Geographic and diagnostic variations in thrombosis risk among patients with immune thrombocytopenia: A systematic review and meta-analysis.

Background: While immune thrombocytopenia (ITP) is primarily characterized by bleeding manifestations, emerging evidence suggests a paradoxical predisposition to thrombotic events. This study aims to systematically evaluate the incidence of thrombosis in patients with ITP and identify associated risk factors, thereby providing evidence-based guidance for clinical practice.

Methods: PubMed, EMBASE, Cochrane Library, Web of Science, and CNKI were searched for literature on thrombosis in ITP patients from the inception of each database to April 1, 2025.

Deep learning-based image reconstruction benefits diffusion tensor imaging for assessing severity of depression.

Objective: This study aimed to evaluate whether deep learning-based image reconstruction (DLR) improves the accuracy of diffusion tensor imaging (DTI) measurements used to assess the severity of depression.

Methods: A total of 52 patients diagnosed with depression in our hospital between March 2023 and July 2023 were enrolled in this study. The severity of depression was measured using the 9-item Patient Health Questionnaire (PHQ-9).

Co-delivery of SN38 and SR717 activates cGAS-STING for near-infrared II image-guided chemoimmunotherapy.

DNA-targeting chemotherapies can activate the stimulator of interferon genes (STING) pathway but elicit limited immune responses. We engineered 3P-SN38, a long-circulating nanoplatform enabling sustained, tumor-targeted SN38 delivery and NIR-II imaging. To further potentiate immune activation and minimize STING agonist toxicity, SR717 was co-encapsulated, forming 3P-SN38@SR717.

Effects of airborne ultrasonic coupled microwave vacuum drying on moisture-heat migration and quality characteristics of shiitake mushrooms.

Ultrasound can enhance the efficiency of moisture migration during drying and processing, and improve the quality characteristics of samples. This paper aims to investigate the effects of ultrasonic-assisted drying on the moisture-heat migration patterns and quality characteristics of shiitake mushrooms. The results showed that the drying time of shiitake mushrooms decreased from 53 min to 42 min as the ultrasonic amplitude increased, improving drying efficiency by 20.

AW-GBGAE: an Adaptive Weighted Graph Autoencoder Based on Granular-Balls for General Data Clustering.

In the current scenario, a vast amount of unlabeled high-dimensional data exhibits intrinsic relationships, making it suitable for information extraction through graph-based clustering methods. However, these datasets often lack edge structure information and contain numerous irrelevant features. To address these challenges, we propose a comprehensive solution that involves: (1) applying a feature weighting approach to manage features, (2) constructing edges based on weighted granular-balls, and (3) integrating graph convolutional networks (GCNs) with edge generation to develop an autoencoder network.

Humic and fulvic acid-mediated dissimilatory iron reduction coupled with phosphate solubilizing bacteria inducing secondary mineral formation for efficient cadmium immobilization.

Cadmium (Cd) pollution in sediments has become an urgent environmental problem. Humus mediated dissimilatory iron reduction and phosphorus solubilizing bacteria (PSB) were widely used for Cd immobilization. Here, we utilized humic acid (HA) and fulvic acid (FA) to promote the efficiency of iron reduction by Geobacter metallireducens GS-15 to immobilize Cd with the involvement of PSB.

Rapid multiparametric quantitative MRI for predicting the activity of thyroid-associated ophthalmopathy: combination with clinical characteristics.

Objectives: To explore the feasibility of synthetic MRI (syMRI), one kind of rapid multiparametric quantitative MRI, and assess the predictive value of combining the syMRI parameters with clinical features for predicting the activity of thyroid-associated ophthalmopathy (TAO).

Materials And Methods: Clinical data and syMRI images were prospectively collected from 136 patients with TAO (72 active and 64 inactive) and 30 healthy controls. Two radiologists outlined the extraocular muscles (EOMs), orbital fat, and lacrimal glands.

Biosynthesis of novel anticoagulant substances, α-salicin and α-isosalicin, using sucrose phosphorylase.

This study reports the enzymatic synthesis of novel anticoagulant glycosides, α-salicin and α-isosalicin, through the transglycosylation of o-hydroxybenzyl alcohol (salicyl alcohol) catalyzed by marine-derived sucrose phosphorylase Suc75290. Under optimized conditions (240 g/L sucrose, 12 g/L o-hydroxybenzyl alcohol, 150 U/mL enzyme, pH 7.5, 45 °C, 20 h), a conversion rate of 79.

A narrative review of preoperative CT for predicting spread through air spaces of lung cancer.

Background And Objective: Spread through air space (STAS) is a recognized mechanism of lung cancer invasion and is associated with patient prognosis. However, current diagnostic accuracy of bronchial cytology and intraoperative frozen section for STAS remains insufficient to meet clinical needs. Therefore, accurate and non-invasive preoperative prediction of STAS is critical for clinical decision-making.

Size-controlled fabrication of silicon nanopore arrays by silver-assisted chemical etching.

Silicon nanopore arrays are widely used in applications such as solution exchange, biomolecule detection, chemical analysis, and plant pathogen detection due to their high stability, long service life, and excellent compatibility with semiconductor and microfluidic technologies. However, existing fabrication methods such as wet etching, ion track etching, and electron beam lithography-assisted reactive ion etching face limitations, including poor size uniformity, uneven pore distribution, and high production costs. To address these challenges, this study proposes an improved metal-assisted chemical etching method for fabricating silicon nanopore arrays.

Fluorescent biosensor for lead ion detection based on GR-5 DNAzyme and self-hybridization chain reaction.

Background: Lead ion (Pb) is a typical heavy metal pollutant, and the water and food contaminated by lead may pose a potential threat to the environment and human health. In the natural environment, it can accumulate in soil and water, affecting the entire food chain. For human health, even if the Pb content is very low, it can cause a series of adverse health effects.

High-resolution computed tomography with 1,024-matrix for artificial intelligence-based computer-aided diagnosis in the evaluation of pulmonary nodules.

Background: Computed tomography (CT) plays an important role in the diagnosis of lung nodules and early screening of lung cancer. The purpose of this study was to compare the efficacy of 1,024×1,024 matrix and 512×512 matrix in an artificial intelligence-based computer-aided diagnosis (AI-CAD) for evaluating lung nodules based on CT images.

Methods: This retrospective analysis included 344 patients from two hospitals between January 2020 and November 2023.

Dual recycling signal amplification strategy based on autocatalytic entropy-driven circuit and DNAzyme for colorimetric detection of platelet-derived growth factor-BB.

Platelet-derived growth factor-BB (PDGF-BB), an important protein biomarker, is closely associated with tumorigenesis. Therefore, it is important to develop a simple and sensitive method to detect PDGF-BB. Herein, we developed a dual recycling signal amplification strategy for colorimetric and sensitive detection of PDGF-BB using a PDGF-BB specific aptamer.

Crosslinked protein-polysaccharide nanocomposite coating for pork preservation: Impact on physicochemical properties and microbial structure.

Edible films are significant in prolonging the shelf life of meat products. Herein, we prepared some edible coatings (EW/TNPCSs) based on egg white/chitosan/pectin as polymer matrix, containing tannic acid-nisin composite nano-crosslinker with antibacterial-antioxidant activities. The results of preservation indicated that the prepared EW/TNPCSs reduced the water loss of chilled pork and delayed the changes of taste, texture and surface color.

Causal impact of gut microbiota on five liver diseases: insights from mendelian randomization and single-cell RNA sequencing.

Background: Liver disease is among the top ten causes of death globally. With studies suggesting a link between gut microbiota (GM) and liver disease.

Method: We selected summary statistics data from the largest available whole-genome association study (n = 13,266) of GM by the MiBioGen consortium as the exposure, and obtained liver disease-related data from IEU Open GWAS and The NHGRI-EBI GWAS Catalog.

Ultrasound-assisted microwave vacuum drying enhances flavor release during stewing of dried shiitake mushrooms.

The introduction of ultrasonic energy into microwave vacuum drying (MVD) enhances drying efficiency and product quality. To investigate the effect of ultrasonically coupled microwave vacuum (USMVD) drying on the flavor release of shiitake mushrooms, differences in the pore structure of dried mushrooms were analyzed in relation to the flavor of mushroom soup. The results showed that ultrasound mainly changed the pore structure of shiitake mushrooms in the range of 5000-50,000 nm, and the total pore volume of shiitake mushrooms was the largest when the ultrasound amplitude was 70 %.

Brick-cement system inspired fabrication of TiC MXene nanosheet reinforced high-performance of chitosan/gelatin/PVA composite films.

The increasing need for convenient, fast, and nutritious of prepared foods elevate the development of biodegradable antibacterial packaging materials with excellent performance. Inspired by the brick-cement-like system, the two-dimensional nanomaterial TiC MXene as nanofillers with optothermal response function was employed to strength the performance of chitosan/gelatin/polyvinyl alcohol composite films (CGPF-Mxs). The results revealed that the high-modulus TiC MXene material improved the microstructures density of macromolecule polymers by physical interactions, as well as enhancements in mechanical properties, thermal stability, barrier properties, water resistance, and antioxidation performance of the composite films.

Aortic Stiffness Measured by Carotid Femoral-Pulse Wave Velocity at Different Stages of Normal Glucose, Prediabetes, and Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Background: To explore aortic stiffness measured by carotid femoral-pulse wave velocity (cf-PWV) at different stages of normal glucose, prediabetes, and diabetes mellitus (DM).

Methods: The literature comparing aortic stiffness (AS) with cf-PWV between DM and non-DM samples was systematically retrieved from Pubmed, Ovid Medline, Web of Science, Embase, Scopus, CNKI, and Wanfang databases. The Newcastle-Ottawa Scale was used to assess the quality of the literature.

Erigeron breviscapus: A Promising Medication for Protecting the Optic Nerve in Glaucoma.

Glaucoma is a common eye condition characterized by the loss of retinal ganglion cells and their axons, optic nerve damage, and visual field defects, which seriously affect a patient's quality of life. The pathogenesis of glaucoma is still unclear at present. It presents as damage to retinal ganglion cells, and the main treatment is primarily to reduce intraocular pressure by surgery or taking medication.

Isolation, purification, characterization and stability analysis of melanin pigment from Mesona chinensis.

In this study, the isolation and purification of melanin pigment from Mesona chinensis (MCM) were conducted, and the structural characterization and stability evaluation of MCM were performed. The results indicate that MCM is consistent with the spectral features of catechins and polyphenols, identified the stretching vibrations of functional groups such as OH, CH, CO, and CO. It is inferred that the structure of MCM is consistent with that of theophylline and it is mainly composed of phenolic acids, terpenoids, and organic acids.