The prognostic value of serum ET-1, MCP-1, and lactic acid levels in patients with ruptured intracranial aneurysm after interventional embolization.

Aim: This study was to evaluate the prognostic value of serum endothelin-1 (ET-1), monocyte chemotactic protein-1 (MCP-1), and lactic acid (LA) levels in patients with ruptured intracranial aneurysm (IA) after interventional embolization Material and Methods: Patients with ruptured IA were divided into mild, moderate, and severe groups according to Hunt-Hess grades, and the correlation between serum parameters and disease severity was analyzed. Multivariate logistic regression was employed to analyze the influence of serum ET-1, MCP-1, and LA levels on the prognosis of patients, and ROC curves were plotted to analyze the predictive value of these parameters.

Results: There were 29 cases in the mild group (grade Ⅰ), 49 cases in the moderate group (grade Ⅱ-Ⅲ), and 25 cases in the severe group (grade Ⅳ-Ⅴ).

LGI3 promotes the progression of TFE3-rearranged renal cell carcinoma through GEMIN6/AURKB axis.

Transcription factor binding to IGHM enhancer 3-rearranged renal cell carcinoma (TFE3-RCC) is characterized by its aggressive nature, limited treatment options, and poor prognosis. However, the downstream targets of TFE3 fusion protein responsible for its tumorigenesis and progression remain unclear. Here, we demonstrated that leucine-rich repeat LGI family member 3 (LGI3) is a direct target of TFE3 fusion protein.

Vegetation variations and driving mechanisms in northern China based on kNDVI.

Northern China is an ecologically fragile region, making it highly significant for studying the temporal and spatial variations of vegetation cover and their driving factors. In this study, we analyze the temporal and spatial variations of vegetation cover in northern China from 2001 to 2022 by using a kernel normalized difference vegetation index (kNDVI) dataset, and quantify the contributions of influencing factors by random forest. The results indicate that the spatial distribution of kNDVI in northern China follows a pattern of "low in the west and high in the east," with a gradual increase from west to east.

Understanding the Degradation and Stress Response Mechanisms of Cypermethrin by J6 Isolated from Broiler Gastrointestinal Tract.

Pyrethroid residues in the environment and agricultural products have caused significant negative effects on food safety and human health. In this study, a novel strain of J6, isolated from the cecum of broilers, exhibited the ability to degrade cypermethrin and its major metabolite, 3-phenoxybenzoic acid. The identified intermediates indicated that J6 degrades cypermethrin through ester bond hydrolysis, benzene hydroxylation, and ether bond cleavage.

Development of a CXCR4 antagonistic peptide, P12, to suppress pancreatic cancer progress enhancing T cell responses and sensitizing cells to gemcitabine.

The C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed by pancreatic cancer cells. This work developed a CXCR4 antagonistic peptide P12, which was identified by pancreatic-cell-based selection from among the designed peptides and was able to specifically bind to the pancreatic cancer cells as well as fibroblasts and macrophages and . CXCL12-mediated migration of tumor cells and adhesion to stromal cells were effectively inhibited by P12, and the phosphorylation of Erk and P38 was down-regulated.

Deoxynivalenol triggers pyroptosis in mouse hippocampal neurons by activating oxidative stress and interfering with neurotransmitter release.

As a prevalent natural pollutant, deoxynivalenol (DON) exhibits high toxicity, affects multiple organs, can penetrate the blood-brain barrier and induce neurotoxicity, thereby threatening food safety. In this study, we investigated the effects of DON on hippocampal neuronal injuries using both in vivo and in vitro models to evaluate its potential risks. Results showed that subchronic exposure of DON exposure (500 ng/mL in cells and 1 mg/kg.

Multistable metamaterials enabled by arched beams for high-efficiency energy absorption.

Energy-absorbing materials with high absorption efficiency are ideal candidates for impact protection. Multistable metamaterials, composed of bistable primitives, have attracted much attention in recent years owing to their unique advantages in energy absorption. However, developing multistable metamaterials with excellent energy absorption performance remains a formidable challenge.

Extracellular vesicle-mediated transmission of circPDLIM5 promotes lymphatic metastasis in prostate cancer.

For patients with prostate cancer (PCa), pelvic lymph node (LN) metastasis remains a major poor prognostic factor associated with cancer-specific mortality. VEGF-C is a major lymphangiogenic ligand that plays a vital role in LN metastasis in PCa. However, in some PCa caseswith LN metastasis,VEGF-C is not upregulated, indicating that some VEGF-C-independent mechanisms are essential for lymphangiogenesis.

Unconventional Stiffening Behavior of Amphiphilic Triblock Copolymers in Aqueous Environments for Thermally Activated Artificial Muscles.

Biological systems achieve multifunctionality through dynamic stiffness modulation, yet replicating this adaptability in synthetic actuators remains challenging. Paradigm-shifting thermally triggered shape-memory polymers (SMPs) are reported that defies conventional thermal softening behavior. By designing amphiphilic triblock copolymers with various block chain lengths, water-induced microphase separation is exploited to achieve anomalous enhancement in stiffness-specially, a remarkable 170-fold modulus increase in aqueous environments at 25 °C, along with a sustained 1.

Effects of eight-week resistance and complex training on the biomechanical characteristics of lower limbs during badminton backhand forward lunge.

Objectives: This study aimed to examine the effects of an 8-week resistance training (RT) or complex training (CT) program on lower limb biomechanical characteristics during the backhand forward lunge in male amateur badminton players.

Methods: Twenty male amateur badminton players were randomly assigned to either a complex training group or a resistance training group for an eight-week intervention. Lower limb kinematics and dynamics were captured before and after the intervention using an eight-camera Vicon motion system and two AMTI force plates.

Decoupling of Interfacial Ionic Diffusion from Segmental Dynamics in Silica-Filled Silicone Gel through Experiments.

This study experimentally investigates and models the ionic diffusion coefficient at inert particle/polymer interfaces in silica-filled silicone gels, aiming to elucidate the relationship between ion diffusion and segmental dynamics at interfaces. As the specific surface area of silica increases, more loop-type structure chains form at the silica-silicone gel interface. Enhanced silicone chain flexibility at the interface, coupled with a low dielectric constant, strengthens electrostatic interactions and elastic forces, increasing ion jump energy barriers and reducing ion diffusion.

CRABP2 promotes peritoneal metastasis in CRC through TGF-β/Smad-mediated EMT signaling and invadopodia formation.

Peritoneal metastasis (PM) in colorectal cancer (CRC) is typically associated with a lower likelihood of successful conversion therapy and a poorer prognosis compared to metastases at other sites. Invadopodia, cancer-specific protrusive structures, play a vital role in the metastatic cascade by degrading the basement membrane and surrounding stroma. However, the exact mechanism of invadopodia regulation in PM of CRC still remains unclear.

ggClusterNet 2: An R package for microbial co-occurrence networks and associated indicator correlation patterns.

Since its initial release in 2022, has become a vital tool for microbiome research, enabling microbial co-occurrence network analysis and visualization in over 300 studies. To address emerging challenges, including multi-factor experimental designs, multi-treatment conditions, and multi-omics data, we present a comprehensive upgrade with four key components: (1) A microbial co-occurrence network pipeline integrating network computation (Pearson/Spearman/SparCC correlations), visualization, topological characterization of network and node properties, multi-network comparison with statistical testing, network stability (robustness) analysis, and module identification and analysis; (2) Network mining functions for multi-factor, multi-treatment, and spatiotemporal-scale analysis, including and ; (3) Transkingdom network construction using microbiota, multi-omics, and other relevant data, with diverse visualization layouts such as and ; and (4) Transkingdom and multi-omics network analysis, including and visualization algorithms tailored for complex network exploration, including , , and . The updates in enable researchers to explore complex network interactions, offering a robust, efficient, user-friendly, reproducible, and visually versatile tool for microbial co-occurrence networks and indicator correlation patterns.

Quantification of Cisplatin Encapsulated in Nanomedicine: An Overview.

Cisplatin, which kills cancer cells mainly through DNA crosslinking, has been widely used as a first-line chemotherapeutic agent although it also causes severe side effects. To improve anticancer outcomes, various types of cisplatin-based nanomedicines have been developed, either through direct incorporation or coordination of cisplatin within nanoparticles (NPs). During the formulation and characterization of cisplatin-loaded NPs, quantitative determination of cisplatin is crucial for both clinically used and newly developed NPs.

Atypical presentation of pseudohypoparathyroidism with absence of mutations in the GNAS gene: a case report.

Background: This case report aimed to broaden the understanding of pseudohypoparathyroidism (PHP) manifestations when typical mutations in the GNAS gene are absent. The clinical, biochemical, and genetic investigations of a PHP case revealed diagnostic challenges and emphasized the importance of comprehensive genetic analysis for early diagnosis and appropriate management, as well as improved patient outcomes.

Case Presentation: The case involved a 21-year-old man who has experienced recurrent limb convulsions and episodes of altered consciousness since the age of eight.

Itaconic acid production from corn stover hydrolysates for a newly isolated Aspergillus terreus through adaptive evolution.

Itaconic acid can be produced using lignocellulosic biomass; however, the inhibitors from pretreatment process of biorefinery are toxic to the fermenting strains. Here, with 35.70 ± 0.

A Study on the Impact of Brand Ritual on Online Word-of-Mouth Communication.

The study aims to explore the impact mechanism of brand ritual on online word-of-mouth communication, introducing the mediating variable-flow experience-and the moderating variable-consumer-brand relationship norms. The study uses the approach of the experimental research. In Experiment 1, with the watch as the experimental product and the advertisement as the online scene, 62 subjects in the pre-experiment and 132 subjects in the formal experiment are recruited to verify the main effect of brand ritual on online word-of-mouth communication.

Digital design and fabrication of a guiding template for preparing occlusal rest seats in removable partial denture abutments.

Occlusal rest seats, providing support, are essential to a successful removable partial denture (RPD). With the development of computer-aided design and computer-aided manufacturing (CAD-CAM), this report presents a novel method of designing and fabricating a guiding template to precisely prepare occlusal rest seats for RPD abutments.

Microbial community dynamics in the soil-root continuum are linked with plant species turnover during secondary succession.

Grazing exclusion and land abandonment are commonly adopted to restore degraded ecosystems in semiarid and arid regions worldwide. However, the temporal variation in the soil- versus root-associated microbiome over plant species turnover during secondary succession has rarely been quantified. Using the chronosequence restored from fenced grassland and abandoned farmlands on the Loess Plateau of China, we characterized the dynamics of the soil- and root-associated microbiome of host plant with different dominance statuses during secondary succession from 0 to 40 years.

Geriatric nutritional risk index and body composition dictate the prognosis of elderly patients with intrahepatic cholangiocarcinoma.

Background And Aims: Malnutrition is a well-recognized predictor of poor prognosis in malignancies. Recent studies suggest that the geriatric nutritional risk index (GNRI) is a more accurate determinant of prognosis in elderly patients than conventional body mass index (BMI). This study aimed to evaluate the GNRI and body composition parameters in elderly patients with intrahepatic cholangiocarcinoma (ICC) and assess their prognostic impact on long-term outcomes.

The genomic and epigenomic landscape of iridocorneal endothelial syndrome.

Iridocorneal endothelial (ICE) syndrome is a rare, irreversibly blinding eye disease with an unknown etiology. Understanding its genomic and epigenomic landscape could aid in developing etiology-based therapies. In this study, we recruited 99 ICE patients and performed whole-genome sequencing (WGS) on 51 and genome-wide DNA methylation profiling on 48 of them.

Dynamics of antibiotic resistance genes and the bacterial community after stress from a single Dazomet fumigation.

Although chemical fumigants are widely applied in agriculture to control soil-borne diseases, their influence on soil antibiotic resistance genes (ARGs) remains poorly understood. This study employed metagenomic sequencing to investigate the dynamic response and recovery processes of soil bacterial communities and ARGs after the end of fumigation with Dazomet. The results revealed that the effects of Dazomet were both phased and recoverable.

Lateral unicompartmental knee arthroplasty is an effective procedure for lateral post-meniscectomy knee osteoarthritis: a case-control study at a mean 7-year follow-up.

Background: Meniscectomy is a common knee surgery for meniscal tear, and is associated with progressive osteoarthritis (OA). There are few literatures focus on the use of lateral unicompartmental knee arthroplasty (UKA) for lateral post-meniscectomy knee osteoarthritis (PMKO). Therefore, the purpose of this study is to compare the outcomes of lateral UKA performed for lateral PMKO and primary lateral compartment knee osteoarthritis (LCKO).

The burden of injury among elderly individuals in China from 1990 to 2019: An analysis of data from the global burden of disease study 2019.

Background: With the rapid ageing of the population, injuries are increasingly threatening the health of elderly individuals. A comprehensive evaluation of the injury burden is important for selecting and formulating strategies for injury prevention.

Objective: To evaluate the temporal trends of injury burden among elderly Chinese individuals aged 60 years and older.