A real-world pharmacovigilance study of FDA Adverse Event Reporting System events for gefitinib and docetaxel.

Background: In recent years, gefitinib and docetaxel, as targeted and chemotherapeutic agents, respectively, have been widely used in the treatment of non-small cell lung cancer (NSCLC). However, the safety of these drugs remains a significant concern in clinical practice. Comparative studies on the safety of these two drugs have yet to be fully explored.

Adaptation and analysis of the psychometric properties of the Chinese version of the MARA questionnaire to assess breast cancer awareness.

Purpose: This study aimed to cross-culturally adapt the MARA-Chinese version questionnaire and test its psychometric properties among Chinese women.

Methods: This cross-cultural adaptation and validation study included three processes: cross-cultural adaptation, translation, and psychometric properties analysis. Original version of MARA was translated into Chinese.

Insights into efficient removal of cationic and anionic dyes by olive pomace adsorbent.

Olive pomace (OP) is a widely used agricultural by-product with the potential to promote a circular low-carbon bioeconomy. In this work, an environmentally friendly and low-cost olive pomace adsorbent (OPA) was obtained from olive pomace by drying, crushing, sieving and sterilizing, and confirmed to remove anionic and cationic dyes from wastewater. The present study investigated the impact of adsorbent dosage, dye concentration, contact time, temperature, and pH on the adsorption mechanism, providing a more comprehensive understanding of the adsorption mechanism.

The Whole Day Movement Matters to Executive Function Among College Students.

"The whole day movement matters to health." has become an important topic while the associations between executive function and different movement behaviors (i.e.

A Distinct Microporous Metal-Organic Framework with Multiple Accessible Adsorption Sites for Separation of CH/CO/CH Mixtures.

Acetylene (CH), as a crucial chemical feedstock, and its purification from multicomponent light hydrocarbon mixtures is industrially challenging. Herein, we used the 3-methyl-4-(4-1,2,4-triazol-4-yl) benzoic acid (HL) ligand and CoSO·7HO to assemble a novel metal-organic framework (MOF), [Co(L)(OH)(SO) (HO)]·DMA·4HO (), with porous channels decorated with accessible active sites including an open metal center, an uncoordinated carboxylate group, functional methyl groups, and sulfate anions. The adsorption capacities are 64.

[Roles of reactive oxygen species and lactate dehydrogenase isoenzyme X in changes of sperm mitochondrial membrane in patients with varicocele-induced infertility].

Objective: To explore the role of reactive oxygen species (ROS) and lactate dehydrogenase isoenzyme X (LDH-X) in the changes of sperm mitochondrial membrane potential (MMP) in infertility patients with varicocele (VC).

Methods: This study included 38 infertility patients with VC (VCinf), 35 non-VC infertile males (NVCinf), and 30 normal fertile men as controls. We obtained the routine semen parameters using the sperm quality analysis system, examined the contents of LDH-X in the seminal plasma and sperm with the automatic biochemical analyzer, measured the level of malondialdehyde (MDA) in seminal plasma by thiobarbituric acid (TBA) colorimetry, and determined the expressions of mitochondrial membrane potential (MMP) and LDH-X mRNA in the sperm using JC-1 fluorescence probe and RT-PCR.

Comparative transcriptomics of atrazine-tolerant and sensitive alfalfa varieties under atrazine stress.

Background: Alfalfa (Medicago sativa L.) is a vital forage crop with substantial economic and ecological significance in agriculture and animal husbandry. However, atrazine, a widely used herbicide, negatively impacts the growth and yield of alfalfa due to its residual presence in the environment.

Kinesin proteins HUG1 and HUG2 are essential for the formation and transportation of male germ units in Arabidopsis pollen tubes.

Flowering plants rely on double fertilization for their sexual reproduction. A pair of immotile sperm cells (SCs) are conveyed through a pollen tube into the female gametophyte, where they fertilize the egg cell and central cell to give rise to the embryo and endosperm in seeds, respectively. The SCs and the pollen vegetative nucleus (VN) move as a male germ unit (MGU) in pollen tubes.

Mapping the clinical topography and progression of venous thromboembolism in Chinese breast cancer surgical patients: a prospective longitudinal study.

Background: Venous thromboembolism (VTE) is a serious complication in breast cancer patients. However, limited attention has been given to its clinical characteristics and progression, particularly in Asian populations. Therefore, this study aimed to comprehensively investigate the clinical topography and progression of VTE in breast cancer patients using ultrasound in China.

Effect of Neoatherosclerosis and Intervention-Associated Neoatheroma Rupture on Clinical Outcomes in Patients With In-Stent Restenosis: A Retrospective Study.

Background And Aims: Treatment of drug-eluting stents (DES) in-stent restenosis (ISR) was challenging. Neoatherosclerosis (NA) occurs earlier and more frequently in DES-ISR. This study aims to analyze the effect of neoatheroma morphology and intervention-associated neoatheroma intima rupture on intervention strategies and clinical outcomes in patients with DES-ISR.

A novel method for generating baculovirus bacmids using EGFP-mediated purification and linearization.

Baculovirus bacmids have been widely used in over-expression and gene deletion. Traditionally, baculovirus bacmids are developed by inserting an 8.6 kbp bacterial DNA cassette into baculovirus genomes either through homologous recombination in cultured cells or via in vitro cloning.

New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma.

Aims: To investigate the shared genetic mechanisms between type 2 diabetes (T2D) and primary open-angle glaucoma (POAG). Using large-scale genome-wide association study (GWAS) data, we performed single nucleotide polymorphism (SNP) level analysis to detect pleiotropic variants and loci, paired eQTL mapping analysis and gene-level analysis to identify candidate pleiotropic genes. In addition, Mendelian randomisation (MR) analysis was performed to assess causal associations.

Mechanisms of BmSERCA-Mediated Cell Proliferation Through Ca Homeostasis Regulation.

Sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) plays a critical role in maintaining intracellular Ca homeostasis by transporting excess Ca into the endoplasmic reticulum (ER) calcium reservoir. Calcium is essential for regulating key biological processes in Bombyx mori, including development, metamorphosis, and reproduction. To explore the role of BmSERCA in the proliferation of the B.

New mechanistic understanding of FXR agonist Vonafexor: inducing sublethal damage of HBV-positive liver cancer cells via promoting anti-tumor immunity.

Background: In hepatitis B virus (HBV)-infected patients, there's an increase in exhausted T and NK cells, as well as myeloid-derived suppressor cells (MDSCs) in liver, suggesting that boosting immune responses is beneficial. While Vonafexor inhibits HBV transcriptional activity, its effects on the immune microenvironment of HBV-positive hepatocellular carcinoma (HCC) and the mechanisms of immune clearance of these infected cells are not well understood.

Methods: In this study, tumor tissues from HBV-positive HCC patients were orthotopically transplanted into the livers of Hu-SRC mice to replicate the tumor microenvironment of the patients.

Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy.

Conventional drug delivery methods for chronic disease often suffer from low potency and poor patient compliance, while current advanced devices face limitations because of bulkiness, frequent implantation needs, inflammation risk, and lack of precise control. To overcome these challenges, we developed the SUSTAIN-a smart, ultra-long-lasting, sequentially triggerable, and artfully implantable nozzle system. The SUSTAIN integrates an osmotic pressure-triggered module, an airflow-generated T-pipe (AGT), and a drug infusion pump (DIP) for controlled subcutaneous drug release.

Unusual malposition of peripherally inserted central catheters into the thymic vein and middle thyroid vein: A case series.

Rationale: Correct catheter tip placement is the foundation for catheter utilization and the prevention of catheter-related complications. We describe 2 unusual peripherally inserted central catheter (PICC) malpositions in the left thymic vein and the right middle thyroid vein, which are, to our knowledge, the first 2 cases of PICC malposition in these 2 veins.

Patient Concerns: Both patients had subtle clinical signs of catheter malposition on initial post-procedure chest X-ray radiography or during catheter duration.

α-Linolenic Acid-Rich Flaxseed Oil Improves Polycystic Ovary Syndrome via Regulating Lipid Metabolism by GPR120-cAMP Pathway and Restoring Gut Microecology.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects metabolic and reproductive health in women. α-Linolenic acid (ALA)-rich flaxseed oil as a dietary food has been suggested to offer potential therapeutic benefits in managing metabolic disturbances associated with PCOS. This study investigates the effects of ALA-rich flaxseed oil on lipid metabolism and gut microecology in a PCOS rat model.

Perivenous-enhanced cortical veins on contrast-enhanced black-blood MRI: a novel marker for blood-brain barrier disruption in ischemic stroke.

Purpose: To assess the feasibility of using perivenous-enhanced cortical veins (PECVs) visualized on contrast-enhanced black-blood MRI (CEBBI) for detecting and classifying blood-brain barrier disruption (BBBD) in patients with ischemic stroke.

Materials & Methods: This retrospective study included 168 hospitalized patients with acute, subacute, and chronic ischemic stroke who underwent pre- and post-CEBBI imaging. BBBD was classified into three groups based on the enhancement ratio (ER) of normal-appearing white matter (NAWM) before and after contrast administration, as well as leptomeningeal and parenchymal enhancement patterns on CEBBI: no BBBD (NoBBBD), subtle BBBD (SuBBBD), and significant BBBD (SiBBBD).

sp. nov., a copper-resistant bacterium isolated from soil contaminated with heavy metals in Chapala Basin, Mexico.

A polyphasic taxonomic study was carried out on the bacterial EZn1, isolated from heavy-metal-contaminated soil in the Chapala Basin, Mexico. This Gram-negative, aerobic, rod-shaped bacterium formed orange-pigmented colonies, producing the pigment flexirubin. Analysis of the 16S rRNA gene sequence revealed that EZn1 represents a member of the genus in the family and is closely related to GSE06 (98.

Deacetylation of nuclear AIF provides a braking mechanism for caspase-independent chromatinolysis and necrotic brain injury.

Programmed necrosis involves three consecutive stages: initiation, propagation, and execution. The initiation of necrosis has been widely studied, but due to the diversity and pleiotropy of the initiating pathways, it is difficult to identify ideal targets for necrosis inhibition from upstream necrosis pathways. Genetic evidence suggests that caspase-independent chromatinolysis, an execution process in multiple forms of necrosis, could be targeted to inhibit necrosis, but its regulatory mechanisms remain unclear.

Mechanism of Ca in regulating pupation defects of Bombyx mori after exposure to chlorantraniliprole.

Chlorantraniliprole (CAP) is a novel amide insecticide widely used in agriculture. Trace residues of CAP in the environment pose a threat to the development and metamorphosis of silkworm (Bombyx mori). However, the mechanisms by which CAP exposure disrupts insect metamorphosis remain poorly understood.

Growth promotion of synthetic microbial communities influenced by the function, diversity and interactions of their constituent strains and soil types.

The construction of efficient synthetic microbial communities (SMCs) is a major challenge for the scientific community. In this study, we constructed 15 SMCs with a diversity gradient of 1-4 by combining four strains with different functions, and investigated the effects of strain interactions, community diversity and in vitro functions on in vivo rice growth promotion in two soil types. The interactions between the 4 strains were tested using a modified dual culture plate assay.

Self-efficacy as a mediator in the relationship between clinical learning environment and core nursing competence of intern nursing students: a multicentre cross-sectional study.

Objective: The aim of this study was to examine the relationships between Chinese intern nursing students' self-efficacy, the clinical learning environment, and core nursing competence. In addition, self-efficacy was investigated as a mediator in the association between the clinical learning environment and core nursing competence.

Design: This study used a cross-sectional, descriptive research design.

Intratumoral Brevibacillus parabrevis enhances antitumor immunity by inhibiting NK cell ferroptosis in hepatocellular carcinoma.

It is known that intestinal flora affects the number and function of NK cells through metabolites, thereby regulating the response of tumors to chemotherapy or immunotherapy. However, little is known about whether intratumoral bacteria are involved in NK cell-mediated antitumor immunity. In this study, 2bRAD-M analysis was performed on patient hepatocellular carcinoma and paired tissues to determine the composition of the intratumoral microbiota.

Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period.

Background: Drought stress is a predominant abiotic factor contributing to reduced crop yields globally. Therefore, exploring the molecular mechanism of drought control is of great significance to improve drought resistance and ultimately achieve crop yield increase. As a plant endogenous hormone, melatonin plays a key role in the regulation of abiotic stress, but the key genes and metabolic pathways of melatonin mediated drought resistance regulation in alfalfa have not been fully revealed.