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The objective of this study is to develop an enhanced methodology for analysing individuals' perceptions of discomfort due to the pressure exerted by over-ear headphones. Using principal component analysis and K-means clustering, we categorise 602 samples into six clusters and create representative Chinese head-and-ear models. A pressure tester was then developed to quantify the pressure exerted on head and ear regions by the headphone cushions. Thirty participants representing the proportional distribution of each cluster, were selected to evaluate subjective sensations through a long-term wearing test. The findings indicate a strong correlation between the pressure measurements obtained from the tester and the subjective assessments. Statistically significant differences were noted across various head models and clusters for both pressure-related parameters and subjective evaluations ( < 0.001). Additionally, women had higher pressure discomfort values than men in the ear-related regions. Finally, a regression model was developed to estimate overall pressure discomfort based on pressure-related parameters.
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http://dx.doi.org/10.1080/00140139.2025.2519877 | DOI Listing |
Pestic Biochem Physiol
November 2025
Instituto de Biología Molecular y Celular de Plantas (IBMCP), Consejo Superior de Investigaciones científicas, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain. Electronic address:
Essential oils (EOs) are a promising alternative to conventional pesticides, but some challenges like high volatility, poor water solubility, and rapid degradation limit their use in Integrated Pest Management (IPM). To overcome these limitations, this study aimed to develop garlic, eucalyptus, and clove EO-based nano-emulsions (EO-NEs) in a bait treatment format through the high-pressure microfluidization technique and investigated the biological activities against Ceratitis capitata. In addition, the adverse effects of the most promising nano-emulsion were evaluated towards a non-target parasitoid Anagaspis daci.
View Article and Find Full Text PDFBehav Brain Res
September 2025
Department of Pharmacology of the School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049-900, Brazil. Electronic address:
Aims: Acute restraint stress (RS) has been reported to activate the supraoptic nucleus of the hypothalamus (SON). The aim of the present study was to evaluate the role of glutamatergic neurotransmission in the SON on autonomic [mean arterial pressure (MAP), heart rate (HR), and tail cutaneous temperature], neuroendocrine (plasma levels of corticosterone, oxytocin, and vasopressin), and behavioral responses to RS.
Methods: Male Wistar rats with bilateral SON cannulas received microinjections of NMDA or non-NMDA receptor antagonists or vehicle before restraint stress, and the effects on cardiovascular, tail temperature, hormonal, and behavioral responses were evaluated RESULTS: Microinjection of DL-AP7 or NBQX into the SON reduced MAP increases and tail temperature decreases induced by RS.
IEEE J Biomed Health Inform
September 2025
Understanding foot kinetics is fundamental to analyzing human locomotion, offering critical insights into mechanical loads exerted on the feet. While vertical ground reaction force (vGRF) is widely used in biomechanics research, comprehensive 3D kinetic measurements, including ground reaction force (GRF), ground reaction moment (GRM), and center of pressure (CoP) along the anterior-posterior and medial-lateral axes, provide deeper insights for various applications. Smart insoles, though portable, cost-effective, and user-friendly, primarily capture vGRF and often generate lower-quality data than force plates and instrumented treadmills.
View Article and Find Full Text PDFAntipyretic analgesics are typical pharmaceutical and personal care products (PPCPs) that are widely used in our daily life because they relieve fever and pain, and have anti-inflammatory and anti-rheumatic properties. These drugs inhibit the synthesis and release of prostaglandins (PGs) in the neurons of the anterior hypothalamus and exert therapeutic effects as a consequence. However, these drugs are relatively commonly misused and abused, often owing to a lack of proper medication guidance.
View Article and Find Full Text PDFBisphenol A (BPA) and its analogs are collectively termed bisphenol compounds (BPs), which are predominantly utilized in the manufacturing of polycarbonate plastics and epoxy resins. BPs are ubiquitous in diverse environmental matrices, human tissues, and metabolic products. Extensive research has demonstrated that BPs exert adverse effects on the nervous, reproductive, immune, and metabolic systems.
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