Efficacy and safety of induction immunotherapy plus chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a meta-analysis.

Background: Locally advanced nasopharyngeal carcinoma (LA-NPC) has a heterogeneous prognosis, with approximately one-fourth of patients experiencing poor outcomes. Studies have explored the application of induction chemoimmunotherapy followed by chemoradiotherapy, but its efficacy was controversial.

Methods: The protocol was registered in the Prospective Register of Systematic Reviews (PROSPERO, CRD42024619387).

Synergizing a knowledge graph and large language model for relay catalysis pathway recommendation.

Relay catalysis integrates multiple catalytic reactions to efficiently transform intermediates and enhance conversion and selectivity. However, designing these pathways and multifunctional catalysts is often lengthy and costly, heavily relying on in-depth literature analysis by experienced researchers. To address this, we developed an approach that combines a knowledge graph (KG) and large language models (LLMs) to automatically recommend multistep catalytic reaction pathways.

Anoikis-related biomarkers PARP1 and SDCBP as diagnostic and therapeutic targets for asthma.

This study aims to explore the association between anoikis-related genes (ARGs) and asthma. The dataset GSE143303 for asthma were sourced from the GEO database, while ARGs were retrieved from the Harmonizome web portal and the GeneCards database. Differentially expressed genes (DEGs) identification and GO, KEGG enrichment analysis were performed to reveal potential biological pathways.

Effectiveness of pay it forward intervention compared to free and user-paid vaccinations on seasonal influenza vaccination among older adults across seven cities in China: study protocol of a three-arm cluster randomized controlled trial.

Background: Seasonal influenza poses an enormous burden worldwide, with older adults facing preventable morbidity and mortality. However, seasonal influenza vaccination coverage is poor among older populations in China. Pay-it-forward (giving a person a free vaccine and an opportunity to donate to support others) and financial incentives (e.

Neural activities of theory of mind in individuals with schizophrenia: A meta-analysis of fMRI studies.

Neuroimaging evidence regarding the activation of brain regions associated with the Theory of Mind (ToM) in individuals with schizophrenia remains inconsistent. Some studies identified decreased activation in various regions, such as the insula, frontal gyrus, superior temporal gyrus, and precuneus, during ToM tasks in schizophrenia compared with healthy people; others reported increased activation in these areas. Additionally, neural activity of individuals with schizophrenia compared with individuals at risk of schizophrenia has not been uniformly demonstrated.

Application of Indolyl Ynones in the Construction of Chiral Carbazoles and Pyrroloindolines by Organo and Metal Sequential Catalysis.

The enantioselective synthesis of carbazoles and pyrroloindolines has been achieved through organo-catalyzed and metal sequential-catalyzed one-pot reactions of indolyl ynones. Chiral carbazoles can be synthesized from the reactions of indolyl ynones and nitroolefins through an organo-catalyzed Michael addition followed by a gold-catalyzed Friedel-Crafts reaction/aromatization process. The reactions of indolyl ynones and N-tosyl imines lead to the generation of pyrroloindolines via an organo-catalyzed Mannich reaction and a silver-catalyzed dearomatizing spirocyclization/N,N-acetalization cascade reaction.

Assessment of sanitation facilities in primary healthcare institutions across seven provinces in China: a cross-sectional study.

Objective: This study aims to assess the current status of sanitation facilities across primary healthcare institutions in China, offering valuable insights for improving sanitary facilities in middle-income settings.

Methods: Data were draw from the ACACIA project (March 2021-April 2023) across seven provinces in China. A total of 2139 visits were made to 1167 primary healthcare institutions.

Magnetic sculpture-like tumor cell vaccines enable targeted immune activation and potent antitumor effects.

Tumor cells are ideal candidates for developing cancer vaccines due to their antigenic profiles, yet existing whole-cell vaccines lack efficacy. This study aimed to develop a novel whole-cell vaccine platform that combines immunogenicity, structural integrity, and tumor-targeting capabilities. We created "Magnetic Sculpture-like (MASK) Cells" by treating tumor cells with high-concentration FeCl, inducing rapid morphological fixation without traditional chemical crosslinking.

[CBCT study on the measurement of occlusal plane and molars in adolescent patients with Class Ⅱ subdivision malocclusion].

Purpose: To study the CBCT imaging features of occlusal plane inclination, molar inclination, and molar height in adolescent patients with Class Ⅱ subdivision malocclusion, in order to provide reference for clinical diagnosis and treatment.

Methods: A total of 80 adolescent patients with malocclusion admitted to Suzhou Stomatological Hospital from January 2019 to December 2022 were selected, including 40 cases of Class Ⅱ subdivision malocclusion as the experimental group and 40 cases of Class Ⅰ malocclusion as the control group. The angles of the anterior, posterior and maxillary occlusal planes, as well as the inclination of the upper and lower molars in the mesial and distal direction, the inclination of the buccal and lingual direction, and the height of the molars were analyzed based on CBCT data.

Development and validation of a HPLC-MS/MS method the determination of genistein and equol in serum, urine and follicular fluid.

Soy isoflavones exert estrogen-like synergistic or antagonistic effects by binding to estrogen receptors, and potentially impact the function of female reproductive system, but their distribution profile in human remains little clarified. To determination of genistein (GEN) and equol (EQ) in human urine, serum and follicular fluid (FF), an analytical method based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed and validated. The enrichment and clean-up are performed on a solid-phase extraction (SPE) column; the elution is a gradient one, with the mobile phase (A) of 0.

Erratum: Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma: Erratum.

[This corrects the article DOI: 10.7150/thno.90322.

[Analysis of risk factors for adjacent vertebral fractures after conservative treatment of osteoporotic vertebral compression fractures in elderly women].

Objective: To study the relevant factors affecting the occurrence of adjacent vertebral fractures in women with osteoporotic vertebral compression fractures after conservative treatments.

Methods: A total of 98 elderly female patients diagnosed with osteoporotic vertebral compression fractures and treated from January 2020 to January 2022 were retrospectively analyzed. The average age was (73.

The impact of curve radius variations on vehicle driving states on 2-lane roads.

Objective: The complex alignment of 2-lane roads results in a higher risk of traffic crashes. This study aims to identify key factors influencing vehicle driving states on curves.

Methods: Five curve radii were selected to create simulated driving scenarios.

[Spatial Effect of the New-type Urbanization in the Beijing-Tianjin-Hebei Region and Its Surrounding Areas on the Carbon Emission Intensity].

Given that the Beijing-Tianjin-Hebei Region and its surrounding areas are one of the key areas for air pollution prevention and control in China, testing the impact of air quality on the relationship between new-type urbanization and carbon emission intensity is related to the sustainable development of the region. Based on the panel data of the Beijing-Tianjin-Hebei Region and the surrounding "2+26" cities from 2009 to 2021, the nesting weight matrix of air quality distance was constructed, and the internal relationship was tested with the help of the spatial Dubin model and the threshold effect model. The research results showed that： ① The new-type urbanization in this region had a strong inhibitory effect on carbon emission intensity.

Metabolite Profiling of Danatinib in Mice Using Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry In Vitro and In Vivo.

Danatinib, a brand-new compound synthesized in our laboratory for the treatment of acute myeloid leukemia (AML), demonstrates remarkable antitumor activity. However, the pharmacokinetic profile of Danatinib in mice was short with its half-life was only 0.476 h.

Chemoimmunotherapy as induction treatment in concurrent chemoradiotherapy for patients with nasopharyngeal carcinoma stage IVa.

Background: Chemoimmunotherapy is the first-line therapy for patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) and is currently the main induction treatment option for patients with locoregionally advanced NPC. However, it remains unclear whether combining immunotherapy with standard induction chemotherapy enhances its efficacy. This study aimed to evaluate the efficacy, toxicity, and survival outcomes of induction chemoimmunotherapy in patients with locoregionally advanced NPC.

Design, Synthesis, and Biological Evaluation of 3,4-Dihydroisoquinolin-1()-one Derivatives as Protein Arginine Methyltransferase 5 Inhibitors for the Treatment of Non-Hodgkin's Lymphoma.

Through catalyzing the transfer of methyl groups onto the guanidinium of arginine, protein arginine methyltransferase 5 (PRMT5) was essential to the cell growth of cancer cells. By utilizing a scaffold hopping strategy, a novel series of 3,4-dihydroisoquinolin-1()-one derivatives were designed and synthesized. Through a systematic SAR study, demonstrated excellent PRMT5 inhibitory activity, potent antiproliferative activity against Z-138, favorable pharmacokinetic profiles, and low hERG toxicity.

Kinase-Bench: Comprehensive Benchmarking Tools and Guidance for Achieving Selectivity in Kinase Drug Discovery.

Developing selective kinase inhibitors remains a formidable challenge in drug discovery because of the highly conserved structural information on adenosine triphosphate (ATP) binding sites across the kinase family. Tailoring docking protocols to identify promising kinase inhibitor candidates for optimization has long been a substantial obstacle to drug discovery. Therefore, we introduced "Kinase-Bench," a pioneering benchmark suite designed for an advanced virtual screen, to improve the selectivity and efficacy of kinase inhibitors.

Design, Synthesis, and Biological Activities Evaluation of Type I FLT3 Inhibitors for the Treatment of Acute Myeloid Leukemia.

The abnormal overexpression of FLT3 kinase is intimately associated with pathogenesis of acute myeloid leukemia (AML), positioning FLT3 inhibitors as pivotal therapeutic agents. Despite the availability of three FDA-approved FLT3 inhibitors, their clinical utility is hampered by resistance stemming from tyrosine kinase domain (TKD) mutations. Through an integrative analysis of case studies, we identified a potential advantage of type I FLT3 inhibitors in overcoming TKD mutation-induced resistance.

Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F-53B Exposure: The Role of PKA Cytoplasmic Retention.

Chlorinated polyfluorinated ether sulfonate (F-53B), a chromium-fog depressant widely utilized as an alternative to perfluorooctanesulfonate, can transfer from mother to fetus. Recent research has demonstrated that prenatal exposure to F-53B results in synaptic damage in weaning mice. However, the mechanism underpinning F-53B-triggered synaptic damage during fetal development remains unclear.

Discovery of 1-(Phenylsulfonyl)-1,2,3,4-tetrahydroquinoline Derivative as Orally Bioavailable and Safe RORγt Inverse Agonists for Potential Treatment of Rheumatoid Arthritis.

The retinoic acid receptor-related orphan receptor γt (RORγt) is a key regulator of Th17 cells, associated with autoimmune diseases, making it a significant drug target. Herein, we designed and synthesized 1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinoline derivatives, improving upon GSK2981278 to enhance bioavailability. Of which, exhibited superior bioavailability (F = 48.

Enhanced anti-inflammatory activity of chlorogenic acid via folic acid-TPGS-modified liposomes encapsulation: characterization and evaluation on colitis mice.

Introduction: Chlorogenic acid (CGA) has been identified to possess salient anti-inflammatory, antioxidant, and anticancer attributes. However, its application is limited by its instability and low bioavailability. Liposomes have been considered effective pharmaceutical delivery vehicles due to their ability to continuously release loaded drugs, improve drug stability, and display good biocompatibility.