Cortical and Corticomuscular Beta-Gamma Phase-Amplitude Coupling During Different Locomotion States and the Effects of Levodopa in Parkinson's Disease.

Background: Phase-amplitude coupling (PAC) in the beta-gamma range has emerged as a promising electrophysiological biomarker of Parkinson's disease (PD).

Objective: This study aims to investigate how levodopa and locomotion modulate cortical (central electroencephalogram [cEEG]) and corticomuscular (cEEG-gEMG [gastrocnemius electromyography]) beta-gamma PAC in patients with PD.

Methods: Thirty patients with PD underwent simultaneous cEEG and gEMG recordings during sitting, standing, and free walking in both off and on dopaminergic states.

Tea Polyphenol Modulates Mitochondria-Associated Endoplasmic Reticulum Membrane of Hippocampal Neurons Targeting Grp75 to Ameliorate Memory Impairment in the Aged T2DM Rats.

Tea polyphenol (TP), as the most abundant and unique functional substance of tea, has been widely studied for the neuroprotective effects. Previous studies also found that TP improves the memory impairment of the aged T2DM rats, but the underlying molecular mechanism has not been fully clarified. The model of aged T2DM was induced by injecting D-galactose and STZ intraperitoneally, as well as feeding with a high-glucose-fat diet in rats, and D-galactose and D-glucose were used in PC12 cells.

Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.

Tea polyphenols (TP), as representative bioactive compounds of tea, exhibit anti-inflammatory and hypolipidemic effects on aging-associated Diabetic kidney disease (DKD), but the exact mechanism is unclear. Inflammation resulting from the dynamic imbalance of macrophage polarization and the injury of podocytes caused by lipid accumulation together drives the disease process. This study aims to explore the mechanism of TP alleviating aging with DKD via macrophage polarization and podocyte lipid accumulation.

The effects of sleep deprivation on cognitive flexibility: a scoping review of outcomes and biological mechanisms.

Background: Sleep is vital for physical and mental health, yet sleep deprivation is a widespread issue that may impair cognitive flexibility, leading to rigid thinking and slower decision-making. This scoping review synthesizes evidence on the impact of sleep deprivation or sleep loss on cognitive flexibility.

Objective: To provide a comprehensive understanding of the complex and multifaceted effects of sleep deprivation on cognitive flexibility.

XASDB: a new database of experimental interactive X-ray absorption spectra.

We present a dedicated and comprehensive database for experimental X-ray absorption spectroscopy (XAS) data, an integrated and user-friendly platform that combines spectrum visualization, raw data processing, spectrum matching and downloading, thereby offering a holistic solution for understanding XAS data. Leveraging the unique nature of XAS data, we have designed the MySQL table structure and developed professional plotting tools to present the data. Furthermore, the database - named XASDB - incorporates a variety of data processing tools, including data normalization as well as flexible searching and downloading options.

Plant-based diet and risk of arthritis: a nationwide cohort study of the Chinese elderly population.

. This study was aimed at investigating the association between a plant-based diet and the risk of arthritis and at identifying a strategy that achieves the ambitious goal of healthy aging. .

A new framework for X-ray absorption spectroscopy data analysis based on machine learning: XASDAML.

X-ray absorption spectroscopy (XAS) is a critical analytical technique for comprehensively characterizing the electronic configurations and atomic structures of materials. The rapid growth in both data volume and complexity, driven by modern synchrotron radiation facilities, necessitates computational frameworks capable of efficiently processing large-scale XAS datasets. To address this need, we introduce XASDAML, a machine-learning-based platform that integrates the entire data processing workflow.

A novel antimicrobial peptide NDYT-8 with broad-spectrum activity from Bacillus subtilis natto: Antibacterial mechanism and sequence simplification.

The discovery of antimicrobial peptides (AMPs) holds critical significance in combating antibiotic resistance. In this study, a novel efficient antimicrobial peptide NDYT-8 with broad-spectrum activity was isolated and identified from Bacillus subtilis natto. Whole-genome sequencing revealed that NDYT-8 potentially derived from the minimal domain of 6-phosphogluconate dehydrogenase, exhibited broad-spectrum antibacterial activity against common foodborne pathogens, particularly Escherichia coli and Salmonella enterica, with a minimum inhibitory concentration (MIC) value of 16 μg/mL.

HD-EEG source imaging with simultaneous SEEG recording in drug-resistant epilepsy.

Objective: This study aimed to assess the complementary role of high-density electroencephalography (HD-EEG)-based electrical source imaging (ESI) in localizing the seizure-onset zone (SOZ) during ictal events and the irritative zone (IZ) during the interictal period, using simultaneous acquired stereo-EEG (SEEG) recordings as a reference. In addition, we investigated the relationship of ictal cortical source activity with their scalp and intracranial EEG correlates, focusing on factors influencing ESI accuracy.

Methods: We enrolled 29 patients with drug-resistant epilepsy who underwent simultaneous HD-EEG and SEEG recordings.

Comparison of Post-Consumption Attention Between Two Different Aroma Types of Baijiu Using the Stroop Task.

As attention reflects cognitive comfort after drinking, and consumers increasingly value mental clarity, there is a growing need for objective methods to quantify such post-consumption cognitive states. However, conventional expert sensory panels rely on subjective judgments and cannot objectively quantify post-consumption changes in attention. To address this gap, this experimental study applied and validated an established electroencephalogram (EEG)-based behavioral index and then investigated whether two aroma types of Chinese Baijiu with equal alcohol content differ in their effects on attention.

p53/PD-L1 co-expression predicts poor prognosis in diffuse large B-cell lymphoma.

Objective: To investigate the clinical characteristics and survival of p53 and Programmed death-ligand 1 (PD-L1) co-expression in diffuse large B-cell lymphoma (DLBCL) patients.

Methods: Immunohistochemistry (IHC) was used to detect the expression of p53 and PD-L1 in tumor cells of 176 patients with DLBCL. Clinical data were retrospectively examined along with long-term follow-up.

Expanding point cloud statistical shape model applications: Generalized vascular modeling for population-level hemodynamic simulations.

Background And Objective: Population-scale hemodynamic research faces limitations due to the trade-off between computationally expensive patient-specific Computational Fluid Dynamics (CFD) and overly idealized cylindrical models. To overcome this, we propose a novel Tier-2 workflow that integrates point-cloud statistical shape modeling (Pcd-SSM) with HDBSCAN clustering. This approach aims to efficiently characterize the C1 geometries of the internal carotid artery (ICA) and analyze their corresponding flow patterns.

Effects of city design on transport mode choice and exposure to health risks during and after a crisis: a retrospective observational analysis.

Background: Rapid declines in city mobility during the early stages of the COVID-19 pandemic in 2020 resulted in reductions in citizens' exposure to transport-related air pollution and associated health risks as many cities introduced non-pharmaceutical interventions designed to curb the spread of COVID-19. However, these benefits soon reversed during the pandemic's recovery phase (ie, from September, 2020, onwards), especially in cities with designs that afforded mode shifts away from public and active transport in favour of private motor vehicles. The aim of this study was to understand the association between global city designs, transport mode choices, and population-level risk exposure during 2020.

Buried Interface Modification Strategy for Efficient Tin-Based Perovskite Light-Emitting Diodes.

Tin (Sn)-based perovskites show great potential for environmentally friendly and high-performance light-emitting diodes (LEDs). However, the development of Sn-based perovskite LEDs (PeLEDs) lags significantly behind that of lead-based perovskites. This is mainly due to the faster crystallization rate of Sn-based perovskites that leads to a higher defect density in Sn-based perovskite films, thereby serious nonradiative recombination.

Siglec6 CAR T cells suppressed progression of AML via inhibiting Siglec6 and SHP2 induced Src and ERK signaling activation.

To explore the specific molecular mechanisms of Siglec6 CAR-T therapy in acute myeloid leukemia (AML). AML samples were selected from the GEO database for bioinformatics analysis. Siglec6 was knocked down and overexpressed in MOLM-13 cells through lentiviral infection, and then injected into NOD/SCID mice via the tail vein to detect the distribution of AML in mice using in vivo imaging.

Association of serum 25(OH)D3 and cognitive levels with biological aging in the elderly: a cross-sectional study.

Background: Biological aging, a fundamental process affecting health and longevity, is pivotal to understanding the physiological decline associated with aging. Serum vitamin D3 deficiency and cognitive impairment are common health issues among older adults. However, the joint associations of serum vitamin D levels and cognitive impairment with biological aging remain poorly understood.

Selenium biofortification during barley (Hordeum vulgare L.) germination: Comparative analysis of selenate, selenite, and selenomethionine on se-protein accumulation and phenolic acid profile.

Selenate (NaSeO), selenite (NaSeO) and selenomethionine (Se-Met) treatments were performed to evaluate the impact of selenium (Se) enrichment on Se accumulation, selenoprotein distribution, and phenolic acid metabolism in barley. Selenium was primarily distributed in protein, and Se-Met treatment led to the highest Se-protein concentration (246.91 mg/kg DW).

Ultrabright Blue Lead-Halide Perovskite Light-Emitting Diodes Based on Phosphonic Acid Functionalized Hole Injection Layer.

Lead-halide perovskite light-emitting diodes (PeLEDs) are intrinsically capable of delivering high efficiency at high current densities compared to conventional solution-processed light-emitting diodes. While such performance and relevant high radiance have been well demonstrated in green and near-infrared ones, blue PeLEDs have lagged far behind due to extremely severe luminance-efficiency roll-off, especially in the pure-blue region (<480 nm, a CIEy coordinate below 0.15).

Transcriptome profiling unravels improved ethanol production and acetic acid tolerance in yeast by preculture of wheat gluten hydrolysates.

The effects of wheat gluten hydrolysates (WGH) preculture on yeast acetic acid tolerance and fermentation performances were investigated. Results showed that WGH preculture significantly increased yeast growth and viability under acetic acid stress. Particularly, the WGH fraction precipitated with 90 % (v/v) gradient ethanol (WGH-C) preculture significantly improved yeast cell membrane integrity and H-ATPase activity, thereby decreasing the intracellular accumulation of ROS and acetic acid.

Follicular lymphoma grade 3A: aggressiveness and curability in an Asian cohort of 781 patients.

Follicular lymphoma grade 3A (FL3A) is an uncommon subtype of FL with histology falling between FL grade 1/2 (FL1/2) and FL grade 3B (FL3B). The behavior of FL3A is currently debated, with some studies suggesting it may be potentially curable while others deem it incurable. However, the lack of large-scale studies with prolonged follow-up and changes in prognosis due to the use of rituximab (R) call for further investigation into the clinical course, prognosis, and treatment of FL3A in the R era.

Knowledge, attitudes, and practices regarding hypertension diet among patients with hypertension.

To explore the knowledge, attitudes, and practices (KAP) concerning hypertension diets among hypertensive patients, a cross-sectional survey was conducted across designated institutions in Heilongjiang Province and Jiangsu Province from December 2023 to February 2024. Data on sociodemographic factors and KAP scores were collected via questionnaires. A total of 661 valid responses were obtained, with 33.

Metabolomics analysis of osmotic tolerance enhancement mechanism of wheat gluten peptides on industrial yeast.

Plant-derived wheat gluten peptides have an effective protective ability on industrial yeast against osmotic stress, the enhancement mechanism of osmotic tolerance in yeast by wheat gluten peptides addition was clarified in this study. Results showed that wheat gluten peptides addition increased the intracellular pH and trehalose levels of yeast under osmotic stress, compared to the control. Furthermore, peptides supplementation could regulate the antioxidant defense system and reduce the reactive oxygen species accumulation in yeast, including the increase of intracellular glutathione levels and the activities of antioxidant enzymes catalase and glutathione peroxidase.

One-degree-of-freedom flat-foldable thick-panel origami-kirigami structures: modular arrays and closed polyhedra.

Origami structures hold promising potential in space applications, such as ultra-large-area solar arrays, deployable space stations, and extra-terrestrial modular foldable buildings. However, the development of thick-panel origami structures has been limited, relying on a few typical origami patterns without a comprehensive design theory for multi-crease, multi-vertex thick-panel configurations. Additionally, realizing closed Polyhedra in thick-panel origami presents substantial challenges.

Quantitative MRI reveals infrapatellar fat pad changes after running a marathon.

Background: Marathon running, while offering health benefits, is associated with a high incidence of knee injuries. The infrapatellar fat pad (IFP) plays a critical role in knee joint homeostasis and injury mitigation. This study investigated IFP adaptations to the acute stress of marathon running using quantitative magnetic resonance imaging (MRI).