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This study seeks to investigate the changes in the anatomical structure of the alveolar bone after the extraction of the mandibular second molar at 3, 6, and 12 months using cone-beam computed tomography (CBCT). This study analyzed CBCT images from 87 cases following the extraction of mandibular second molars. The anatomical structures of the alveolar bone were measured immediately after extraction, as well as at 3 months, 6 months, and 12 months post-operation. The changes in the anatomical structures of the alveolar bone corresponding to different types of alveolar bone after the extraction of mandibular second molars were also assessed. The inverted fossa type of alveolar bone was the most common, accounting for 66.6%, followed by the parallel type at 11.5% and the confluent type at 21.9%. The available buccal bone width decreased in the order of inverted fossa type, confluent type, and parallel type. The lingual mandibular fossa of the inverted fossa type was classified into three categories: Type I (48.3%), Type II (41.4%), and Type III (10.3%). Within 12 months after the extraction of the mandibular second molar, the width of the inverted fossa type and the distance between the crest and the canal had the least absorption. The lingual inclination of the alveolar bone increased. In Type I, L2, L3, and L4 were all greater than 2 mm. In Type II, L2 was less than 2 mm, while L3 and L4 were greater than 2 mm. In Type III, L2 and L3 were less than 2 mm, and L4 was greater than 2 mm. Within 12 months after the extraction of the mandibular second molar, both the height and horizontal width of the alveolar bone decreased, and the degree of decrease is correlated with the type of alveolar bone. The deeper the lingual depression, the higher the risk of mandibular nerve injury and lingual perforation. The increase in lingual inclination of the alveolar bone after extraction is a contributing factor to the risk of lingual perforation.
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http://dx.doi.org/10.1038/s41598-025-02705-5 | DOI Listing |
iScience
September 2025
Department of Geriatric Dentistry, NMPA Key Laboratory for Dental Materials, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
This study highlights the biomedical relevance of injectable TS (tannic acid-silk fibroin)-Mg/Sr hydrogels in alveolar bone repair, particularly their prospective role as carriers for stem cells from the apical papilla (SCAPs) in tissue regeneration. By utilizing self-assembling silk material, noted for its favorable handling properties, we present a useful approach for single-wall bone defects, such as bone fenestration and fractures in the oral cavity. Furthermore, our findings regarding the involvement of the TRPM7 ion channel indicate a possible regulatory pathway for improving alveolar bone defect repair.
View Article and Find Full Text PDFJ Immunother Precis Oncol
August 2025
Department of Medicine, Sylvester Comprehensive Cancer Center/University of Miami, Miami, FL, USA.
The combination of targeted therapies and immunotherapies for advanced and metastatic sarcomas has been proposed owing to the enhanced effect of antiangiogenic therapies on the tumor microenvironment. We found eight studies published to date assessing the effectiveness of combined multitargeted vascular endothelial growth factor (VEGF)-tyrosine kinase inhibitors with immune checkpoint inhibitors (ICIs) in sarcoma. It is difficult to draw conclusions owing to limited data and primarily single-arm studies, although initial literature appears promising and requires further study.
View Article and Find Full Text PDFJ Dent Res
September 2025
Beijing Laboratory of Oral Health, Capital Medical University School of Basic Medicine, Beijing, China.
Periodontitis, a pervasive chronic inflammatory disorder, is distinguished by the progressive degradation of periodontal tissues and alveolar bone. Despite remarkable progress in understanding the pathogenesis of periodontitis, the involvement of TCRαβCD4CD8 T cells, also known as double-negative T (DNT) cells, in the pathophysiology of this disease has not been thoroughly investigated. In this study, we observed a significant reduction in the frequency of TCRαβ DNT cells within the gingival tissues of patients afflicted with periodontitis when compared with healthy individuals.
View Article and Find Full Text PDFObjective: Previous studies of nerve distribution in the orofacial complex have focused primarily on the anatomic courses of nerve fibers and have rarely addressed the density of nerve distribution. The nerve distribution in the mandible was described in only one report which showed an increase in nerve distribution density moving from the alveolar crest toward the inferior alveolar nerve. However, no previous reports have focused on the nerve distribution density in the maxilla.
View Article and Find Full Text PDFEur Arch Paediatr Dent
September 2025
Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, Brazil.
Purpose: This systematic review provides a critical evaluation, synthesis of the existing literature on isotretinoin's effects on craniomaxillofacial bone.
Methods: Following the PRISMA guidelines and registered in PROSPERO, the review was conducted in August 2024 across various databases. Eligible in vivo studies were analysed for their assessment of isotretinoin's effects on craniomaxillofacial bone.