Quality and Reliability of Adolescent Sexuality Education on Chinese Video Platforms: Sentiment-Topic Analysis and Cross-Sectional Study.

Background: Adolescence is a critical period for lifelong health, which makes access to accurate and comprehensive sexuality education essential. As video platforms become a primary source of information for adolescents, the quality of their content significantly impacts their physical and mental health.

Objective: This study aimed to evaluate the quality, reliability, understandability, and actionability of adolescent sexuality education videos on major Chinese platforms (Bilibili, TikTok or Douyin, and Kwai), analyze associated user comment sentiment and topics, identify predictors of quality and reliability, and provide recommendations.

Increasing Facial Attractiveness by Lateralizing the Auricle-Analyzing the Pan-Facial Effects of the Postauricular Injection Technique in Chinese Patient Populations.

Background: The postauricular injection technique is a needle-based technique that places soft tissue fillers behind the ears into the supra-periosteal plane of the mastoid process of the temporal bone. The resulting clinical effect pushes the auricles more laterally mimicking the inverse effects of a surgical otoplasty.

Objective: The purpose of this study is to investigate the aesthetic outcome of the postauricular injection technique by having the treatment results evaluated by several international, independent, and blinded reviewers.

Osteocytic vinculin controls bone mass by modulating Mef2c-driven sclerostin expression in mice.

The focal adhesion (FA) is the structural basis of the cell-extracellular matrix crosstalk and plays important roles in control of organ formation and function. Here we show that expression of FA protein vinculin is dramatically reduced in osteocytes in patients with aging-related osteoporosis. Vinculin loss severely impaired osteocyte adhesion and dendrite formation.

Quality Grading of "Fubaiju" Based on Inflorescence Diameter and Content of Polyphenolic Substances.

Flos encompasses numerous cultivars. Fubaiju (FBJ) is a subvariety of Hangbaiju introduced from Tongxiang City, Zhejiang Province. Due to the variable quality of FBJ on the market, establishing a standardized grading system is necessary.

Unraveling novel variants in the NF1 gene and investigating potential therapeutic strategies.

Germline mutations in the NF1 gene disrupt neurofibromin function, leading to autosomal-dominant neurofibromatosis type I (NF1). As a tumor suppressor, neurofibromin negatively regulates the RAS signaling. NF1 presents notable phenotypic variability, progressive symptoms with age, and potential malignant transformation.

Mechanistic Insight into the Enhanced Anti-Pulmonary Hypertension Efficacy of Wogonin Co-Amorphous.

Pulmonary hypertension (PH) remains a life-threatening rare disease characterized by inflammation and oxidative stress in pulmonary artery smooth muscle cells (PASMCs). Wogonin (Wog), a plant-derived polyphenolic compound extracted from Georgi, exhibits notable antioxidant activity and anti-PH efficacy, whereas its clinical applications are greatly limited by poor aqueous solubility. : Herein, an innovative wogonin-aloperine co-amorphous (Wog-Alop) was developed to improve the aqueous solubility and, thus, anti-PH efficacy of Wog.

Electronic Structure Modulation of NbO by Ru Single Atoms Enabling Efficient Hydrogen Storage of Magnesium Hydrides.

Magnesium hydride (MgH) is a promising solid-state hydrogen storage material due to its high capacity and low cost, but its high dehydrogenation temperature and poor kinetic limit its applications. Although catalytic modification of MgH has been extensively studied, existing efforts focus on optimizing hydrogen transfer, with limited exploration of electron transfer and transport. This study investigated the enhancement of electron transfer and transport rates during MgH de/hydrogenation by introducing a single-atom catalyst composed of Ru single atoms on a NbO substrate.

Fluorination-Assisted Interfacial Dipole for CsPbI Perovskite Solar Cells with Over 22% Efficiency.

Inorganic CsPbI perovskite attracts widespread attention in photovoltaic applications due to its superior thermal stability and optoelectronic properties. However, CsPbI perovskite solar cells (PSCs) still suffer from severe energy losses due to interface nonradiative recombination and undesirable charge carrier transfer, predominantly limiting their photovoltaic performance. Herein, an interfacial dipole engineering is introduced for CsPbI PSCs, in which azetidinium chloride (Az) and its fluorinated derivative 3,3-difluoroazetidinium chloride (DFAz) are employed to manipulate the interface properties of PSCs and thus diminish energy losses.

Pilot Study: Hyaluronic Acid Filler Injection Techniques to Achieve Facial Balance in Asian Patients.

Background: Current standard beauty practices in East Asia focus on enhancing and refining Asian features within cultural normalities.

Methods: This pilot study presents injection techniques using hyaluronic acid filler (YVOIRE), focusing on East Asian facial balance factors (line, angle, and proportion of the face). The Balance-L injection technique is suggested to achieve single convexity of the outer contour.

Risk prediction for recurrent pregnancy loss based on routine inspections in the first trimester of pregnancy, a retrospective study in China.

Background: Recurrent pregnancy loss (RPL) is one of the most common pregnancy complications in obstetrics and gynecology, and the incidence rate of RPL is about 2%. To establish a risk prediction model for recurrent pregnancy loss based on routine inspections in the first trimester of pregnancy.

Materials And Methods: A total of 3,010 women at Henan Provincial People's Hospital between January 2019 and December 2023.

Inverse Opal Photonic Crystal Structured Bifacial-Iridescent Efficient Perovskite Solar Cells and Modules.

Colorful perovskite solar cells exhibit excellent potential for building-integrated photovoltaics (BIPVs), which increase the utilization of clean power. However, their efficiencies are lower than those of uncolored devices. Moreover, traditional mono-facial colored devices cannot satisfy diverse BIPV scenarios.

Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma.

Background: Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancers in women, yet lacks specific and sensitive tumor markers for diagnosis, as traditional markers like CA125 show limited specificity. This study investigates the clinical significance and prognostic value of CDH18, a calcium-dependent adhesion protein linked to tumor progression, in UCEC.

Methods: Clinical data from UCEC patients were sourced from The Cancer Genome Atlas (TCGA) database.

Identification of novel biallelic mutations in CFAP53 associated with fetal situs inversus totalis and literature review.

Visceral heterotaxy is a congenital malformation characterized by the abnormal arrangement of left-right axis of visceral organs. To date, several genes implicated in the regulation of laterality patterning have been identified. Notably, CFAP53, also referred to as CCDC11, is involved in the regulation of ciliary motility, and mutations in this gene have been linked to a rare condition of heterotaxy.

Minute-Level Room-Temperature Switching and Long Cycle Stability of Thermochromic Inorganic Perovskite Smart Windows.

Perovskite smart windows (PSWs) are widely investigated owing to excellent thermochromic properties, while restricted by poor transition performance and cycle stability. Herein, dimethyl sulfoxide vapor is utilized as an induction reagent for rapid reversible switching at room temperature between the colored and bleached phases. To obtain PSWs with different optical properties and transition performance, red CsPbIBr, yellow RbCsPbIBr and brown CsSnPbIBr are prepared through alloying.

Unveiling sialoglycans' immune mastery in pregnancy and their intersection with tumor biology.

Sialylation is a typical final step of glycosylation, which is a prevalent post-translational modification of proteins. Sialoglycans, the products of sialylation, are located on the outmost of cells and participate in pivotal biological processes. They have been identified as glyco-immune checkpoints and are currently under rigorous investigation in the field of tumor research.

CpG hypomethylation at proximal promoter and 5'UTR along with IL6 signaling loop associates with MYD88 upregulation in epithelial ovarian cancer.

MYD88 is an IL-6 primary response gene and, its upregulation of expression has been shown to be a poor prognostic factor in epithelial ovarian cancer (EOC). We investigated the effects of CpG methylation at the proximal promoter/5'UTR and IL-6/SP1/IRF1 signaling on upregulation of MYD88 and prognosis in EOC. We assessed CpG methylation at the proximal promoter/5'UTR of MYD88 using bisulfite sequencing/PCR in 103 EOC patients, 28 normal ovarian tissues and two EOC cell lines with differential expression of MYD88 and identified the impact of the level of CpG methylation on MYD88 upregulation by SP1/IRF1 with knockdown or blockade of IL-6.

Transcriptome analyses reveal molecular mechanisms of novel compound heterozygous variants causing infantile cerebellar retinal degeneration.

Background And Purpose: Infantile cerebellar retinal degeneration (ICRD) (OMIM #614559) is a rare autosomal recessive inherited disease associated with mutations in the aconitase 2 (ACO2) gene. We report a Chinese girl with novel compound heterozygous variants in , who presented at 7 months of age with psychomotor retardation, truncal hypotonia, and ophthalmologic abnormalities. This study aims to investigate the potential molecular mechanisms underlying deficiency-induced neuropathy.

Delocalization State-Stabilized Zn Active Sites for Highly Selective and Durable CO Electroreduction.

Zinc (Zn)-based materials are cost-effective and promising single-metal catalysts for CO electroreduction to CO but is still challenged by low selectivity and long-term stability. Undercoordinated Zn (Zn) sites have been demonstrated to be powerful active centers with appropriate COOH affinity for efficient CO production However, electrochemical reduction conditions generally cause the inevitable reduction of Zn, resulting in the decline of CO efficiency over prolonged operation. Herein, a Zn cyanamide (ZnNCN) catalyst is constructed for highly selective and durable CO electroreduction, wherein the delocalized Zn d-electrons and resonant structure of cyanamide ligand prevent the self-reduction of ZnNCN and maintain Zn sites under cathodic conditions.

Constructing Bionic Perovskite Smart Photovoltaic Windows with Switchable Colors and High Cycling Stability.

Smart photovoltaic windows (SPWs) provide a high-efficiency and energy-saving strategy owing to the dual capabilities of electricity generation and sunlight modulation achieved by tunable colors and transmittances. Due to the deterioration of chromic process on photovoltaic layers, SPWs usually suffer from poor cycling stability. Moreover, thermochromic SPWs with a multilayer structure usually change transmittance without reversible color transitions.

Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept.

Introduction: Podophyllotoxin (PPT) is a high-content and high-activity compound extracted from the traditional Chinese medicinal plant () which exhibits various biological activities. However, its severe toxicity limits its use. In clinical settings, patients with poisoning often experience adverse reactions when taking large doses in a short period.

Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development.

This study was conducted retrospectively on a cohort of 68 patients with steroid 5 α-reductase 2 (SRD5A2) deficiency and 46,XY disorders of sex development (DSD). Whole-exon sequencing revealed 28 variants of SRD5A2 , and further analysis identified seven novel mutants. The preponderance of variants was observed in exon 1 and exon 4, specifically within the nicotinamide adenine dinucleotide phosphate (NADPH)-binding region.

Evaluation of the effect of death education based on the Peace of Mind Tea House: a randomized controlled trial of nursing trainees at Xiamen University, China.

Background: There are few studies on death education models for nursing students in China. It is of great significance to construct a model of nursing students' death education combined with clinical practice. This study aims to evaluate the effect of death education on nursing students based on the Peace of Mind Tea House.

Clinical predictive value of pre-pregnancy tests for unexplained recurrent spontaneous abortion: a retrospective study.

Introduction: Early prediction and intervention are crucial for the prognosis of unexplained recurrent spontaneous abortion (uRSA). The main purpose of this study is to establish a risk prediction model for uRSA based on routine pre-pregnancy tests, in order to provide clinical physicians with indications of whether the patients are at high risk.

Methods: This was a retrospective study conducted at the Prenatal Diagnosis Center of Henan Provincial People's Hospital between January 2019 and December 2022.