Effect of short-term exposure to fine particulate matter components on respiratory mortality - evidence from a study of inland cities in China.

There is a lack of research on the association between fine particulate matter (PM) fractions and respiratory disease mortality. Therefore, this study aims to investigate how short-term exposure to fine particulate matter components affects the mortality risk of patients with respiratory diseases.We collected data on the number of respiratory deaths and fine particulate matter components, including sulfate (SO), nitrate (NO), ammonium (NH), organic matters (OM), and black carbon (BC), in Hefei, Anhui Province, between 2017 and 2020.

Circulating tumor DNA methylation in colorectal cancer: a meta-analysis.

Objectives: To synthetically evaluate the diagnostic performance of circulating tumor DNA (ctDNA) methylation for colorectal cancer (CRC).

Methods: Relevant articles published before March 4, 2025 were searched. The pooled sensitivity, specificity, positive and negative likelihood ratio, diagnostic odds ratio (DOR), and the areas under the summary receiver operating characteristic curve (AUC) were calculated.

[Mechanism of Yishen Jiangtang Decoction in regulating endoplasmic reticulum stress-mediated NLRP3 inflammasome to improve renal damage in diabetic nephropathy db/db mice].

This study aims to explore the mechanism through which Yishen Jiangtang Decoction(YSJTD) regulates endoplasmic reticulum stress(ERS)-mediated NOD-like receptor thermal protein domain associated protein 3(NLRP3) inflammasome to improve diabetic nephropathy(DN) in db/db mice. Thirty db/db mice were randomly divided into the model group, YSJTD group, ERS inhibitor 4-phenylbutyric acid(4-PBA) group, with 10 mice in each group. Additionally, 10 db/m mice were selected as the control group.

Research Progress on Organic Fluorescent Probes Based on Pesticide Detection.

The widespread use of pesticides has led to their residues posing a serious threat to the environment and the health of plants and animals, making the development of efficient and convenient detection technologies an urgent priority. Organic fluorescent probes have become a research hotspot owing to their rapid response, visual detection capabilities, and potential for portability. Therefore, this paper reviews the research progress of organic fluorescence detection of pesticides based on the mechanisms of enzymatic reactions, competitive complexation with metal ions, nucleophilic/electrophilic reactions and hydrogen bonding in the past three years (From 2023 to 2025).

Association of NLRC4 inflammasome targeting Caspase1 to regulate monocyte pyroptosis involved in ankylosing spondylitis pathogenesis.

Background: While the NLRC4 inflammasome has been associated with multiple autoimmune pathologies, its role in ankylosing spondylitis (AS) remains undefined. This study aimed to investigate the mechanistic involvement of NLRC4-regulated pyroptosis in the pathogenesis of AS.

Methods: This study collected peripheral blood samples and epidemiological data from 50 AS patients and 50 matched controls, with quantification of NLRC4/CASP1/GSDMD-N mRNA expression levels in peripheral blood mononuclear cells (PBMCs) and inflammatory cytokine levels in plasma.

Association of short-term exposure to air pollutants with mortality from respiratory diseases: a case-crossover study of individual cases based in Hefei, China.

Background: Although short-term exposure to air pollutants has been linked to heightened hospital admissions for respiratory diseases (RDs), evidence regarding its association with the risk of mortality from such diseases remains scarce. We aimed to examine the impact of short-term exposure to air pollutants on RD-related mortality.

Methods: We employed a time-stratified case-crossover design to explore the impact of short-term exposure to various air pollutants (fine particulate matter (PM), coarse particulate matter (PM), nitrogen dioxide (NO2), sulfur dioxide (SO), carbon monoxide (CO), and ozone (O)) on mortality due to RDs.

Screening key genes differentially expressed in ankylosing spondylitis based on bioinformatics analysis and its clinical correlation study.

Objective: This study aimed to identify potential biomarkers for Ankylosing Spondylitis (AS) through integrated bioinformatics analysis and case-control validation, thereby providing a theoretical basis for understanding the underlying pathogenesis of AS.

Methods: We first performed a comprehensive bioinformatics analysis integrated with a literature review to identify key candidate genes. Following this, a case-control validation study was carried out to verify the differential expression of these genes.

Advances in Organic Synthesis and Properties Based On Tetraphenylimidazole Derivatives.

1,2,4,5-Tetraphenylimidazole derivatives exhibit unique conjugated structures, photophysical properties, and multifunctional properties by virtue of the phenyl functional groups introduced at specific positions of the imidazole ring. However, there is still a lack of systematic research on them, which limits their further development and application. In this paper, we comprehensively review the research progress in the fields of organic synthesis, mechanistic fluorescence color change, chemiluminescence, OLED and fluorescent sensors, especially focusing on the hotspot of fluorescent sensors.

Advances, Challenges, and Perspectives in Glomalin-Related Soil Protein Research.

Glomalin-related soil protein (GRSP), a glycoprotein primarily exuded by arbuscular mycorrhizal fungi (AMF), exerts key roles in ecological processes in terrestrial ecosystems. Nevertheless, the intricate nature of GRSP, coupled with constraints in its extraction and analytical methodologies, impedes a comprehensive understanding of its compositional attributes and ecological functions. Moreover, the scope of current GRSP research has undergone significant expansion, necessitating a comprehensive synthesis in this field.

Impact of non optimal ambient temperature and temperature variation on the mortality of cardiovascular diseases: a research in Wuhu, China.

Given the backdrop of global climate change, future temperatures are anticipated to exhibit increased variability and extremity, amplifying health risks and the burden of diseases, a matter of heightened concern. The aim of this research was to evaluate the mortality risk associated with cardiovascular diseases (CVD) due to suboptimal temperatures (daily mean temperature) and temperature variations (diurnal temperature range). Daily data spanning from 2014 to 2020 in Wuhu City were gathered, encompassing meteorological factors, environmental pollutants, and cardiovascular disease mortality information, involving 64,758 CVD deaths.

Continuous Transition between Bosonic Fractional Chern Insulator and Superfluid.

The properties of fractional Chern insulator (FCI) phases and the phase transitions between FCIs and Mott insulators in bosonic systems are well studied. The continuous transitions between FCI and superfluids (SFs), however, despite the inspiring field theoretical predictions [M. Barkeshli and J.

Pd/Ag-Cocatalyzed Merging Intramolecular Oxidative Coupling and Cascade [4 + 2] Cycloaddition: Synthesis and Photophysical Properties of Novel Polycyclic -Heterocycles Fused Naphthoquinones.

We report a step-economic strategy for the direct synthesis of novel polycyclic -heterocycle-fused naphthoquinones by merging intramolecular oxidative coupling and cascade [4 + 2] cycloaddition. In the protocol, mechanistic investigations suggest that the cascade reaction involves the intermediate spiro polycyclic -heterocycles and [4 + 2] cycloaddition processes. This protocol is featured with moderate to excellent yields, wide substrate scope, and divergent structures of products.

Regnase-1 regulates inflammation in T cells of ankylosing spondylitis through the TRAF6.

The study aimed to investigate the regulatory role of Regnase-1 in ankylosing spondylitis (AS) inflammation. We collected 10 ml peripheral venous blood and epidemiological data from 45 AS patients and 45 healthy controls and performed enzyme-linked immunosorbent assay (ELISA) experiments to measure the levels of inflammatory cytokines. Then CD3 + T lymphocytes were isolated by magnetic bead sorting method, and the transcriptional levels of Regnase-1 and TNF receptor-associated factor 6 (TRAF6) were detected by real-time quantitative PCR (qRT-PCR).

From fractional quantum anomalous Hall smectics to polar smectic metals: nontrivial interplay between electronic liquid crystal order and topological order in correlated topological flat bands.

Symmetry-breaking orders can not only compete with each other, but also be intertwined, and the intertwined topological and symmetry-breaking orders make the situation more intriguing. This work examines the archetypal correlated flat band model on a checkerboard lattice at fillingν=2/3and we find that the unique interplay between smectic charge order and topological order gives rise to two novel quantum states. As the interaction strength increases, the system first transitions from a Fermi liquid (FL) into FQAH smectic (FQAHS) state, where the topological order coexists cooperatively with smectic charge order with enlarged ground-state degeneracy and interestingly, the Hall conductivity isσxy=ν=2/3, different from the band-folding or doping scenarios.

"Turn-on" fluorescent sensor for glycerol based on hydrazine-bridged bis-tetraphenylimidazole.

Glycerol is an important biological molecule, but no facile and on-site fluorescence sensor for detecting glycerol has been reported up to now. In this work, the organic fluorescent sensor for glycerol was prepared based on hydrazine-bridged bis-tetraphenylimidazole (HBT), which exhibited an excellent "turn-on" blue fluorescence response in detecting glycerol for the first time. The good sensing selectivity for glycerol among all kinds of organic molecules and ions was confirmed with the low detection limitation (LOD=0.

Thermodynamic Response and Neutral Excitations in Integer and Fractional Quantum Anomalous Hall States Emerging from Correlated Flat Bands.

Integer and fractional Chern insulators have been extensively explored in correlated flat band models. Recently, the prediction and experimental observation of fractional quantum anomalous Hall (FQAH) states with spontaneous time-reversal symmetry breaking have garnered attention. While the thermodynamics of integer quantum anomalous Hall (IQAH) states have been systematically studied, our theoretical knowledge on thermodynamic properties of FQAH states has been severely limited.

Optical spatial differentiation enabled layer sensing of two-dimensional atomic crystals.

Zero-thickness model and slab model are two important models in the description of optical behaviors in two-dimensional atomic crystals. The predicted difference in optical behaviors between the two models is very small, which is difficult to distinguish by established measurement methods. Here, we present an optical spatial differentiation method to examine the difference in edge images of different graphene layers.

Spin-degree manipulation for one-dimensional room-temperature ferromagnetism in a haldane system.

The intricate correlation between lattice geometry, topological behavior and charge degrees of freedom plays a key role in determining the physical and chemical properties of a quantum-magnetic system. Herein, we investigate the introduction of the unusual oxidation state as an alternative pathway to modulate the magnetic ground state in the well-known = 1 Haldane system nickelate YBaNiO (YBNO). YBNO is topologically reduced to incorporate d-Ni ( = 1/2) in the one-dimensional Haldane chain system.

XAF1 overexpression inhibits the malignant progression and cisplatin resistance of NSCLC by activating endoplasmic reticulum stress.

Background: XIAP-associated factor 1 (XAF1) has been found to participate in the progression of multiple human cancers. Nevertheless, its role as well as the reaction mechanism in non-small cell lung cancer (NSCLC) still remains obscure.

Methods: In this study, the protein expression of XAF1 in NSCLC cell lines was evaluated using western blot.

Strengthen interactions among fungal and protistan taxa by increasing root biomass and soil nutrient in the topsoil than in the soil-rock mixing layer.

Soil depth plays a crucial role in shaping the interactions between soil microbes and nutrient availability. However, there is limited understanding of how bacterial, fungal, and protistan communities respond to different soil depths, particularly in the unique geological context and soil properties of karst regions. Organic matter, total nitrogen, and phosphorus, ammonium, nitrate, and plant root biomass, as well as bacterial and fungal abundances, bacterial and protistan diversity were higher in the 0-20 cm soil layer than those in the 20-40 cm and soil-rock mixing layers.

Exploring the interrelations and driving factors among typical ecosystem services in the Yangtze river economic Belt, China.

Exploring the spatiotemporal characteristics of ecosystem services (ESs) and their drivers is crucial for managers to develop significant scientific policies that further sustainable development. We used the Yangtze River Economic Belt (YREB) to explore the trends, hotspots, and drivers of water yield (WY), soil conservation (SC), carbon sequestration (CS), and food supply (FS) between 2000 and 2020. Similarly, we analyzed relationships among ESs and drivers of the multiple ecosystem services landscape index (MESLI).

Isolation, characterization and genomic analysis of the novel Arthrobacter sp. phage SWEP2.

A new virulent phage, SWEP2, infecting the Arthrobacter sp. 5B strain, was isolated from black soil samples in northeastern China. SWEP2 has a latent period of 80 min and a burst size of 45 PFU (evaluated at an MOI of 0.

Impacts of landscape pattern evolution on typical ecosystem services in Ganjiang River Basin, China.

Understanding the response mechanism of ecosystem services (ES) to landscape patterns is important in regional landscape planning and sustainable development. In this study, the landscape index and InVEST model were used to quantitatively analyze the spatio-temporal evolution of landscape patterns and ES in the Ganjiang River Basin of China from 1990 to 2020. Furthermore, the bivariate Moran's I method and spatial error model were used to test the spatial correlation between landscape index and ES.