Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement.

Background: The bone marrow microenvironment, comprising various cell types and molecular signals, finely orchestrates the self-renewal and lineage commitment of hematopoietic stem cells (HSCs). Although most investigations have centered on mesenchymal stem cells (MSCs) from long bones, the distinct properties and immunoregulatory functions of craniofacial bone marrow derived MSCs remain largely unexplored. Notably, jawbone MSCs not only exhibit a robust capacity for promoting hematopoietic regeneration but also offer therapeutic potential in infectious diseases.

Aminated Graphite-Reinforced MnO Anode Interfacial Interaction via Mn-N-C Bonds for Enhanced Lithium-Ion Storage Performance.

Constructing strong interfacial interactions between the carbon coating layer and the MnO anode is highly desirable for enhancing its structural stability and electronic conductivity. Herein, an aminated graphite/MnO composite (MnO@300NG) with a strong Mn-N-C heterointerface has been designed via coupling hydrothermal self-assembly with a calcination strategy. This stable structure can fully expose more Li-ion storage active sites and accelerate the charge transfer rate and Li-ion diffusion kinetics.

Orchestrating Nutrient Homeostasis: RNA-Binding Proteins as Molecular Conductors in Metabolic Disease Pathogenesis.

RNA-binding proteins (RBPs) are critical regulators of post-transcriptional processes, playing essential roles in nutrient metabolism and metabolic homeostasis. This literature review explores how RBPs influence the metabolism of glucose, lipid, and amino acid metabolism by controlling processes like mRNA stability and translation regulation. The dysregulation of RBPs, including HuR, PTB, and YTHDF1, is linked to metabolic diseases such as obesity, diabetes, and non-alcoholic fatty liver disease.

Mitochondrial thermal proteome profiling reveals aberrant activation of pyruvate dehydrogenase upon cuproptosis.

Cuproptosis, a copper-induced form of regulated cell death, holds therapeutic promise in cancer but remains mechanistically unclear. We developed Mito-TPCA, a mitochondrial thermal proximity coaggregation strategy combining enzyme-catalyzed proteome labeling with thermal profiling, to map mitochondrial protein-protein interaction dynamics during cuproptosis. This approach revealed that copper disrupts the association of pyruvate dehydrogenase kinases (PDKs) with the pyruvate dehydrogenase (PDH) complex by targeting lipoyl domains, triggering PDH dephosphorylation and aberrant activation.

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated-B Cells.

In children, hyper-IgM syndrome type 1 (HIGM1) is a type of severe antibody disorder, the pathogenesis of which remains unclear. The antibody diversity is partially determined by the alternative splicing (AS) in the germline, which is mainly regulated by RNA-binding proteins, including Breast cancer amplified sequence 2 (Bcas2). However, the effect of Bcas2 on AS and antibody production in activated B cells, the main immune cell type in the germline, remains unknown.

The Pathological Role and Therapeutic potential of ALDH2 in acrolein detoxification Following Spinal Cord Injury in Mice.

Oxidative stress and lipid peroxidation-derived aldehydes, such as acrolein, play a central role in the pathology of spinal cord injury (SCI) and have emerged as promising therapeutic targets. Mitochondrial aldehyde dehydrogenase-2 (ALDH2) is a key oxidoreductase responsible for detoxifying reactive aldehydes. Pharmacological activation of ALDH2 using Alda-1, a selective agonist, has been shown to reduce aldehyde accumulation, alleviate inflammation, and enhance functional recovery in experimental SCI models.

How to view the effectiveness of spinal deformity surgery for adult degenerative scoliosis in octogenarian population? A comprehensive analysis and judgment.

This study aims to explore the connections between risk factors and clinical outcomes in octogenarian patients diagnosed with adult degenerative scoliosis (ADS). A total of 394 patients participated in this study, with 206 individuals in the younger group and 188 in the octogenarian group. We meticulously gathered patient demographics, including basic information, comorbidities, radiographic data, clinical scoring systems, and details on medical and surgical complications as well as revision surgeries.

Anti-S2 antibodies responsible for the SARS-CoV-2 infection-induced serological cross-reactivity against MERS-CoV and MERS-related coronaviruses.

Sarbecoviruses, such as SARS-CoV-2, utilize angiotensin-converting enzyme 2 (ACE2) as the entry receptor; while merbecoviruses, such as MERS-CoV, use dipeptidyl peptidase 4 (DPP4) for viral entry. Recently, several MERS-related coronaviruses, NeoCoV and PDF-2180, were reported to use ACE2, the same receptor as SARS-CoV-2, to enter cells, raising the possibility of potential recombination between SARS-CoV-2 and MERS-related coronaviruses within the co-infected ACE2-expressing cells. However, facing this potential recombination risk, the serum and antibody cross-reactivity against MERS/MERS-related coronaviruses after SARS-CoV-2 vaccination and/or infection is still elusive.

Construction of MnX (X = P, O, S) nanoparticles embedded in porous carbon/graphene nanocomposite fibers as efficient bifunctional oxygen electrocatalyst for Zn-air batteries.

Porous carbon coated manganese compounds nanoparticles (MnX, X = P, O or S) is a kind of potential catalysts for oxygen electrocatalysis due to the controllable d-band center, while the complex mechanism and performance difference is yet to reveal due to the lack of catalyst platform. Herein, the ORR catalytic activity and difference reason between manganese phosphide, oxide, and sulfide are tested and discussed via manganese compounds contained carbon-based catalyst platforms synthesis and Density functional theory (DFT). Manganese compounds nanoparticles active sites are uniformly distributed in porous carbon fibers/graphene composite, which guarantees the high mass transfer ability and conductive ability.

Anionic regulation Fe/NiOOH electrocatalysts to boost electrooxidation performance of biomass derived 5-hydroxymethylfurfural.

Nickel-based catalysts show great potential as promising candidates for the electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF). However, the limited adsorption capacity of nickel-based catalysts for OH and HMF limits their further development. In this study, amorphous Fe/NiOOH-SO was generated from nanosheets (Fe/NiOOH-NiS), which was pre-fabricated on nickel foam via pre-reconstruction and anionic regulation strategy.

An analog of phenelzine demonstrates effective acrolein scavenging and neuroprotection without monoamine oxidase inhibition in a rat SCI model.

Oxidative stress is widely recognized as a critical factor in the functional deficits after spinal cord injury (SCI). Oxidative stress and lipid peroxidation-derived aldehydes such as acrolein are known to play a key role in SCI pathology and have therefore emerged as valuable therapeutic targets. This study introduces a novel phenelzine analogue (PhzA), designed to retain the acrolein scavenging capability of phenelzine (Phz) while removing its undesirable monoamine oxidase (MAO) inhibition effects through structure-based modification.

ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway.

Nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a serious clinical complication with no effective treatments available. Modulating the intestinal microbiota through dietary and nutritional targets is a promising strategy for preventing NSAID enteropathy. This study aimed to investigate the protective effect and underlying mechanisms of the probiotic (CB) on indomethacin (IND)-induced enteropathy.

Probiotics and Prebiotics: Meeting Dietary Requirements for Optimal Health and Planetary Sustainability.

Background And Objectives: Probiotics and prebiotics are valuable in enhancing human health and fostering sustainable development.

Methods: This review focuses on the role of probiotics and prebiotics at all stages of life to promote nutrient absorption, boost immunity, and support healthy aging by mitigating cognitive decline and chronic disease.

Results And Conclusions: Health and environmental sustainability are deeply connected, making probiotics and prebiotics promising tools for promoting well-being and achieving global sustainability goals.

Corrigendum: The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation.

[This corrects the article DOI: 10.3389/fimmu.2025.

Potential mechanism of traditional Chinese medicine intervention in gastric cancer: targeted regulation of autophagy.

Gastric cancer (GC) is a prevalent malignant tumor that originates from the epithelial cells of the gastric mucosa, predominantly in the form of adenocarcinoma. Extensive research has confirmed the significant role of autophagy in the initiation, progression, and chemoresistance of GC. The potential of traditional Chinese medicine (TCM) to exert anti-tumor effects by modulating autophagy has been demonstrated, particularly in the context of GC prevention and treatment.

The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation.

Metabolic syndrome (Mets) is an important contributor to morbidity and mortality in cardiovascular, liver, neurological, and reproductive diseases. Short-chain fatty acid (SCFA), an organismal energy donor, has recently been demonstrated in an increasing number of studies to be an important molecule in ameliorating immuno-inflammation, an important causative factor of Mets, and to improve lipid distribution, blood glucose, and body weight levels in animal models of Mets. This study reviews recent research advances on SCFA in Mets from an immune-inflammatory perspective, including complications dominated by chronic inflammation, as well as the fact that these findings also contribute to the understanding of the specific mechanisms by which gut flora metabolites contribute to metabolic processes in humans.

Maternal Milk Orchestrates the Development of Infant Gut Microbiota: Implications for Health and Future Research Directions.

Human breast milk serves as a vital source of nutrition for infants, and it also plays a critical role in shaping the infant gut microbiota and establishing intestinal homeostasis. This process substantially impacts immune function, neurodevelopment, and overall health. The noninvasive nature of breast milk collection makes it an ethical and accessible area for research, positioning it as a key focus for future studies.

The effect of breastfeeding on early childhood caries: A prospective cohort study of 3-year-old Chinese children.

Objectives: Early childhood caries (ECC) is a highly prevalent disease. Breastfeeding is a beneficial feeding method, but existing studies lack consensus on its association with the occurrence of ECC. This study aimed to analyse the effect of breastfeeding on ECC occurrence and possible microbiological mechanisms.

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography.

To model craniofacial malformations caused by vitamin A deficiency (VAD), we expressed a dominant-negative retinoid receptor mutation in osteoblasts to specifically inhibit RAR transcriptional activity in mice. This approach allowed us to investigate the effects of VAD on cranial hypomineralization, mandibular deformity, and clavicular hypoplasia in clinical cases. In this study, microcomputed tomography (microCT) scanning of the craniomaxillofacial region of mice represented a valuable tool for studying the growth and development of this animal model.

Ambient ozone exposure and pregnancy complications and adverse birth outcomes: A systematic review and meta-analysis.

Background: Ambient ozone pollution is becoming a global health threat under global warming. Evidence on the association between ambient ozone and pregnancy complications and adverse birth outcomes has grown enormously. To provide a comprehensive assessment of the evidence, we performed a systematic review and meta-analysis to outline current epidemiological evidence.

Phase regulation of Ni(OH) nanosheets induced by W doping as self-supporting electrodes for boosted water electrolysis.

Developing high-performance and low-cost electrodes for hydrogen and oxygen evolution reactions (HER and OER, respectively) represents a pivotal challenge in the field of water electrolysis. Herein, W doped NiFe LDH nanosheets (NiFe-W/NF) were immobilized on nickel foam (NF) through one-step corrosion engineering, which induced the coexistence of α-Ni(OH) and β-Ni(OH). The doping of large atomic radius W influenced the growth of crystal planes of Ni(OH), promoting the formation of α-Ni(OH), which results in large layer spaces and neatly arranged nanosheets structure.