Cost-effective poly(3-alkylthiophene)-based organic photovoltaics: advancing solar energy conversion and photodetection technologies.

Poly(3-alkylthiophene)s (P3ATs), particularly poly(3-hexylthiophene) are cornerstone materials for organic photovoltaics, bridging efficiency, scalability, and solution processability. This article systematically outlines advancements in P3AT-based organic solar cells (OSCs) and photodetectors (OPDs), focusing on materials physics principles, structure-property relationships, and application-driven optimization. Innovations in polymerization methods enable high regioregularity and eco-friendly production.

-Palmitoleic Acid Regulates Lipid Metabolism via Diacylglycerol Metabolic Shunting.

Obesity and related metabolic disorders are closely linked to dysregulated lipid metabolism, where the metabolic balance of diacylglycerol (DAG) played a pivotal role. Although -palmitoleic acid (POA) exhibits anti-obesity effects, its efficacy varies across dietary conditions, and its molecular mechanisms remains unclear. In this study, we investigated the dose-dependent regulatory effects of POA on DAG metabolic shunting in db/db mice, employing lipidomics, pathway analysis, and gene/protein expression assays.

Advances in MCFA to ameliorate lipoatrophic hepatocyte injury and lipid metabolism disorders (Review).

With the improvement in the material standard of living of individuals and a decrease in physical activity, which has led to a significant increase in the incidence of obesity and its related metabolic diseases, non‑alcoholic fatty liver disease (NAFLD) is increasingly becoming one of the more common metabolic disorders of the liver that threatens public health. Lipid deposits in the liver cause simple hepatic steatosis to develop into non‑alcoholic steatohepatitis (NASH), which causes severe damage to the organism; however, the key mechanisms responsible for the progression of NASH remain unclear. Therefore, the active and effective correction of the imbalance of energy metabolism in the organism is a common health challenge for humans.

A facile approach to lignin-based biochar derived from black liquor and the study of its removal to tetracycline from water.

The present study focuses on preparing lignin-biochar (L-Bio) from papermaking black liquor-lignin and the study its effectiveness and mechanism in removing tetracycline (TC) from water. Results showed that the yield, BET surface area and pore size of L-Bio were 36.3707-40.

Irisin improves ROS‑induced mitohormesis imbalance in H9c2 cells.

Abnormal mitohormesis is a key pathogenic mechanism that induces a variety of cardiac diseases, including cardiac hypertrophy and heart failure. Irisin as a muscle factor serves a cardioprotective role in response to cellular oxidative stress injury. Rat cardiomyocyte cells (H9c2) were treated with 40 µM exogenous HO to establish an oxidative stress model, followed by addition of 75 nM exogenous irisin for experiments to determine mitochondrial membrane potential, reactive oxygen species, and Mitohormesis‑related factors by attrition cytometry.

Unraveling the Solution Aggregation Structures and Processing Resiliency of High-Efficiency Organic Photovoltaic Blends.

The solution aggregation structure of conjugated polymers is crucial to the morphology and resultant optoelectronic properties of organic electronics and is of considerable interest in the field. Precise characterizations of the solution aggregation structures of organic photovoltaic (OPV) blends and their temperature-dependent variations remain challenging. In this work, the temperature-dependent solution aggregation structures of three representative high-efficiency OPV blends using small-angle X-ray/neutron scattering are systematically probed.

Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model.

Glioblastoma (GBM) is the most common and aggressive primary brain cancer; angiogenesis and immunosuppression exacerbate GBM progression. COUP-TFII demonstrates pro-angiogenesis activity; however, its role in glioma progression remains unclear. This study revealed that COUP-TFII promotes angiogenesis in gliomas by inducing transdifferentiation of glioma cells into endothelial-like cells.

Comparative proteomics analysis of revealed a variety of regulatory systems on conidiospore formation.

is a typical parasitic medicinal fungus of the family Shiraiaceae. The fruiting bodies of cannot be cultivated artificially, and active substances can be effectively produced via fermentation. The mechanism of conidia production is a research hotspot in the industrial utilization and growth development of .

[Teaching reform and practice of 'Production Internship' course for biotechnology specialty from the perspective of training application-oriented talents].

Production internship is an important teaching tache for undergraduate students to carry out engineering training by using professional skills, and it is a key starting point for fostering application-oriented talents in biotechnology. The Course Group of 'production internship of biotechnology majors' of Binzhou University is investigating application-oriented transformation for local regular colleges and universities, as well as fostering high-level application-oriented talents. By taking green fluorescent protein (GFP) polyclonal antibody as an example, the reform and practice on teaching content, teaching mode, assessment method, continuous improvement of curriculum were carried out.

Comparative genomic analysis of plasmids harboring -like genes in .

The emergence and spread of carbapenem-resistant (CRKP) is a serious medical problem worldwide. Acquired OXA-48-like carbapenemases encoded by plasmids are important causes of carbapenem resistance in . To explore the links between plasmids and -like genes in , we systematically analyzed the variants of -like plasmid replicon types, phylogenetic patterns, geographic distribution, conjugative transfer regions, and the genetic environments surrounding -like of 191 -like-harboring plasmids, which were identified from 4451 plasmids of downloaded from GenBank.

Renal Clearable Catalytic 2D Au-Porphyrin Coordination Polymer Augmented Photothermal-Gas Synergistic Cancer Therapy.

As a gasotransmitter, carbon monoxide (CO) possesses antitumor activity by reversing the Warburg effect at higher concentrations. The targeted delivery of carbon monoxide-releasing molecules (CORMs) using nanomaterials is an appealing option for CO administration, but how to maintain CO above the threshold concentration in tumor tissue remains a challenge. Herein, a nanozyme-catalyzed cascade reaction is proposed to promote CO release for high-efficacy photothermal therapy (PTT)-combined CO therapy of cancer.

Simultaneous determination of cis- and trans-palmitoleic acid in rat serum by UPLC-MS/MS.

Palmitoleic acid, a monounsaturated fatty acid which could affect glucose and lipid metabolism and reduce insulin resistance has two isomers, i.e. cis-palmitoleic acid (cPOA) and trans-palmitoleic acid (tPOA).

Recombinant human β-defensin130 inhibited the growth of foodborne bacteria through membrane disruption and exerted anti-inflammatory activity.

Unlabelled: Foodborne pathogens causing food poisoning and infections are detrimental to human health, and the abuse of antibiotics induced severe antibiotic resistance in past decades. Thus, it is urgent to develop new antimicrobial agents. In the current study, human β-defensin 130 (hBD130), which is an antimicrobial peptide identified in human macrophages in 2017, was initially produced in .

Antibacterial activity of antimicrobial peptide gcDefb1 against foodborne pathogenic bacteria and its application in pork storage.

Unlabelled: Pork and its products are preferably contaminated by bacteria; thus, it is essential to develop low-cost, high-efficiency and biologically safe preservatives to prevent the growth of bacteria during storage. In the current study, grass carp β-defensin 1 (gcDefb1) was produced and purified from through the heterologous expression method. The in vitro antimicrobial assay demonstrated that yeast-derived gcDefb1 possesses a broad antibacterial spectrum, including both Gram-positive and -negative bacteria, and the MIC values against ATCC 25,922 were as low as 30 μg/mL and showed no cytotoxicity or hemolytic activity.

[Teaching reform and practice of bioengineering comprehensive experiment based on virtual simulation technology].

Bioengineering majors require students to acquire excellent abilities of thinking and analyzing complex problems and have high requirements for students' comprehensive practical skills. Because of the professional characteristics, it is necessary to develop students' abilities to solve complex problems via the teaching of a series of experiments. Therefore, it is particularly important to reform the traditional experiment teaching for students majoring in bioengineering to improve the teaching quality, which have great significance for the cultivation of comprehensive talents.

Evaluation of the self-assembled functional PPFS-P-AM composite for treating oilfield sewage.

Oilfield sewage has a complex composition with large amounts of emulsified oils, polymers and surfactants. Efficient coagulants are required to purify such sewage to meet emissions standards. In this study, oxidized FeSO·7HO and NaHCOwere condensed by basic titration and polyferric sulfate phosphate (PPFS) was prepared by the addition of NaHPO·2HO to improve its charge and stability.

Antimicrobial property of -derived natto peptide against foodborne bacteria and its preservative potential to maintain pork quality during refrigerated storage.

Pork spoilage caused by foodborne bacteria contamination always leads to substantial economic loss in the meat industry. The toxicity and drug resistance of chemical preservatives have raised public concerns about their safety and stability. In this study, natto peptide from was prepared using DNA recombinant technology.

Design, synthesis and application of near-infrared fluorescence probe IR-780-Crizotinib in detection of ALK positive tumors.

At present, the early diagnosis and treatment of NSCLC has become an international research hotspot. However, how to realize the organic combination of highly sensitive and high-resolution tumor imaging diagnosis and effective treatment, and to provide effective information for the diagnosis and treatment of cancer is still a major problem in the integration of cancer diagnosis and treatment. In this study, based on the Crizotinib has a good targeted inhibitory effect on ALK positive tumor cells, the near-infrared targeted fluorescent dye IR-780 was covalently bound with the drug molecule Crizotinib, thus the near-infrared fluorescent probe IR-780-Crizotinib targeting ALK positive tumor cells was synthesized.

Dual-Signal Amplification Strategy for Sensitive MicroRNA Detection Based on Rolling Circle Amplification and Enzymatic Repairing Amplification.

MicroRNAs (miRNAs) play crucial regulatory roles as post-transcriptional regulators for gene expression and serve as promising biomarkers for diagnosis and prognosis of diseases. Herein, a dual-signal amplification method has been developed for sensitive and selective detection of miRNA based on rolling circle amplification (RCA) and enzymatic repairing amplification (ERA) with low nonspecific background. This strategy designs a padlock probe that can be cyclized in the presence of target miRNA to initiate the RCA reaction, after which the TaqMan probes that are complementary to the RCA products can be cyclically cleaved to produce obvious fluorescence signals with the help of endonuclease IV (Endo IV).

Production of an invertebrate lysozyme of Scylla paramamosain in E.coli and evaluation of its antibacterial, antioxidant and anti-inflammatory effects.

Lysozymes, which are secreted in many organisms, including invertebrates, mammals, plants, bacteria and fungus, exhibit antimicrobial, antiviral, antioxidant, and anti-inflammatory activities. Splys-i is an invertebrate-type (i-type) lysozyme isolated from Scylla paramamosain in 2017 and is involved in immune defense against bacteria. However, the antibacterial, antioxidant, and anti-inflammatory activities of Splys-i remain to be elucidated.

Research progress of near-infrared fluorescence probes based on indole heptamethine cyanine dyes in vivo and in vitro.

Near-infrared (NIR) fluorescence imaging is a noninvasive technique that provides numerous advantages for the real-time in vivo monitoring of biological information in living subjects without the use of ionizing radiation. Near-infrared fluorescent (NIRF) dyes are widely used as fluorescent imaging probes. These fluorescent dyes remarkably decrease the interference caused by the self-absorption of substances and autofluorescence, increase detection selectivity and sensitivity, and reduce damage to the human body.

Diversity and antimicrobial activity of endophytic fungi isolated from Securinega suffruticosa in the Yellow River Delta.

Securinega suffruticosa (Pall.) Rehd is an excellent natural secondary shrub in the Shell Islands of Yellow River Delta. The roots of S.

Fast and robust reconstruction algorithm for fluorescence diffuse optical tomography assuming a cuboid target.

A fast algorithm for fluorescence diffuse optical tomography is proposed. The algorithm is robust against the choice of initial guesses. We estimate the position of a fluorescent target by assuming a cuboid (rectangular parallelepiped) for the fluorophore target.

Mesoporous Layered Graphene Oxide/FeO/CNS Polymer Hybrids for Rapid Removal of Pb and Cd from Water.

Mesoporous layered magnetic hybrid GFP2 composed of CNS polymers, FeO nanoparticles (FeO NPs), and graphene oxide with a mesoporous layered "sandwich"-like structure was successfully explored by in situ simple polymerization tactic for rapid removal of Pb and Cd from water. It shows good selectivity and high adsorption capacity (277.78 and 49.