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[This corrects the article DOI: 10.1371/journal.pone.0308926.].
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[This corrects the article DOI: 10.1371/journal.pone.
View Article and Find Full Text PDFDiabetes Obes Metab
October 2025
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.
Aims: This study aimed to determine the efficacy of oral administration of sodium-glucose co-transporter 2 inhibitors (SGLT2i) therapy for early diabetic macular oedema (DMO).
Materials And Methods: We conducted a post-hoc analysis of the COMET trial, a prospective, randomized, parallel, investigator-driven protocol. Sixty patients with DMO eligible for anti-vascular endothelial growth factor (VEGF) therapy were randomized to receive either the SGLT2i luseogliflozin or sulfonylurea (SU) glimepiride.
BMC Med Res Methodol
July 2025
Université Paris Cité, IAME, Inserm, 75018, Paris, France.
Parallel designs with an end-of-treatment analysis are commonly used for randomised trials, but they remain challenging to conduct in rare diseases due to small sample size and heterogeneity. A more powerful alternative could be to use model-based approaches. We investigated the performance of longitudinal modelling to evaluate disease-modifying treatments in rare diseases using simulations.
View Article and Find Full Text PDFBMJ Paediatr Open
July 2025
Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, UK.
Background: Being born with an anorectal malformation (ARM) often leads to lifelong issues with faecal and urinary function, as well as challenges in sexual, emotional and psychosocial development. Even when anatomical correction is achieved, full functional recovery is not guaranteed. Despite several international consensus meetings with leading medical professionals in the ARM field, there is still no agreement on the essential outcome domains that should be measured for ARM treatment and follow-up.
View Article and Find Full Text PDFDiabetes Ther
September 2025
Abteilung für Diabetologie, Endokrinologie, Gastroenterologie und Klinische Forschung, Kinder- und Jugendkrankenhaus Auf der Bult, Hannover, Germany.