Iron-Catalyzed Photochemical Defluorinative Functionalization of Polyfluorinated Aromatics.

Iron photocatalysis has emerged as a sustainable platform for C-H functionalization. This study describes a photocatalytic strategy for the selective defluorinative functionalization of polyfluorinated aromatics. The developed methodology enables selective defluorosulfonylation with sulfur dioxide and defluorinative alkylation with alkanes under visible light irradiation.

Recent advances in photocatalytic and transition metal-catalyzed synthesis of disulfide compounds.

Disulfide bonds are essential in protein folding, cellular redox balance, materials science, and drug development. Despite existing synthetic methods, the efficient and selective synthesis of unsymmetrical disulfides remains challenging. This review highlights innovative approaches in visible light photocatalysis, including decarboxylation, deoxydisulfidation of alcohols, and direct C-H disulfidation, showcasing broad substrate applicability and functional group tolerance under mild conditions.

Photoinduced Ligand-to-Copper Charge Transfer for Aryl Decarboxylative Allylation, Thiolation, and Bromination.

Herein, aryl decarboxylative allylation, thiolation, and bromination reactions via photoinduced ligand-to-copper charge transfer are described. Utilizing inexpensive copper metal, the transformations of various aryl carboxylic acids enable the rapid synthesis of the corresponding alkene, thioether, and aryl bromide derivatives under visible light irradiation, which offers significant synthetic value. The reaction conditions are mild and straightforward, exhibiting a broad substrate compatibility.

Direct C(sp)-H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents.

Recent years have witnessed the emergence of direct intermolecular C(sp)-H bond functionalization using generated aryl/alkyl radicals as a unique class of hydrogen atom transfer (HAT) agents. A variety of precursors have been exploited to produce these radical HAT agents under photocatalytic, electrochemical or thermal conditions. To date, viable aryl radical precursors have included aryl diazonium salts or aryl azosulfones, diaryliodonium salts, -benzoyl oximes, aryl sulfonium salts, aryl thioesters, and aryl halides; and applicable alkyl radical sources have included tetrahalogenated methanes (, CClBr, CBr and CFI), -hydroxyphthalimide esters, alkyl bromides, and acetic acid.

Titanium in photocatalytic organic transformations: current applications and future developments.

Titanium, as an important transition metal, has garnered extensive attention in both industry and academia due to its excellent mechanical properties, corrosion resistance, and unique reactivity in organic synthesis. In the field of organic photocatalysis, titanium-based compounds such as titanium dioxide (TiO), titanocenes (CpTiCl, CpTiCl), titanium tetrachloride (TiCl), tetrakis(isopropoxy)titanium (Ti(OPr)), and chiral titanium complexes have demonstrated distinct reactivity and selectivity. This review focuses on the roles of these titanium compounds in photocatalytic organic reactions, and highlights the reaction pathways such as photo-induced single-electron transfer (SET) and ligand-to-metal charge transfer (LMCT).

Iron-Catalyzed Multicomponent C-H Alkylation of in Situ Generated Imines via Photoinduced Ligand-to-Metal Charge Transfer.

Herein, we describe a novel photoinduced iron-catalyzed strategy for multicomponent C-H alkylation of in situ generated imines. By utilizing the alkyl radicals generated through iron-mediated photocatalytic C-H activation, the imines formed in situ are further subjected to addition reactions, resulting in the synthesis of various secondary and tertiary amine products. This method is simple to operate and does not require additional oxidants.

Photoinduced decatungstate-catalyzed C(sp)-H thioetherification by sulfinate salts.

Thiols and thioesters play crucial roles in pharmaceuticals, biology, and material science as essential organosulfur compounds. Leveraging readily available and cost-effective inert alkanes through direct thioetherification holds promise for yielding high-value-added products. Herein, we present a photoinduced strategy for sulfur-containing modification of inert alkanes utilizing decatungstate as hydrogen atom transfer reagent, offering a straightforward and practical approach for synthesizing thioethers and thioesters.

Photoelectrochemical oxidative C(sp)-H borylation of unactivated hydrocarbons.

Organoboron compounds are of high significance in organic synthesis due to the unique versatility of boryl substituents to access further modifications. The high demand for the incorporation of boryl moieties into molecular structures has witnessed significant progress, particularly in the C(sp)-H borylation of hydrocarbons. Taking advantage of special characteristics of photo/electrochemistry, we herein describe the development of an oxidative C(sp)-H borylation reaction under metal- and oxidant-free conditions, enabled by photoelectrochemical strategy.

Iron-Catalyzed C(Sp)-H Borylation, Thiolation, and Sulfinylation Enabled by Photoinduced Ligand-to-Metal Charge Transfer.

Catalytic C(sp)-H functionalization has provided enormous opportunities to construct organic molecules, facilitating the derivatization of complex pharmaceutical compounds. Within this framework, direct hydrogen atom transfer (HAT) photocatalysis becomes an appealing approach to this goal. However, the viable substrates utilized in these protocols are limited, and the site selectivity shows preference to activated and thermodynamically favored C(sp)-H bonds.

Bacillus coagulans 13002 and fructo-oligosaccharides improve the immunity of mice with immunosuppression induced by cyclophosphamide through modulating intestinal-derived and fecal microbiota.

This study aims to evaluate the effects of probiotic Bacillus coagulans 13,002 (BCS) and prebiotic fructo-oligosaccharides (FOS) on mice treated with the alkylating agent cyclophosphamide (CTX). We found that both BCS and FOS, especially BCS, significantly alleviated CTX-induced injury by modulating intestinal-derived and fecal microbiota. BCS and BCS + FOS increased serum immunoglobulin levels, which were reduced by CTX.

Iminyl-Radical-Promoted C-C Bond Cleavage/Heck-Like Coupling via Dual Cobaloxime and Photoredox Catalysis.

We report herein an unprecedented protocol for radical-olefin coupling of α-imino-oxy acids and alkenes for the synthesis of alkene-containing nitriles via synergistic photoredox and cobaloxime catalysis. With visible-light irradiation, the transformation provides a variety of corresponding alkene-containing nitriles under mild reaction conditions. The C-C bond cleavage/Heck-like coupling reaction could generate -selective coupling products with excellent chemo- and stereo-selectivity.

Visible-Light-Promoted Intramolecular α-Allylation of Aldehydes in the Absence of Sacrificial Hydrogen Acceptors.

We report herein an unprecedented protocol for radical cyclization of aldehydes with pendant alkenes via synergistic photoredox, cobaloxime, and amine catalysis. The transformation was achieved in the absence of external oxidants, providing a variety of 5-, 6-, and 7-membered ring products with alkene transposition in satisfactory yields. The reaction exhibits wide functional group compatibility and occurs under mild conditions with extrusion of H.

Radical Aza-Cyclization of α-Imino-oxy Acids for Synthesis of Alkene-Containing -Heterocycles via Dual Cobaloxime and Photoredox Catalysis.

Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive molecules. We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime catalysis. With or without alkenes as the intermolecular cross-coupling partners, the transformation provides a variety of corresponding alkene-containing dihydropyrrole products in satisfactory yields.

Ni-Catalyzed deaminative hydroalkylation of internal alkynes.

A regioselective cis-hydroalkylation of internal alkynes with readily prepared Katritzky pyridinium salts for the synthesis of tri-substituted alkenes is described. This reaction is the first example of a metal-catalyzed hydroalkylation of an alkyne via C-N bond activation of an amine. The reaction demonstrates broad scope and functional group tolerance, allowing access to desired products with high diversity.

[Detecting effect comparison between MPAIA, DDIA and IHA for screening advanced schistosomiasis].

Objective: To evaluate the effects of the magnetic particle antibody immunoassay (MPAIA), dipstick dye immunoassay (DDIA) and indirect hemagglutination assay (IHA), on detecting advanced schistosomiasis.

Methods: The sera of 224 cases of advanced schistosomiasis were detected by MPAIA, DDIA, and IHA, and the positive rates were compared.

Results: The positive rates of MPAIA, DDIA and IHA, were 67.