Aberrant histone acetylation and dysregulated synaptic plasticity in cognitive impairment induced by a high-methionine diet.

Cognitive impairment is a complex neurodegenerative disorder, and increased homocysteine levels are recognized as a major risk factor for this condition. Epigenetic modifications, particularly histone acetylation, have been implicated in the progression of cognitive impairment; however, the mechanisms underlying hyperhomocysteinemia-induced cognitive impairment remain unclear. In this study, we developed an hyperhomocysteinemia-induced cognitive impairment model by feeding mice a high-methionine diet and conducted behavioral and molecular analyses to elucidate the mechanisms involved in cognitive impairment.

A Dynamic Multi-Scale Hypergraph Learning Framework Driven by Features and Structures for ceRNA-Disease Association Prediction.

Competitive endogenous RNA (ceRNA) networks are pivotal for uncovering disease molecular mechanisms. Graph representation learning is a cornerstone for modeling biological regulatory networks and predicting disease-related biomarkers. However, current methods face challenges: traditional graph neural network (GNN) rely on low-order graph structures, which struggle to capture highorder molecular interactions, resulting in topological information loss; shallow GNN fail to model long-range dependencies, while deep architectures suffer from oversmoothing, limiting complex regulatory expression; static embeddings overlook dynamic molecular interactions, reducing biomarker accuracy.

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5.

Okanin is a natural product with few known biological activities. Its anti-cancer effects and the underlying mechanisms are investigated. It is found that okanin inhibits cancer cell growth (25-50 µm) with minimal effects on non-cancerous colorectal cells except at much higher doses (i.

Tuning of excitation wavelength to achieve dual-channel detection of Cr(VI) by cellulose-based carbonized polymer dots.

Carbonized polymer dots (CPDs), a new nanofluorescent materials inheriting the advantages of CDs, have been widely studied for their excellent physicochemical stability and tunable fluorescence properties, and have extensive application in the fields of optoelectronic devices and environmental monitoring. In this study, nitrogen-doped CPDs (CMC-M-CPDs) were synthesized via hydrothermal reaction using carboxymethyl cellulose (CMC) and melamine (M), which allowed N doping to improve the luminescence of CPDs through cross-linking and reduction of the energy gap. Due to the excitation-dependent, the luminescence wavelength of CPDs can be tuned, so these CPDs exhibit two optimal emission centers in the fluorescence spectra, which originate from the carbon core and the surface, respectively.

Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Polysaccharide in the Treatment of Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a chronic, systemic, and progressive autoimmune-inflammatory disease primarily affecting small joints. polysaccharide (IOP) is the main component of the parasitic fungus obliquus, which has anti-tumor, anti-inflammatory, and antioxidant effects. However, whether IOP has a therapeutic effect on RA is still unclear.

Ultrasound-Assisted Enhancement of Gel Properties in Surimi.

Surimi gel quality is crucial for seafood product texture and water retention, yet conventional processing often fails to maximize the potential of underutilized species like . This study investigated the effects of ultrasonic power (100, 200, 400, 800 W) and time (5, 10, 15, and 20 min) on gel properties to establish optimal processing conditions. Results demonstrated that moderate ultrasonic treatment (200 W, 10 min) significantly enhanced gel quality, yielding a dense, uniform network with improved ( < 0.

Bioinspired Twisted Artificial Muscles with Enhanced Performance for Underwater Applications.

Twisted artificial muscles (TAMs) demonstrate great promise in robotic applications involving locomotion and manipulation. However, their functionality in underwater environments remains challenging due to limitations in deformation, output force, and heat dissipation especially for thermally driven TAMs. To address these challenges, a novel TAM configuration inspired by the twining structures of climbing plants that consists of braided and pre-twisted fiber bundles is proposed.

[Clinical Characteristics and Prognosis of 7 Patients with T-Cell Large Granular Lymphocytic Leukemia].

Objective: To analyze the clinical characteristics and prognosis of patients with T-cell large granular lymphocytic leukemia (T-LGLL).

Methods: The clinical data of 7 patients with T-LGLL in Gansu Provincial Hospital from March 2016 to June 2023 were analyzed retrospectively.

Results: Among the 7 patients, 5 were male and 2 were female, with a median age of 51(28-83) years old.

Mechanism of Ginsenosides in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking.

Diabetes mellitus (DM) is a multifactorial metabolic disorder characterized by chronic hyperglycemia and systemic metabolic dysregulation. Although ginsenosides, the primary bioactive components of Meyer, exhibit regulatory effects on glucose and lipid metabolism, their precise mechanisms and key targets in DM remain incompletely understood. Unlike previous studies focusing solely on crude extracts or individual ginsenosides, this study integrates network pharmacology, molecular docking, and molecular dynamics (MD) simulations to systematically elucidate the multi-target mechanisms of ginsenosides, with experimental validation using the ginsenoside derivative AD-1.

Assessing the impact of common pain medications on gut microbiota composition and metabolites: insights from a Mendelian randomization study.

The relationship between analgesic use and gut microbiota alterations has garnered increasing attention. However, the causal link between these two factors remains to be elucidated. Given the prevalence of analgesic use and the significant role of gut microbiota in human health, clarifying this relationship is of great importance.

Spinal cord infarction following neurointerventional procedures in the posterior cerebral circulation: a case analysis and systematic literature review.

Background: Spinal cord infarction, though rare, represents a severe complication of neurointerventional procedures involving the posterior vertebrobasilar circulation.

Methods: We report the case of a 49-year-old male with acute basilar artery occlusion treated with staged endovascular therapy. Initial thrombectomy and balloon angioplasty successfully restored basilar artery flow.

Rapid detection of avipoxvirus using a fluorescent probe-based multienzyme isothermal amplification assay.

Avipoxvirus (APV) is a prevalent DNA virus in avian species, causing clinical symptoms of fowlpox and leading to reduced egg production, slower broiler growth, and increased mortality. The spread of APV poses a significant threat to the global poultry industry, potentially causing substantial economic losses. Effective control of APV, particularly its major species such as fowlpoxvirus and pigeonpoxvirus, requires the development of rapid and specific diagnostic tools.

Lipid metabolism in health and disease: Mechanistic and therapeutic insights for Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons and the accumulation of Lewy bodies, leading to motor and nonmotor symptoms. While both genetic and environmental factors contribute to PD, recent studies highlight the crucial role of lipid metabolism disturbances in disease progression. Altered lipid homeostasis promotes protein aggregation and oxidative stress, with significant changes in lipid classes such as sphingolipids and glycerolipids observed in patients with PD.

Efficient Beamforming Based on High-Transmittance Conformal Metasurface Fed by Slot-Coupled Patch Antenna Array.

We propose a beamforming method based on curved conformal metasurfaces fed by a slot-coupled patch antenna array. This conformal metasurface comprises five distinct planar metasurface subarrays and their corresponding feed array antennas, which are deployed on a cylindrical surface with a central angle of 60°. The feed array antenna, operating at 25 GHz, is designed based on the architecture of T-junction power dividers and slot-coupled patches, and this antenna is used as the feed for the metasurface subarray.

Insight into Cys and its derivatives metabolism in living system with 3D-printed portable smartphone platform via multifunctional fluorescent probe.

Cysteine (Cys) is a crucial biological thiol that facilitates broad range of biological circumstances and health conditions. Especially the aberrant Cys level in human serum is an independent risk factor for cardiovascular diseases. What more, Cys metabolism (Cys to SO) is typically connected with illnesses such as lung cancer, and are recognized as biomarker.

Atrial remodelling and atrial fibrillation self-sustaining: the role of circulating circDGCR8.

Aims: The prediction of atrial fibrillation (AF) progression and post-ablation recurrence is currently based on empirical estimates, leading to suboptimal predictive accuracy. This study investigates whether atrial remodelling, a key factor in the severity of atrial cardiomyopathy, could serve as a shared substrate influencing both AF progression and recurrence. We aimed to identify circular RNAs (circRNAs) associated with atrial remodelling and to evaluate their ability to predict AF progression and recurrence.

[The Significance of Bone Marrow Plasma Cell Percentage and Immature Plasma Cells in the Prognosis of Newly Diagnosed Multiple Myeloma Patients].

Objective: To explore the significance of the plasma cell percentage and immature plasma cells in the prognosis of patients with multiple myeloma (MM).

Methods: The clinical data of 126 newly diagnosed MM patients in Gansu Provincial Hospital from June 2017 to November 2022 were retrospectively analyzed. The enrolled patients were divided into a higher plasma cell percentage group (group A) and a lower plasma cell percentage group (group B) according to the median plasma cell percentage (33.

[Clinical Characteristics and Prognosis of Patients with IgD Multiple Myeloma].

Objective: To investigate the clinical characteristics and prognosis of patients with IgD multiple myeloma (MM).

Methods: The clinical data of 8 patients with IgD MM admitted to Gansu Provincial Hospital from September 2013 to February 2023 were collected, and their clinical characteristics and prognosis were retrospectively analyzed and summarized.

Results: Among the 8 enrolled patients, there were 4 males and 4 females, with a median age of 60 (44-74) years.

[Clinical Characteristics and Prognosis of Primary Pulmonary Lymphoma].

Objective: To investigate the clinical characteristics and prognosis of primary pulmonary lymphoma (PPL).

Methods: The clinical data of 17 patients with PPL admitted to Gansu Provincial Hospital from January 2013 to June 2023 were collected, and their clinical characteristics and prognosis were retrospectively analyzed and summarized.

Results: The median age of the 17 patients was 56 (29-73) years old.

In vitro expression of the goose astrovirus Cap protein delivered with a duck enteritis virus vector.

Background: Goose astrovirus (GAstV) is an emerging pathogen that is widely distributed throughout China and can cause visceral gout, resulting in serious economic losses for the goose industry. Open reading frame 2 (ORF2) of this virus encodes the precursor capsid protein, which is essential for the assembly and antigenicity of these virions. To construct a bi-valent vaccine for controlling GAstV and duck enteritis virus (DEV) infection, an infectious bacterial artificial chromosome (BAC) clone of the DEV vaccine strain pDEV-EF1 was used to establish a recombinant DEV vector for GAstV ORF2 gene delivery.

spores displaying GRA12 induce immunity against acute toxoplasmosis.

Background: () is a widely prevalent intracellular parasite that infects almost all warm-blooded animals and causes serious public health problems. The drugs currently used to treat toxoplasmosis have the disadvantage of being toxic and prone to the development of resistance, and the only licensed vaccine entails a risk of virulence restoration. The development of a safe and effective vaccine against is urgently needed.

Evidence for evolution of a new sex chromosome within the haploid-dominant Marchantiales plant lineage.

Sex chromosomes have evolved independently in numerous lineages across the Tree of Life, in both diploid-dominant species, including many animals and plants, and the less studied haploid-dominant plants and algae. Strict genetic sex determination ensures that individuals reproduce by outcrossing. However, species with separate sexes (termed dioecy in diploid plants, and dioicy in haploid plants) may sometimes evolve different sex systems, and become monoicous, with the ability to self-fertilize.

Artificial intelligent recognition for multiple supernumerary teeth in periapical radiographs based on faster R-CNN and YOLOv8.

Objectives: The aim of this study was to compare the effectiveness of automated supernumerary tooth (ST) detection systems on periapical radiographs using Faster R-CNN and YOLOv8 with detection by 8 dental residents.

Methods: This was a diagnostic accuracy study of 469 periapical radiographs (419 training vs. 50 test datasets).

Endovascular Therapy for Progressive Stroke due to Intracranial Atherosclerotic Large Vessel Occlusion Beyond the 24-Hour Time Window: A Single-Center Retrospective Cohort Study.

Background: The optimal management for treating progressive strokes caused by anterior circulation intracranial atherosclerotic large vessel occlusion (ICAS-LVO) remains unclear.

Methods: A retrospective analysis was conducted on our stroke database. Among the patients presenting with mild ischemic stroke (National Institutes of Health Stroke Scale ≤5), 273 were diagnosed with anterior circulation ICAS-LVO.