Functional characterization of CsSTK in floral organ development and its positive regulation by CsBPC5 in tea plants.

Background: As an important economic crop, the development of floral organs in tea plants plays an essential role in tea yield, quality, and varietal improvement. Previous studies have shown significant downregulation of the CsSTK gene in the pistil-deficient mutant 'Yuncha Qirui' (CRQS) during flower development, suggesting its involvement in floral organ and pistil development.

Results: This study investigated CsSTK function and regulatory mechanisms, concurrently conducting a systematic identification of the BPC transcription factor family members in tea plants.

MHLC, a novel tea germplasm with cyanidin-dominant anthocyanin profiling and low-catechin trait driven by flavonoid pathway Divergence.

The tea plant (Camellia sinensis) is a vital economic crop whose quality and health benefits are primarily determined by flavonoid compounds, particularly catechins and anthocyanins. However, the dynamic regulatory mechanisms of governing flavonoid accumulation remain unclear. A novel tea germplasm, MHLC, with a reddish-purple phenotype was identified in this study.

Eosinophilic gastroenteritis with negative endoscopic biopsy and no peripheral eosinophilia: A case report.

Rationale: Eosinophilic gastroenteritis (EoGE) is a rare inflammatory disease that can affect the entire gastrointestinal tract. Klein et al classified EoGE into 3 distinct subtypes according to the depth of eosinophilic infiltration: mucosal, muscular, and serosal.

Patient Concerns: We herein report a case of a 29-year-old woman who presented with abdominal pain, nausea, and vomiting, with no history of adverse reactions to any allergens.

Improper use of spinetoram on tea plants can inhibit the predation ability of Arma chinensis.

The application of pesticides is indispensable in agricultural production and mitigate the negative impact is crucial nowadays. The Agriophara rhombata is a major pest on tea trees and the Arma chinensis is a beneficial insect and its natural enemy in field production. Application of the Spinetoram to control A.

Multi-Omics Analysis Revealed the Accumulation of Flavonoids and Shift of Fungal Community Structure Caused by Tea Grafting ( L.).

Grafting is an important approach to improving tea plant varieties, and tea grafting can result in changes in secondary metabolites. However, the shifting pattern of secondary metabolites between scions, rootstocks, and non-grafted tea leaves is unclear. We employed "Yuncha 1" as the scion and "Zijuan" as the rootstock with significant differences in leaf color traits to reveal the influences of grafting on the generation of secondary metabolites and transcriptional activities.

A case report of gastric antral vascular ectasia treated by endoscopic band ligation combined with lauromacrogol injection.

Rationale: Gastric antral vascular ectasia (GAVE) is a rare acquired lesion characterized by vascular dilation in the gastric antrum, frequently results in occult or overt gastrointestinal bleeding. Endoscopic intervention remains the cornerstone of therapy. Argon plasma coagulation was previously considered a first treatment option.

Metabolomic profiling identifies metabolites in the pheromone glands of associated with the synthesis and release of female pheromone signals.

The tea moth pest, is an economically important and highly damaging pest that drastically affects tea plant leaves. The chemical composition of its pheromone glands metabolites before and during calling period has not been reported yet. Therefore, the present study aimed at the metabolomic profiling of female moths' sex pheromones glands before and during calling period using gas chromatography time-of-flight mass spectrometry.

Comparative investigation of metabolite signatures and hypoadiposity effect between Dali tea and Yunkang tea.

Dali tea (DLT) made by wild tea plant ( has been very popular in the market。However, the signature compounds and health benefits of DLT were not reported yet. To comprehensively understand metabolite signatures and potential health-function, the distinct metabolite signatures and hypoadiposity effect between DLT and Yunkang tea (YKT, made by Yunkang 10) were comparative investigated. Our data found that catechins, and dimeric catechins were lower in DLT than YKT.

Deciphering the anthocyanin metabolism gene network in tea plant (Camellia sinensis) through structural equation modeling.

Background: Tea is an important cash crop that significantly contributes to rural development, poverty reduction and food security in many developing countries. It provides livelihoods for millions of smallholder producers and aids their economic stability. Anthocyanins in tea leaves provides excellent commercial quality and germplasm exploration potential.

Design and Synthesis of c-Met and HDAC Dual Inhibitors for the Treatment of Breast Cancer.

In recent years, it has been proposed that c-mesenchymal-to-epithelial transition factor (c-Met) and histone deacetylase (HDAC) dual inhibition is a promising cancer treatment strategy. Herein, a series of c-Met/HDAC dual inhibitors were designed and synthesized given their synergistic anticancer effect in breast cancer cells. Compound exhibited excellent inhibitory activity against c-Met (IC = 28.

Cadmium activates the innate immune system through the AIM2 inflammasome.

Cadmium (Cd) is a widely used heavy metal and has recently been recognized as a possible source of human toxicity due to its ability to accumulate in organs. Accumulation of heavy metals has several adverse effects, including inducing inflammation, in multiple organs, such as the testis. However, how Cd ions are sensed by host cells and how tissue inflammation eventually occurs remains unclear.

Diversity and Abundance of Bacterial and Fungal Communities Inhabiting Leaf, Rhizospheric Soil, and Gut of .

is a tea leaf moth that is considered one of the most destructive pests of (tea plant). Several recent studies have shown that many insects acquire part of the microbiome from their host and soil, but the pattern and diversity of their microbiome have not been clearly demonstrated. The present study aimed to investigate the bacterial and fungal communities present in the rhizospheric soil and leaf of tea plant compared to the gut of tea moth at different developmental stages (larvae, pupae, adult female and male) using Illumina MiSeq technology.

Patterns and abiotic drivers of soil organic carbon in perennial tea (Camellia sinensis L.) plantation system of China.

Understanding soil organic carbon (SOC), the largest carbon (C) pool of a terrestrial ecosystem, is essential for mitigating climate change. Currently, the spatial patterns and drivers of SOC in the plantations of tea, a perennial leaf crop, remain unclear. Therefore, the present study surveyed SOC across the main tea-producing areas of China, which is the largest tea producer in the world.

NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.

Mitochondrial biogenesis is the process of generating new mitochondria to maintain cellular homeostasis. Here, we report that viruses exploit mitochondrial biogenesis to antagonize innate antiviral immunity. We found that nuclear respiratory factor-1 (NRF1), a vital transcriptional factor involved in nuclear-mitochondrial interactions, is essential for RNA (VSV) or DNA (HSV-1) virus-induced mitochondrial biogenesis.

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function.

Ectopic lipid deposition and mitochondrial dysfunction are common etiologies of obesity and metabolic disorders. Excessive dietary uptake of saturated fatty acids (SFAs) causes mitochondrial dysfunction and metabolic disorders, while unsaturated fatty acids (UFAs) counterbalance these detrimental effects. It remains elusive how SFAs and UFAs differentially signal toward mitochondria for mitochondrial performance.

Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.

ATG9A is a highly conserved membrane protein required for autophagy initiation. It is trafficked from the trans-Golgi network (TGN) to the phagophore to act as a membrane source for autophagosome expansion. Here, we show that ATG9A is not just a passenger protein in the TGN but rather works in concert with GRASP55, a stacking factor for Golgi structure, to organize Golgi dynamics and integrity.

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.

DBC1 has been characterized as a key regulator of physiological and pathophysiological activities, such as DNA damage, senescence, and tumorigenesis. However, the mechanism by which the functional stability of DBC1 is regulated has yet to be elucidated. Here, we report that the ubiquitination-mediated degradation of DBC1 is regulated by the E3 ubiquitin ligase SIAH2 and deubiquitinase OTUD5 under hypoxic stress.

Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein.

In this work, a series of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein were designed and synthesized for treatment of liver cancer. After structural optimization for several rounds, C11 displayed a relatively better affinity with 14-3-3η, as well as the best inhibitory activities against several typical human liver cancer cell lines, including Bel-7402, SMMC-7721, SNU-387, Hep G2 and Hep 3B cells. Compound C11 also displayed best inhibitory activity against chemotherapy-resistant Bel-7402/5-Fu cells.

BCKDK Promotes Ovarian Cancer Proliferation and Migration by Activating the MEK/ERK Signaling Pathway.

Background: Ovarian cancer (OC) is the most fatal gynecologic cancer. The branched-chain -keto acid dehydrogenase kinase (BCKDK) plays an important role in many serious human diseases, including cancers. Its function in promoting cell proliferation and migration has been reported in various cancers.

Rg1 Protects Hematopoietic Stem Cells from LiCl-Induced Oxidative Stress via Wnt Signaling Pathway.

Background: Ginsenoside Rg1 is a major component of ginseng with antioxidative and antiaging effects, which is a traditional Chinese medicine. In this study, we investigated the potential spillover and mechanism of action of Rg1 on LiCl-driven hematopoietic stem cell aging.

Results: Collect the purified Sca-1 hematopoietic cells for differentiation ability detection and biochemical and molecular labeling.

Identifying key genes involved in yellow leaf variation in 'Menghai Huangye' based on biochemical and transcriptomic analysis.

Albino tea plants generally have higher theanine, which causes their tea leaves to taste fresher, and they are an important mutant for the breeding of tea plant varieties. Earlier, we reported an albino germplasm, 'Menghai Huangye' (MHHY), from Yunnan Province and found that it has a lower chlorophyll content during the yellowing stage, but the mechanism underlying low chlorophyll and the yellowing phenotype is still unclear. In this study, the pigment contents of MHHY_May (yellowing, low chlorophyll), MHHY_July (regreening, normal chlorophyll), and YK10_May (green leaves, normal chlorophyll) were determined, and the results showed that the lower chlorophyll content might be an important reason for the formation of the yellowing phenotype of MHHY.

Functional Analyses of Flavonol Synthase Genes From Reveal Their Roles in Anther Development.

Flavonoids, including flavonol derivatives, are the main astringent compounds of tea and are beneficial to human health. Many researches have been conducted to comprehensively identify and characterize the phenolic compounds in the tea plant. However, the biological function of tea flavonoids is not yet understood, especially those accumulated in floral organs.

Menghai Huangye, a novel albino tea germplasm with high theanine content and a high catechin index.

Yunnan Province has a very wide diversity of tea germplasm resources. A variety of special tea germplasms with outstanding traits have been discovered, including tea germplasms with high anthocyanin content and low caffeine content. Albino tea cultivars generally have higher contents of theanine that contribute to the umami taste, and the quality of tea brewed from it is higher.