Effect of intraoperative music intervention on anxiety and pain control in patients undergoing kidney surgery: a systematic review and meta-analysis of randomized controlled trials.

Objectives: To report the first systematic review and meta-analysis of randomized controlled trials (RCT) for the effect of intraoperative music intervention on anxiety and pain control in patients undergoing kidney surgery.

Methods: A systematic literature search was conducted across PubMed, Embase, Web of Science, and Cochrane up to November 2024. Outcomes included visual analog score (VAS) and State-Trait Anxiety Inventory (STAI).

Voriconazole-induced liver injury: incidence patterns and risk factors in a retrospective cohort.

Voriconazole, a first-line therapy for invasive aspergillosis, carries hepatotoxicity risks lacking comprehensive epidemiological characterization. Current evidence is limited by heterogeneity in diagnostic criteria (e.g.

Global, regional and national burden of depressive disorders in adolescents and young adults, 1990-2021: systematic analysis of the global burden of disease study 2021.

Background: To promote evidence-based policymaking, this research attempts to investigate global trends in depressive disorders among individuals aged 15-39 from 1990 to 2021, determine risk factors, and forecast the next trends from 2022 to 2050.

Methods: Data from the Global Burden of Disease (GBD) 2021 database were analyzed to look at the global, national, and regional burden of depressive disorders among individuals aged 15-39 from 1990 to 2021. Incidence rates, disability-adjusted life years (DALYs), and contributions of various risk factors to DALYs were also examined in this research.

A machine learning model for predicting anatomical response to Anti-VEGF therapy in diabetic macular edema.

Purpose: To develop a machine learning model to predict anatomical response to anti-VEGF therapy in patients with diabetic macular edema (DME).

Methods: This retrospective study included patients with DME who underwent intravitreal anti-VEGF treatment between January 2023 and February 2025. Baseline data included optical coherence tomography (OCT) features and blood-based metabolic and hematologic markers.

Discovery of Novel Potent Molecule for Treating Cisplatin-Induced Acute Kidney Injury Driven by Phenotypic Screening.

Cisplatin-induced acute kidney injury (cis-AKI) is the primary organ toxicity that occurs during cisplatin-based cancer treatment, and currently, there is a lack of effective treatment methods. The occurrence of cis-AKI involves complex pathophysiological processes, therefore, phenotypic screening-based drug discovery may be more applicable for identifying lead compounds to treat cis-AKI. In this study, a cascading phenotypic screening was designed and implemented.

Hedyotis chrysotricha aqueous extract inhibits hepatitis B surface antigen and viral replication via hepatocyte nuclear factor 4α regulation.

Background: Chronic hepatitis B virus (HBV) infection continues to pose a significant global public health challenge, as current antiviral treatments have not yet succeeded in completely eradicating the virus. Traditional Chinese Medicine (TCM) offers unique advantages in treating chronic hepatitis B. Furthermore, the aqueous extract of Hedyotis chrysotricha (Palib.

Advanced and interpretable corneal staining assessment through fine grained knowledge distillation.

The assessment of corneal fluorescein staining is essential, yet current AI models for Corneal Staining Score (CSS) assessments inadequately identify punctate lesions due to annotation challenges and noise, risk misrepresenting treatment responses through "plateau" effects, and highlight the necessity for real-world evaluations to enhance disease severity assessments. To address these limitations, we developed the Fine-grained Knowledge Distillation Corneal Staining Score (FKD-CSS) model. FKD-CSS integrates fine-grained features into CSS grading, providing continuous and nuanced scores with interpretability.

Relationship between adolescent gaming addiction and myopia, ocular surface condition, and health status: a questionnaire based cohort study.

This study explores the relationship between gaming addiction among Chinese adolescents and their myopia, ocular surface conditions, and overall health. A cross-sectional questionnaire-based cohort study included 835 participants aged 13-17, selected from 3300. Tools included the Hospital Anxiety and Depression Scale (HADS), Van Dream Anxiety Scale (VDAS), 36-Item Short-Form Health Survey (SF-36), Ocular Surface Disease Index (OSDI), Internet Addiction Test (IAT), and Internet Gaming Disorder Scale-20 (IGD-20).

Associations of obesity defined comprehensively by body mass index and body fat percentage with osteopenia.

Objective: To explore the association of obesity comprehensively defined by Body Mass Index (BMI) and Body Fat percentage (BF%) with osteopenia.

Methods: In this cross-sectional study, data of adult men and postmenopausal women aged ≥ 50 years old were obtained from the National Health and Nutrition Examination Surveys (NHANES) database. Weighted logistic regression analysis was conducted to investigate the association of BF% obesity with osteopenia in participants who had different gender and BMI obesity conditions.

Facilitators and barriers in managing older chronic heart failure patients in community health care centers: a qualitative study of medical personnel's perspectives using the socio-ecological model.

Background: Community health care centers (CHCs) plays a crucial role in ensuring timely diagnosis and effective management of congestive chronic heart failure (CHF) in older patients. Understanding the current status of CHF management in CHCs can therefore be effective in reducing the disease burden of CHF.

Objectives: This study evaluates the current state of CHF services in community healthcare facilities and identifies key facilitators and obstacles faced by medical personnel in China.

NAE1 protein: a prognostic, immunomodulatory, and therapeutic biomarker associated with neddylation in hepatocellular carcinoma.

Current predictive biomarkers for clinical outcomes and treatment in hepatocellular carcinoma (HCC) are not reliable enough. Neddylation, a novel post-translational modification, plays a crucial role in the immunomodulation, metabolism, and pathogenesis of HCC. However, whether it can function as a powerful predictive biomarker for HCC remains unknown.

Discovery of the 2,3-Dihydrobenzopyrane-4-one as a Potent FTO Inhibitor against Obesity-Related Metabolic Diseases.

The involvement of the fat mass and obesity-associated gene (FTO) in the development and advancement of metabolic disorders is widely recognized. However, the existing FTO inhibitor entacapone has been limited in clinical application due to its low potency and short plasma elimination half-life. Here, through drug library screening and in depth structure-activity relationship analysis, title compound , eriodictyol was identified as a potent FTO inhibitor, and showed good binding to FTO by surface plasmon resonance (SPR) and Microscale thermophoresis (MST) detection.

Closed genome sequences of 14 serovar Newport isolates from various sources.

serovar Newport is a major contributor to the burden of salmonellosis in the United States. We report the closed genomic sequences of 14 . Newport isolates collected from various sources in the United States.

Knowledge, attitude, and practice towards occupational burnout among doctors and nurses in intensive care unit.

Background: Occupational burnout is prevalent among doctors and nurses. This study aimed to investigate the knowledge, attitude, and practice (KAP) of ICU doctors and nurses regarding occupational burnout.

Methods: A cross-sectional study was conducted between December 2023 and June 2024 at the Zhejiang Medical & Health Group Hangzhou Hospital in Zhejiang Province.

Investigating the causal relationship between the plasma lipidome and cholangiocarcinoma mediated by immune cells: a mediation Mendelian randomization study.

The plasma lipidome and immune cells are instrumental in shaping the health profile of an organism, and their influence on diseases is profound. However, the intricate interactions between cholangiocarcinoma (CCA) and these physiological components have yet to be comprehensively explored. Employing Mendelian randomization (MR), our study delved into the causal links among immune cells, the lipidome, and CCA.

Acyl-anchored metal-organic cages with interior cryptand-like recognition sites for selective removal of radioactive strontium(II).

Tailored design of organic linkers or metal nodes can introduce desirable functionalities into metal-organic cages (MOCs), significantly expanding their potential applications. In this study, we present a viable approach for engineering acyl-type metal nodes to create interior oxygen-rich sites within MOCs, enabling specific recognition of metal ions, including radioactive contaminants, while maintaining the structural integrity of the MOCs. A novel MOC featuring a uranyl-sealed calix[4]resorcinarene (C[4]R)-based multisite cavity, referred to as UOC, is synthesized as a prototype.

Pelvic floor muscle training for the prevention and management of low anterior resection syndrome in patients with rectal cancer: An evidence-based summary.

Objective: This study aims to summarize the best available evidence on the effectiveness of pelvic floor muscle training (PFMT) in preventing and managing low anterior resection syndrome (LARS) among patients with rectal cancer, with the goal of enhancing quality of care.

Methods: A systematic search was conducted across databases, including BMJ Best Practice, UpToDate, WHO, GIN, UK NICE, NGC, SIGN, RNAO, NCCN, JBI Library, Cochrane Library, CINAHL, Web of Science, Embase, OVID, PubMed, Chinese Wanfang, CNKI, SinoMed, and VIP, covering publications from inception through June 30, 2024. We targeted clinical decisions, guidelines, evidence summaries, expert consensus statements, systematic reviews, and randomized controlled trials related to PFMT for LARS in patients with rectal cancer.

Research progress on the correlation between estrogen and estrogen receptor on postmenopausal sarcopenia.

Estrogen is a necessary sex steroid and potent neuroprotective hormone. It plays a multifaceted role beyond the reproductive system, extending its influence to the brain, skeletal muscle, and other organs. Estrogen's role in cognition, mood, autonomic regulation, and neuroprotection involves interactions with neurotransmitters, neuromodulators in a distributed manner.

Prediction model for ocular metastasis of breast cancer: machine learning model development and interpretation study.

Background: Breast cancer (BC) is caused by the uncontrolled proliferation of breast epithelial cells followed by malignant transformation, and it has the highest incidence among female malignant tumors. The metastasis of BC occurs through direct and lymphatic spread. Although ocular metastasis is relatively rare, it is a good indicator of a worse prognosis.

Identification of molecular subtypes based on bile acid metabolism in cholangiocarcinoma.

Background: Cholangiocarcinoma is a highly heterogeneous tumor with bile acid metabolism involving in its development. The aim of this study was to characterize bile acid metabolism and identify specific subtypes to better stratify cholangiocarcinoma patients for individualized treatment and prognostic assessment.

Methods: A total of 30 bile acids were quantified using the ultra-performance liquid chromatography tandem mass spectrometry.

A Qualitative Study Investigating Health Care Professionals' Views on Barriers to Integrating Physical Activity Into Mild Cognitive Impairment/Dementia Care.

This study aimed to investigate health care professionals' (HCPs) views on barriers to integrating physical activity (PA) into mild cognitive impairment/dementia care. Semistructured online interviews form 16 HCPs were completed between November 2022 and December 2022. Data were subjected to thematic analysis and were later mapped deductively to the Theoretical Domains Framework.