Synthesis of polymer-clindamycin conjugates through lipase-catalyzed esterification and RAFT polymerization.

Relative to free antibiotics, polymer-antibiotic conjugates (PACs) can possess modified solubility, sustained release behavior, and prolonged bioactivity in biological systems. As one of the most potent and ubiquitous antibiotics, clindamycin (Clin) has broad-spectrum antibiotic activity with versatile medical applications. However, polymer-Clin conjugates have not been reported yet.

Supporting Personalized prEgnancy Care wIth Artificial inteLligence (SPECIAL): An Acceptability Study of a Personalized Educational Platform.

Postpartum depression (PPD) affects approximately 20% of pregnant individuals, yet half of these cases remain under-treated despite the availability of educational interventions. To address this gap, the Supporting Personalized prEgnancy Care wIth Artificial inteLligence (SPECIAL) project leverages Artificial Intelligence (AI) to deliver personalized health education materials for PPD prevention and management. This study evaluated the acceptability of a web-based prototype in SPECIAL, developed with patient input, using the Unified Theory of Acceptance of Use of Technology (UTAUT) framework.

Synthesis, Characterization, and In Vitro Properties of Zwitterionic Dendrimers with a Reactive Focal Functionality for Biomedical Applications.

As novel, well-defined, highly branched macromolecules with numerous superhydrophilic terminal groups, zwitterionic dendrimers (ZDs) are expected to possess charge-neutral outer layers, which can be highly hydrated to exhibit superior antifouling properties and minimized undesirable interactions within biological systems. The incorporation of ZDs with degradable structures and reactive functionality can further expand their applicability. Here, we present the design, synthesis, characterization, and in vitro properties of such ZDs carrying quantitatively one reactive group at the focal point.

Quantification of Cisplatin Encapsulated in Nanomedicine: An Overview.

Cisplatin, which kills cancer cells mainly through DNA crosslinking, has been widely used as a first-line chemotherapeutic agent although it also causes severe side effects. To improve anticancer outcomes, various types of cisplatin-based nanomedicines have been developed, either through direct incorporation or coordination of cisplatin within nanoparticles (NPs). During the formulation and characterization of cisplatin-loaded NPs, quantitative determination of cisplatin is crucial for both clinically used and newly developed NPs.

Unexpected clustering pattern in dwarf galaxies challenges formation models.

The galaxy correlation function serves as a fundamental tool for studying cosmology, galaxy formation and the nature of dark matter. It is well established that more massive, redder and more compact galaxies tend to have stronger clustering in space. These results can be understood in terms of galaxy formation in cold dark matter (CDM) halos of different mass and assembly history.

A pH-Sensitive NIR Fluorescent Probe as a Protagonist in the Discovery of New LC3 Ligands Facilitating the Construction of ATTECs.

Autophagy-tethering compounds (ATTECs) as a new targeted protein degradation technology could directly bind targets to LC3 (a key autophagosome-associated protein) and subsequently result in the degradation of targets via the autophagolysosomal pathway. Herein, we developed a new LC3 ligand screening strategy using an NIR fluorescent probe with both pH-sensitive and LC3-targeted features. The presence of both the probe and a potential LC3 ligand leads to competitive binding to LC3 in cells and hinders the probe from entering and being activated in acidic lysosomes via the autophagy pathway.

Clinical Correlation of the Severity of Vascular Calcification with Calcium and Phosphorus Metabolism and Microinflammation in Malnourished Uremic Patients.

The research assessed calcium (Ca) and phosphorus (P) metabolism and microinflammation in malnourished uremic patients, focusing on the severity of vascular calcification, and examined the relationship between Ca and P metabolism indicators and microinflammation and the severity of vascular calcification. Seventy-eight patients undergoing hemodialysis treatment for ≥6 mo were collected. General information and anthropometric and blood biochemical indices were recorded, including gender, age, body mass index, mid-arm muscle circumference, albumin, intact parathyroid hormone, and Ca and P product (Ca×P).

Perivascular Niche-Resident Alveolar Macrophages Promote Interstitial Pneumonitis Related to Trastuzumab Deruxtecan Treatment.

Trastuzumab deruxtecan (T-DXd) is a transformative HER2-targeting antibody-drug conjugate (ADC) for treating breast cancer. Unfortunately, T-DXd has also been implicated in causing fatal interstitial lung disease (ILD) in multiple clinical trials. A better understanding of the mechanistic basis of these ADC-induced adverse effects could enable development of strategies to prevent or treat T-DXd-related ILD.

Acid-sensing ion channel 1a promotes LPS-induced acute lung injury through the circRNA 18-658/miR-127-5p/TRIM72 axis.

Acute lung injury (ALI) is a serious disease with sudden onset, rapid progression, poor treatment response and high mortality. Acid-sensitive ion channels (ASICs) are a type of cation channel activated by extracellular acidification and are involved in the pathogenesis of inflammatory and immune diseases. Our previous research revealed that ASIC1a promotes ALI, but the specific mechanism is unclear.

PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.

Atherosclerosis is a multifaceted disease involving various cell types and complex mechanisms, and it is the main cause of cardiovascular disease. Proprotein convertase subtilisin/kexin type-9 (PCSK9) has been identified as an effective target for treating atherosclerosis; however, most current research focuses on biological drugs. Our work optimized the previously reported autophagosome-tethering compound , and specifically, compound induced PCSK9 degradation with a 5-fold increase in activity and a 6-fold increase in bioavailability.

Efficient and Rapid Enrichment of Extracellular Vesicles Using DNA Nanotechnology-Enabled Synthetic Nano-Glue.

Swift and efficient enrichment and isolation of extracellular vesicles (EVs) are crucial for enhancing precise disease diagnostics and therapeutic strategies, as well as elucidating the complex biological roles of EVs. Conventional methods of isolating EVs are often marred by lengthy and laborious processes. In this study, we introduce an innovative approach to enrich and isolate EVs by leveraging the capabilities of DNA nanotechnology.

Doxazosin Attenuates Development of Testosterone Propionate-induced Prostate Growth by regulating TGF-β/Smad Signaling Pathway, Prostate-specific Antigen Expression and Reversing Epithelial-mesenchymal Transition in Mice and Stroma Cells.

Background: Finasteride and doxazosin are used for the treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Epithelial-mesenchymal transition (EMT) plays an important role in BPH, little is known about the growth inhibition and anti-fibrosis effects of doxazosin on the regulation of EMT and morphology in the prostate.

Objectives: The present study examined the effects of doxazosin on testosterone propionate (TP)-induced prostate growth in vivo and in vitro and its impact on the EMT and TGF-β/Smad signaling pathway.

Probing Deep Hydrogen Polysulfides Fluctuations In Vivo by Engineering Activatable Fluorescence Reporters with Second Near-Infrared Window Emission.

Deep and comprehensive understanding of the intricate biochemical processes mediated by HS ( ≥ 1), but not HS, is of paramount importance. A few fluorescent probes have been developed with the intention of addressing this issue. However, there is currently no evidence of any activatable NIR-II fluorescent probes for HS-specific imaging over HS.

Morpho-molecular analysis of two new species and in Agaricales from Mount Tianmu, China.

Two new species of Agaricales, and , are described from Mount Tianmu, Zhejiang Province, Eastern China. Two new species are distinct and monophyletic based on morphology and phylogenetic analyses. differs from other species in that the pileus is brow shallow in the center and stipe with yellowish white fibrils, scatted on litter under coniferous and broad-leaved mixed forest at 1162 m.

Digital technology and psychological happiness: the mediating roles of interpersonal relationships and employment situations.

Psychological happiness represents the ultimate pursuit of human beings, and the impact of digital technology on psychological happiness is becoming increasingly significant in the era of the digital economy. Based on data from 2020 China Family Panel Studies (CFPS), this study constructs an empirical model that examines the effect and mechanism of digital technology on happiness. Additionally, this study investigates the heterogeneity and robustness of the impact of digital technology on happiness.

Porphyrin-based-MOF nanocomposite hydrogels for synergistic sonodynamic and gas therapy against tumor.

The glioma is one of the most aggressive tumors in humans, which is difficult to eradicate clinically. Therefore, we devised a porphyrin-based metal-organic frameworks (MOFs) crosslinking hyaluronic acid (HA) hydrogel nanocomposite through double-network (Cu-MOF-S-S-HA-Gel, CSSH-Gel), which is tumor responsive for enhanced gas therapy and sonodynamic therapy (SDT). Firstly, the hydrogels show extraordinary injectability and biocompatibility, which enables intratumor administration to circumvent the danger associated with surgery.

Coevolution of specific gut microbiota of Min pig with host cold adaptation through enhanced vitamin B1 synthesis.

Min pigs exhibit remarkable cold tolerance, where vitamin B1 synthesis by gut microbiota is crucial for the host's energy metabolism. However, the role of this synthesis in cold adaptation of Min pigs are not yet fully understood. This study utilized 16S rRNA amplicon and metagenomic sequencing to examine seasonal variations in the gut microbiota of Min pigs.

Design, Synthesis, and Bioevaluation of Novel NLRP3 Inhibitor with IBD Immunotherapy from the Virtual Screen.

NLRP3, a crucial member of the NLRP family, plays a pivotal role in immune regulation and inflammatory modulation. Here, we report a potent and specific NLRP3 inhibitor obtained though docking-based virtual screening and structure-activity relationship studies with an IC of 0.26 μM in THP-1 cells and 0.

Biodegradable Zwitterionic Polymers as PEG Alternatives for Drug Delivery.

Poly(ethylene glycol) (PEG) is a highly biocompatible and water-soluble polymer that is widely utilized for biomedical applications. Unfortunately, the immunogenicity and antigenicity of PEG severely restrict the biomedical efficacy of pegylated therapeutics. As emerging PEG alternatives, biodegradable zwitterionic polymers (ZPs) have attracted significant interest in recent years.

Plasmonic Radiation from Spin-Momentum Locking.

Chiral light emission plays a key role in sensing, tomography, quantum communication, among others. Whereas, achieving highly pure, tunable chirality emission across a broad spectrum currently presents significant challenges. Free-electron radiation emerges as a promising solution to surpass these barriers, especially in hard-to-reach regimes.

Vacancy-engineered Mn-doped iron oxide nano-crystals for enhanced sonodynamic therapy through self-supplied oxygen.

Sonodynamic therapy (SDT) is a minimally invasive therapeutic approach, that uses ultrasound activating sonosensitizers to generate reactive oxygen species (ROS) for inducing the tumor cell death. However, the SDT is always limited by the dissatisfactory performance of sonosensitizers and hypoxic tumor microenvironment (TME). Nano iron oxide is a narrow bandgap semiconductor material with good biocompatibility.

Advanced seismic resilient performance of steel MRF equipped with viscoelastic friction dampers.

This paper demonstrates the enhanced resilience performance of steel structures with viscoelastic friction dampers (VEFDs) based on numerical simulations of building responses. Velocity-dependent dampers, which are widely used to increase seismic resilience, may increase the axial force of the column under strong earthquake conditions because the generated force depends on the interstory velocity. This often leads to plastic hinges being placed on the columns of the structure, which can lead to structural collapse via weak-layer failure.

Dynamic measurement for the impact of project portfolio synergy.

Measuring the impact of project portfolio synergy (PPSI) is crucial for making informed decisions to improve the strategic realization of a project portfolio. However, the literature has failed to measure PPSI effectively from the perspective of project element flow and to explore the differences in synergy relationships between homogeneous and heterogeneous projects. Consequently, this study proposes a framework for measuring PPSI from the perspective of project element flow.