Early cellular events of osteomucosal healing in the tooth extraction socket.

Healing after dentoalveolar trauma, such as tooth extraction, is unique to the oral cavity that involves osteomucosal healing - healing of soft and hard tissues at the same time - through a series of healing stages. The healing process of soft or hard tissues is well-documented previously; however, inter-dependency and cross-talks during the progression of their simultaneous healing processes remain unclear. In this study, we investigated spatial and temporal changes of epithelial, connective, and bone tissues, as well as the presence of osteoclasts, during the early stages of osteomucosal healing.

-Palmitoleic Acid Regulates Lipid Metabolism via Diacylglycerol Metabolic Shunting.

Obesity and related metabolic disorders are closely linked to dysregulated lipid metabolism, where the metabolic balance of diacylglycerol (DAG) played a pivotal role. Although -palmitoleic acid (POA) exhibits anti-obesity effects, its efficacy varies across dietary conditions, and its molecular mechanisms remains unclear. In this study, we investigated the dose-dependent regulatory effects of POA on DAG metabolic shunting in db/db mice, employing lipidomics, pathway analysis, and gene/protein expression assays.

Application of absorbable internal fixation system in secondary rhinoplasty of patients with unilateral cleft lip.

Background: Postoperative nasal asymmetry is a common secondary deformity following correction of unilateral cleft lip, with insufficient structural reinforcement along the nasal midline representing a key etiological factor.

Purpose: To address the clinical challenge of nasal asymmetry in unilateral cleft lip patients caused by insufficient midline nasal support, this study proposes the use of an absorbable internal fixation system for nasal scaffold reconstruction and evaluates its therapeutic efficacy.

Methods: This retrospective study included patients with unilateral cleft lip nose.

Cervical Incision-Free Technique for R0 Resection in Cervicothoracic Esophageal Carcinoma: A Novel Approach of the Chai's Supra-Thoracic Apex Technique.

Esophageal squamous cell carcinoma (ESCC) located at the cervicothoracic junction (CTJ-ESCC), approximately 18-21 cm from the incisors, poses unique surgical difficulties given its proximity to the trachea and recurrent laryngeal nerves. This investigation evaluated a new approach that avoids cervical incisions by combining the EGIARADMT™ curvilinear stapling method with OrVil™-based three-dimensional suspension anastomosis (TriSAS) to achieve R0 resection. A retrospective analysis was performed on 11 consecutive cases of CTJ-ESCC treated between February 2019 and March 2024, with follow-up data available until February 2025.

Finerenone in Primary IgA Nephropathy: A Matched Case-Control Study.

Introduction: This study aimed to evaluate whether supplementation of finerenone to renin-angiotensin system inhibitor (RASi) therapy confers additional renoprotective benefit versus RASi therapy only in clinical IgA nephropathy (IgAN).

Methods: Primary IgAN patients administered RASi therapy at Ruijin Hospital from January 2023 to December 2023 were retrospectively enrolled, with an estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m.

Factors influencing AI adoption by Chinese mathematics teachers in STEM education.

This study refines the Extended Unified Theory of Acceptance and Use of Technology (UTAUT2) to explore the factors influencing the adoption and utilization of artificial intelligence (AI) by Chinese mathematics teachers in STEM education, aiming to promote broader integration of AI within this domain. Utilising structural equation modelling (SEM) on survey data collected from 503 in-service mathematics teachers across China, the findings indicate that performance expectancy (PE), hedonic motivation (HM), and price value (PV) significantly affect teachers' behavioural intention (BI). Moreover, the study finds that effort expectancy (EE), facilitating conditions (FC), and price value (PV) significantly influence teachers' actual usage behaviour (UB).

Advances in MCFA to ameliorate lipoatrophic hepatocyte injury and lipid metabolism disorders (Review).

With the improvement in the material standard of living of individuals and a decrease in physical activity, which has led to a significant increase in the incidence of obesity and its related metabolic diseases, non‑alcoholic fatty liver disease (NAFLD) is increasingly becoming one of the more common metabolic disorders of the liver that threatens public health. Lipid deposits in the liver cause simple hepatic steatosis to develop into non‑alcoholic steatohepatitis (NASH), which causes severe damage to the organism; however, the key mechanisms responsible for the progression of NASH remain unclear. Therefore, the active and effective correction of the imbalance of energy metabolism in the organism is a common health challenge for humans.

Temporal and spatial distribution of histone acetylation in mouse molar development.

Histone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood. Using the mouse molar as a model, we mapped the distribution patterns of histone H3 and H4, as well as their corresponding acetylation sites during tooth formation in order to unveil the connection between histone acetylation modification and tooth development.

Quantitative MRI reveals infrapatellar fat pad changes after running a marathon.

Background: Marathon running, while offering health benefits, is associated with a high incidence of knee injuries. The infrapatellar fat pad (IFP) plays a critical role in knee joint homeostasis and injury mitigation. This study investigated IFP adaptations to the acute stress of marathon running using quantitative magnetic resonance imaging (MRI).

A Nomogram for Predicting Pulmonary Embolism in Silicosis Patients.

Background: As one of the most severe occupational diseases that prevention efforts have supported for several decades, silicosis is still a public health issue that lacks a prediction model for pulmonary embolism.

Methods: A total of 162 patients confirmed to have silicosis were all involved in a training cohort to construct a nomogram with the outcome diagnosed by the CTPA using logistic regression. Univariate and LASSO analyses were used to select variables for the nomogram.

What factors influence secondary students' active participation in mathematics classrooms: A theory of planned behavior perspective.

Active Student Participation (ASP) is important for academic success and increased motivation in educational processes. This is because the mathematics outcomes can be significantly improved when students engage actively in the learning process. However, limited studies have been conducted on the factors influencing ASP in mathematics classrooms and strategies for enhancement despite the benefits.

Tripartite motif-containing 32 regulated by miR-6236-p5 inhibited silica-induced apoptosis of alveolar macrophages.

Apoptosis of alveolar macrophages (AMs) induced by silica is one of the crucial driving factors of silicosis inflammation and fibrosis. However, the mechanism of silica-induced AMs apoptosis remains unclear. In this study, transcriptome sequencing identified 11 differentially expressed (DE)-mRNAs enriched in the regulation of apoptotic signaling pathways in AMs treated with 250 μg/mL silica for 24 h, of which tripartite motif-containing 32 (Trim32) was the most significant and down-regulated.

Predictive Value of TyG and TyG-BMI Indices for Non-Alcoholic Fatty Liver Disease in High-Altitude Regions of China: A Cross-Sectional Study.

The associations between triglyceride glucose (TyG), triglyceride glucose-body mass index (TyG-BMI), and non-alcoholic fatty liver disease (NAFLD) in high-altitude regions remain unclear. This is a cross-sectional, population-based study comprising 1384 adults living in Jianchuan county, China, which has an average altitude of over 2200 m. Logistic regressions were used to examine the associations between TyG, TyG-BMI, and NAFLD.

Putative Allele of Gene Alters Rice Tiller Response to Nitrogen.

The number of tillers in rice significantly affects final yield, making it a key trait for breeding and nitrogen-efficient cultivation. By investigating agronomic characteristics, we analyzed phenotypic differences between the wild-type P47-1 and the mutant , performing genetic analysis and gene mapping through population construction and BSA sequencing. The mutant, exhibiting dwarfism and multiple tillering, is controlled by a single gene, , which is tightly linked to .

CAD/CAM surgical guides and pre-bent distractors: Enhancing precision in MDO for severe dentofacial deformities secondary to TMJ ankylosis.

Background: This study aimed to compare the different outcomes of mandibular distraction osteogenesis (MDO) using computer-aided design and manufacturing (CAD/CAM) surgical guides accompanied by pre-bent distractors versus CAD/CAM surgical guides with commercial distractors.

Methods: Twenty-eight patients with severe dentofacial deformities secondary to unilateral temporomandibular joint ankylosis (TMJA) were retrospectively enrolled. Ten parameters associated with MDO were measured preoperatively, virtually, and postoperatively.

Effects of Two Strains on Apple Replant Disease Suppression and Plant Growth Stimulation.

, the pathogen responsible for apple replant disease (ARD), is seriously threatening the apple industry globally. We investigated the antagonistic properties of strains against HS2, aiming to find a biological control solution to minimize the dependence on chemical pesticides. Two of the thirty-one strains assessed through plate confrontation assays, L7 () and M19 (), markedly inhibited = , with inhibition rates of 86.

Irisin improves ROS‑induced mitohormesis imbalance in H9c2 cells.

Abnormal mitohormesis is a key pathogenic mechanism that induces a variety of cardiac diseases, including cardiac hypertrophy and heart failure. Irisin as a muscle factor serves a cardioprotective role in response to cellular oxidative stress injury. Rat cardiomyocyte cells (H9c2) were treated with 40 µM exogenous HO to establish an oxidative stress model, followed by addition of 75 nM exogenous irisin for experiments to determine mitochondrial membrane potential, reactive oxygen species, and Mitohormesis‑related factors by attrition cytometry.

Machine learning-assisted diagnosis of parotid tumor by using contrast-enhanced CT imaging features.

Purpose: This study aims to develop a machine learning diagnostic model for parotid gland tumors based on preoperative contrast-enhanced CT imaging features to assist in clinical decision-making.

Materials And Methods: Clinical data and contrast-enhanced CT images of 144 patients with parotid gland tumors from the Peking University School of Stomatology Hospital, collected from January 2019 to December 2022, were gathered. The 3D slicer software was utilized to accurately annotate the tumor regions, followed by exploring the correlation between multiple preoperative contrast-enhanced CT imaging features and the benign or malignant nature of the tumor, as well as the type of benign tumor.

Three-Dimensional Morphological Changes in the Upper Airway After Maxillary Reconstruction With an Anterolateral Thigh Flap.

Background: Reconstruction of maxillary defects may lead to changes in the upper airway. These changes may cause postoperative airway obstruction issues.

Purpose: The purpose was to evaluate the postoperative changes in the upper airway following maxillary reconstruction with an anterolateral thigh flap (ALTF) and to identify the factors associated with these changes.

Uromodulin and progression of IgA nephropathy.

Background: This study investigates the link between genetic variants associated with kidney function and immunoglobulin A (IgA) nephropathy (IgAN) progression.

Methods: We recruited 961 biopsy-proven IgAN patients and 651 non-IgAN end-stage renal disease (ESRD) patients from Ruijin Hospital. Clinical and renal pathological data were collected.

Postoperative facial prediction for mandibular defect based on surface mesh deformation.

Objectives: This study aims to introduce a novel predictive model for the post-operative facial contours of patients with mandibular defect, addressing limitations in current methodologies that fail to preserve geometric features and lack interpretability.

Methods: Utilizing surface mesh theory and deep learning, our model diverges from traditional point cloud approaches by employing surface triangular mesh grids. We extract latent variables using a Mesh Convolutional Restricted Boltzmann Machines (MCRBM) model to generate a three-dimensional deformation field, aiming to enhance geometric information preservation and interpretability.

Association of complete blood count parameters with the risk of incident pulmonary heart disease in pneumoconiosis: a retrospective cohort study.

Background: Pneumoconiosis mostly combines pulmonary and cardiovascular diseases, among which pulmonary heart disease (PHD) is of major concern due to its significant impact on the survival of pneumoconiosis patients. White cell count (WCC), red cell distribution width (RDW) and platelet parameters are thought to affect inflammatory responses and may be predictors of various cardiovascular diseases. However, very few studies have focused on PHD.

Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells.

Calorie restriction increases lifespan. Among the tissue-specific protective effects of calorie restriction, the impact on the gastrointestinal tract remains unclear. We report increased numbers of chromogranin A-positive (+), including orexigenic ghrelin+ cells, in the stomach of calorie-restricted mice.

Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model.

Glioblastoma (GBM) is the most common and aggressive primary brain cancer; angiogenesis and immunosuppression exacerbate GBM progression. COUP-TFII demonstrates pro-angiogenesis activity; however, its role in glioma progression remains unclear. This study revealed that COUP-TFII promotes angiogenesis in gliomas by inducing transdifferentiation of glioma cells into endothelial-like cells.

Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement.

The development of ectodermal organs begins with the formation of a stratified epithelial placode that progressively invaginates into the underlying mesenchyme as the organ takes its shape. Signaling by secreted molecules is critical for epithelial morphogenesis, but how that information leads to cell rearrangement and tissue shape changes remains an open question. Using the mouse dentition as a model, we first establish that non-muscle myosin II is essential for dental epithelial invagination and show that it functions by promoting cell-cell adhesion and persistent convergent cell movements in the suprabasal layer.