Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Patients with somatization symptoms are at elevated risk of depression, yet underdiagnosis persists due to cultural tendencies (e.g., in China) to express psychological distress via physical complaints. Existing predictive models lack integration of sociocultural and physiological factors, particularly in non-Western populations.
Objective: To develop a culturally tailored risk-prediction model for depression in patients with somatization symptoms, emphasizing early identification and personalized intervention.
Methods: A prospective cohort study included 200 somatization patients (SSS≥38, PHQ-2<3) from a Chinese hospital (May 2020-August 2022). LASSO regression identified predictors from 18 variables, followed by multivariate logistic regression to construct a nomogram. Model performance was assessed via ROC-AUC, calibration curves, Hosmer-Lemeshow test, and decision curve analysis (DCA). Internal validation used 200 bootstrap resamples.
Results: Five independent predictors were identified: advanced age (OR=1.11, 95% CI: 1.02-1.20), poor self-rated health (OR=2.07, 95% CI: 1.04-4.30), lack of co-residence with children (OR=1.63, 95% CI: 1.10-2.42), low income (OR=1.45, 95% CI: 1.05-2.01), and self-medication (OR=1.32, 95% CI: 1.01-1.73). The nomogram demonstrated strong discrimination (AUC=0.810, 95% CI: 0.728-0.893) and calibration (Hosmer-Lemeshow p=0.32). DCA confirmed clinical utility: at threshold probabilities >5%, the model provided higher net benefit than "treat-all" or "treat-none" strategies.
Conclusion: This model integrates sociocultural (e.g., family structure) and behavioral factors to predict depression risk in somatizing patients, particularly in East Asian contexts. It offers a practical tool for clinicians to prioritize high-risk individuals, reducing diagnostic delays and healthcare burdens. Future multicenter studies should validate its generalizability and incorporate biomarkers (e.g., inflammatory markers) to enhance mechanistic insights.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997386 | PMC |
| http://dx.doi.org/10.3389/fpsyt.2025.1555513 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of Facial Botulinum Toxin A Injections in Alleviating Neuropsychiatric Symptoms in Parkinson's Disease Patients: An Open-Label, Nonrandomized Controlled Trial.
Brain Behav
September 2025
Department of Neurology, Huai'an First People's Hospital, the Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Background And Purpose: Parkinson's disease (PD), a prevalent neurodegenerative disorder characterized by motor impairments, frequently accompanied by neuropsychiatric symptoms that significantly impair daily functioning and quality of life. The present study aimed to assess the efficacy of botulinum toxin A (BTX-A) in alleviating neuropsychiatric symptoms among PD patients.
Methods: This is an open-label, nonrandomized controlled trial.
A Model of Body Perception Disturbances in Chronic Limb Pain: The Predictive Role of Kinesiophobia, Depersonalization and Symptom Severity.
Eur J Pain
October 2025
Physical Therapy Department, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.
Background: Body Perception Disturbances (BPD) are common in chronic limb pain conditions characterised by negative feelings toward the limb and a reduced sense of agency. Prior research has focused on isolated associations between psychological factors, pain hypersensitivity and BPD. Therefore, an integrated examination of the interconnections between these variables within a theory-driven model is necessary.
View Article and Find Full Text PDFImpact of social-psychological factors on anxiety before gastrointestinal endoscopy and quality of life.
Front Psychiatry
August 2025
Department of Gastrointestinal Endoscopy, Guangxi International Zhuang Medical Hospital, Nanning, China.
Introduction: This study aimed to examine the impact of social-psychological factors on anxiety before gastrointestinal endoscopy and its effect on patients' quality of life (QoL).
Methods: Patients scheduled for gastrointestinal endoscopy were recruited for the study. Demographic characteristics, social factors, lifestyle information and endoscopy-related data were obtained through self-reports and the hospital information system.
Association between somatic symptoms and depression and anxiety in adolescents: a cross-sectional school-based study.
BMJ Open
September 2025
The Institute of Social and Family Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Objectives: To explore the associations between somatic symptoms, depression and anxiety among Chinese adolescents in non-clinical settings.
Design: A cross-sectional study.
Setting: The questionnaire was distributed among Chinese students in Grades 10-11 from four vocational high schools (two in Anhui Province and two in Sichuan Province).
Somatic Symptom and Related Disorders and Mild Traumatic Brain Injury: A Systematic Review.
Biopsychosoc Sci Med
August 2025
Objective: A comprehensive systematic review of the relationship between somatic symptom and related disorders (SSRD) and mild traumatic brain injury (mTBI).
Methods: Searches for SSRD, mTBI and related terms were performed and combined from the following databases on March 7th, 2024: Ovid MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL, SPORTDiscus, PsycINFO, Embase, and Scopus. Studies were included if they met the following criteria: (a) recruitment of human participants; (b) diagnosis of SSRD or validated measure of somatization (c) reported on patients meeting diagnostic criteria for mTBI; (d) evaluated an association between mTBI and SSRD as a main outcome (e) published in a peer-reviewed journal; (f) published before March 7th, 2024.