confirmed by single-crystal analysis. In addition, the selective adsorption performance of Cd-MOF for CH/CH/CH was investigated. The matching of the functionality and size/shape between porous materials and guest molecules clarified the specific recognition of 1 for linear alkyne molecules.

A metal-organic cage-based nanoagent for enhanced photodynamic antitumor therapy.

Herein, we report, for the first time, a Pd6L8(NO3)5.4(ICG)6.6 (ICG = indocyanine green) cage-based hexagonal nanoplate (3) via a combined nanoprecipitation and solid-state anion-exchange approach.

Association between blood urea nitrogen and incidence of type 2 diabetes mellitus in a Chinese population: a cohort study.

To examine the association between blood urea nitrogen (BUN) and risk of type 2 diabetes (T2DM) among Chinese adults, we performed an ongoing cohort study of 38578 Chinese adults (56.3% males; average age, 41.6 y) who underwent repeated health check-up examinations between 2009 and 2016 and without T2DM at baseline.

Structural Diversity in Oxadiazole-Containing Silver Complexes Dependent on the Anions.

Two coordination polymers, namely [Ag2(L)(SO3CF3)(H2O)](SO3CF3)•CH2Cl2 (1) and [Ag5(L)4(H2O)2](SbF6)5•5THF (2), were obtained by reacting oxadiazole-containing tri-armed ligand 1,3,5-tri(2-methylthio-1,3,4-oxadiazole-5yl) ben-zene (L) and silver salts in CH2Cl2/THF medium. The two complexes crystallized in the tetragonal space group I41/a and orthorhombic space group Fdd2, respectively. The Single-crystal X-ray diffraction revealed that the two complexes ex-hibit strikingly different 3D polymeric structures, which can be ascribed to the different counter anions.

Syntheses and structures of three macrocyclic supramolecular complexes and one Zn-containing coordination polymer generated from a semi-rigid multidentate N-containing ligand.

Semirigid organic ligands can adopt different conformations to construct coordination polymers with more diverse structures when compared to those constructed from rigid ligands. A new asymmetric semirigid organic ligand, 4-{2-[(pyridin-3-yl)methyl]-2H-tetrazol-5-yl}pyridine (L), has been prepared and used to synthesize three bimetallic macrocyclic complexes and one coordination polymer, namely, bis(μ-4-{2-[(pyridin-3-yl)methyl]-2H-tetrazol-5-yl}pyridine)bis[dichloridozinc(II)] dichloromethane disolvate, [ZnCl(CHN)]·2CHCl, (I), the analogous chloroform monosolvate, [ZnCl(CHN)]·CHCl, (II), bis(μ-4-{2-[(pyridin-3-yl)methyl]-2H-tetrazol-5-yl}pyridine)bis[diiodidozinc(II)] dichloromethane disolvate, [ZnI(CHN)]·2CHCl, (III), and catena-poly[[[diiodidozinc(II)]-μ-4-{2-[(pyridin-3-yl)methyl]-2H-tetrazol-5-yl}pyridine] chloroform monosolvate], {[ZnI(CHN)]·CHCl}, (IV), by solution reaction with ZnX (X = Cl and I) in a CHCl/CHOH or CHCl/CHOH mixed solvent system at room temperature. Complex (I) is isomorphic with complex (III) and has a bimetallic ring possessing similar coordination environments for both of the Zn cations.

Synthesis of fulvene-containing boron complexes with aggregation-induced emission and mechanochromic luminescence.

Two donor-acceptor motif fulvene-containing boron complexes were synthesized with fulvene diketonate boron difluoride (FDB) as the organic acceptor. Both difluoroboron complexes present aggregation-induced emission (AIE) properties and cell tracing function with excellent biocompatibility. And mechanochromic luminescence has been accomplished by the synthesis, isolation and characterization of BL2.

1,2,4-Triazolato paddlewheel dibismuth complexes with very short Bi(II)-Bi(II) bonds: bismuth(III) oxidation of 1,2,4-triazolato anions into neutral -1,2,4-triazolyl radicals.

Bismuth(iii) oxidation of 3,5-di-substituted-1,2,4-triazolato anions afforded a paddlewheel 1,2,4-triazolato dibismuth complex [L2(Bi-Bi)L2] (L = η1,η1-3,5-R2tz, R = Ph (3), iPr (4)) with very short Bi(ii)-Bi(ii) bonds (2.8650(4)-2.8721(3) Å).

Photochromic Rhenium-Based Molecular Rectangles: Syntheses, Structures, Photophysical Properties, and Electrochemistry.

Two novel -Re(CO)-based rectangles {[(CO)Re(μ-Cl)Re(CO)](μ-L)} () and {[(CO)Re(μ-OCH)Re(CO)](μ-L)}() based on new photochromic dithienylethene-containing ligand 2,7-di(pyridin-4-yl)-9,10-bis(5-chloro-2-methylthien-3-yl)-phenanthrene () were prepared. They displayed varying photochromic properties both in solution and in the single-crystal state. Through a judicious choice of the bridging ligands along the short sides of the rectangles, the photophysical and electrochemical properties of the complexes could also be readily tuned.

Design of GeSn-on-Si waveguide photodetectors featuring high-speed high-sensitivity photodetection in the C- to U-bands.

We present the design of -on-Si waveguide photodetectors for the applications in the C- to U-bands. The GeSn photodetectors have been studied in respect to responsivity, dark current, and bandwidth, with light butt- or evanescent-coupled from an Si waveguide. With the introduction of 4.

Syntheses of four porous 3-D Cd(ii) metal-organic frameworks from a new multidentate ligand 5-(imidazol-1-yl)--(pyridin-4-ylmethylene) nicotinohydrazide and their characterization and adsorption properties.

Herein, a new multidentate ligand, 5-(imidazol-1-yl)-(pyridin-4-ylmethylene) nicotinohydrazide (L), with an acylhydrazone group was synthesized and characterized. Subsequently, four porous Cd(ii)-MOFs, [Cd(L)(NO)] (1), [Cd(L)Cl] (2), [Cd(L)Br] (3), and [Cd(L)I] (4), were assembled using the ligand L by a solvothermal method and characterized by single-crystal X-ray diffraction, infrared spectroscopy, thermogravimetric analysis, and powder X-ray diffraction. Structural analysis shows that the coordination environments around Cd(ii) in all the four compounds are different due to the different coordinated anions.

Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study.

Introduction: Brachial-ankle pulse wave velocity (ba-PWV), as a simple and easily measured marker of arterial stiffness, has not been prospectively explored for its role in type 2 diabetes mellitus (T2DM) risk among the general population. This study aimed to explore the association between baseline ba-PWV value and new-onset T2DM among Chinese adults.

Research Design And Methods: Using data from Xiaotangshan Hospital, we conducted a prospective cohort study among those who underwent annual or biennial health check-up examinations and who had their ba-PWV measured from 2009 to 2016.

Syntheses and structures of two novel fluorescent metal-organic frameworks generated from a tridentate donor-acceptor motif ligand.

The tridentate organic ligand 4,4',4''-(4,4,8,8,12,12-hexamethyl-8,12-dihydro-4H-benzo[9,1]quinolizino[3,4,5,6,7-defg]acridine-2,6,10-triyl)tribenzoic acid (HL) has been synthesized (as the methanol 1.25-solvate, CHNO·1.25CHOH).