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Introduction: Adolescent idiopathic scoliosis (AIS) often imposes a significant psychological burden on teenagers. Cognitive and behavioural strategies have demonstrated the potential to alleviate these challenges. Chatbots, with their real-time interaction capabilities, provide a promising and accessible approach to delivering psychological interventions for young people.
Method And Analysis: This pilot trial will evaluate a chatbot-delivered, structured psychological intervention (SPI-Bot) incorporating cognitive and behavioural strategies for teenagers with AIS. Conducted as a single-centre, parallel-group randomised controlled trial, the study aims to assess the feasibility, acceptability and preliminary effectiveness of SPI-Bot. Fifty-two teenagers with AIS and mild to moderate psychological symptoms will be block-randomised into two groups. The intervention group will complete an 8-week, evidence-based SPI-Bot programme, while the control group will engage in casual conversations with another chatbot that does not include specific psychological health content. Assessments will be conducted at baseline, postintervention (8 weeks) and follow-up (12 weeks). Primary outcomes include feasibility and acceptability, measured through recruitment rates, adherence rates, attrition rates, engagement, working alliance, usability, user experience and adverse events. Secondary outcomes focus on effectiveness, including psychological distress, psychological well-being, perceived social support and quality of life. Participants in the intervention group will be purposively sampled for semistructured interviews to explore their perceptions of the intervention process.
Ethics And Dissemination: This study has been approved by the Institutional Review Board of the Hong Kong Polytechnic University (Reference: HSEARS20240919007). The results of this pilot study will be disseminated through peer-reviewed journals and conference presentations.
Trial Registration Number: NCT06698952.
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http://dx.doi.org/10.1136/bmjopen-2025-098734 | DOI Listing |
Ann Rheum Dis
September 2025
Department of Pediatrics, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.
Objectives: Juvenile dermatomyositis (JDM) is a heterogeneous autoimmune condition needing targeted treatment approaches and improved understanding of molecular mechanisms driving clinical phenotypes. We utilised exploratory proteomics from a longitudinal North American cohort of patients with new-onset JDM to identify biological pathways at disease onset and follow-up, tissue-specific disease activity, and myositis-specific autoantibody (MSA) status.
Methods: We measured 3072 plasma proteins (Olink panel) in 56 patients with JDM within 12 weeks of starting treatment (from the Childhood Arthritis and Rheumatology Research Alliance Registry and 3 additional sites) and 8 paediatric controls.
J Epidemiol
September 2025
Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University.
Background: The potential impacts of polygenic scores (PGS) on health-behavior changes are not fully understood. The Iwate PGS Assessment and Risk Communication Study aims to investigate the effects of reporting PGS-based risk for ischemic stroke on health behaviors.
Methods: Participants wishing to know their PGS-based ischemic stroke risk were recruited from health checkup venues for workers in Iwate Prefecture in 2023.
Pestic Biochem Physiol
November 2025
Corteva Agriscience, Indianapolis, IN 46268, USA; Retired - Present address Agrilucent LLC, Morro Bay, CA 93442, USA.
Since their registration more than 25 years ago, the spinosyns have become a significant insect management tool in farmers' battles to protect crop quality and yield. Spinosad (Qalcova™ active) and spinetoram (Jemvelva™ active), the two members of the Insecticide Resistance Action Committee (IRAC) Group 5 nicotinic acetylcholine receptor (nAChR) allosteric modulators Site I, class of insecticides, have proven highly effective at controlling chewing insect pests on over 250 different crops. Their importance as an integral rotation partner in insect pest management programs has stimulated a large body of research into their mode of action (MoA) and mechanisms of resistance.
View Article and Find Full Text PDFPediatr Obes
October 2025
National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA.
Background: The National Health and Nutrition Examination Survey provides nationally representative data on child obesity using measured height and weight. Due to COVID-19, the NHANES August 2021-August 2023 cycle had design changes and smaller sample sizes for certain race/Hispanic origin groups. The objective is to explore sex and race/Hispanic origin-specific childhood obesity trends.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
September 2025
Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital and the University of Hong Kong, China.
Title: Can Radiotherapy Quality Assurance (RT QA) improve nasopharyngeal cancer (NPC) outcomes in low- and middle-income countries (LMICs) -Reporting phase 2 of a prospective International Atomic Energy Agency (IAEA) study (E33039).
Background: Most of new NPC cases occur in LMICs, but these patients experience poorer survival than new NPC cases in high income countries. This study seeks to determine whether a radiotherapy quality assurance (RT QA) programme can improve NPC patient outcomes in LMICs.