Analysis of the Longitudinal Association Between Parental Feeding Practices and Body Composition Among Children in Shenzhen.

: A national study from China in 2023 predicted that the prevalence of overweight and obesity among children aged 7-18 will increase from 23.4% in 2019 to 32.7% by 2030.

Transcriptomic combined physiological analysis illuminated the gastrointestinal stress mechanism of .

Gastrointestinal stress significantly influences the functionality and survival of food-derived probiotics after ingestion. is widely recognized for its remarkable resilience to gastrointestinal challenges, yet the molecular mechanisms underlying this tolerance remain incompletely understood. In this study, an integrated physiological and transcriptomic approach was employed to elucidate the adaptive responses of to gastrointestinal stress.

Association of Parental Feeding Styles with Body Composition Among Children in Two Regions in China.

This study aimed to investigate the correlation between parental feeding practices and children's body composition in two Chinese regions with distinct socioeconomic characteristics. A cross-sectional study was conducted in Shenzhen (economically developed) and Yulin (economically underdeveloped) regions. Data were collected in 2023 from 1298 (age 8-10 years) children and their parents in two regions.

Therapeutic potential of Saccharomyces boulardii in alleviating gastrointestinal stress through preservation of intestinal cell membrane integrity.

Background: Saccharomyces boulardii shows great promise as a treatment for osteoporosis since it plays a crucial role in protecting against inflammatory bone loss and demonstrates exceptional resilience to gastrointestinal stress during oral administration. This study delved into the impacts of gastrointestinal stress on S. boulardii and the corresponding adaptive mechanisms employed by the yeast at the membrane level using physiological methodologies.

Multimodal learning audio-visual detection for obtaining object-level sound sources in Japanese-language teaching room.

The combination of artificial intelligence and education is one of the current trends in research. While observing the daily teaching and learning process at school, we have considered the possibility of using multimodal learning, in particular audio-visual detection (AVD), to improve the teaching and learning process in Japanese-language teaching rooms. AVD can be effectively used to locate sounding objects (e.

Enhancing the application of probiotics in probiotic food products from the perspective of improving stress resistance by regulating cell physiological function: A review.

Probiotic foods are foods containing probiotics, including dairy and non-dairy products, that exert significant beneficial impacts on human health. Benefiting from the rapid progress in systems biology, diverse types of probiotics with prominent health-promoting functionalities are unraveled, albeit such functions could be substantially influenced by the stress environments. Here, we conducted a comprehensive review to characterize the state-of-the-art research on probiotic foods and specific probiotics employed in their production.

Temporal dynamics of immune cell patterns in bladder cancer patients receiving Bacillus Calmette-Guérin therapy.

Background: Bacillus Calmette-Guérin (BCG) is capable of enhancing the infiltration of immune cells into the tumour. However the temporal dynamics of immune cell patterns in patients receiving BCG instillation remains unclear.

Methods: Ninety-six patients who underwent intravesical BCG therapy, comprising 46 responders and 50 non-responders, were retrospectively enroled to explore the evolving immune landscape.

Engineering the synthesis of unsaturated fatty acids by introducing desaturase improved the stress tolerance of yeast.

Background: Yeast is often used to build cell factories to produce various chemicals or nutrient substances, which means the yeast has to encounter stressful environments. Previous research reported that unsaturated fatty acids were closely related to yeast stress resistance. Engineering unsaturated fatty acids may be a viable strategy for enhancing the stress resistance of cells.

Engineering acetyl-CoA metabolism to enhance stress tolerance of yeast by regulating membrane functionality.

Zygosaccharomyces rouxii has excellent fermentation performance and good tolerance to osmotic stress. Acetyl-CoA is a crucial intermediate precursor in the central carbon metabolic pathway of yeast. This study investigated the effect of engineering acetyl-CoA metabolism on the membrane functionality and stress tolerance of yeast.

Arginine deiminase pathway of Tetragenococcus halophilus contributes to improve the acid tolerance of lactic acid bacteria.

Arginine deiminase pathway, controlled by arginine deiminase, ornithine carbamoyltransferase and carbamate kinase, could affect and modulate the intracellular pH homeostasis of lactic acid bacteria under acid stress. Herein, strategy based on exogenous addition of arginine had been proposed to improve the robustness of Tetragenococcus halophilus during acid stressed condition. Results indicated cells cultured in the presence of arginine acquired high tolerance to acid stress mainly through maintaining the homeostasis of intracellular microenvironment.

EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma.

The biological function of many mitochondrial proteins in mechanistic detail has not been well investigated in clear cell renal cell carcinoma (ccRCC). A seven-mitochondrial-gene signature was generated by Lasso regression analysis to improve the prediction of prognosis of patients with ccRCC, using The Cancer Genome Atlas and Clinical Proteomic Tumor Analysis Consortium cohort. Among those seven genes, EFHD1 is less studied and its role in the progression of ccRCC remains unknown.

Effects of salt concentration on the quality and microbial diversity of spontaneously fermented radish paocai.

Paocai is a traditional Chinese fermented vegetable product popular in Asian countries. As an important additive, salt concentration is closely related to the quality of paocai. The aim of this study was to investigate the effect of salt concentration on the physicochemical characteristics, microbial diversity, and flavor profiles of spontaneously fermented radish, and the cross-correlation between microorganisms and flavor compounds was also revealed.

Food yeasts: occurrence, functions, and stress tolerance in the brewing of fermented foods.

With the rapid development of systems biology technology, there is a deeper understanding of the molecular biological mechanisms and physiological characteristics of microorganisms. Yeasts are widely used in the food industry with their excellent fermentation performances. While due to the complex environments of food production, yeasts have to suffer from various stress factors.

Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner.

As one of the hallmarks of cancer, metabolic reprogramming leads to cancer progression, and targeting glycolytic enzymes could be useful strategies for cancer therapy. By screening a small molecule library consisting of 1320 FDA-approved drugs, we found that penfluridol, an antipsychotic drug used to treat schizophrenia, could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma (ESCC). Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.

Metabolomics analysis of salt tolerance of Zygosaccharomyces rouxii and guided exogenous fatty acid addition for improved salt tolerance.

Background: Zygosaccharomyces rouxii plays an irreplaceable role in the manufacture of traditional fermented foods, which are produced in a high-salt environment. However, there is little research on strategies for improving salt tolerance of Z. rouxii.

Structural characterization and bioactivity of novel exopolysaccharides produced by Tetragenococcus halophilus.

In this study, exopolysaccharides produced by Tetragenococcus halophilus were extracted and purified. Two fractions named EPS-1 and EPS-2 were obtained with average molecular weights of 2613.4 and 93.

Semantic segmentation of microscopic neuroanatomical data by combining topological priors with encoder-decoder deep networks.

Understanding of neuronal circuitry at cellular resolution within the brain has relied on neuron tracing methods which involve careful observation and interpretation by experienced neuroscientists. With recent developments in imaging and digitization, this approach is no longer feasible with the large scale (terabyte to petabyte range) images. Machine learning based techniques, using deep networks, provide an efficient alternative to the problem.

Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy.

Colorectal cancer (CRC) is one of the most common malignancies worldwide, and effective therapy remains a challenge. In this study, we take advantage of a drug repurposing strategy to screen small molecules with novel anticancer activities in a small-molecule library consisting of 1056 FDA-approved drugs. We show, for the first time, that lomitapide, a lipid-lowering agent, exhibits antitumor properties in vitro and in vivo.

Incorporation of Exogenous Fatty Acids Enhances the Salt Tolerance of Food Yeast .

Fatty acids have great effects on the maintenance of the cell membrane structure, cell viability, and cell metabolisms. In this study, we sought to elucidate the effects of exogenous fatty acids on the salt tolerance of food yeast . Results showed that can grow by using exogenous fatty acids (C12:0, C14:0, C16:0, C16:1, C18:0, C18:1, and C18:2) as the sole carbon source.

Targeted Immunotherapies in Gastrointestinal Cancer: From Molecular Mechanisms to Implications.

Gastrointestinal cancer is a leading cause of cancer-related mortality and remains a major challenge for cancer treatment. Despite the combined administration of modern surgical techniques and chemoradiotherapy (CRT), the overall 5-year survival rate of gastrointestinal cancer patients in advanced stage disease is less than 15%, due to rapid disease progression, metastasis, and CRT resistance. A better understanding of the mechanisms underlying cancer progression and optimized treatment strategies for gastrointestinal cancer are urgently needed.

A Study of Nitrogen Deficiency Inversion in Rice Leaves Based on the Hyperspectral Reflectance Differential.

To achieve rapid, accurate, and non-destructive diagnoses of nitrogen deficiency in cold land japonica rice, hyperspectral data were collected from field experiments to investigate the relationship between the nitrogen (N) content and the difference in the spectral reflectance relationship and to establish the hyperspectral reflectance difference inversion model of differences in the N content of rice. In this study, the hyperspectral reflectance difference was used to invert the nitrogen deficiency of rice and provide a method for the implementation of precision fertilization without reducing the yield of chemical fertilizer. For the purpose of constructing the standard N content and standard spectral reflectance the principle of minimum fertilizer application at maximum yield was used as a reference standard, and the acquired rice leaf nitrogen content and leaf spectral reflectance were differenced from the standard N content and standard spectral reflectance to obtain N content.

A Silicon Optical Bench-Based Forward-View Two-Axis Scanner for Microendoscopy Applications.

Optical microendoscopy enabled by a microelectromechanical system (MEMS) scanning mirror offers great potential for in vivo diagnosis of early cancer inside the human body. However, an additional beam folding mirror is needed for a MEMS mirror to perform forward-view scanning, which drastically increases the diameter of the resultant MEMS endoscopic probe. This paper presents a new monolithic two-axis forward-view optical scanner that is composed of an electrothermally driven MEMS mirror and a beam folding mirror both vertically standing and integrated on a silicon substrate.

Heat preadaptation improved the ability of Zygosaccharomyces rouxii to salt stress: a combined physiological and transcriptomic analysis.

Zygosaccharomyces rouxii plays important roles in the brewing process of fermented foods such as soy sauce, where salt stress is a frequently encountered condition. In this study, effect of heat preadaptation on salt tolerance of Z. rouxii and the protective mechanisms underlying heat preadaptation were investigated based on physiological and transcriptomic analyses.

MEMS Mirrors for LiDAR: A review.

In recent years, Light Detection and Ranging (LiDAR) has been drawing extensive attention both in academia and industry because of the increasing demand for autonomous vehicles. LiDAR is believed to be the crucial sensor for autonomous driving and flying, as it can provide high-density point clouds with accurate three-dimensional information. This review presents an extensive overview of Microelectronechanical Systems (MEMS) scanning mirrors specifically for applications in LiDAR systems.