Uniform spherical chiral polyrotaxanes with steerable circularly polarized luminescence.

Spherical chiral polyrotaxanes (CPRs) with steerable circularly polarized luminescence (CPL) are intriguing as advanced chiroptical materials but have not been reported to date. Here, we constructed spherical chiral polyrotaxane (CPR) materials with steerable CPL by utilizing cyclodextrins (α-, β-, or γ-CyD) as the chiral wheel. Importantly, the structure and the CPL performance of the CPR materials can be regulated by varying the feeding amount and the type of cyclodextrin (α-, β-, or γ-CyD).

Circ_Slc7a11 Aggravates Intestinal Mucosa Barrier Damage by Regulating SIRT1 Acetylation Through miR-624-5p.

SIRT1 plays a crucial role in the production of reactive oxygen species (ROS) and ischemia/reperfusion (I/R), yet the upstream mechanisms that directly regulate SIRT1 expression during intestinal I/R remain unclear. Recent studies have shown that noncoding RNAs, such as circular RNAs (circRNAs), are important players in physiological and pathological processes based on their multiple regulatory roles in gene expression. This study aimed to elucidate the role of SIRT1 in intestinal mucosa barrier damage and to investigate the regulation of SIRT1 by circRNA sponges.

Acoustic Metasurface for Space-time Reflection Manipulation.

Recently, space-time modulation has revolutionized the wave engineering technologies, providing unprecedented opportunities beyond traditional static systems. This advancement is crucial across diverse fields, ranging from non-reciprocal transmission to wireless communication. However, the current approaches to sound modulation require bulky artificial structures and are limited in achieving space-time-variable sound-matter interactions.

Thermophiles, Thick-Walled Bacteria, and Pseudomonads in High-Altitude Gut Microbiota.

Background And Aim: High-altitude environments are characterized by low oxygen and reduced low pressure, which impose significant physiological challenges on organisms. Among various adaptive systems, the intestinal flora plays a crucial role in maintaining gut health and barrier integrity function under such conditions. This study aimed to elucidate the regulatory mechanisms of intestinal flora in high-altitude environments, focusing on downregulating intracellular Bone Morphogenetic Protein 4 (BMP4) to influence glycolysis metabolism, thereby affecting intercellular communication of the intestinal mucosal barrier and matrix remodeling.

DreamComposer++: Empowering Diffusion Models with Multi-View Conditions for 3D Content Generation.

Recent advancements in leveraging pre-trained 2D diffusion models achieve the generation of high-quality novel views from a single in-the-wild image. However, existing works face challenges in producing controllable novel views due to the lack of information from multiple views. In this paper, we present DreamComposer++, a flexible and scalable framework designed to improve current view-aware diffusion models by incorporating multi-view conditions.

Enhanced mucosal immune response through nanoparticle delivery system based on chitosan-catechol and a recombinant antigen targeted towards M cells.

In mucosal vaccination, the targeted delivery of antigens through M (microfold) cells is essential for initiating a robust antigen-specific immune response. In the present study, we devised a nano-delivery platform to target M cells. This platform involved coating mesoporous silica nanoparticles (MSN) with a mucoadhesive chitosan-catechol (Chic) layer, incorporating a recombinant antigen to form nanoparticles that enhance the immune response.

Imidazole Cationic-Bridged Pillar[5]arene Polymer as a Recycle Adsorbent for Iodine Capture.

Developing efficient and recyclable iodine adsorbents is crucial for addressing radioactive iodine pollution. An imidazole cation-bridged pillar[5]arene polymer (P5-P5I) was synthesized via a salt formation reaction. P5-P5I exhibited a high iodine vapor capture capacity of 2130.

USP36 SUMOylates Las1L and Promotes Its Function in Pre-Ribosomal RNA ITS2 Processing.

Unlabelled: Ribosome biogenesis is a highly regulated cellular process requiring a large cohort of accessory factors to ensure the accurate production of ribosomes. Dysregulation of ribosome biogenesis is associated with the development of various human diseases, including cancer. The Las1L-Nol9 endonuclease-kinase complex is essential for the cleavage of the rRNA internal transcribed spacer 2 (ITS2), the phosphorylation of the 5'-hydroxyl end of the resulting precursor, and, thus, the maturation of the 60S ribosome.

Pathogen-Mimicking Nanoparticles Based on Rigid Nanomaterials as an Efficient Subunit Vaccine Delivery System for Intranasal Immunization.

Despite the safety profile of subunit vaccines, the inferior immunogenicity hinders their application in the nasal cavity. This study introduces a novel antigen delivery and adjuvant system utilizing mucoadhesive chitosan-catechol (Chic) on silica spiky nanoparticles (Ssp) to enhance immunity through multiple mechanisms. The Chic functionalizes the Ssp surface and incorporates with SARS-CoV-2 spike protein receptor-binding domain (RBD) and toll-like receptor (TLR)9 agonist unmethylated cytosine-guanine (CpG) motif, forming uniform virus-like nanoparticles (Ssp-Chic-RBD-CpG) via electrostatic and covalent interactions.

HIF-1α Pathway Orchestration by LCN2: A Key Player in Hypoxia-Mediated Colitis Exacerbation.

In this study, we investigated the role of hypoxia in the development of chronic inflammatory bowel disease (IBD), focusing on its impact on the HIF-1α signaling pathway through the upregulation of lipocalin 2 (LCN2). Using a murine model of colitis induced by sodium dextran sulfate (DSS) under hypoxic conditions, transcriptome sequencing revealed LCN2 as a key gene involved in hypoxia-mediated exacerbation of colitis. Bioinformatics analysis highlighted the involvement of crucial pathways, including HIF-1α and glycolysis, in the inflammatory process.

Water-Regulated Evolution of Inversion, Reinversion, and Amplification of Circularly Polarized Luminescence of Supramolecular Organogels Based on Glutamide-Cyanostilbene Amphiphile.

Water incorporated with supramolecular building blocks in organic solvents can play a key role in the circularly polarized luminescence (CPL) inversion and amplification of supramolecular assemblies. Herein, we demonstrate that fine-tuning the water content regulated the assembly structure evolution and made the circular dichroism and CPL sign of the system undergo intriguing inversion, reinversion, and amplification processes based on a unique and interesting glutamide-cyanostilbene system, as supported by morphology, spectroscopic observations, and time-dependent density functional theory calculation.

SUMOylation regulation of ribosome biogenesis: Emerging roles for USP36.

Ribosome biogenesis is essential for cell growth, proliferation, and animal development. Its deregulation leads to various human disorders such as ribosomopathies and cancer. Thus, tight regulation of ribosome biogenesis is crucial for normal cell homeostasis.

Metal-ion-triggered symmetry breaking of completely achiral azobenzene amphiphiles in water.

Achieving control over symmetry breaking of completely achiral components in the aqueous phase is a significant challenge in supramolecular chemistry. Herein, we demonstrate that it is possible to construct chiral nanoassemblies by introducing metal ions (Zn, Fe, Al, Cu, and Ca) into completely achiral azobenzene amphiphiles with key structural factors in the pure aqueous phase. It is found that the coordination interactions, π-π stacking, hydrophilic and hydrophobic interactions, hydrogen bonding, and electrostatic interactions are crucial to the metal-ion-induced symmetry breaking of completely achiral building blocks.

Comparative study on Al-SBA-15 prepared by spray drying and traditional methods for bulky hydrocarbon cracking: Properties, performance and influencing factors.

Mesoporous aluminosilicates Al-SBA-15 with large pore sizes and suitable acid properties are promising substitutes to zeolites for catalytic cracking of bulky hydrocarbons without molecular diffusion limitation. The conventional processes to synthesize Al-SBA-15 are time-consuming and often suffer from low "framework" Al contents. Herein, Al-SBA-15 microspheres are synthesized using the rapid and scalable microfluidic jet spray drying technique.

Designing and preparing supramolecular encapsulation systems based on fraxetin and cyclodextrins for highly selective detection of nicotine.

Herein, a series of water-soluble supramolecular inclusion complexes (ICs) probes were prepared using cyclodextrins (CDs) and fraxetin (FRA) to detect nicotine (NT) with high selectivity in vitro and in vivo. The FRA/CD ICs prepared through the saturated solution method exhibited excellent water solubility, stability, and biocompatibility. A clear host-guest inclusion model was provided by the theoretical calculations.

Immune function, gastrointestinal hormone levels, and their clinical significance in patients with gastric ulcers complicated with depression.

Background: Gastric ulcer (GU) is a common digestive tract disease, and medical records of GU combined with depression are increasingly common. Currently, the risk factors and pathogenesis of GU complicated with depression remain unclear. Low immune function and gastrointestinal hormone levels may also be significant risk factors.

Fabrication of molecularly-imprinted gold nanoparticle-embedded Fe-MOFs for highly selective SERS detection of 17β-estradiol in milk.

17β-Estradiol (17β-E2) could accumulate in humans through milk, thus causing diseases by interfering with the function of the endocrine system. However, its detection at a trace level in milk is still a challenge because of matrix interferences. In this work, a core-shell structured polydopamine molecular-imprinted gold nanoparticles (AuNP@MIP-PDA) were embedded into Fe metal-organic framework materials to form a well-defined hexagonal microspindle structure of AuNP@MIP-PDA@MIL-101(Fe).