Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation.

Hypoxia is a characteristic feature of the tumor microenvironment that significantly influences cancer progression and treatment responses. Hypoxia-inducible factor (HIF), a key regulator of hypoxic adaptation, has been demonstrated to modulate hypoxic gene expression profiles and signaling networks, thereby serving as a potential therapeutic target. Long-stranded non-coding RNAs (lncRNAs), defined as non-coding RNAs exceeding 200 nucleotides in length, regulate various cellular processes by modulating gene expression at transcriptional, post-transcriptional, and epigenetic levels.

Tea Polyphenol Modulates Mitochondria-Associated Endoplasmic Reticulum Membrane of Hippocampal Neurons Targeting Grp75 to Ameliorate Memory Impairment in the Aged T2DM Rats.

Tea polyphenol (TP), as the most abundant and unique functional substance of tea, has been widely studied for the neuroprotective effects. Previous studies also found that TP improves the memory impairment of the aged T2DM rats, but the underlying molecular mechanism has not been fully clarified. The model of aged T2DM was induced by injecting D-galactose and STZ intraperitoneally, as well as feeding with a high-glucose-fat diet in rats, and D-galactose and D-glucose were used in PC12 cells.

Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification.

Renal epithelioid angiomyolipoma (EAML) is frequently misdiagnosed due to nonspecific imaging findings. This study aimed to explore the radiographic characteristics of EAML, with the goal of enhancing the accuracy of preoperative diagnoses. A total of 27 patients with histopathologically confirmed renal EAML were included in the study.

Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.

Tea polyphenols (TP), as representative bioactive compounds of tea, exhibit anti-inflammatory and hypolipidemic effects on aging-associated Diabetic kidney disease (DKD), but the exact mechanism is unclear. Inflammation resulting from the dynamic imbalance of macrophage polarization and the injury of podocytes caused by lipid accumulation together drives the disease process. This study aims to explore the mechanism of TP alleviating aging with DKD via macrophage polarization and podocyte lipid accumulation.

The role of ubiquitination and deubiquitination in urological tumours.

The ubiquitin (Ub) system has been demonstrated to play a crucial role in various cellular processes, including immune responses, cell development, and programmed cell death. Ubiquitination, a form of post-translational modification, occurs in eukaryotic cells and involves several key components, such as Ub-activating enzymes, Ub-binding enzymes, and Ub-protein ligases. Recently, deubiquitinating enzymes-proteases that reverse the modification of proteins by removing Ub or Ub-like molecules, or by remodeling Ub chains on target proteins-have been identified as significant regulators of ubiquitination-mediated degradation.

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update.

Ferroptosis is a newly discovered form of programmed cell death, primarily caused by an imbalance between iron-dependent oxidative damage and antioxidant defense mechanisms within the cell. It differs from previously reported forms of cell death, such as apoptosis, necrosis, and autophagy, in terms of morphology, biochemistry, and genetics. Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by pathological features including neurofibrillary tangles (NFTs), senile plaques (SPs), and abnormal iron deposition, suggesting that ferroptosis may be involved in its disease progression.

Comprehensive workflow with optical navigation in minimally invasive transforaminal lumbar interbody fusion: a retrospective study.

Background: Degenerative lumbar diseases (LDD) are increasingly common among the elderly due to extended life expectancy. Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a preferred surgical technique for LDD, offering advantages over traditional methods, although it presents technical challenges. In this study, we compared the clinical outcomes and radiological accuracy between optical navigation-assisted MIS-TLIF (OMIS-TLIF) and conventional C-arm navigation-assisted MIS-TLIF (CMIS-TLIF) for the treatment of LDD.

MicroRNA-145 in urologic tumors: biological roles, regulatory networks, and clinical translation.

Tumors of the urinary system primarily encompass prostate, bladder, and kidney cancers, which exhibit high morbidity and mortality rates worldwide and pose a particularly significant threat to men's health. Given the associated high morbidity and mortality, early diagnosis and effective treatment are crucial. Consequently, innovative research is urgently needed to enhance the clinical care of patients with urologic cancers.

Directed Evolution for the Discovery of Engineered Proteins and Small Peptides Using Molecular Mutagenesis.

Random mutagenesis is an essential technique in the directed evolution of proteins and peptides, driving advancements in protein engineering and biotechnology. This review provides a critical analysis of various error-prone polymerase chain reaction (epPCR) techniques employed for random mutagenesis, highlighting their mechanisms, advantages, and limitations. We compare conventional methods with emerging approaches, including combinative techniques and specialized protocols for small amplicons.

The Impact of Imidacloprid in Dietary Residues on Intestinal Damage and the Increased Risk of Enterotoxigenic Infection.

Pesticide residues in foods can disturb the intestinal barrier and microbiota, even at a very low dose; however, studies on direct consequences on intestinal health are still lacking. Here, we evaluated the damage of imidacloprid (IMI) to the intestine and the resulting defense against enterotoxigenic (ETEC) in C57BL/6J mice. After 8-week exposure to 0.

[Rules of moxibustion for low back pain by based on data mining and knowledge graph technology].

Objective: To analyze the rules of moxibustion for low back pain by by using data mining and knowledge graph technology.

Methods: Taking the medical cases of moxibustion for low back pain from 's legacy manuscripts and existing works as the research objects, information on disease types, symptoms, tongue manifestations, pulse conditions, syndrome patterns, moxibustion methods and acupoints were collected. Frequency statistics and community analysis were conducted by the ancient and modern medical record cloud platform V 2.

Patterns of care in the management of high-risk COPD in Australia (2015-2019): an observational study for the CONQUEST quality improvement program.

Background: We compared the management of patients with 'high-risk' COPD in Australia to national/international guidelines and quality standards, including the COllaboratioN on QUality improvement initiative for achieving Excellence in STandards of COPD care (CONQUEST).

Methods: Eligible patients in the Optimum Patient Care Research Database Australia were categorized as newly diagnosed (≤12 months after diagnosis), already diagnosed, or patients with potential undiagnosed COPD, in each year from 2015 to 2019. 'High-risk' patients had ≥2 COPD exacerbations/exacerbation-like events in the last 24 months.

Inhibitory effect and molecular mechanism on polyphenol oxidase by ultraviolet-C and L-cysteine treatment.

The emerging technology of inhibiting polyphenol oxidase (PPO) is crucial for preventing enzymatic browning in food. This study aimed to investigate the effects of 4.5 kJ/m ultraviolet (UV)-C radiation and 0.

Association of serum 25(OH)D3 and cognitive levels with biological aging in the elderly: a cross-sectional study.

Background: Biological aging, a fundamental process affecting health and longevity, is pivotal to understanding the physiological decline associated with aging. Serum vitamin D3 deficiency and cognitive impairment are common health issues among older adults. However, the joint associations of serum vitamin D levels and cognitive impairment with biological aging remain poorly understood.

Chlorpyrifos Inhibits Intestinal Stem Cell Proliferation and Differentiation at the Acceptable Daily Intake and Disrupts Immune Responses at High Doses.

The acceptable daily intake (ADI) and maximum residue limits in food for chlorpyrifos (CPF), a widely used organophosphorus pesticide, may damage the intestine. Here, we evaluated damage to the intestine by CPF at the ADI (0.01 mg/kg bodyweight/day) and at 10 times the ADI (10ADI; 0.

Oat beta-glucan inhibited obesity in mice though stem cell remodeling.

Oat beta-glucan has been reported to be beneficial to glucose and lipid metabolism in human and animal studies. However, weight-loss was shown only in animal studies, whereas human studies reported an improvement in hyperlipidemia. This study investigated the effects of oat beta-glucan on obesity and related metabolic disturbances at the doses based on the Chinese recommended daily intake of 100 g of whole grains which contain approximately 10 % β-glucan.

Research progress of extracellular vesicles in the pathogenesis of type IIIA chronic prostatitis.

Chronic prostatitis is a prevalent urological condition that significantly impacts patients' quality of life. Advances in the study of Extracellular Vesicles (EV) have revealed their close involvement in the pathogenesis of prostatitis. This paper reviews the progress in understanding the role of EV in the pathogenesis of chronic prostatitis type IIIA, particularly their involvement in inflammatory responses, cell signaling, and interactions with immune cells.

Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs.

Bladder cancer (BC) is a malignant tumor characterized by a high incidence of urinary system diseases. The complex pathogenesis of BC has long been a focal point in medical research. With the robust development of epigenetics, the crucial role of epigenetic modifications in the occurrence and progression of BC has been elucidated.

Characterization of phospholipid profiles of egg yolks: Newly classified plasmalogens, distribution of polyunsaturated fatty acids, and the effects of dietary enrichment.

Egg yolk phospholipids are commercially valuable products that are beneficial to human health. Previous research on phospholipids in egg yolk mainly focuses on phosphatidyl choline (PC), phosphatidyl ethanolamine (PE), and fatty acid compositions, and neglects the esterification position and other bioactive phospholipids. This study found a total of 19 classes of phospholipids and 275 subclasses using lipidomics.

Calcium sensing receptor regulate claudin-14 via PKA-STAT3 pathway in rat model of nephrolithiasis.

Background: The calcium-sensitive receptor (CaSR) has been identified as a key factor in the formation of kidney stones. A substantial body of research has illuminated the function of CaSR in stone formation with respect to oxidative stress, epithelial injury, crystal adhesion, and stone-associated proteins. Nevertheless, as a pivotal molecule in renal calcium excretion, its pathway that contributes to stone formation by regulating calcium supersaturation remains underexplored.

Integrating trauma-informed care in nursing practice and education: A hybrid systematic narrative review.

Aim: This study aims to synthesize and analyze a trauma-informed care (TIC) framework and its applications in nursing practice and education.

Design: This study employed a hybrid systematic narrative review.

Methods: Eligible studies were reviewed following the hybrid systematic narrative review guidelines.

Subtle Modifications in Interface Configurations of Iron/Cobalt Phthalocyanine-Based Electrocatalysts Determine Molecular CO Reduction Activities.

Strain engineering has emerged as a powerful approach in steering material properties. However, the mechanism and potential limitations remain poorly understood. Here we report that subtle changes in molecular configurations can profoundly affect, conducively or adversely, the catalytic selectivity and product turnover frequencies (TOFs) of CO reduction reaction.

Critical role of non-coding RNA-mediated ferroptosis in urologic malignancies.

Urologic malignancies, characterized by their high aggressiveness and metastatic potential, pose a significant public health challenge globally. Ferroptosis, a novel mode of cell death, typically arises from intracellular iron ion overload and the accumulation of lipid peroxides. This process has been shown to play a crucial regulatory role in various pathological conditions, particularly in cancer, including urologic cancers.

The prevention and improvement effects of vitamin D on type 2 diabetes mellitus: evidence from an umbrella review on Meta-analyses of cohort studies and randomized controlled trials.

Background: To clarify whether Vitamin D prevent the occurrence of type 2 diabetes mellitus (T2DM) and improve glucose control in T2DM patients, we conducted this umbrella review, taking into account the inconsistent results of existing Meta-analyses. We aim to reveal the causal relationship between Vitamin D and T2DM through summarizing Meta-analyses of observational studies, and clarify the improvement on glucose control in T2DM patients through summarizing Meta-analyses of RCT studies between Vitamin D supplementation and T2DM patients, especially in T2DM patients with Vitamin D deficiency.

Methods: We collected the Meta-analyses of observational studies and RCTs in PubMed, Scopus, Embase, Web of Science, and Cochrane.

Attenuates High-Fat-Diet-Induced Obesity and Especially Glucose Intolerance.

Obesity, a global disease, can lead to different chronic diseases and a series of social health problems. Lifestyle changes, especially dietary changes, are the most effective way to treat obesity. , a novel food, has attracted much attention.