Peptide Coacervates with Metal-Phenolic Membranes Modulate Glucose Metabolism and Enhance Cancer Immunotherapy.

Glucose consumption by tumors induces metabolic restriction of T cells, which results in immune evasion and tumor progression. Regulating cellular metabolism represents a promising strategy to enhance cancer immunotherapy; however, redirecting glucose utilization from tumor cells to T cells is challenging. Herein, the activation of cytotoxic T cells using engineered peptide coacervates (PCs) containing interferon alpha (IFNα) and membranized with metal-phenolic networks (MPNs) (PC-IFNα@MPNs), which promote glucose uptake and glycolysis, is reported.

Expression and clinical significance of CD155, FGL1, Galectin-9, and PD‑L1 in breast cancer with neoadjuvant chemotherapy.

Neoadjuvant chemotherapy (NACT) plays a pivotal role in modulating the immune microenvironment. However, its impact on immune checkpoint expression and the prognostic significance of immune checkpoints in breast cancer (BC) remain unclear. In this retrospective study, we used immunohistochemistry assays to evaluate PD-L1, CD155, FGL1, and Galectin-9 expression in pre- and post-NACT BC samples.

Predictive value of androgen receptor in distant metastasis of triple-negative breast cancer: a retrospective multi-center study.

Background: Although androgen receptor (AR) is highly expressed in triple-negative breast cancer (TNBC), but its role in predicting distant metastasis remains uncertain. This study aimed to investigate the association between AR expression and distant metastasis, including bone metastasis, in TNBC patients.

Materials And Methods: We retrospectively analyzed clinical and pathological data from TNBC patients treated at two cancer centers between January 2016 and December 2022.

Metabolic acclimation to warming links unexpected immune activation and sexual dimorphism attenuation in Xenopus tropicalis.

Maintaining a dynamic balance among various life-history traits is crucial for survival in a warming world, yet the underlying mechanisms remain enigmatic. In this study, we employed the western clawed frog (Xenopus tropicalis) as a model and conducted a long-tern experiment from zygotes to adult stage. We find that even within the previously considered normal temperature range, a 5 °C increase in ambient temperature can establish a new metabolic state, resulting in elevated oxidative stress and a shift in energy allocation towards immune defense at the expense of sexual development.

The challenges and progress of CAR-T cell therapy in the treatment of solid tumors.

Current traditional cancer treatment methods include surgery, chemotherapy, radiotherapy, etc., which lack targeted killing functions and may damage normal tissues. Immunotherapy, targeted therapy, and personalized medicine have become promising methods for cancer treatment, providing more precise and effective treatment for patients.

Anatomical changes in alveolar bone structure following the extraction of the mandibular second molar using CBCT measurements.

This study seeks to investigate the changes in the anatomical structure of the alveolar bone after the extraction of the mandibular second molar at 3, 6, and 12 months using cone-beam computed tomography (CBCT). This study analyzed CBCT images from 87 cases following the extraction of mandibular second molars. The anatomical structures of the alveolar bone were measured immediately after extraction, as well as at 3 months, 6 months, and 12 months post-operation.

The impostor of chest pain: a case of lung cancer mimicking angina.

Chest pain is a common symptom with a complex etiology involving multiple organs and systems. Cardiovascular, digestive and respiratory diseases can cause chest pain. A single condition usually reformulates and can cause this symptom, but a combination of conditions can also cause it.

3D-printed multifunctional bilayer scaffold with sustained release of apoptotic extracellular vesicles and antibacterial coacervates for enhanced wound healing.

Full-thickness skin defects pose significant challenges to physical and psychological health while traditional skin grafting techniques are associated with limitations. Herein, we present a 3D-printed multifunctional bilayer scaffold that incorporates apoptotic extracellular vesicles (ApoEVs) and antibacterial coacervates to prevent wound infection and promote wound healing. The ApoEVs were continuously released from the lower layer of the scaffold with large pores to promote angiogenesis and collagen deposition.

Enrichment of Methanothrix species via riboflavin-loaded granular activated carbon in anaerobic digestion of high-concentration brewery wastewater amidst continuous inoculation of Methanosarcina barkeri.

Effective treatment of high-concentration brewery wastewater through anaerobic digestion (AD) has always been a challenging issue. Enhancing direct interspecies electron transfer (DIET) was demonstrated to increase methane production during AD under high organic loading rate (OLR). Herein, the feasibility of enhancing DIET with the addition of riboflavin-loaded granular activated carbon (RF-GAC) as well as co-addition with Methanosarcina barkeri (Rf-GAC+M.

Multifunctional polymeric nanocapsules with enhanced cartilage penetration and retention for osteoarthritis treatment.

Osteoarthritis (OA) is a prevalent joint disease characterized by cartilage degeneration and subchondral bone homeostasis imbalance. Effective topical OA therapy is challenging, as therapeutic drugs often suffer from insufficient penetration and rapid clearance. We develop miniature polydopamine (PDA) nanocapsules (sub-60 nm), which are conjugated with collagen-binding polypeptide (CBP) and loaded with an anabolic drug (i.

Patterns of Cross-Peaks in Two-Dimensional Correlation Spectra to Probe Intermolecular Interactions Described by Two Reversible Reactions.

Two-dimensional correlation spectroscopy is used to investigate the intermolecular interaction between two substances dissolved in the same solutions, where the intermolecular interaction is described by two reversible reactions producing two supramolecular aggregates. The severe overlappings expected among the characteristic peaks of the original solute and aggregates make conventional one-dimensional spectra difficult to accurately reflect the physiochemical nature of the intermolecular interaction. The double asynchronous orthogonal sample design (DAOSD) approach is utilized to analyze the simulated data for proof-of-principle demonstration.

Construction of preclinical evidence for propofol in the treatment of reperfusion injury after acute myocardial infarction: A systematic review and meta-analysis.

Propofol, a commonly used intravenous anesthetic, has demonstrated potential in protecting against myocardial ischemia/reperfusion injury (MIRI) based on preclinical animal studies. However, the clinical benefits of propofol in this context are subject to debate. We conducted a systematic search across eight databases to identify all relevant animal studies investigating the preventive effects of propofol on MIRI until October 30, 2023.

Effect of different hydrogen evolution rates at cathode on bioelectrochemical reduction of CO to acetate.

Microbial electrosynthesis (MES) offers a promising approach for converting CO into valuable chemicals such as acetate. However, the relative low conversion rate severely limits its practical application. This study investigated the impact of different hydrogen evolution rates on the conversion rate of CO to acetate in the MES system.

Granular activated carbon enhances volatile fatty acid production in the anaerobic fermentation of garden wastes.

Garden waste, one type of lignocellulosic biomass, holds significant potential for the production of volatile fatty acids (VFAs) through anaerobic fermentation. However, the hydrolysis efficiency of garden waste is limited by the inherent recalcitrance, which further influences VFA production. Granular activated carbon (GAC) could promote hydrolysis and acidogenesis efficiency during anaerobic fermentation.

Riboflavin-loaded carbon cloth aids the anaerobic digestion of cow dung by promoting direct interspecies electron transfer.

Cow dung generates globally due to increased beef and milk consumption, but its treatment efficiency remains low. Previous studies have shown that riboflavin-loaded conductive materials can improve anaerobic digestion through enhance direct interspecies electron transfer (DIET). However, its effect on the practical anaerobic digestion of cow dung remained unclear.

Peptide-Based Coacervate Protocells with Cytoprotective Metal-Phenolic Network Membranes.

Protocells have garnered considerable attention from cell biologists, materials scientists, and synthetic biologists. Phase-separating coacervate microdroplets have emerged as a promising cytomimetic model because they can internalize and concentrate components from dilute surrounding environments. However, the membrane-free nature of such coacervates leads to coalescence into a bulk phase, a phenomenon that is not representative of the cells they are designed to mimic.

Natural products modulate cell apoptosis: a promising way for treating endometrial cancer.

Endometrial cancer (EC) is a prevalent epithelial malignancy in the uterine corpus's endometrium and myometrium. Regulating apoptosis of endometrial cancer cells has been a promising approach for treating EC. Recent and studies show that numerous extracts and monomers from natural products have pro-apoptotic properties in EC.

Neuroglobin inhibits pancreatic cancer proliferation and metastasis by targeting the GNAI1/EGFR/AKT/ERK signaling axis.

Pancreatic cancer is an extremely aggressive malignancy with a very disappointing prognosis. Neuroglobin (NGB), a member of the globin family, has been demonstrated to have a significant role in a variety of tumor forms. The possible role of NGB as a tumor suppressor gene in pancreatic cancer was investigated in this work.

Simultaneous nitrification and denitrification by Pseudomonas sp. Y-5 in a high nitrogen environment.

Pseudomonas sp. Y-5, a strain with simultaneous nitrification and denitrification (SND) capacity, was isolated from the Wuhan Municipal Sewage Treatment Plant. This strain could rapidly remove high concentrations of inorganic nitrogen.

Electro-acupuncture for protracted amphetamine abstinence syndrome: study protocol for a pragmatic randomized controlled trial.

Background: Protracted amphetamine abstinence syndrome is one of the primary causes of relapse for amphetamine-type drug abusers during withdrawal. However, the importance of the management of protracted amphetamine abstinence syndrome is underestimated. Electro-acupuncture may be a safe and effective alternative therapy for protracted amphetamine abstinence syndrome, but the evidence is limited.

Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease impacting patients' quality of life and imposing heavy societal and economic burdens. Apoptosis of intestinal epithelial cells (IECs) has been considered an early event during the onset of UC and plays a crucial role in disease development. Thus, effectively inhibiting apoptosis of IECs is of critical significance for the clinical management of UC, presenting a potential direction for the research and development of pharmacotherapeutic agents.

Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis.

Methamphetamine (METH), an amphetamine-type psychostimulant, is highly abused worldwide. Chronic abuse of METH causes neurodegenerative changes in central dopaminergic neurons with numerous neuropsychiatric consequences. Neuronal apoptosis plays a critical role in METH-induced neurotoxicity and may provide promising pharmacological targets for preventing and treating METH addiction.

Transcutaneous electrical acupoint stimulation (TEAS) for cancer-related fatigue: study protocol for a systematic review and meta-analysis.

Introduction: Cancer-related fatigue (CRF) is a prevalent symptom in cancer survivors. Transcutaneous electrical acupoint stimulation (TEAS) has been reported as a promising therapy for CRF. This protocol is proposed for a systematic review that aims to assess the efficacy and safety of TEAS for CRF.