Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site.

Objective: This study investigated the biomechanical properties of the dura mater from 29 Chinese adult donors (20 -86 years), focused on the influence of age, anatomical region, sex and loading direction, to establish Chinese population - specific material parameters for cranial finite element (FE) models and enhance forensic traumatic brain injury analysis.

Methods: In this study, a total of 275 dural specimens were prepared and categorized into young adult (20-44 years), middle aged (45-64 years), and elderly (≥65 years) cohorts. Samples were excised from frontal, temporal, parietal and occipital regions and tested uniaxially in sagittal and coronal directions, with strain measured via digital image correlation (DIC) techniques.

First determination of diagnostic doses of the pesticide-sensitive strain of Haemaphysalis longicornis in China.

Owing to the lack of research on pesticide-sensitive strains of Chinese Haemaphysalis longicornis, monitoring the resistance status of H. longicornis field populations is impossible, thus posing a risk to the control of drug resistance. For this purpose, the diagnostic doses (DDs) of 8 neurotoxic chemical acaricides in the Chinese pesticide-sensitive strain H.

Associations of family support and loneliness with underlying depression in Chinese children and adolescents.

Objective: This study aimed to examine whether loneliness mediate associations of family support with depression and the extent of interaction of family support and loneliness with depression in children and adolescents.

Methods: There were 2755 children and adolescents aged 18 and below from the China Family Panel Studies (CFPS) that participated in our study. Depression in children and adolescents was assessed by the Center for Epidemiologic Studies Depression Scale (CES-D).

Evaluation of live surgery continuing education course in implantology for dentists: a retrospective cross-sectional survey.

Background: Continuing education courses are vital for cultivating dental specialists. In traditional dental continuing education, training for implant surgery is typically delivered through various forms of demonstrations (such as videos, images) in courses, but this learning method lacks interactivity and detailed information on surgical procedures. However, live surgery can address these limitations.

Unraveling novel variants in the NF1 gene and investigating potential therapeutic strategies.

Germline mutations in the NF1 gene disrupt neurofibromin function, leading to autosomal-dominant neurofibromatosis type I (NF1). As a tumor suppressor, neurofibromin negatively regulates the RAS signaling. NF1 presents notable phenotypic variability, progressive symptoms with age, and potential malignant transformation.

Naringin attenuates myocardial ischemia-reperfusion injury by promoting mitochondrial translocation of NDUFS1 and suppressing cardiac microvascular endothelial cell ferroptosis.

Cardiac microvascular injury plays a pivotal role in the progression of myocardial ischemia-reperfusion injury (MI/RI). Previous studies have demonstrated the cardioprotective effects of naringin (Nar) in cardiovascular diseases. However, the involvement of cardiac microvessels in Nar-mediated protection against MI/RI remains unexplored.

SNP-based molecular diagnostic platform: rapid single-step identification of Theileria annulata and its buparvaquone-resistant strains.

Background: Theileria annulata, a tick-borne protozoan that causes tropical theileriosis, poses a serious threat to livestock production in endemic regions. The emergence of resistance to buparvaquone, the primary chemotherapeutic treatment, has been attributed to acquired mutations in the cytochrome b (Cytb) gene, with identical resistance-associated polymorphisms observed in both laboratory-adapted strains and field isolates from China.

Methods: A dual probe-specific real-time polymerase chain reaction (PCR) assay was developed to detect point mutations in the Cytb gene.

Safety and Immunogenicity of a Canine Distemper DNA Vaccine Formulated with Lipid Nanoparticles in Dogs, Foxes, and Raccoon Dogs.

Background: canine distemper (CD) is a highly contagious and fatal disease caused by canine distemper virus (CDV), posing a significant threat to carnivores. New CDV strain circulation and multi-species infection may lead to the potential dilemma of safety concern and insufficient efficacy of the commercial modified live vaccines. Safe and effective vaccines for canine and wildlife prevention of CD need to be continuously updated and developed.

The complete mitogenome of Hyalomma anatolicum: novel insights into the phylogenetics of Hyalomma.

Ticks are obligate blood-sucking ectoparasite and common vector of a wide variety of zoonotic pathogens. In this research, we sequenced and assembled the circular complete mitogenome information of Chinese isolates of Hyalomma anatolicum maintained at the Laboratory. The 14,714 bp mitogenome consists of 37 genes, including 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes and 2 ribosomal RNA (rRNA).

Cloud-edge collaborative data anomaly detection in industrial sensor networks.

Industrial sensor networks exhibit heterogeneous, federated, large-scale, and intelligent characteristics due to the increasing number of Internet of Things (IoT) devices and different types of sensors. Efficient and accurate anomaly detection of sensor data is essential for guaranteeing the system's operational reliability and security. However, existing research on sensor data anomaly detection for industrial sensor networks still has several inherent limitations.

Systematic proteomic and small RNA profiling of extracellular vesicles from cattle infected with a naturally occurring buparvaquone-resistant strain of Theileria annulata and from uninfected controls.

Background: Extracellular vesicles (EVs) play a pivotal role in host-parasite interactions, particularly in facilitating parasite pathogenesis and immune modulation, and are crucial mediators of intercellular communication. Theileria annulata, an apicomplexan parasite, induces severe alterations in host cells, promoting uncontrolled proliferation, resistance to apoptosis, and immune evasion. Although EVs contribute to these processes, the proteins and small RNA cargo involved in T.

Expanding the molecular understanding of Theileria infections in cattle and yaks from Gansu and Qinghai, China.

Piroplasmosis is a major tick-borne disease that causes significant economic losses in livestock production across various regions. The present study aimed to provide a comprehensive assessment of the prevalence of bovine piroplasmosis in Gansu and Qinghai provinces, China, offering crucial baseline data for the development of effective control and prevention strategies. A total of 736 bovine blood samples were collected from Tianshui, Pingliang, and Lanzhou in Gansu, and Xining and Haidong in Qinghai.

O-GalNAc Glycosylation Activates MBL-Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis.

Liver metastasis is prevalent among patients with neuroendocrine prostate cancer (NEPC) and other types of neuroendocrine (NE) cancers, featuring with an aggressive clinical course and a dismal prognosis. However, the cellular and molecular mechanisms underlying liver-specific metastatic tropism in NE cancers remain poorly understood. Intriguingly, it is found that NEPC liver metastatic foci are frequently associated with thrombi.

A phage-displayed nanobody-based competitive immunoassay for the detection of African swine fever virus antibodies.

African swine fever (ASF) is a highly infectious and devastating disease that poses a significant threat to the global swine industry. The rapid spread of ASF and its ongoing pandemics continue to impact pig farming worldwide. The absence of an effective vaccine, coupled with the complexity of the African swine fever virus (ASFV), makes the control and eradication of ASF a formidable challenge.

Corrigendum: Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China.

[This corrects the article DOI: 10.3389/fmed.2025.

Heteroanionic Halogenated TiBT MBene Protective Layer With Dual-Functional Zincophilic and Hydrophobic Characteristics for Dendrite-Free Zinc Anode.

Two-dimensional (2D) hexagonal transition metal borides (h-MBenes), emerging members of 2D materials, demonstrate significant potential as protective layers for metal anodes. However, conventional MBenes synthesized by wet etching have massive oxygen-containing terminations imported during the chemical synthesis process, with zincophobic and hydrophilic, resulting in severe dendrite growth kinetics and compromising electrode performance. In this study, we report a novel hetero-halogen TiBT (T = Cl and I) h-MBenes through a halogen-radius-isomerization strategy, enabling precise mixed-halogen functionalization to create an ultrahigh zincophilic and hydrophobic microenvironment.

Risk prediction for recurrent pregnancy loss based on routine inspections in the first trimester of pregnancy, a retrospective study in China.

Background: Recurrent pregnancy loss (RPL) is one of the most common pregnancy complications in obstetrics and gynecology, and the incidence rate of RPL is about 2%. To establish a risk prediction model for recurrent pregnancy loss based on routine inspections in the first trimester of pregnancy.

Materials And Methods: A total of 3,010 women at Henan Provincial People's Hospital between January 2019 and December 2023.

Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China.

Background And Objective: Increased nuchal translucency (NT) thickness measured at 11-14 weeks of gestation in fetuses has been linked to adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in fetuses with NT ≥3.0 mm.

Optimizing data privacy and security measures for critical infrastructures via IoT based ADP2S technique.

The sensitive nature of the data processed by the critical infrastructures of a shared platform like the internet of things (IoT) makes it vulnerable to a wide range of security risks. These infrastructures must have robust security measures to protect the privacy of the user data transmitted to the processing systems that utilize them. However, data loss and complexities are significant issues when handling enormous data in IoT applications.

A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway.

The spleen plays a critical role in the pathogenesis of leukemia. However, our understanding of the splenic niche is very limited. Herein, we report that induced expression of the secreted protein Gremlin 1 in a mouse model restrains chronic myeloid leukemia (CML) progression and synergizes with tyrosine kinase inhibitor treatment, whereas blockade of Gremlin 1 promotes CML development.

A nanotwinned-alloy strategy enables fast sodium deposition dynamics.

Sodium (Na) metal batteries are considered promising solutions for next-generation electrochemical energy storage because of their low costs and high energy densities. However, the slow Na dynamics result in unfavorable Na deposition and dendrite growth, which compromise cycling performance. Here we propose a nanotwinned alloy strategy prepared by high-pressure solid solution followed by Joule-heating treatment to address sluggish Na dynamics, achieving homogeneous Na deposition.

UBE2I depletion regulated tumor-associated macrophage polarization into M1 type through reprogramming glycolysis and increases immunotherapy efficacy of anti-PD-L1 in ovarian cancer.

There is ample evidence that ubiquitin-conjugating enzyme E2I (UBE2I) is involved in progression of diverse cancers. However, the influence of UBE2I on ovarian cancer (OC) has been poorly reported. This study tries to discover the mechanisms and functions of UBE2I in OC.

5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis.

Serotonin (5-HT) is a neurotransmitter that has been linked to tumorigenesis. Whether and how 5-HT modulates cells in the microenvironment to regulate tumor metastasis is largely unknown. Here, we demonstrate that 5-HT was secreted by neuroendocrine prostate cancer (NEPC) cells to communicate with neutrophils and to induce the formation of neutrophil extracellular traps (NETs) in the liver, which in turn facilitated the recruitment of disseminated cancer cells and promoted liver metastasis.

Evaluation of fipronil efficacy and first molecular report of gamma-aminobutyric acid (GABA) gated chloride channel gene of Rhipicephalus microplus ticks in China and Pakistan.

Southern cattle tick, Rhipicephalus (R) microplus, is a major challenge in transmitting Babesia spp., Theileria spp., and Anaplasma spp.