Effect of Gene Polymorphism on the Pharmacokinetics and Clinical Outcomes of Rivaroxaban: State-of-the-Art Review.

Rivaroxaban is a direct oral anticoagulant (DOAC) that directly inhibits coagulation factor Xa and exerts its anticoagulant effects. Although rivaroxaban generally exhibits predictable pharmacokinetic (PK) and pharmacodynamic (PD) profiles, significant interindividual variability in therapeutic responses exists. Research on the role of genetic factors in the clinical variability of rivaroxaban is relatively new and extensive.

Pharmacovigilance insights into drug-associated venous thromboembolism.

Background: Venous thromboembolism (VTE), affecting 1-2 per 1,000 adults annually, represents a major preventable cause of hospitalization and mortality. The use of specific medications is an acquired risk factor for VTE. This pharmacovigilance study systematically evaluated medication-associated VTE risk using the largest publicly available adverse event database.

Integration of BSA-seq and high-resolution mapping reveals genomic regions and candidate genes controlling seed oil accumulation in peanut (Arachis hypogaea L.).

Three environmentally stable major QTL controlling seed oil content in peanut were identified, and their genetic effects were evaluated in near‑isogenic lines and a peanut germplasm panel. Increasing seed oil content (SOC) is a primary objective in peanut (Arachis hypogaea L.) breeding, meeting the rising global demand for edible oil.

Causal insights into the role of metabolites in venous thromboembolism pathogenesis: a metabolome-wide Mendelian randomization study.

Background: Venous thromboembolism (VTE) is a significant global health burden, and metabolic alterations play a key role in its pathogenesis. However, previous studies have been constrained by several limitations, hindering clarification of the causal role of metabolites.

Objectives: To comprehensively evaluate the causal roles of metabolites in the pathogenesis of VTE and determine whether metabolites mediate the relationships between modifiable risk factors and VTE.

Evaluation of immunological effects of two DNA vaccines against Nocardia seriolae in hybrid snakehead.

Although DNA vaccines hold significant potential, their practical application in aquaculture remains limited. In both mammals and teleost fish, B cells, which recognize antigens and produce antibodies, play an important role in immunity. In this study, B-cell epitopes capable of inducing fish immunity from IS701 family transposase (IS701) and molybdopterin-dependent oxidoreductase (Mol) proteins of Nocardia seriolae were screened.

Domino volumetric metamaterial resonator for very-low-field MRI.

Background: Very-low-field magnetic resonance imaging (VLF-MRI) plays a significant role in medical imaging diagnosis due to its low cost and light weight. High-quality MR images are essential for accurate medical diagnosis. It is urgent to explore a low-cost, simple and convenient approach to boost the signal-to-noise ratio (SNR) of VLF-MRI system to make medical diagnosis more accurate.

Identification of two QTLs for web blotch resistance in peanut (Arachis hypogaea L.) based on BSA-seq.

Background: Peanut (Arachis hypogaea L.) is a globally important oilseed and cash crop. Web blotch is one of the most important peanut foliar diseases, causing severe yield losses worldwide.

Oral anticoagulants-induced intracranial hemorrhage: a real-world pharmacovigilance study over 2008-2024.

Background: This study aims to review and describe the national post-market cases of oral anticoagulants (OACs)-induced intracranial hemorrhage (ICH) to enhance patient safety.

Research Design And Methods: All ICH cases of OACs as primary suspected medicines were extracted from the FAERS. The disproportionality analysis was utilized for signal detection.

Magnetic Resonance Imaging Radiomics Predicts Histological Response to Neoadjuvant Chemotherapy in Localized High-grade Osteosarcoma of the Extremities.

Rationale And Objectives: Research involving radiomics models based on magnetic resonance imaging (MRI) has mainly used radiomics features derived from a single MRI sequence at a single time point to develop predictive models. This study aimed to construct radiomics models based on before and after neoadjuvant chemotherapy (NAC) MRI for predicting the histological response to NAC in patients with high-grade osteosarcoma.

Materials And Methods: We included 109 patients with localized high-grade osteosarcomas of the extremities, who underwent pre- and post-NAC MRI examinations, from which radiomics features were extracted.

Development and evaluation of immunological effects of a DNA vaccine encoding phosphoketolase family protein against Nocardia seriolae in hybrid snakehead.

Fish nocardiosis is a chronic disease mainly caused by Nocardia seriolae, which occurs in a variety of economically cultured freshwater and marine fish. Studies have shown that DNA vaccine is an effective treatment to protect fish from bacterial infection. In our previous experiment, an in vivo-induced gene of N.

An improved sampled-data control for a nonlinear dynamic positioning ship with Takagi-Sugeno fuzzy model.

This article considered the sampled-data control issue for a dynamic positioning ship (DPS) with the Takagi-Sugeno (T-S) fuzzy model. By introducing new useful terms such as second-order term of time, an improved Lyapunov-Krasovskii function (LKF) was constructed. Additionally, the reciprocally convex method is introduced to bound the derivative of LKF.

Comparative Bleeding Risk of Brand Vs Generic Rivaroxaban in Elderly Inpatients with Atrial Fibrillation.

Objective: Atrial fibrillation (AF) is the most common abnormal heart rhythm in elderly patients. Rivaroxaban has been widely used for stroke prevention. The anticoagulant response to rivaroxaban increases with age, which may make elderly patients susceptible to adverse outcomes resulting from small differences in bioavailability between generic and brand products.

Development and application of whole-chromosome painting of chromosomes 7A and 8A of based on chromosome-specific single-copy oligonucleotides.

For peanut, the lack of stable cytological markers is a barrier to tracking specific chromosomes, elucidating the genetic relationships between genomes and identifying chromosomal variations. Chromosome mapping using single-copy oligonucleotide (oligo) probe libraries has unique advantages for identifying homologous chromosomes and chromosomal rearrangements. In this study, we developed two whole-chromosome single-copy oligo probe libraries, LS-7A and LS-8A, based on the reference genome sequences of chromosomes 7A and 8A of .

Identifying the in vivo-induced antigenic genes is a strategy to develop DNA vaccine against Nocardia seriolae in hybrid snakehead (Channa maculata ♀ × Channa argus ♂).

Nocardia seriolae has been identified as the causative agent of fish nocardiosis, resulting in serious economic losses in aquaculture. With an aim to screen potential candidates for vaccine development against N. seriolae, the in vivo-induced genes of N.

Dosimetric Comparison of Commonly Used Volumetric Modulated Arc Therapy Field Arrangements Based on Flattening Filter-Free Beams for Synchronous Bilateral Breast Carcinoma Radiation Therapy.

Purpose: Flattening filter-free (FFF)-based volumetric modulated arc therapy (VMAT) has been shown to be feasible and significantly improves treatment efficiency and lung protection for synchronous bilateral breast irradiation (SBBI). This research compared the commonly used VMAT field arrangements using FFF beams.

Methods: Twenty-eight patients underwent SBBI were retrospectively enrolled to design irradiation plans using tangential arc VMAT (taVMAT), half arc VMAT (haVMAT), and large arc VMAT (laVMAT).

Anticoagulation strategies in patients with extracorporeal membrane oxygenation: A network meta-analysis and systematic review.

Objectives: Extracorporeal membrane oxygenation (ECMO) plays an important role in providing temporary life support for patients with severe cardiac or pulmonary failure, but requires strict anticoagulation and monitoring. This network meta-analysis systematically explored the most effective anticoagulation and monitoring strategies for patients receiving ECMO.

Methods: MEDLINE, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials were searched up to January 31, 2023, for studies comparing unfractionated heparin (UFH), argatroban (Arg), bivalirudin (Biv), and/or nafamostat mesylate (NM) in patients receiving ECMO.

Characterization of chromatin accessibility and gene expression reveal the key genes involved in cotton fiber elongation.

Cotton (Gossypium hirsutum L.) is an important economic crop, and cotton fiber is one of the longest plant cells, which provides an ideal model for the study of cell elongation and secondary cell wall synthesis. Cotton fiber length is regulated by a variety of transcription factors (TF) and their target genes; however, the mechanism of fiber elongation mediated by transcriptional regulatory networks is still unclear to a large extent.

Anticoagulant in atrial fibrillation patients with prior intracranial haemorrhage: a meta-analysis.

Background: The benefit of resuming anticoagulation in atrial fibrillation (AF) patients with prior intracranial haemorrhage (ICH) and which anticoagulant to choose are controversial.

Summary Of Review: PubMed, Embase, Web of Science and the Cochrane Library were searched from their inception until 13 February 2022. Thirteen eligible articles (17 600 participants) were collected, including 11 real-world studies (n=17 296) and 2 randomised controlled trials (RCTs) (n=304).

A brassinosteroid transcriptional regulatory network participates in regulating fiber elongation in cotton.

Brassinosteroids (BRs) participate in the regulation of plant growth and development through BRI1-EMS-SUPPRESSOR1 (BES1)/BRASSINAZOLE-RESISTANT1 (BZR1) family transcription factors. Cotton (Gossypium hirsutum) fibers are highly elongated single cells, and BRs play a vital role in the regulation of fiber elongation. However, the mode of action on how BR is involved in the regulation of cotton fiber elongation remains unexplored.

GhBES1 mediates brassinosteroid regulation of leaf size by activating expression of GhEXO2 in cotton (Gossypium hirsutum).

We proposed a working model of BR to promote leaf size through cell expansion. In the BR signaling pathway, GhBES1 affects cotton leaf size by binding to and activating the expression of the E-box element in the GhEXO2 promoter region. Brassinosteroid (BR) is an essential phytohormone that controls plant growth.

Potential Roles of 1-Aminocyclopropane-1-carboxylic Acid Synthase Genes in the Response of Species to Abiotic Stress by Genome-Wide Identification and Expression Analysis.

Ethylene plays a pivotal role in plant stress resistance and 1-aminocyclopropane-1-carboxylic acid synthase (ACS) is the rate-limiting enzyme in ethylene biosynthesis. Upland cotton (Gossypium hirsutum L.) is the most important natural fiber crop, but the function of ACS in response to abiotic stress has rarely been reported in this plant.

Ultra-Broadband Tunable Terahertz Metamaterial Absorber Based on Double-Layer Vanadium Dioxide Square Ring Arrays.

Based on the phase transition of vanadium dioxide(VO), an ultra-broadband tunable terahertz metamaterial absorber is proposed. The absorber consists of bilayer VO square ring arrays with different sizes, which are completely wrapped in Topas and placed on gold substrate. The simulation results show that the absorption greater than 90% has frequencies ranging from 1.

High-mobility group box chromosomal protein-1 deletion alleviates osteoporosis in OVX rat model via suppressing the osteoclastogenesis and inflammation.

Background: Osteoporosis is a skeletal metabolic disease that constitutes a great threaten to human health. However, there is currently no gold standard for its treatment. High-mobility group box chromosomal protein-1 (HMGB-1) has been reported to play an important role in various orthopedic diseases.