Establishment of a Comprehensive Quality Evaluation Model for Japonica Rice With Different Degrees of Milling.

Japonica is considered one of the better tasting varieties, so it is important to balance the quality and taste of japonica rice produced by moderate processing. This study analyzed the changes in bioactive components, heavy metal elements, and sensory quality of northern japonica rice after gradient milling, and constructed a comprehensive quality evaluation model for japonica rice with different degrees of milling. The results showed that as the degree of milling (DOM) increased from 0% to 10%, the bioactive components in japonica rice decreased, with dietary fiber (3.

Nutrient-Enriched Germinated Brown Rice Alters the Intestinal Ecological Network by Regulating Lipid Metabolism in Rats.

Metabolic diseases such as high blood lipids, high blood sugar, and disrupted gut microbiota pose a serious threat to people's physical health. The occurrence of these diseases is closely related to the lack of nutrients in daily rice staple foods, but there is a lack of comprehensive analysis of the underlying mechanisms. This study used fully nutritious brown rice as raw material, and after germination under various stress conditions, it significantly increased the levels of gamma aminobutyric acid (GABA, four carbon non protein amino acid), resistant starch, flavonoids, and other components that regulate metabolic diseases.

Dual Bioconversion Strategy: Synergistic Germination and Fermentation Engineering for a γ-Aminobutyric Acid-Enriched Beverage from Brown Rice.

Growing demand for plant-based nutraceuticals drives the need for innovative bioprocessing strategies. This study developed an integrated approach combining germination and Lactobacillus-mediated fermentation to produce a γ-aminobutyric acid (GABA)-enriched functional beverage from brown rice. Systematic screening identified an optimal rice cultivar for germination.

Treatment patterns of menopausal hormone therapy in South Korea: a nationwide cohort study.

Objective: Menopausal hormone therapy (MHT) is the most effective treatment for menopausal symptoms. While guidelines recommend an individualized risk-benefit assessment of MHT, real-world studies on use of MHT are limited.

Method: Nationwide claims data in South Korea (2015-2020) were used to assess the prevalence of hospital visits for menopausal symptoms and use of MHT among women aged 40-59 years.

Cost-effectiveness analysis of two inhaled antibiotics for stable Bronchiectasis with Pseudomonas aeruginosa infections in China.

Objective: To evaluate the cost-effectiveness of two available options for inhaled antibiotic treatment for patients with Bronchiectasis (BE) with Pseudomonas aeruginosa (PA) infections from the perspective of China's healthcare system.

Methods: A four-state Markov model was developed over a one-year horizon to simulate the cost-effectiveness of two inhaled antibiotic strategies: Tobramycin inhalation solution (TIS) versus nebulized colistimethate sodium (CMS). The inputs for the model were derived from phase III clinical trials and published literature, with cost data were sourced from public and real-world databases, etc.

Risk for Angioedema With the Use of Dipeptidyl Peptidase 4 Inhibitors: A Population-Based Cohort Study.

Background: Dipeptidyl peptidase 4 (DPP4) inhibitors, which are widely used antidiabetic medications, may induce the accumulation of bradykinin and substance P, and thus possibly increase the risk for angioedema.

Objective: To assess the risk for angioedema with the use of DPP4 inhibitors compared with other second-line oral antidiabetics (OADs) in patients with type 2 diabetes.

Methods: A cohort study was conducted using a nationwide health care data of South Korea (2010-2022).

Safety of combination therapy of azilsartan medoxomil and amlodipine: a population-based cohort study.

Objectives: This study investigated the safety of azilsartan and amlodipine combination therapy versus other angiotensin receptor blockers (ARBs) and amlodipine in patients with hypertension.

Methods: We conducted a cohort study utilizing healthcare databases from Korea and Taiwan. Patients aged between 18 years and 75 years who were newly prescribed both an ARB and amlodipine within 6 months of hypertension diagnosis were included.

Targeted high-level production of chuangxinmycin and its halogenated derivatives with antitubercular activity.

Background: Chuangxinmycin (CM) is an old antibiotic from Actinoplanes tsinanensis CPCC, 200056, characterized by a dihydrothiopyrano[4,3,2-cd]indole scaffold and potent activity against Mycobacterium tuberculosis. Its congener norchuangxinmycin (NCM), which lacks antibacterial activity against various bacteria, unexpectedly retains antitubercular activity, indicating new mechanisms of action against M. tuberculosis in addition to tryptophan-tRNA synthetase inhibition.

Selective Inhibition Mechanism of Tryptophan-tRNA Synthetase by Chuangxinmycin.

Tuberculosis (TB), caused by (Mtb), represents a global health challenge, necessitating new treatments with distinct mechanisms of action (MOA) to combat drug resistance. Chuangxinmycin (CM), characterized by its indole-dihydrothiopyran heterocyclic skeleton, exhibits potent antibacterial activity both and , with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Mtb.

Changes in Bioactive Constituents in Black Rice Metabolites Under Different Processing Treatments.

In this study, liquid chromatography-mass spectrometry (LC-MS) was employed to conduct untargeted metabolomics analysis on black rice (BR), milled black rice (MBR), wet germinated black rice (WBR), and high-temperature and high-pressure-treated WBR (HTP-WBR). A total of 6988 positive ions and 7099 negative ions (multiple difference ≥1.2 or ≤0.

Interface Dominated Spin-to-Charge Conversion in Terahertz Emission by Band Structure Engineering of Topological Surface States.

The rapid advancement of future information technologies necessitates the development of high-efficiency and cost-effective solutions for terahertz emitters, which hold significant practical value in next-generation communication, terahertz sensing, and quantum computing applications. Distinguished from trivial materials, three-dimensional topological insulators exhibit spin-momentum locking in helical Dirac surface states, making them highly efficient spin-to-charge converters that have the potential to revolutionize electronics. However, the efficiency of utilizing topological insulators for spin terahertz emission has not yet matched that of spin manipulation in other spintronic devices.

Facile and Universal Strategy to Construct Piezo-Photocatalytic Systems via Building Electron Bridges for Highly Efficient Overall Water Splitting.

The integration of piezoelectric and photocatalytic materials to enhance the separation of photogenerated charge carriers for overall water splitting (OWS) gives prospects for the application of solar-to-chemical energy conversion. However, high interfacial resistance and poor charge transport remain challenges for the construction of piezo-photocatalytic systems. In this study, we applied the piezoelectric effect to photocatalysts in a simple and universal manner through building electron bridges, achieving an apparent quantum efficiency of 4.

Incretin-based drugs and the risk of gallbladder or biliary tract diseases among patients with type 2 diabetes across categories of body mass index: a nationwide cohort study.

Background: Despite emerging evidence of gallbladder or biliary tract diseases (GBD) risk regarding incretin-based drugs, population-specific safety profile considering obesity is lacking. We aimed to assess whether stratification by body mass index (BMI) modifies the measures of association between incretin-based drugs and the risk of GBD.

Methods: We conducted an active-comparator, new-user cohort study using a nationwide claims data (2013-2022) of Korea.

Optimization of NADES-based green extraction of ellagitannins from rambutan peel with enhanced antioxidant activity.

Rambutan (Nephelium lappaceum L.) peel contains bioactive compounds such as geraniin, corilagin, ellagic acid, and gallic acid, known for their antioxidant, anti-inflammatory, and anticancer properties. Traditional extraction methods involve toxic solvents like methanol and ethanol, posing environmental and safety concerns.

Effects of Korean red ginseng on auditory, cognitive, and liver functions in a naturally aged mouse model.

Background: Korean Red Ginseng and ginsenosides have been studied for their efficacy against various diseases, including those related to aging. However, most aging studies use D-galactose to induce aging, which often does not accurately represent natural aging. This study aimed to verify improvements in auditory, cognitive, and liver function through administering red ginseng to an 18-month-old naturally aging mouse model.

Preparation of magnetic rice husk carbon nanocomposite for efficiently extracting aflatoxin B1 from rice followed by time-resolved fluorescent immunochromatographic assay.

An on-site, sensitive, and cost-effective method for determining aflatoxin B1 (AFB1) in rice samples is proposed, combining magnetic solid phase extraction (MSPE) and time-resolved fluorescence immunochromatography (TRFICA) techniques. Cost-effective rice husks were carbonized and combined with nanomaterials to make magnetic nanocomposites that acted as effective adsorbents in MSPE. Under optimal conditions, the entire process was completed in 15 min with a visual detection limit of 0.

Rational Design of a Novel DNA Polymerase From Clostridium thermocellum to Improve LAMP Detection Performance.

Loop-mediated isothermal amplification (LAMP) is a detection method widely used in pathogen detection and clinical diagnosis. Nevertheless, it is highly constrained by thermal stability, catalytic activity, and resistance to inhibitors of Bst DNA polymerase. In this study, a novel DNA polymerase was characterized from Clostridium thermocellum, exhibiting potential in LAMP detection.

Design, synthesis, and structure-activity relationships of xanthine derivatives as broad-spectrum inhibitors of coronavirus replication.

Illuminated by insights into the hijacking of host cellular metabolism by coronaviruses, we identified an initial hit compound 7030B-C5, characterized by a xanthine scaffold, via a cellular-level phenotypic screening from a domestic repertoire of lipid-modulating agents. A series of derivatives were synthesized and optimized through comprehensive structure-activity relationship (SAR) studies focusing on the N-1, C-8, and N-7 positions of xanthine and preliminary exploration on the N-3 position and parent nucleus. Compounds 10e, 10f and 10o, featuring modifications at the N-7 position, showed inhibitory activity with half maximal effective concentration (EC) values in the three-digit nanomolar range against human coronavirus-229E (HCoV-229E).

Research Progress on the Quality, Extraction Technology, Food Application, and Physiological Function of Rice Bran Oil.

Rice bran oil is recommended by the World Health Organization as one of the three major healthy edible oils (along with corn and sesame oils), owing to its unique fatty acid composition and functional components. This study screened, organized, and analyzed a large number of studies retrieved through keyword searches, and investigated the nutritional value and safety of rice bran oil. It reviews the stability of raw rice bran materials and the extraction and refining process of rice bran oil and discusses food applications and sub-health regulations.

Preparation and Characterization of Hydroxylated Recombinant Collagen by Incorporating Proline and Hydroxyproline in Proline-Deficient .

Collagen possesses distinctive chemical properties and biological functions due to its unique triple helix structure. However, recombinant collagen expressed in without post-translational modifications such as hydroxylation lacks full function since hydroxylation is considered to be critical to the stability of the collagen triple-helix at body temperature. Here, a proline-deficient strain was constructed and employed to prepare hydroxylated recombinant collagens by incorporating proline (Pro) and hydroxyproline (Hyp) from the culture medium.

Sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase IV inhibitors and risk of dementia among patients with type 2 diabetes and comorbid mental disorders: A population-based cohort study.

Aim: To evaluate whether the use of sodium-glucose cotransporter-2 (SGLT2) inhibitors which have shown potential neuroprotective effects, is associated with lower risk of dementia in patients with type 2 diabetes (T2D) and comorbid mental disorders, who are considerably more susceptible to dementia.

Methods: Using the nationwide healthcare data of South Korea between 2010 and 2022, we conducted a retrospective cohort study among patients with T2D and comorbid mental disorders initiating SGLT2 inhibitors versus active comparator (Dipeptidyl Peptidase IV (DPP4) inhibitors). Hazard ratios (HRs) and rate differences (RDs) per 1000 person-years of incident dementia were estimated after weighting by propensity score fine stratification method.

Effects of on Sensorineural Hearing Loss via Neuronal Gene Regulation.

Sensorineural hearing loss (SNHL), characterized by damage to the inner ear or auditory nerve, is a prevalent auditory disorder. This study explores the potential of (CAE) as a therapeutic agent for SNHL. In vivo experiments were conducted using zebrafish and mouse models.

Sodium-Glucose Cotransporter-2 Inhibitors, Dulaglutide, and Risk for Dementia : A Population-Based Cohort Study.

Background: Both sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may have neuroprotective effects in patients with type 2 diabetes (T2D). However, their comparative effectiveness in preventing dementia remains uncertain.

Objective: To compare the risk for dementia between SGLT2 inhibitors and dulaglutide (a GLP-1 RA).

Simulation of the dynamic processes of microplastic suspension and deposition in a lake sediment-water system.

The occurrence of microplastics in aquatic environments has attracted increasing interest from both the public and scientists, especially their migration behaviors. Although several environmental behaviors of microplastics have been studied, the issue of microplastic suspension and deposition in lake sediment-water systems remains to be elucidated. In this study, we built an indoor sediment-water system with input and output rivers that simulated the actual situations in lakes, and aimed to explore the suspension and deposition behavior of microplastics using eight group experiments.

Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed -1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element.

The pandemic of SARS-CoV-2 worldwide with successive emerging variants urgently calls for small-molecule oral drugs with broad-spectrum antiviral activity. Here, we show that carrimycin, a new macrolide antibiotic in the clinic and an antiviral candidate for SARS-CoV-2 in phase III trials, decreases the efficiency of programmed -1 ribosomal frameshifting of coronaviruses and thus impedes viral replication in a broad-spectrum fashion. Carrimycin binds directly to the coronaviral frameshift-stimulatory element (FSE) RNA pseudoknot, interrupting the viral protein translation switch from ORF1a to ORF1b and thereby reducing the level of the core components of the viral replication and transcription complexes.