Intraoperative pain assessment using a digital force gauge during vitreoretinal surgery: a prospective feasibility study.

Purpose: This study aimed to evaluate the feasibility of real-time intraoperative pain assessment using a digital force gauge during vitreoretinal surgery under sub-Tenon's anesthesia.

Methods: In this prospective observational study, 63 patients undergoing vitreoretinal surgery under sub-Tenon's anesthesia were enrolled between April and August 2023. The participants were asked to constantly compress a digital force gauge during the operation.

The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution.

Background: Large-scale characterization of gut viral genomes provides strain-resolved insights into host-microbe interactions. However, existing viral genomes are mainly derived from Western populations, limiting our understanding of global gut viral diversity and functional variations necessary for personalized medicine and addressing regional health disparities.

Results: Here, we introduce the Chinese Gut Viral Reference (CGVR) set, consisting of 120,568 viral genomes from 3234 deeply sequenced fecal samples collected nationwide, covering 72,751 viral operational taxonomic units (vOTUs), nearly 90% of which are likely absent from current databases.

Autoregulated resistance training for maximal strength enhancement: A systematic review and network meta-analysis.

Objectives: This study aims to systematically review the effects of Autoregulating Progressive Resistance Exercise (APRE), Rating of Perceived Exertion (RPE), and Velocity-based Resistance Training (VBRT) on maximal strength through a network meta-analysis.

Methods: Forest plots and network diagrams visualized training modality differences and intervention relationships. Pooled standard mean difference (SMD) of different studies and the corresponding 95 % confidence intervals (CIs) quantified effect sizes, with inconsistency models assessing heterogeneity and surface under the cumulative ranking curve (SUCRA) values ranking protocols by optimal probability.

Epiretinal membrane formation following laser photocoagulation for peripheral retinal degeneration: incidence and risk factors.

Purpose: Laser photocoagulation remains the most common treatment for peripheral retinal degeneration. However, potential side effects, particularly inflammation and gliosis, raise concerns about an increased risk of epiretinal membrane (ERM) formation. This study aims to further investigate the association between laser photocoagulation and ERM formation and identify associated risk factors.

Identification of glycolysis-related genes and analysis of potential prognostic clinical application in oral squamous cell carcinoma.

Background: Glycolysis is a crucial metabolic pathway for energy production in tumor cells. This study aimed to identify glycolysis-related genes (GRGs) that are linked to the prognosis of oral squamous cell carcinoma (OSCC) and to develop a prognostic model based on these GRGs.

Methods: Transcriptomic data were obtained from The Cancer Genome Atlas (TCGA) database.

Cyclocryotherapy applied at the 3 o'clock and 9 o'clock positions combined with anti-VEGF injections for advanced neovascular glaucoma.

Objective: This study aimed to investigate the efficacy of cyclocryotherapy applied at the 3 o'clock and 9 o'clock positions in combination with intravitreal anti-vascular endothelial growth factor (VEGF) injections in patients with advanced neovascular glaucoma (NVG).

Methods: Medical records of patients diagnosed with NVG who underwent cyclocryotherapy at the 3 o'clock and 9 o'clock positions combined with intravitreal anti-VEGF injections between January 2021 and January 2023 were retrospectively reviewed. Baseline and follow-up data including intraocular pressure (IOP), best-corrected visual acuity, perioperative pain scores using numeric rating scale, intraocular cytokines levels, and surgical complications, were analyzed.

Prognostic value of lymphocyte-to-monocyte ratio in patients with endometrial cancer: an updated systematic review and meta-analysis.

Background: Evaluating the risk of metastasis at diagnosis and the likelihood of future recurrence is crucial for the effective management of endometrial cancer (EC). While conventional prognostic indicators hold importance, they often fall short in predicting recurrence, especially in low-risk patients. This study evaluates the prognostic value of the lymphocyte-to-monocyte ratio (LMR) for overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) in EC patients.

Reciprocal regulation between AtFH5-labeled secretory vesicles and PI(4,5)P oscillation at the plasma membrane directs pollen germination.

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P) is known to be an instrumental anionic phospholipid in governing pollen germination and pollen tube growth. However, the precise functions and regulatory mechanisms of PI(4,5)P in pollen polarity establishment and germination remain poorly understood. Our previous studies demonstrated the pivotal involvement of Arabidopsis formin homology 5 (AtFH5)-dependent vesicle trafficking in polarity establishment of pollen.

Engineering archaeal membrane-spanning lipid GDGT biosynthesis in bacteria: Implications for early life membrane transformations.

Eukaryotes are hypothesized to be archaeal-bacterial chimeras. Given the different chemical structures of membrane phospholipids in archaea and bacteria, transformations of membranes during eukaryogenesis that led to the bacterial-type membranes of eukaryotic cells remain a major conundrum. One of the possible intermediates of eukaryogenesis could involve an archaeal-bacterial hybrid membrane.

A novel sensitizer reduces EGFR-TKI resistance by regulating the PI3K/Akt/mTOR pathway and autophagy.

Background: The incidence and mortality of lung cancer are high, and treatment with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is the preferred first-line treatment for patients suffering from non-small cell lung cancer (NSCLC) with EGFR mutations. However, EGFR-TKI resistance leads to treatment failure. Yifei-Sanjie pill (YFSJ) is a novel type of Chinese patent medicine for lung cancer.

Risk factors and prognostic analysis of vitreous cavity opacification after silicone oil removal.

Purpose: This study aims to investigate the risk factors for postoperative vitreous cavity opacification following pars plana silicone oil removal and its impact on prognostic visual acuity.

Methods: A retrospective case-control study was conducted. A total of 66 eyes from 66 patients were enrolled in the study.

Effects of variable resistance training within complex training on strength and punch performance in elite amateur boxers.

Objectives: This study explored the effects of 6 weeks of variable resistance training (VRT) and constant resistance training (CRT) within complex training, on muscle strength and punch performance.

Methods: Twenty-four elite female boxers from the China National team were divided randomly between an experimental group (VRT) and a control group (CRT). Maximum strength of the upper and lower limbs, countermovement jump (CMJ) performance, and punch performance (single, 10s and 30s continuous) were assessed pre- and post- intervention.

Refractive outcomes following simultaneous silicone oil removal and ciliary sulcus intraocular lens implantation.

PurposeThis study aimed to assess the refractive outcomes following the combined intervention of silicon oil (SO) removal and ciliary sulcus intraocular lens (IOL) implantation in aphakic eyes after phacovitrectomy.MethodsA retrospective examination of medical records from patients who underwent a combined procedure of SO removal and ciliary sulcus IOL implantation from 2019 to 2022 was performed. The primary outcomes of interest included uncorrected distance visual acuity (UDVA), predictive error (PE) and mean absolute predictive error (MAE).

Clinical macular edema following uneventful cataract surgery in eyes without pre-existing fundus diseases: risk factors and treatment prognosis.

Background: To investigate the risk factors and prognosis of clinical pseudophakic cystoid macular edema (PCME) after uneventful phacoemulsification surgery in patients without pre-existing fundus diseases.

Methods: This was a retrospective case-control study. Medical records between August 2020 and August 2023 were reviewed for patients who had no previous fundus diseases and developed clinical PCME.

Preoperative Intravitreal Conbercept Injection Reduced Both Angiogenic and Inflammatory Cytokines in Patients With Proliferative Diabetic Retinopathy.

To investigate the impact of intravitreal injection of conbercept, a recombinant fusion protein with decoy receptors for the vascular endothelial growth factor (VEGF) family, on intraocular concentrations of angiogenic and inflammatory mediators in patients with proliferative diabetic retinopathy (PDR), analyzed its potential impact on surgical outcomes. Forty eyes from 40 patients with PDR were included in this prospective study. Patients received intravitreal injection of conbercept followed by vitrectomy or phacovitrectomy in 1 week.

Effects of Progressive and Velocity-Based Autoregulatory Resistance Training on Lower-Limb Movement Ability in Taekwondo Athletes.

Background: Both autoregulatory progressive resistance exercise (APRE) and velocity-based resistance training (VBRT) utilize real-time monitoring of athlete physical performance to adjust training loads to provide appropriate training stimuli. However, the monitoring and adjustment approaches differ between both methods. This study aimed to compare the effects of APRE and VBRT on the muscle strength, power, and agility of college taekwondo athletes.

Non-Apoptotic Programmed Cell Death as Targets for Diabetic Retinal Neurodegeneration.

Diabetic retinopathy (DR) remains the leading cause of blindness among the global working-age population. Emerging evidence underscores the significance of diabetic retinal neurodegeneration (DRN) as a pivotal biomarker in the progression of vasculopathy. Inflammation, oxidative stress, neural cell death, and the reduction in neurotrophic factors are the key determinants in the pathophysiology of DRN.

Evaluation of combined epiretinal membrane removal with intravitreal triamcinolone injection utilizing ectopic inner foveal layer staging scheme.

Objective: To investigate the macular morphological and visual outcomes of combined idiopathic epiretinal membrane (iERM) removal with triamcinolone acetonide (TA) injection based on consideration of the ectopic inner foveal layer (EIFL) staging scheme.

Methods: Retrospective case-control study. The clinical data of 84 eyes of 84 patients who underwent vitrectomy for iERM between 2018 and 2022 were reviewed.

Age-effects of sport education model on basic psychological needs and intrinsic motivation of adolescent students: A systematic review and meta-analysis.

Objective: This study explores the age effects of the sport education model(SEM) on the impact of basic psychological needs (autonomy, competence, relatedness) and intrinsic motivation (interest, enjoyment, satisfaction) among adolescent students.

Method: Retrieval of relevant literature from PubMed, Web of Science, Scopus, and China National Knowledge Infrastructure (CNKI). The search period ranged from the starting year to January 7, 2024.

The enhancement of explosive power contributes to the development of anaerobic capacity: A comparison of autoregulatory progressive resistance exercise and velocity-based resistance training.

Objectives: Due to the character of the taekwondo, the adenosine triphosphate-phosphocreatine system provides the energy for each kick, the glycolytic system supports the repeated execution of kicks, and the aerobic system promotes recovery between these movements and the bout. Therefore, taekwondo athletes require high explosive power and anaerobic capacity in order to carry out sustained and powerful attacks. So, the purpose of this study is to compare the effects of APRE and VBRT on lower-limb explosive power and anaerobic capacity in college taekwondo players.

Subthreshold micropulse laser therapy for early postoperative macular thickening following surgical removal of epiretinal membrane.

Background: This study aimed to investigate the functional and anatomical outcomes of subthreshold micropulse laser (SMPL) therapy in eyes with early postoperative macular thickening after idiopathic epiretinal membrane (iERM) removal.

Methods: This was a prospective and interventional study. Forty-eight eyes from 48 patients with macular edema at 1 month after iERM removal were randomly divided into two groups.

High-Speed and Ultrasensitive Solar-Blind Ultraviolet Photodetectors Based on Grown β-GaO Single-Crystal Films.

Deep-level defects in β-GaO that worsen the response speed and dark current () of photodetectors (PDs) have been a long-standing issue for its application. Herein, an grown single-crystal GaO nanoparticle seed layer (NPSL) was used to shorten the response time and reduce the of metal-semiconductor-metal (MSM) PDs. With the NPSL, the was reduced by 4 magnitudes from 0.