Biobased Self-Driven Triboelectric Sensor for Multimodal Analysis of Exercise Fatigue.

Traditional exercise fatigue monitoring technologies have faced challenges, including high costs, operational complexity, and invasiveness, which limit their practicality for daily training and health management. A biobased pulp wool triboelectric nanogenerator (PW-TENG) has been developed and integrated with a heart rate strap (HRS) and inertial measurement unit (IMU) to establish a multimodal fatigue monitoring system. Doping BaTiO particles, spraying conductive graphite, and bidirectional W-shape encapsulation have enhanced its output performance by 100%, tripled the contact-separation efficiency, and achieved ultrafast response and recovery times (8.

Establishment of a low-temperature immersion method for extracting high-activity and high-purity mitochondria from Syntrichia caninervis Mitt.

Background: Mitochondria are central to plant growth, development, and stress resilience. Despite their importance, mitochondrial research in desiccation-tolerant mosses remains underexplored. To unravel the stress resistance mechanisms of the extremotolerant desert moss, establishing a method to isolate highly active and pure mitochondria is critical.

Insights into the adaptive response of extremotolerant desert moss Syntrichia caninervis to extreme high temperature.

Moss has remarkable abilities to survive harsh environmental conditions, making it a key species in habitat restoration following disturbances such as fire, exploring these abilities informs efforts to improve stress tolerance in other plants and enhances our understanding of the evolution of stress tolerance. Here, we report a new record of thermal tolerance for the dried moss Syntrichia caninervis. Dry moss cuttings survived 60 min at 120 °C, exceeding the previous record of 30 min at 120 °C.

SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma.

Glioma is a highly aggressive brain tumor with limited treatment success due to its resistance to conventional therapies. Sirtuin 5 (SIRT5) has emerged as a promising target for cancer therapy, though it exhibits dual roles in different cancer types. In this study, we investigate the role of SIRT5 in glioma and its corresponding mechanisms.

Correction Strategies for Isotopic Ratios in Overspiked Samples Using the Double Spike Technique.

The double spike (DS) technique is a highly effective approach for measuring the isotope ratios of many elements. However, it is common for some fraction of the prepared samples to be "overspiked." The usual solution for this problem involves repurifying and reanalyzing the samples to ensure data accuracy.

CHIP-mediated ubiquitin degradation of BCAT1 regulates glioma cell proliferation and temozolomide sensitivity.

Glioma, a malignant and infiltrative neoplasm of the central nervous system, poses a significant threat due to its high mortality rates. Branched-chain amino acid transaminase 1 (BCAT1), a key enzyme in branched-chain amino acid (BCAA) catabolism, exhibits elevated expression in gliomas and correlates strongly with poor prognosis. Nonetheless, the regulatory mechanisms underlying this increased BCAT1 expression remains incompletely understood.

Targeted inhibition of branched-chain amino acid metabolism drives apoptosis of glioblastoma by facilitating ubiquitin degradation of Mfn2 and oxidative stress.

Glioblastoma is one of the most challenging malignancies with high aggressiveness and invasiveness and its development and progression of glioblastoma highly depends on branched-chain amino acid (BCAA) metabolism. The study aimed to investigate effects of inhibition of BCAA metabolism with cytosolic branched-chain amino acid transaminase (BCATc) Inhibitor 2 on glioblastoma, elucidate its underlying mechanisms, and explore therapeutic potential of targeting BCAA metabolism. The expression of BCATc was upregulated in glioblastoma and BCATc Inhibitor 2 precipitated apoptosis both in vivo and in vitro with the activation of Bax/Bcl2/Caspase-3/Caspase-9 axis.

Word distance assisted dual graph convolutional networks for accurate and fast aspect-level sentiment analysis.

Aspect-level sentiment analysis can provide a fine-grain sentiment classification for inferring the sentiment polarity of specific aspects. Graph convolutional network (GCN) becomes increasingly popular because its graph structure can characterize the words' correlation for extracting more sentiment information. However, the word distance is often ignored and cause the cross-misclassification of different aspects.

Enhancement of salt tolerance of alfalfa: Physiological and molecular responses of transgenic alfalfa plants expressing Syntrichia caninervis-derived ScABI3.

Alfalfa (Medicago sativa L.), a perennial forage plant, is a rich source of nutrients such as vitamins, minerals, and proteins. Salt stress, however, impedes its growth.

Association of immune checkpoint inhibitors therapy with arterial thromboembolic events in cancer patients: A retrospective cohort study.

Background: Immune checkpoint inhibitors (ICIs) have emerged as a standard treatment for various malignancies. However, research indicates blocking the immune checkpoint pathway may exacerbate atherosclerotic lesions.

Objectives: We aimed to investigate whether ICI therapy increases the risk of arterial thromboembolic events (ATEs).

First babies conceived with Automated Intracytoplasmic Sperm Injection.

Research Question: Can an automated sperm injection robot perform Automated Intracytoplasmic Sperm Injection (ICSIA) for use in human IVF?

Design: The ICSIA robot automated the sperm injection procedure, including injection pipette advancement, zona pellucida and oolemma penetration with piezo pulses, and pipette removal after sperm release. The robot was first tested in mouse, hamster and rabbit oocytes, and subsequently using discarded human oocytes injected with microbeads. A small clinical pilot trial was conducted with donor oocytes to study the feasibility of the robot in a clinical setting.

FedLGA: Toward System-Heterogeneity of Federated Learning via Local Gradient Approximation.

Federated learning (FL) is a decentralized machine learning architecture, which leverages a large number of remote devices to learn a joint model with distributed training data. However, the system-heterogeneity is one major challenge in an FL network to achieve robust distributed learning performance, which comes from two aspects: 1) device-heterogeneity due to the diverse computational capacity among devices and 2) data-heterogeneity due to the nonidentically distributed data across the network. Prior studies addressing the heterogeneous FL issue, for example, FedProx, lack formalization and it remains an open problem.

Double Spike-Standard Addition Technique and Its Application in Measuring Isotopes.

Double spike (DS) method has been extensively used in determining stable isotope ratios of many elements. However, challenges remain in obtaining high-precision isotope data for ultra-trace elements owing to the limitations of instrumental signal-to-noise ratios and the systematics of precision of DS-based measurements. Here, the DS-standard addition (SA) (DSSA) technique is proposed to improve measurements of isotope compositions of ultra-trace elements in natural samples.

Chrysophanol-8-O-glucoside protects mice against acute liver injury by inhibiting autophagy in hepatic stellate cells and inflammatory response in liver-resident macrophages.

Acute liver failure (ALF) is an unfavorable condition characterized by the rapid loss of liver function and high mortality. Chrysophanol-8-O-glucoside (CPOG) is an anthraquinone derivative isolated from . This study aims to evaluate the protective effect of CPOG on lipopolysaccharide (LPS)/D-GalN-induced ALF and its underlying mechanisms.

Safety Evaluation of Employing Temporal Interference Transcranial Alternating Current Stimulation in Human Studies.

Temporal interference transcranial alternating current stimulation (TI-tACS) is a new technique of noninvasive brain stimulation. Previous studies have shown the effectiveness of TI-tACS in stimulating brain areas in a selective manner. However, its safety in modulating human brain neurons is still untested.

Single-cell multiomics analyses of spindle-transferred human embryos suggest a mostly normal embryonic development.

Mitochondrial DNA (mtDNA) mutations are often associated with incurable diseases and lead to detectable pathogenic variants in 1 out of 200 babies. Uncoupling of the inheritance of mtDNA and the nuclear genome by spindle transfer (ST) can potentially prevent the transmission of mtDNA mutations from mother to offspring. However, no well-established studies have critically assessed the safety of this technique.

Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis.

Inhibiting cancer metabolism via glutaminase (GAC) is a promising strategy to disrupt tumor progression. However, mechanism regarding GAC acetylation remains mostly unknown. In this study, we demonstrate that lysine acetylation is a vital post-translational modification that inhibits GAC activity in non-small cell lung cancer (NSCLC).

Characteristics and Predictors of Venous Thromboembolism Among Lymphoma Patients Undergoing Chemotherapy: A Cohort Study in China.

Venous thromboembolism (VTE) is a potential complication among lymphoma patients. We evaluated the incidence rate and predictors of VTE in lymphoma patients undergoing chemotherapy. The present study retrospectively studied 1,069 patients with lymphoma who were treated with chemotherapy from 2018 to 2020.

A Flexible TENG Based on Micro-Structure Film for Speed Skating Techniques Monitoring and Biomechanical Energy Harvesting.

Wearable motion-monitoring systems have been widely used in recent years. However, the battery energy storage problem of traditional wearable devices limits the development of human sports training applications. In this paper, a self-powered and portable micro-structure triboelectric nanogenerator (MS-TENG) has been made.

High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions.

Temporal interference (TI) stimulation is a new technique of non-invasive brain stimulation. Envelope-modulated waveforms with two high-frequency carriers can activate neurons in target brain regions without stimulating the overlying cortex, which has been validated in mouse brains. However, whether TI stimulation can work on the human brain has not been elucidated.