SHR-2005, an FcγR-Dependent CD40 Agonistic Antibody with Potent Antitumor Activities and Favorable Safety Profile.

Activation of CD40, a pivotal component of immune oncology, could facilitate the infiltration of immune cells into the tumor microenvironment. In this investigation, we characterized SHR-2005, a second-generation CD40 agonistic mAb, as a potential candidate for cancer immune therapy. Our results showed that SHR-2005 possessed high affinity in binding to both human and rhesus CD40 and could effectively compete with CD40L for CD40 binding.

Dielectric and Interface Properties of Aluminum-Laminated Lanthanum Oxide on Silicon for Nanoscale Device Applications.

By embedding an aluminum-laminated layer within LaO thin films and subjecting them to high-temperature rapid thermal annealing, a LaO/LaAlO/LaO sandwich dielectric was formed. This structure enhances the interface properties with both the silicon substrate and the metal gate electrode, improving current conduction. Comprehensive analysis using X-ray Photoelectron Spectroscopy (XPS) revealed that this novel process not only facilitates the formation of a high-quality lanthanum aluminate layer, as indicated with Al 2p peak at 74.

Hsa-miR-7974 Suppresses Epstein-Barr Virus Reactivation by Directly Targeting and .

Epstein-Barr virus (EBV) reactivation, a key factor in Epstein-Barr virus (EBV)-associated malignancies, is regulated by specific cellular microRNAs (miRNAs). This study investigated the role of Hsa-miR-7974 (miR-7974) in this process. miRNA sequencing revealed significant downregulation of miR-7974 in reactivated EBV-positive cell lines (Raji and C666-1).

Emerging Copper-to-Copper Bonding Techniques: Enabling High-Density Interconnects for Heterogeneous Integration.

As CMOS technology continues to downsize to the nanometer range, the exponential growth predicted by Moore's Law has been significantly decelerated. Doubling chip density in the two-dimensional domain will no longer be feasible without further device downsizing. Meanwhile, emerging new device technologies, which may be incompatible with the mainstream CMOS technology, offer potential performance enhancements for system integration and could be options for a More-than-Moore system.

Exploring customers' reuse intention to robots under different service failures: A mind perception perspective.

Artificial intelligence-based service robot failures (hereafter referred to as robot service failures) are inevitable in service practice, making the mitigation of their adverse effects a critical concern for service managers. The present paper investigates the unique classification of robot service failures with the help of mind perception theory and a consumer-centered perspective. Moreover, we further examine the impact of robot service failures on consumer behavioral responses (i.

Long-Term Effects of the COVID-19 Open Strategy on the Mental Health of Chinese University Students: A Prospective Cohort Study.

Background: In December 2022, the Chinese government shifted its COVID-19 prevention and control policy to full openness, leading to a widespread pandemic within a short period. This study aimed to examine the trajectories of stress, anxiety, and depressive symptoms among Chinese university students within 1 year after the implementation of the open policy. Additionally, it investigated the influence of sleep quality, psychological resilience, and medical specialization on these psychological trajectories.

The Application of Checklist in Chronic Disease: A Comprehensive Bibliometric Analysis.

Background: Increasing evidence suggests that checklist plays an important role in chronic disease. This study aims to use bibliometric methods to explore the evolving global research trends, hotspots, and emerging frontiers of the application of checklist in chronic disease research, providing deeper insights into the current research landscape and guiding future chronic disease management development efforts.

Methods: Bibliometrics analysis was performed utilizing RStudio and VOSviewer software.

On the Current Conduction and Interface Passivation of Graphene-Insulator-Silicon Solar Cells.

Interface-passivated graphene/silicon Schottky junction solar cells have demonstrated promising features with improved stability and power conversion efficiency (PCE). However, there are some misunderstandings in the literature regarding some of the working mechanisms and the impacts of the silicon/insulator interface. Specifically, attributing performance improvement to oxygen vacancies and characterizing performance using Schottky barrier height and ideality factor might not be the most accurate or appropriate.

Rapid simultaneous quantification of arsenic and lead in grain using improved monochromatic excitation energy dispersive X-ray fluorescence spectrometry.

In most cases, conventional energy dispersive X-ray fluorescence (EDXRF) analysis of trace arsenic (As) and lead (Pb) in grains encounters technical difficulties due to sensitivity challenges and the overlapping of characteristic X-ray lines. By utilizing high-definition X-ray technology and doubly curved crystal (DCC), along with establishing interference correction models for As and Pb, we can significantly improve analytical sensitivity for specific portions of the spectrum while reducing interference. This study demonstrates that the improved monochromatic excitation energy dispersive X-ray fluorescence spectrometry (MEDXRF), combined with an algorithmic analysis of fundamental parameters (FP), exhibits higher sensitivity compared to existing EDXRF methods.

Identification of the Granule-Bound Starch Synthase (GBSS) Genes Involved in Amylose Biosynthesis in Tartary Buckwheat ( (L.) Gaertn.).

Tartary buckwheat is a nutrient-rich pseudo-cereal whose starch contents, including amylose and amylopectin contents, and their properties hold significant importance for enhancing yield and quality. The granule-bound starch synthase (GBSS) is a key enzyme responsible for the synthesis of amylose, directly determining the amylose content and amylose-to-amylopectin ratio in crops. Although one has already been cloned, the genes at the genome-wide level have not yet been fully assessed and thoroughly analyzed in Tartary buckwheat.

Graphene oxide nanoparticles inhibit H9N2 influenza A virus infectivity by destroying viral coat proteins.

Nanoparticles have gained attention as potential antiviral agents, but the effects of graphene oxide nanoparticles (GONPs) on influenza virus remain unclear. In this study, we evaluated the antiviral activity of GONPs against influenza virus strain A/Hunan-Lengshuitan/11197/2013(H9N2). Our results show that GONPs with a diameter of 4 nm exerted an antiviral effect, whereas those with a diameter of 400 nm had no effect.

Variation Analysis of Starch Properties in Tartary Buckwheat and Construction of Near-Infrared Models for Rapid Non-Destructive Detection.

Due to the requirements for quality testing and breeding Tartary buckwheat ( Gaerth), it is necessary to find a method for the rapid detection of starch content in Tartary buckwheat. To obtain samples with a continuously distributed chemical value, stable Tartary buckwheat recombinant inbred lines were used. After scanning the near-infrared spectra of whole grains, we employed conventional methods to analyze the contents of Tartary buckwheat.

Time trends and regional variations in prices of anticancer medicines in China.

Introduction: High prices, as a main factor, contributed to the lack of adequate access to essential anticancer medicines, especially for patients in developing countries. The Chinese Government has introduced a series of policies to control the prices of medicines during the last decade, but the effect on anticancer medicine is not yet clear.

Methods: To evaluate the time trends and regional variation in the price of essential anticancer medicines in China, we used the procurement data of anticancer medicines from 2015 to 2022.

Personal mastery and quality of life in patients with atrial fibrillation after radiofrequency ablation: The mediating role of health promoting behavior.

Background: Improving quality of life is vital for patients with atrial fibrillation (AF) after radiofrequency ablation. Quality of life can be affected not only by personal mastery but also by health promoting behavior as previously studied. However, it remains unclear whether health promoting behavior mediates the relationship between personal mastery and quality of life.

Time trends and regional variation in utilization of antidiabetic medicines in China, 2015-2022.

Aim: To assess the use of non-insulin antidiabetic medicines in China.

Materials And Methods: We analysed the national procurement data for 29 non-insulin antidiabetic medicines from nine subgroups in China from 2015 to 2022. We estimated the number of defined daily doses (DDDs) procured per year in seven regions of China for nine subgroups and adjusted the data by the number of patients with diabetes.

Contacts at the Nanoscale and for Nanomaterials.

Contact scaling is a major challenge in nano complementary metal-oxide-semiconductor (CMOS) technology, as the surface roughness, contact size, film thicknesses, and undoped substrate become more problematic as the technology shrinks to the nanometer range. These factors increase the contact resistance and the nonlinearity of the current-voltage characteristics, which could limit the benefits of the further downsizing of CMOS devices. This review discusses issues related to the contact size reduction of nano CMOS technology and the validity of the Schottky junction model at the nanoscale.

Studies on adsorption properties of magnetic composite prepared by one-pot method for Cd(II), Pb(II), Hg(II), and As(III): Mechanism and practical application in food.

A one-pot synthesis afforded a magnetic, crosslinked polymer adsorbent (m-P6) with a variety of functional groups to realize simultaneous adsorption of Cd, Pb, Hg, and As. The material was characterized by TEM-EDS, XRD, FT-IR, VSM, and XPS. Kinetic and isothermal analyses suggested mainly chemisorption processes of heavy metal ions that form multiple layers on heterogeneous surfaces.

Epidemiology and genotypes analysis of human papillomavirus infection in Beijing, China.

Background: This study aimed to investigate the epidemiology of high-risk human papillomavirus (HPV) in the female population in Beijing, China, and identify the relationship between HPV genotypes and host factors.

Methods: HPV testing was performed on women aged 15-89 (mean age 38.0 ± 10.

Evaluation of the impact of repeated intravenous phage doses on mammalian host-phage interactions.

Phage therapy has shown great promise for the treatment of multidrug-resistant bacterial infections. However, the lack of a thorough and organized understanding of phage-body interactions has limited its clinical application. Here, we administered different purified phages ( phage SE_SZW1, phage AB_SZ6, and phage PA_LZ7) intravenously to healthy animals (rats and monkeys) to evaluate the phage-induced host responses and phage pharmacokinetics with different intravenous (IV) doses in healthy animals.

The impact of drug shortages on drug prices: evidence from China.

Introduction: Drug shortages pose a serious global public health challenge, affecting China and other countries. Evidence from USA shows that short-supplied drugs demonstrated a very high price growth during and after a shortage. However, the effect of shortages on drug prices in China remains unknown.

An automatic and smart platform for rapid detection of cadmium and lead simultaneously in rice using triple-amplified chemiluminescence immunoassay.

Rapid detection of trace ions is urgently needed for large-scale screening to ensure food safety. This study developed an innovative and automatic strategy, based on a smart-designed platform for rapid detection of cadmium and lead in rice. As bridge antibody, the antigen was conjugated with goat anti-mouse immunoglobulin G labeled alkaline phosphatase.

Astrocytic expression of Yes-associated protein (YAP) regulates retinal neovascularization in a mouse model of oxygen-induced retinopathy.

Pathological neovascularization is the hallmark of many vascular oculopathies. There is still a great deal of uncertainty surrounding retinal neovascularization research. A working hypothesis that astrocytic Yes-associated protein (YAP) act as a key factor in retinal neovascularization was proposed.

An immune-based tool platform for in vivo cell clearance.

Immunological targeting of pathological cells has been successful in oncology and is expanding to other pathobiological contexts. Here, we present a flexible platform that allows labeling cells of interest with the surface-expressed model antigen ovalbumin (OVA), which can be eliminated via either antigen-specific T cells or newly developed OVA antibodies. We demonstrate that hepatocytes can be effectively targeted by either modality.