Research Trends and Hotspots of Acupuncture Therapy on Allergic Diseases From 2004 to 2024: A Bibliometric Analysis.

Background: Over the past two decades, acupuncture has increasingly been applied in the treatment of allergic diseases, with a corresponding increase in the number of published articles.

Objective: To investigate the hotspots and frontiers of global scientific output in acupuncture research for allergic diseases over the past two decades.

Methods: The Web of Science Core Collection was used to collect literature on acupuncture therapy for allergic diseases, which spanned from 2004 to 2024.

Efficacy and safety of acupuncture-related therapies in symptomatic endometriosis: a systematic review and network meta-analysis.

Objective: To compare the effectiveness and safety of different acupuncture-related therapies combined with pharmacotherapies for treating symptomatic endometriosis.

Methods: A pre-defined search strategy was conducted across eight databases (Chinese Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, China Science and Technology Journal Database, PubMed, Embase, Cochrane Library, and Web of Science) from inception to May 1, 2023. The included studies were evaluated for methodological quality using the Cochrane risk of bias assessment tool.

CHO-S expression of a novel human recombinant IgG1 of anti-ALD antibody isolated by phage mutation display.

Aldosterone (ALD) is elevated in the serum and plasma of patients with various metabolism-related diseases, and anti-ALD antibodies are important materials in early diagnostic kits. However, current anti-ALD antibodies for clinical diagnosis are not specific, resulting in high false positives. We have developed an anti-ALD-601# rabbit monoclonal antibody that is commercially available and licensed for diagnosis.

Effectiveness and safety of Chinese herbal footbaths as an adjuvant therapy for dysmenorrhea: a systematic review and meta-analysis.

Objectives: To evaluate the effectiveness and safety of Chinese herbal footbaths (CHF) as an adjunctive therapy in managing dysmenorrhea.

Methods: Ten electronic databases were searched to identify eligible randomized clinical trials (RCTs) from inception until June 2023. Outcome measurements encompassed the total effective rate, visual analog scale (VAS) score of pain intensity, Cox menstrual symptom scale (CMSS) score, symptom score, Traditional Chinese Medicine (TCM) syndrome scale, and any reported adverse events.

[Preparation of HSV-IgM human-mouse chimeric antibody and development of stable recombinant cell line].

In order to achieve large-scale production of HSV-IgM (HSV1, HSV2) human-mouse chimeric antibody , the gene sequence of the corresponding hybridoma cell was harvested by RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE) technique to clone the chimeric antibody into eukaryotic expression vectors, and express the target proteins in CHO-S cells. At the same time, the screening process of stable cell lines was optimized, and the pressure conditions of pool construction stage and monoclonal screening stage were explored. Finally, the target protein was purified by protein L affinity purification method and the biological activity was detected.

Flipped classroom improves student learning outcome in Chinese pharmacy education: A systematic review and meta-analysis.

The application of flipped classroom (FC) pedagogy has recently become increasingly popular in Chinese pharmacy education. However, its effectiveness in improving student learning has not yet been assessed. This study aimed to evaluate the effects of teaching with such pedagogical approach by examining studies that compare the FC approach with the traditional lecture-based learning (LBL) module through a systematic review and meta-analysis.

Optimization of plant harvest and management patterns to enhance the carbon sink of reclaimed wetland in the Yangtze River estuary.

Estuarine wetlands are often located in economically developed and densely populated estuarine deltas, which are frequently disturbed and threatened by human activities. Reclamation, as an important way to alleviate the demand for local land resources, can lead to habitat destruction of natural coastal wetlands and weakening of ecological service functions, including carbon sink capacity. Research has shown that poor plant growth and weakened carbon fixation were the main reasons for the reduced carbon sequestration in a reclaimed wetland.

Predicting acupuncture efficacy for functional dyspepsia based on routine clinical features: a machine learning study in the framework of predictive, preventive, and personalized medicine.

Background: Acupuncture is safe and effective for functional dyspepsia (FD), while its efficacy varies among individuals. Predicting the response of different FD patients to acupuncture treatment in advance and therefore administering the tailored treatment to the individual is consistent with the principle of predictive, preventive, and personalized medicine (PPPM/3PM). In the current study, the individual efficacy prediction models were developed based on the support vector machine (SVM) algorithm and routine clinical features, aiming to predict the efficacy of acupuncture in treating FD and identify the FD patients who were appropriate to acupuncture treatment.

Induction of PI3K/Akt-Mediated Apoptosis in Osteoclasts Is a Key Approach for Pills to Treat Osteonecrosis of the Femoral Head.

The pill (BTP) is a self-made pill with the functions of nourishing blood, promoting blood circulation, dredging collaterals, and relieving pain. It consists of (Oliv.) Diels, (E.

Transcutaneous electrical acupoint stimulation (TEAS) for cancer-related fatigue: study protocol for a systematic review and meta-analysis.

Introduction: Cancer-related fatigue (CRF) is a prevalent symptom in cancer survivors. Transcutaneous electrical acupoint stimulation (TEAS) has been reported as a promising therapy for CRF. This protocol is proposed for a systematic review that aims to assess the efficacy and safety of TEAS for CRF.

Discovery of Novel Markers for Identifying Cognitive Decline Using Neuron-Derived Exosomes.

Alzheimer's disease (AD), the predominant cause of late-life dementia, has a multifactorial etiology. Since there are few therapeutic options for symptomatic AD, research is increasingly focused on the identification of pre-symptomatic biomarkers. Recently, evaluation of neuron-derived exosomal markers has emerged as a promising novel approach for determining neuronal dysfunction.

Can Control Infections Slow Down the Progression of Alzheimer's Disease? Talking About the Role of Infections in Alzheimer's Disease.

Alzheimer's disease as the most common age-related dementia affects more than 40 million people in the world, representing a global public health priority. However, the pathogenesis of Alzheimer's disease (AD) is complex, and it remains unclear. Over the past decades, all efforts made in the treatments of AD, with targeting the pathogenic amyloid β (Aβ), neurofibrillary tangles, and misfolded tau protein, were failed.

Role of Adaptive Immune and Impacts of Risk Factors on Adaptive Immune in Alzheimer's Disease: Are Immunotherapies Effective or Off-Target?

The pathogenesis of Alzheimer's disease (AD) is complex. Still it remains unclear, which resulted in all efforts for AD treatments with targeting the pathogenic factors unsuccessful over past decades. It has been evidenced that the innate immune is strongly implicated in the pathogenesis of AD.

Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer's Disease.

Alzheimer's disease (AD) is commonly an age-associated dementia with neurodegeneration. The pathogenesis of AD is complex and still remains unclear. The inflammation, amyloid β (Aβ), and neurofibrillary tangles as well misfolded tau protein in the brain may contribute to the occurrence and development of AD.

[Effects of different signal peptides on the secretion of human-mouse chimeric CMV-IgM].

In order to prepare human-mouse chimeric cytomegalovirus-immunoglobulin M (CMV-IgM) in vitro and study the effects of different signal peptides on the secretion of CMV-IgM, genes were amplified from hybridoma cell line using RLM-RACE to construct the expression vector of chimeric CMV-IgM. Then, the signal peptide of SigF itself was replaced by five different secreted signal peptides (SigA-SigE) by PCR method, and the CHO cell was chosen as host cell for in vitro expression. SDS-PAGE, SEC-HPLC and ELISA experiments were carried out to evaluate the protein expression level and immunoreactivity of the purified CMV-IgM.

Which subtype of functional dyspepsia patients responses better to acupuncture? A retrospective analysis of a randomized controlled trial.

Background: Whether subgroups of functional dyspepsia (FD) should be treated with different approaches is controversially discussed in research. As our previous study has demonstrated the effect of acupuncture in FD treatment, we now further analyze the therapeutic effect of acupuncture in the treatment of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).

Methods: A retrospective analysis was conducted in 465 eligible PDS patients and 241 EPS patients.

The multiple lifestyle modification for patients with prehypertension and hypertension patients: a systematic review protocol.

Introduction: The objective of this systematic review is to investigate the effectiveness, efficacy and safety of multiple concomitant lifestyle modification therapies for patients with hypertension or prehypertension.

Methods And Analysis: Electronic searches will be performed in the Cochrane Library, OVID, EMBASE, etc, along with manual searches in the reference lists of relevant papers found during electronic search. We will identify eligible randomised controlled trials utilising multiple lifestyle modifications to lower blood pressure.

CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies.

Lung cancer is the second most common human malignant disease and the leading cause of cancer-related mortality worldwide. The effect of CYP1A1 IleVal polymorphism on susceptibility to lung cancer has been researched extensively over the last two decades. However, controversial results were obtained.

Disclosure of the tuberous lectin composed of homogeneous tetramers in Pinellia pedatisecda Schott.

Pinellia pedatisecta (Schott) and Pinellia ternata (Thumb) Breit, whose tuberous stems are an important Chinese medicine, taxonomically belong to Pinellia, Araceae species. Pinellia contains various lectins in their tubers, leading to distinct roles in Chinese medicine. Difference of the lectins, however, is little known between P.

Acupuncture as a treatment for functional dyspepsia: design and methods of a randomized controlled trial.

Background: Acupuncture is widely used in China to treat functional dyspepsia (FD). However, its effectiveness in the treatment of FD, and whether FD-specific acupoints exist, are controversial. So this study aims to determine if acupuncture is an effective treatment for FD and if acupoint specificity exists according to traditional acupuncture meridians and acupoint theories.

Genomic analyses of recombinant adenovirus type 11a in China.

Whole-genome sequencing of human adenovirus type 11 (HAdV-11) strain QS, isolated in China, was conducted, and its sequence was compared with the sequences of strains within the species of HAdVs. The HAdV-11 QS genome contains 34,755 nucleotides. Similar to the other HAdV subgenus B sequences, the HAdV-11 QS genome coded 37 functional proteins and could be divided into four early, two intermediate, and five late transcription regions.

Translation and validation of the Nepean Dyspepsia Index for functional dyspepsia in China.

Aim: To assess the reliability and validity of the translated version of Nepean Dyspepsia Index (NDI) in Chinese patients with documented functional dyspepsia (FD).

Methods: The translation process included forward translation, back translation, pretest and cross-cultural adaptation. Reliability and validity of the translated version were examined by asking 300 subjects to complete the Chinese version of the NDI.