Granulomatous Mastitis with Erythema Nodosum and Erysipelas-like Lesions: Expanding the GMENA Syndrome.

Granulomatous mastitis (GM) is a rare, benign inflammatory breast condition that occasionally presents with systemic features such as erythema nodosum (EN) and arthritis, collectively termed GMENA syndrome. We report a unique case of a 32-year-old woman with GM, EN, and an erysipelas-like skin lesion (ELL) in the absence of arthritis. Despite antibiotic therapy, her condition deteriorated with persistent fever and elevated inflammatory markers.

Multi-omics data reveal that SAA1 + fibroblasts exacerbate periodontitis by regulating macrophage inflammation and chemotaxis.

Background: Traditional techniques are limited in their ability to analyze the complex interaction mechanisms among multiple cell types within the periodontal microenvironment, thereby restricting the development of targeted therapies for periodontitis (PD). Utilizing multiomics technologies to investigate the interaction networks of key cell clusters can systematically uncover regulatory mechanisms and identify critical therapeutic targets.

Methods: Through integrative analysis of single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and bulk transcriptome datasets from periodontal tissues, we systematically characterized the spatial architecture and intercellular communication networks within the inflammatory periodontal microenvironment, identifying a functionally serum amyloid A1 + fibroblasts (SAA1 + Fib) that critically drives disease progression.

Stabilization of OLFML1 via mA Reader IGF2BP3 Drives CSC Characteristics Through Hedgehog Pathway Activation in CRC.

Colorectal cancer (CRC) progression is closely associated with cancer stemness, which contributes to poor prognosis and therapeutic resistance. This study identifies OLFML1 as a key target accounting for CRC progression. High expression of OLFML1 promotes CRC cell proliferation and cancer stemness.

Dynamic Reconstruction of Pt Gradient Doping in High-Entropy Alloys for Efficient Hydrogen Production.

Hydrogen energy, as a zero-carbon energy carrier, urgently requires high-performance acidic hydrogen evolution reaction (HER) electrocatalysts. To address the challenges posed by costly Pt-based catalysts and the morphology-composition synergy in high-entropy alloys (HEAs), PtFeCoNiCuMn (x = 0-34 at%) HEAs are developed using a multicomponent synergy design principle. Through the synergistic regulation of atomic radius matching and reduction potential gradients, dynamic morphological evolution from nanosheets (amorphous) → nanosheet-nanoparticle heterostructures → single-phase nanospheres (2.

Three-dimensional printing in modern orthopedic trauma surgery: a comprehensive analysis of technical evolution and clinical translation.

Three-dimensional (3D) printing has emerged as a transformative technology in orthopedic trauma surgery, offering unprecedented possibilities for personalized surgical solutions. Despite its increasing adoption, there remains a lack of comprehensive reviews systematically evaluating its technical considerations and evidence-based outcomes across different anatomical regions. Through systematic review of literature from major databases and analysis of clinical evidence, this comprehensive review examines the current state of advanced 3D printing technologies in orthopedic trauma.

AI-Driven segmentation and morphogeometric profiling of epicardial adipose tissue in type 2 diabetes.

Background: Epicardial adipose tissue (EAT) is associated with cardiometabolic risk in type 2 diabetes (T2D), but its spatial distribution and structural alterations remain understudied. We aim to develop a shape-aware, AI-based method for automated segmentation and morphogeometric analysis of EAT in T2D.

Methods: A total of 90 participants (45 with T2D and 45 age-, sex-matched controls) underwent cardiac 3D Dixon MRI, enrolled between 2014 and 2018 as part of the sub-study of the Swedish SCAPIS cohort.

The Nuclear Transcription Factor Regulates the Protrusion of Tomato Fruit Tip.

NF-Y transcriptional regulators play crucial roles in diverse biological processes in plants, primarily through the formation of NF-Y complexes that bind to specific DNA motifs. These complexes modulate the expression of downstream genes, which influence plant development and growth. In our research, the function of the NF-Y family C subunit member gene in tomato was investigated with the CRISPR/Cas9 method.

Evaluating the importance of load and morphology to regional tibial strength.

Monitoring tibial bone strength is critical for assessing fatigue fracture risk. This study aimed to evaluate the contributions of morphological features, muscle forces, and ankle contact forces to tibial stress-strain distribution and to analyse the effect of feature quantity on tibial stress-strain prediction accuracy. Tibial cortical morphologies were described using a statistical shape model based on CT scans from 40 young males.

The diagnostic and prognostic role of novel biomarkers in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Background: ANCA-associated vasculitis (AAV) is a group of autoimmune diseases characterized by small vessel inflammation, diagnosed primarily through clinical features, histopathology, and ANCA testing. Novel biomarkers derived from routine blood counts, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), may support disease assessment. This study evaluated their utility in distinguishing AAV patients, reflecting disease activity, and predicting prognosis.

Early combined conbercept and dexamethasone implant therapy for diabetic macular edema.

Aim: This study evaluated the clinical effectiveness and safety of a combined dexamethasone implant (Ozurdex) with Conbercept injections for diabetic macular edema (DME).

Methods: A prospective case-control clinical trial was conducted on 46 DME patients. Patients were randomly assigned to either the combination group, receiving Conbercept injections followed by Ozurdex (24 patients) using a 2 + 1 + 1 + PRN protocol, or the monotherapy group, receiving only Conbercept injections (22 patients) following a 5 + PRN protocol.

Self-efficacy as a mediator in the relationship between clinical learning environment and core nursing competence of intern nursing students: a multicentre cross-sectional study.

Objective: The aim of this study was to examine the relationships between Chinese intern nursing students' self-efficacy, the clinical learning environment, and core nursing competence. In addition, self-efficacy was investigated as a mediator in the association between the clinical learning environment and core nursing competence.

Design: This study used a cross-sectional, descriptive research design.

Machine Learning Classification Based on Individual Whole-Brain Functional Connectivity in Male OSA Patients.

Purpose: Previous studies have shown altered paired brain functional connectivity (FC) in obstructive sleep apnea (OSA) patients, linked to cognitive impairment. This study utilized individual FC analysis to investigate the distinctive FC characteristics in OSA and evaluate their classification efficiency.

Methods: We included 82 moderate to severe OSA patients [41 OSA with normal cognition (OSA-NC), 41 OSA with mild cognitive impairments (OSA-MCI)] and 84 healthy control (HC).

Corrigendum: Early identification of macrophage activation syndrome in adult-onset Still's disease: a case report and literature review.

[This corrects the article DOI: 10.3389/fmed.2025.

Ramsdellite-MnO Regeneration via Acid-Mediated Redox Tuning toward Rechargeable Aqueous Zinc-Ion Batteries.

The mounting accumulation of spent alkaline batteries (SABs) elicits concerns over both environmental threats and the recycling industry's profitability, closely tied to the chemical reactions in manganese-based waste treatment. Herein, we design an acid-modulated phase-reconstruction strategy for sustainable recovery of manganese oxides from SABs, where moderate proton participation facilitates the preformation of MnOOH intermediates before the initial transformation to -MnO (RM- orthorhombic) and the final conversion to -MnO (RM-β tetragonal) nanomaterials. This rarely reported metastable RM- phase features a unique tunneled framework (1 × 2 edge-shared MnO octahedra) enabling reversible H/Zn (de)intercalation, though its traditional synthesis remains challenging due to thermodynamic instability.

An update on the role and mechanisms of periodontitis in cardiovascular diseases.

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Despite extensive studies into the causes and therapies for CVDs, their incidence and prevalence continue to increase. Periodontitis is a multifactorial, chronic inflammatory disease related to systemic health.

Cassane butenolides from the fruits of Caesalpinia pulcherrima.

Seven undescribed cassane diterpenes, caeslpulrins A-G (1, 3, 4, and 6-9), the C-12 ethoxy derivatives of caeslpulrins A and C (2 and 5), along with five artificial or known cassane diterpenes (10-14) and eight known sesquiterpenoids (15-22) were isolated from the fruits of Caesalpinia pulcherrima. Their structures were elucidated by extensive spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR, and electronic circular dichroism (ECD) calculations. Caeslpulrins A-F were identified as a group of rare cassane butenolides possessing a C-3 benzoyloxy unit.

Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway.

Periodontitis, a common dental illness, causes periodontal tissue inflammation and irreversible bone loss, inevitably resulting in tooth loss. Hyperhomocysteinaemia (HHcy), defined as blood total homocysteine (Hcy) levels greater than 15 µmol/L, is linked to increased cardiovascular disease risk. Mounting evidence indicates a connection between HHcy and periodontitis; however, the underlying processes remain unknown.

2-Methoxybenzoic acid ameliorates arterial thrombosis via inhibiting carbon anhydrase activity in platelet.

Background: 2-Methoxybenzoic acid (2MOA) is a natural compound with potential salicylate-like effects; however, its impact on arterial thrombosis remains unclear.

Objectives: This study aimed to investigate the effects of 2MOA on thrombogenesis and its underlying mechanisms.

Methods: FeCl-induced carotid artery injury and laser-induced cremaster artery injury thrombosis assays were used to explore the effect of 2MOA on thrombogenesis in vivo.

A Comparative Investigation on Clinical Characteristics in Pediatric Obstructive Sleep Apnea Based on Two Distinct Guidelines.

Objective: To investigate the differences in assessment of clinical characteristics between children with obstructive sleep apnea (OSA) diagnosed according to the 2007 and 2020 guidelines and those without OSA, together with the relationships between polysomnography (PSG) parameters and cognitive tests scores in preschool and school-aged children with OSA.

Methods: Eighty children were totally recruited and divided into OSA and non-OSA groups based on two distinct guidelines, with further subclassification into preschool and school-aged subgroups. Differences in PSG parameters and cognitive tests scores between groups and subgroups were analyzed and compared, followed by partial correlation analysis to determine the correlations between these characteristics.

Dual-enhancements of stability and wettability in O3-NaNiFeMnO cathodes by converting surface residual alkali into ultrathin NaTiO coatings.

Na-based layered transition metal oxides with an O3-type structure are considered as promising cathode materials for sodium-ion batteries (SIBs) due to their low cost, wide two-dimensional ion channels and high theoretical specific capacity. However, during storage, exposure to moisture and carbon dioxide in the air results in the formation of increased residual sodium compounds. This degradation exacerbates side reactions with the electrolyte and induces structural collapse, ultimately impairing their electrochemical performance.

Case report: Spontaneous renal hemorrhage in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic necrotizing vasculitis that predominantly affects small vessels. In this report, we present a typical case of granulomatosis with polyangiitis (GPA) complicated by spontaneous renal hemorrhage (SRH), a rare but potentially severe condition. The patient developed SRH during immunosuppressive therapy but recovered following conservative treatment.

Early identification of macrophage activation syndrome in adult-onset Still's disease: a case report and literature review.

Background: Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder characterized by high spiking fevers, evanescent rash, and polyarthritis. A serious complication of AOSD is macrophage activation syndrome (MAS), a life-threatening hyperinflammatory condition that can lead to multiorgan failure if not promptly diagnosed and treated.

Objective: This case report and literature review focus on the early identification of MAS in patients with AOSD, highlighting diagnostic challenges, differential diagnoses, and the utility of scoring systems like the HScore and MS score in clinical practice.

Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer's, and liver cancer.

Background: Nicastrin, a subunit of the γ-secretase complex, is encoded by the NCSTN gene and regulates notch signaling, it is involved in the pathogenesis of hidradenitis suppurativa (HS), Alzheimer disease (AD), and liver cancer. However, the animal models for studying HS are relatively scarce.

Methods: CRISPR/Cas-mediated genetic engineering was used to generate targeted knockout offspring mice (C57BL/6J).

Effect of morphology and cortical thickness variations on tibial strains in different movements.

Morphology and cortical thickness of tibia bone influence the strength and strain distribution of bone and also influence fatigue fracture risk. However, current studies have not extensively explored the effect of morphology and cortical thickness on tibial strain distribution during different activities. This study aims to assess the effect of tibial morphology and cortical thickness on tibial strain during six different sports movements.