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http://dx.doi.org/10.1016/j.iliver.2025.100145 | DOI Listing |
Immunotherapy
September 2025
Department of Dermatology and Allergology, University Hospital, LMU Munich, Munich, Germany.
Currently, the first-line treatment of non-metastatic Merkel cell carcinoma (MCC) is complete resection. In case of unresectable or metastatic MCC, immune checkpoint inhibitor (ICI) therapy with avelumab (or in the US also pembrolizumab or retifanlimab) is indicated. We report on a patient with a primary, non-metastatic MCC on the left eyelid and amyotrophic lateral sclerosis (ALS).
View Article and Find Full Text PDFJ Am Coll Surg
September 2025
Departments of Endocrine and General Surgery, Cleveland Clinic, Cleveland, OH.
Background: Although traditionally reserved for unresectable lesions, recent studies have provided evidence that in selected patients, microwave ablation (MWA) may provide similar oncologic outcomes compared to liver resection (LR). This study aimed to compare oncologic outcomes of patients with solitary small (<3 cm) colorectal liver metastasis (CRLM) undergoing LR vs laparoscopic MWA.
Study Design: This retrospective study included patients with a solitary CRLM <3cm treated with LR or MWA in three centers over 25-years.
Ann Gastroenterol Surg
September 2025
We reviewed the current status and perspectives on salvage esophagectomy for initially unresectable locally advanced esophageal squamous cell carcinoma (ESCC) in the era of minimally invasive surgery and immunotherapy. Although the standard treatment for these patients is definitive chemoradiotherapy (CRT), the complete response rate to CRT alone remains unsatisfactory. Salvage esophagectomy, which is defined as surgery for residual or recurrent lesions after definitive CRT, is considered a curative treatment in clinical practice.
View Article and Find Full Text PDFCancer Rep (Hoboken)
September 2025
Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.
Background: Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) is resistant to chemotherapy and is associated with poor prognosis. Pediatric gastric cancer has an incidence of 0.02% among gastric cancer patients, with a median survival of 5 months.
View Article and Find Full Text PDFJ Gastroenterol Hepatol
September 2025
Department of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Osaka, Japan.
Background And Aim: Atezolizumab plus bevacizumab is used as a first-line treatment for unresectable hepatocellular carcinoma (uHCC). However, the relationship between its adverse events (AEs) and treatment efficacy remains unclear. In this study, we aimed to clarify this association.
View Article and Find Full Text PDF