The NMDAR/TRPM4 death complex is a major promoter of disease progression in the 5xFAD mouse model of Alzheimer's disease.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by cognitive decline and neuronal degeneration. The formation of amyloid β plaques and neurofibrillary tangles are key morphological features of AD pathology. However, the specific molecules responsible for the cell destruction triggered by amyloid β and tau proteinopathies in AD has not yet been identified.

Boosting Electrochemical CO Reduction to Formate over La-Doped SnO via Pinning Effect and Water Activation.

Electrochemical reduction of CO to formate over Sn-based catalysts offers an effective carbon-neutral approach for chemical production and renewable energy storage. However, poor selectivity under high current densities persists, primarily due to the instability of Sn-O active sites and slow water dissociation. In this work, a La-doped SnO catalyst is synthesized for efficient CO conversion to formate.

Establishment and Evaluation of an In Vitro Human-Based Advanced Model of Pulmonary Fibrosis.

Pulmonary fibrosis is characterized by irreversible destruction of alveolar structure and excessive deposition of extracellular matrix. Although animal models have been widely used in pulmonary fibrosis research, none of the currently available models fully recapitulate the progressive nature of IPF or its defining histological feature, such as fibroblastic foci. Advanced in vitro models, including precision-cut lung slices (PCLS), are often considered the most physiologically relevant pulmonary test system and have been successfully employed for drug screening.

Recurrence of initial angiographic occlusion in intracranial dural arteriovenous fistulas.

Objective: Recurrence after an initial angiography-determined cure of dural arteriovenous fistula (DAVF) has been reported, with risk factors identified in a few studies; however, some findings remain controversial. The objective of this study was to evaluate a large cohort of patients with DAVFs to estimate the recurrence rate and identify factors influencing recurrence.

Methods: Patient data for this study were derived from the Dural Arteriovenous Fistula Research and Management in China (DREAM-INI) database, compiled from a single-center retrospective study conducted in China.

Orthotopic Left Lung Transplantation in Rats.

The rat left lung orthotopic transplantation model is an essential tool in lung transplant research. Although lung transplantation is a complex procedure, its complexity is significantly reduced with the introduction of the cuff technique. Most surgeons can master this technique after training, but its application has been limited due to the long learning curve and low model survival rate.

Decoding EGFR A289 Mutation in Glioblastoma: A Predictive Biomarker Framework and Targeted Therapeutic Insights.

Glioblastoma (GBM) is the most common primary malignant intracranial tumor, accounting for over 50% of central nervous system tumors. Among EGFR mutations in GBM, A289 is a prevalent point mutation associated with poor prognosis, yet its unique characteristics and role in malignant progression remain unclear. To address this, we analyzed EGFR A289 mutation frequency by integrating tumor mutation data from TCGA and CGGA databases as well as Beijing Tiantan Hospital's Neuropathology Center.

Intracranial Dural Arteriovenous Fistulas With and Without Pial Artery Supply: Analysis of Treatment Outcomes.

Background And Objectives: The prevalence of pial arterial supply (PAS) to intracranial dural arteriovenous fistulas (DAVFs) and its implications for the management of these fistulas have been limited to relatively small cohort studies and remain somewhat controversial. We conducted a retrospective study to characterize PAS in DAVFs and explore its implications for treatment.

Methods: Consecutive patients evaluated over a 21-year period were retrospectively reviewed.

Inhibition of P2X7R by hypericin improves diabetic cardiac autonomic neuropathy through the proteasome- Nrf2 - GPX4 signaling axis.

Hypericin (HYP), a primary active compound derived from Hypericum perforatum has been studied in the context of diabetes. The purpose of this study is to observe whether HYP can improve diabetic cardiac autonomic neuropathy (DCAN) and its possible mechanism. The current findings suggest that multiple drivers of ferroptosis in DCAN converge on the antioxidant protein nuclear factor erythroid 2-related factor 2(Nrf2).

Microsurgery Versus Embolization for Spinal Cord Arteriovenous Malformations: A Proposed Grading System.

Background And Objectives: Comparing microsurgery and embolization for spinal cord arteriovenous malformations (SCAVMs) is challenging because of the disease's rarity and the highly heterogeneous angioarchitecture. The aim of this study was to compare outcomes between microsurgery and embolization using a grading system for SCAVMs that effectively stratifies angioarchitectural complexities.

Methods: A total of 714 patients were included, with 308 undergoing microsurgery.

The Efficacy and Disadvantages of Endovascular Therapy for Deep-Seated Cerebral Arteriovenous Malformations: A Long-Term Follow-Up Study.

Arteriovenous malformations (AVMs) in the basal ganglia, the thalamus, and the insular lobe of the brain are rare and difficult-to-treat diseases that require integrated multimodal management. This study aimed to determine the safety and disadvantages of embolization as an independent therapy for deep-seated AVMs. The authors reviewed 76 patients from a single center with cerebral deep-seated AVMs from 2010 to 2020.

P2 purinergic signaling and pruritus.

Pruritus is a common sensation that triggers scratching. Extracellular nucleotides and nucleosides, along with their receptors, primarily compose the purinergic signaling. The purinergic signaling mechanism in itch remains incompletely understood.

Ultramicroporous Ionic Liquid-Supported Aerogel Composites.

Recently, low-concentration ammonia (NH) capture has attracted considerable attention for applications in ammonia-hydrogen fuel cells and confined spaces. The main objective of this study was to develop novel ultramicropore ionic liquid-supported aerogel composites (UILACs), designed to effectively expose the multiple hydrogen bonding sites of the ionic liquid through the constructed ultramicropore structure in order to capture and selectively separate low-concentration NH. UILACs achieved a maximum NH capacity of 164.

Gram-Scale Preparation of Tri-Coordinated Single-Atom Catalysts for CO Electrolysis in Large-Scale Membrane Electrode Assembly.

Accelerating the commercialization of CO electroreduction is essential for carbon utilization, yet it faces challenges of precious metal catalysts cost and scaling-up of the corresponding devices. In this study, a low-cost and tri-coordinated single-atom catalyst (SAC) with Ni-N3 center is fabricated in gram-scale using metal ionic liquids as precursor. The gram-scale Ni-N3 SAC (g-NiN3) achieves efficient electroreduction of CO to CO (eCO-to-CO) with a maximum Faradaic efficiency of 98.

CHO-S expression of a novel human recombinant IgG1 of anti-ALD antibody isolated by phage mutation display.

Aldosterone (ALD) is elevated in the serum and plasma of patients with various metabolism-related diseases, and anti-ALD antibodies are important materials in early diagnostic kits. However, current anti-ALD antibodies for clinical diagnosis are not specific, resulting in high false positives. We have developed an anti-ALD-601# rabbit monoclonal antibody that is commercially available and licensed for diagnosis.

P2Y12-mediated HIV gp120 and ddC-induced neuropathic pain improved by esculin.

We studied whether esculin (ES) has the effect of alleviating peripheral neuropathic pain (NP) in rat models of HIV glycoprotein 120 (gp120) together with zalcitabine (2',3'-dideoxycytidine; ddC) treatment and explored the possible mechanism of it. The rats pain behaviors were evaluated by observing the paw withdrawal threshold (PWT) and the paw withdrawal latency (PWL). The rats were divided into a control group, sham group, gp120 combined with a ddC treatment group (gp120& ddC group), gp120&ddC combined with ES treatment group (gp120&ddC+ES group), which ES was administered intragastrically, and gp120&ddC combined with short hair RNA of P2Y12 receptor (rP2Y12) treatment group (gp120&ddC+shP2Y12 group), which shRNA of rP2Y12 was injected intrathecally with a dose of 25 µg/20 µl for every rat, and a negative control plasmid was administered to the gp120&ddC+nc group.

Dural arteriovenous fistula research and management in China (DREAM-INI): initial characterization and patient cohort outcomes.

Background: Intracranial dural arteriovenous fistulas (DAVFs) are rare lesions, making it challenging to fully understand and improve their management. Globally, only two major large-scale studies have focused on DAVFs. This report outlines the design of the DREAM-INI (Dural arteriovenous fistula research and management in China) project and provides an overview of the 1101-patient cohort it includes.

ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3.

Aberrant release of mitochondrial reactive oxygen species (mtROS) in response to cellular stress is well known for promoting cancer progression. However, precise molecular mechanism by which mtROS contribute to epithelial cancer progression remains only partially understood. Here, using colorectal cancer (CRC) models, we show that upon sensing excessive mtROS, phosphatase PGAM5, which normally localizes to the mitochondria, undergoes aberrant cleavage by presenilin-associated rhomboid-like protein (PARL), becoming released into the cytoplasm.

Clinical, genomic, and histopathologic diversity in cerebral cavernous malformations.

Cerebral cavernous malformations (CCMs) are hemorrhagic vascular disorders with varied clinical and radiological presentations, occurring sporadically due to MAP3K3 or PIK3CA mutations or through inherited germline mutations of CCM genes. This study aimed to clarify the clinical, genetic, and pathological features of CCMs using a multicenter cohort across three Chinese centers. We analyzed 290 surgical specimens from symptomatic CCM patients, utilizing whole-exome sequencing, droplet digital PCR, and targeted panel sequencing, alongside immunohistology to examine genotypic and phenotypic differences.

Potential Distribution Prediction of Retz. in China Under Current and Future Climate Scenarios.

Climate change in the future could potentially expand, shrink, or alter the habitats of numerous species, leading to changes in their spatial distributions. Predicting suitable areas for cultivating medicinal plants through modeling has become an effective tool for assessing site suitability and conserving medicinal plant resources. Utilizing GIS and MaxEnt model, we predicted the spatial distribution of Retz.

Discriminators of Paraclinoid Aneurysm Rupture Based On Morphological Computer-Assisted Semiautomated Measurement (CASAM) and Hemodynamic Analysis.

Background: Paraclinoid aneurysms, arising from the proximal dural ring and extending to the origin of the posterior communicating artery of the internal carotid artery (ICA), represent a significant proportion of all intracranial aneurysms (IAs). Accurate prediction of the rupture risk of paraclinoid aneurysms is crucial for optimal management. The objective of this study was to identify risk factors for the rupture of paraclinoid aneurysms on the basis of computer-assisted semiautomated measurement (CASAM) and hemodynamics.

Updated classification with spinal dysraphism and treatment outcomes of arteriovenous shunts below conus: a retrospective cohort study.

Background: Arteriovenous shunts below conus medullaris (AVS-BC) are understudied, particularly those associated with spinal dysraphism. This study aimed to refine the classification and management of AVS-BC.

Methods: A retrospective analysis of patients with AVS-BC from two centers over two decades was performed, focusing on clinical presentations, angioarchitecture, and treatment outcomes.

Isorhapontigenin alleviates acetaminophen-induced liver injury by promoting fatty acid oxidation.

Acetaminophen (APAP) is a widely used analgesic and antipyretic medicine. It is frequently employed to alleviate pain and mitigate fever-related symptoms, but it can cause liver injury or even liver failure when overdosed. Isorhapontigenin, a compound derived from Chinese herbs and grapes, has been demonstrated to exhibit antioxidant and anti-inflammatory effects.