Constructing hot-spots enriched Ag/MoS hybrid SERS platform for rapid detection of pesticide residue in juice.

Excessive pesticide residues have posed a severe risk to human health and ecological environment, making stringent testing of them a crucial step in food safety supervision. Herein, a flexible paper-based SERS platform composed of AgNPs and MoS nanoflowers was developed for the rapid and ultra-sensitive detection of thiram in juice. Among it, the hydrophobic MoS-modified paper was first fabricated, followed by co-depositing small-sized AgNPs and thiram molecules onto its surface for SERS analysis.

Thermal Transport Modulation via Interfacial Vacancy Defects in Carbon/Boron Nitride Heteronanotubes.

Thermal transfer regulation of one-dimensional heterostructure is essential, but the influence of vacancy defects on interfacial thermal conductance (ITC) remains unclear. In this paper, we demonstrate that vacancy defects at the carbon/boron nitride heteronanotubes (CBNNT) significantly reduce the ITC, with N atoms vacancy exhibiting a more pronounced inhibitory effect than C atoms vacancy. This decline in ITC is attributed to vacancy-induced lattice distortions that diminish the overlap of the phonon density of states, ultimately enhancing phonon localization.

A Moiré Superlattice Induced Thermal Switch for Modulating Interfacial Heat Transfer.

We have invented a heat switch induced by a moiré superlattice for regulating interfacial thermal conductance (ITC). As twist angle increases, ITC decreases significantly, while ITC shows nonmonotonic changes with temperature. Research indicates that periodic structural fluctuations of moiré patterns, combined with uneven atomic stress fields, selectively control the efficiency of heat flux transmission.

Pericyte drives the formation of circulating tumour cell-neutrophil clusters to promote colorectal cancer metastasis.

Background: Circulating tumour cell (CTC)-neutrophil clusters represent a key driver and a hallmark of tumour metastasis; however, efficient approaches for their elimination are still lacking.

Objective: This study sought to elucidate the location and mechanisms of CTC-neutrophil cluster formation and develop more effective antimetastasis strategies.

Design: Immunofluorescence staining of clinical colorectal cancer (CRC) samples was performed to identify the location of CTC-neutrophil clusters.

Modulation of mitochondrial dysfunction: Mechanisms and strategies for the use of natural products to treat stroke.

Modulations of mitochondrial dysfunction, which involve a series of dynamic processes such as mitochondrial biogenesis, mitochondrial fusion and fission, mitochondrial transport, mitochondrial autophagy, mitochondrial apoptosis, and oxidative stress, play an important role in the onset and progression of stroke. With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury, these modulations have emerged as a potential target for stroke prevention and treatment. Additionally, since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages, we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.

Circadian disruption exacerbates cognitive impairment via an intense neuroinflammatory reaction and alpha-synuclein deposition in a Parkinson's disease mouse model.

Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder marked by motor symptoms and nonmotor complications, notably cognitive impairment, which severely impairs patients' quality of life. While circadian disruption (CD) correlates with cognitive decline in PD, it remains unclear whether CD is merely secondary to motor symptoms or directly contributes to cognitive dysfunction. The objective of this study was to investigate whether chronic CD exacerbates cognitive decline in PD.

Promoting nurse participation in hospital antimicrobial stewardship: A realist review.

Background: Antimicrobial stewardship is a collaborative intervention strategy aimed at promoting the selection of optimal antimicrobial regimens to improve and measure the appropriate use of antimicrobials, thereby fostering rational use of these agents, enhancing patient outcomes effectively, and curbing the wide dissemination of antimicrobial resistance. Recently, nurses' pivotal contribution in multidisciplinary antimicrobial stewardship teams is increasingly recognized. However, the contexts and mechanisms able to facilitate nurses' participation in the complex dynamics of antimicrobial stewardship remain unclear.

The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke.

Gut microbiota disturbances can elevate the risk of stroke by contributing to cerebrovascular events. Particularly, the gut tryptophan (TRP) metabolite is an essential mediator of the gut-brain axis. This review highlights the role of TRP metabolism in stroke, the influence of intestinal microbiomes on stroke pathology via TRP metabolism, and the gut-brain axis interactions.

Evaluation scale and behavioral model construction for intention to use postpartum exercise rehabilitation mobile application based on user experience.

Background: Physical exercise is a widely recognized and practical approach to postnatal rehabilitation. In recent years, its delivery through mobile applications has become increasingly prevalent due to their accessibility and affordability. These mobile applications are crucial in supporting postpartum women in restoring physical and mental well-being and promoting sustainable health behaviors.

Pharmacokinetic bioequivalence of the fixed-dose combination of pertuzumab and trastuzumab administered subcutaneously using a handheld syringe or an on-body delivery system.

Purpose: This randomized, open-label, two-arm, parallel-group, single dose, multi-center phase I study (ClinicalTrials.gov ID, NCT05275010) investigated the comparability of the pharmacokinetics of a new formulation combining pertuzumab (P) and trastuzumab (H) in one fixed-dose combination for subcutaneous injection (FDC SC) using a proprietary on-body injector (OBI) or a handheld syringe with hypodermic needle in healthy male subjects.

Methods: Healthy male subjects were randomized 1:1 to either PH FDC SC using a handheld syringe (Arm 1) or an OBI device (Arm 2).

Rising military spending jeopardizes climate targets.

The IPCC's Sixth Assessment Report highlights the reliance on sustainable socio-economic pathways to meet the 1.5 °C or 2 °C targets. However, these scenarios lack a quantitative assessment of the impact of global military spending on CO emissions.

Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors.

Unlabelled: NRAS is commonly mutated in several different types of human cancer. NRAS-mutant tumors are aggressive and associated with poor outcomes. Although the development of targeted therapies as well as immune checkpoint inhibitors has led to a substantial improvement in the overall survival of patients with NRAS wild-type (WT) tumors, current therapies for NRAS-mutant cancers are limited.

Tifcemalimab as monotherapy or in combination with toripalimab in patients with relapsed/refractory lymphoma: a Phase I trial.

Preclinical studies of tifcemalimab (anti-BTLA antibody) in combination with toripalimab (anti-PD-1 antibody) demonstrated synergistic anti-tumor effects. We present the outcomes of tifcemalimab with or without toripalimab in lymphoma patients. This is a 2-part, phase I study (NCT04477772).

Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities.

Background: Super-enhancers (SEs) are critical regulators of tumorigenesis and represent promising targets for bromodomain and extra-terminal domain inhibitors (BETi). However, clinical studies across various solid tumors, including triple-negative breast cancer (TNBC), have demonstrated limited BETi efficacy. This study aims to investigate SE heterogeneity in TNBC and its influence on BETi effectiveness, with the goal of advancing BETi precision treatment strategies and enhancing therapeutic efficacy.

Photothermal effect-assisted reduced graphene oxide biosensor for amplification-free detection of miRNA.

It remains a challenge to achieve high-sensitivity detection of tumor marker miRNA using optical refractive index (RI) sensors without nucleic acid amplification. This study proposes the photothermal effect-assisted reduced graphene oxide (rGO) biosensor that combines the photothermal effect of rGO with the rGO-based RI sensor for high-sensitivity detection of tumor marker miRNA-21. The rGO was functionalized with DNA probes capable of specifically hybridizing with the target miRNA-21.

Efficacy and safety of calcium polystyrene sulphonate and sodium zirconium cyclosilicate as potassium binders for chronic hyperkalemia in hemodialysis patients: A prospective study.

Objective: Sodium zirconium cyclosilicate (SZC) and calcium polystyrene sulfonate (CPS) are indicated for treating hyperkalemia in chronic renal disease. Individuals undergoing maintenance hemodialysis (HD) are at significantly increased risk of developing hyperkalemia, clinically defined as serum potassium concentrations of > 5.0 mmol/L.

Differences in Responses to Neoadjuvant Anti-HER2 Therapy between HER2 2+ISH+ and HER2 3+ in HER2-Positive Breast Cancer.

Purpose: Dual anti-HER2 drugs has become the standard regimen for neoadjuvant systematic treatment (NST) to HER2-positive breast cancer patients. However, the efficacy varies greatly among patients with different HER2 protein expression levels.

Materials And Methods: A total of 575 HER2-positive breast cancer patients from multiple centers throughout China from 2013 to 2022 were retrospectively analyzed.

Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation.

The mechanism of ferroptosis propagation is still unclear. Here our results indicate that the cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation. FOXK1 was phosphorylated by PKCβII and then facilitated the expression and secretion of Galectin-13 during ferroptotic cell death.

Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity.

B7H3, an immune checkpoint molecule, is a highly N-glycosylated membrane protein. However, the key glycosylated asparagine residues that mediate the function of the B7H3 protein are still unclear. Here we identify that N-glycans attached to asparagine residues N91/309 and N104/322 are required for proper B7H3 localization on the cell surface membrane.

Nonmonotonic Enhancement of Friction Regulation via Strain-Induced Moiré Patterns on MoS Substrate Surface.

Traditionally, strain-induced moiré patterns at the friction interface can produce superlubrication. Here, we construct moiré patterns on the surface of a two-layer MoS substrate through applying biaxial strain to the bottom layer of the substrate and investigate the effect of moiré patterns on friction energy dissipation. Results indicate friction enhances nonmonotonically with an increase of strain.

Early NCCT imaging signs for prognostication in intracerebral hemorrhage: a retrospective cohort study with long follow up results.

Objective: This study intends to investigate the connection between non-contrast computed tomography (NCCT) imaging findings and neurological function scores in patients with intracerebral hemorrhage (ICH) in a long follow up of 451 patients.

Methods: Between January 2020 and October 2021, a retrospective review was undertaken on patients with ICH. The NCCT imaging results within 24 h of symptom onset, clinical information, biochemical markers and the one-year outcome post-discharge were collected and analyzed.

Intraventricular silicone oil migration post-retinal detachment surgery: diagnostic features and classification - a case study with literature review.

This case report documents a rare instance of intraventricular migration of silicone oil (IVM-SiO), initially misinterpreted as intraventricular hemorrhage on computed tomography (CT), in a patient with a history of retinal detachment surgery. The report not only describes the unique presentation of this case but also synthesizes findings from previous case reports to summarize the diagnostic characteristics and classification of intracranial silicone oil migration. The patient, a 41-year-old male, presented with dizziness and a history of vitreoretinal surgeries, including silicone oil tamponade for retinal detachment.

Impact of Body Mass Index on Outcome of Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke in China: A Post Hoc Analysis of DIRECT-MT Trial.

Introduction: The impact of body mass index (BMI) on outcomes after mechanical thrombectomy (MT) for large vessel occlusion acute ischemic stroke (LVOS) has been a subject of controversy, mainly due to the so-called obesity paradox. The obesity paradox refers to the phenomenon where, contrary to expectations, overweight or obese individuals seem to have better clinical outcomes in certain disease states. This study aimed to investigate the relationship between BMI and the clinical prognosis of patients with LVOS treated with endovascular thrombectomy (EVT) combined with or without intravenous alteplase in DIRECT-MT (Direct Intra-arterial Thrombectomy to Revascularize Acute Ischemic Stroke Patients with Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals: A Multicenter Randomized Clinical Trial).

Synthesis of fluorinated tubastatin A derivatives with bi-, tri-, and tetracyclic cap groups: molecular docking with HDAC6 and evaluation of antitumor activity.

Herein, we report the synthesis of 16 tubastatin A derivatives with fluorinated bi-, tri-, and tetracyclic cap groups. Most derivatives show strong antitumor activity, achieving micromolar or sub-micromolar efficacy. The most promising compound, 4-(6-bromo-3,3-difluoro-1,2,3,4-tetrahydro-9-carbozol-9-yl)methyl)--hydroxybenzamide (14f), demonstrated potent anti-proliferative effects against human nasopharyngeal carcinoma cells (SUNE1) and human breast cancer cells (MDA-MB-231), with IC values of 0.