Quality and Reliability of Adolescent Sexuality Education on Chinese Video Platforms: Sentiment-Topic Analysis and Cross-Sectional Study.

Background: Adolescence is a critical period for lifelong health, which makes access to accurate and comprehensive sexuality education essential. As video platforms become a primary source of information for adolescents, the quality of their content significantly impacts their physical and mental health.

Objective: This study aimed to evaluate the quality, reliability, understandability, and actionability of adolescent sexuality education videos on major Chinese platforms (Bilibili, TikTok or Douyin, and Kwai), analyze associated user comment sentiment and topics, identify predictors of quality and reliability, and provide recommendations.

Antimony Exposure Induces Bladder Cancer Metastasis Via Activation of the SUMOylation-Dependent TGF-β/Smad2/3 Axis.

Antimony is an important industrial raw material, known as the "industrial monosodium glutamate", and is widely used in alloys, electronics, chemical engineering, and other fields. Due to its extensive applications, its environmental toxicity and carcinogenic risk have attracted increasing attention. In recent years, numerous studies have reported the carcinogenic risk of antimony, but its role in bladder cancer and the underlying molecular mechanisms have not been fully elucidated.

Quality and Dissemination of Uterine Fibroid Health Information on TikTok and Bilibili: Cross-Sectional Study.

Background: The rise of short-video platforms, such as TikTok (Douyin in China) and Bilibili, has significantly influenced how health information is disseminated to the public. However, the quality, reliability, and effectiveness of health-related content on these platforms, particularly regarding uterine fibroids, remain underexplored. Uterine fibroids are a common medical condition that affects a substantial proportion of women worldwide.

Perillyl alcohol promotes autophagy by suppressing the PI3K-AKT-mTOR signalling pathway in osteoarthritic chondrocytes in vitro.

Osteoarthritis (OA) is a common degenerative disease characterized by chondrocyte death and extracellular matrix (ECM) degradation, but the present OA treatments are only symptomatic and not aetiologic. Autophagy is a key protective mechanism for OA through the inhibition of chondrocyte apoptosis and degeneration. Perillyl alcohol (POH) is a monomer derived from Chinese herbal medicines that can regulate autophagy and has anti-inflammatory effects.

GmSop20 Functions as a Key Coordinator of the Oil-To-Protein Ratio in Soybean Seeds.

The seed oil-to-protein ratio has increased remarkably during soybean domestication; however, the principal genetic determinants governing this critical agronomic trait remain elusive. Integrated genome-wide and transcriptome-wide association studies (GWAS/TWAS) are conducted and identified GmSop20 on chromosome 20 as a pivotal regulator of soybean seed oil and its protein content. Genetic diversity analysis reveals a domestication-selected allele, GmSop20, which has undergone intense artificial selection and is dominant in cultivars across northern China and the USA.

Molecular mechanisms of diquat-induced brain injury: Insights from network toxicology and single-cell RNA sequencing.

Objective: This study investigates the molecular mechanisms of diquat (DQ)-induced brain injury through an integrative approach combining network toxicology, single-cell RNA sequencing, and molecular docking technologies.

Methods: DQ target genes were predicted using the STITCH and SwissTargetPrediction databases, while brain injury-related genes were identified from the GeneCards, OMIM, and TTD databases. GO and KEGG enrichment analyses were conducted on the intersected genes.

Dual-mode electrochemical fiber optic surface plasmon resonance sensor (EC-FO-SPR) for real-time and sensitive detection of lipopolysaccharide.

Lipopolysaccharide (LPS), a key component of the outer membrane of Gram-negative bacteria, is the primary trigger of septic shock. The rapid and selective detection of LPS is essential for effective disease prevention and treatment. The conventional prism-based electrochemical surface plasmon resonance (EC-SPR) system is limited by their bulky optical configurations, making it difficult to integrate into portable devices.

The PPARβ/CERK/C1P signaling pathway is a potential mechanism by which antimony exposure promotes prostate cancer cell proliferation.

Prostate cancer (PCa) is the most common malignant tumor in males. Antimony (Sb) is a widespread industrial heavy metal pollutant listed as a Class IIB carcinogen by the International Agency for Research on Cancer (IARC). Previous work found that antimony exposure can promote the proliferation of prostate cancer cells, but the relevant molecular mechanisms have not been fully explored.

Revealing Light-Magnetism Coupling via Anomalous Hall Effect and Magneto-Photoresponse in Proximity-Coupled CrSBr/Graphene Heterostructures.

The interplay between light and magnetism sparks groundbreaking concepts for the next-generation versatile spintronic and nanoelectronic devices. However, direct measurements of light-magnetism coupling remain challenging due to the intrinsic difficulties in characterizing these properties simultaneously. Herein, via harnessing magnetic proximity and anomalous Hall effect (AHE), we report the effective modification of magnetism in the graphene/CrSBr heterostructure by an unpolarized 405 nm light.

Ultralow Thermal Conductivity and Very High Seebeck Coefficient in Two-Dimensional TeSe Semiconductor.

Emerging chalcogenide-based two-dimensional (2D) materials possess various unique yet fully explored properties and are thus considered promising candidates for next-generation optoelectronic and energy conversion applications. Here, TeSe crystals with interesting thermoelectric features were synthesized using a simple solid-state reaction. High-resolution transmission electron microscopy reveals that TeSe stabilizes in a 2D atomic structure with helical chains, resembling 2D tellurene.

Globally distributed marine Gemmatimonadota have unique genomic potentials.

Background: Gemmatimonadota bacteria are widely distributed in nature, but their metabolic potential and ecological roles in marine environments are poorly understood.

Results: Here, we obtained 495 metagenome-assembled genomes (MAGs), and associated viruses, from coastal to deep-sea sediments around the world. We used this expanded genomic catalog to compare the protein composition and update the phylogeny of these bacteria.

Integrated multi-omics analyses reveal microbial community resilience to fluctuating low oxygen in the East China sea.

Climate change and eutrophication are accelerating ocean deoxygenation, leading to a global decline in oxygen levels. The East China Sea, frequently experiencing deoxygenation events, harbors diverse microbial communities. However, the response of these communities to the changing deoxygenation dynamics remains poorly understood.

ACSL4 accelerates osteosarcoma progression via modulating TGF-β/Smad2 signaling pathway.

Osteosarcoma (OS) is a malignant bone sarcoma arising from mesenchymal stem cells. The biological role of Acyl-CoA synthetase long-chain family member 4 (ACSL4), recently identified as an oncogene in numerous tumor types, remains largely unclear in OS. In this study, we investigated the expression of ACSL4 in OS tissues using immunohistochemistry staining (IHC) staining of a human tissue microarray and in OS cells by qPCR assay.

Revealing Strong Flexoelectricity and Optoelectronic Coupling in 2D Ferroelectric CuInPS Via Large Strain Gradient.

The interplay between flexoelectric and optoelectronic characteristics provides a paradigm for studying emerging phenomena in various 2D materials. However, an effective way to induce a large and tunable strain gradient in 2D devices remains to be exploited. Herein, we propose a strategy to induce large flexoelectric effect in 2D ferroelectric CuInPS by constructing a 1D-2D mixed-dimensional heterostructure.

Reduced nitrite accumulation at the primary nitrite maximum in the cyclonic eddies in the western North Pacific subtropical gyre.

Nitrite, an intermediate product of the oxidation of ammonia to nitrate (nitrification), accumulates in upper oceans, forming the primary nitrite maximum (PNM). Nitrite concentrations in the PNM are relatively low in the western North Pacific subtropical gyre (wNPSG), where eddies are frequent and intense. To explain these low nitrite concentrations, we investigated nitrification in cyclonic eddies in the wNPSG.

Effect of L-carnitine in Ameliorating Lipopolysaccharide-Induced Cardiomyocyte Injury via MAPK Signaling.

The present study aimed to elucidate whether L-carnitine (LC) protected H9c2 cells and its underlying mechanisms. Cell counting kit-8 (CCK-8) assay was used to evaluate cell viability. Apoptosis, cell morphology, and lactate dehydrogenase (LDH) assessment were used to prove effects of lipopolysaccharide (LPS) and LC on H9c2 cells.

Increases Palmitic Acid Content to Regulate Seed Oil Content and Nodulation in Soybean ().

Soybean () is an important oil crop, but the regulatory mechanisms underlying seed oil accumulation remain unclear. We identified a member of the transcription factor family, , that is involved in regulating soybean oil content and nodulation. Overexpression of in soybean hairy roots increased the expression of genes involved in glycolysis and de novo lipogenesis, the proportion of palmitic acid (16:0), and the number of root nodules.

Evaluation of effects of 3% diquafosol ophthalmic solution on preocular tear film stability after trabeculectomy.

Objectives: To determine the potential effects of 3% diquafosol (DQS) on tear film stability after glaucoma surgery.

Methods: We retrospectively reviewed consecutive patients who underwent glaucoma surgery at the glaucoma division of the Henan Eye Institute from January 2020 to January 2021. Clinical parameters, including age, sex, intraocular pressure, and number of glaucoma medications, were tested.

Contrasting archaeal and bacterial community assembly processes and the importance of rare taxa along a depth gradient in shallow coastal sediments.

Marine microbial communities assemble along a sediment depth gradient and are responsible for processing organic matter. Composition of the microbial community along the depth is affected by various biotic and abiotic factors, e.g.

A novel rat model of cerebral small vessel disease and evaluation by super-resolution ultrasound imaging.

Cerebral small vessel disease (CSVD), which causes cognitive, functional and emotional decline, is related to stroke events, and it is a major cause of Alzheimer's disease. In the social context of an aging population, the incidence of CSVD is on the rise yearly, and the exact pathogenesis is still controversial and remains unclear. Exploring the pathological mechanism of CSVD on the histological level using animal models is important for the investigation of new clinical diagnostic methods and treatment options.

Transverse Magnetoresistance Induced by the Nonuniformity of Superconductor.

The transverse magnetoresistance () caused by inhomogeneous superconductivity is symmetric about the magnetic field around the critical magnetic field region. This has caused many disturbances during the study of vortex dynamics by Hall signals. Here, we found that the peak of measured in our samples was induced by the nonuniformity of the superconductors.

Charge Reversal Polypyrrole Nanocomplex-Mediated Gene Delivery and Photothermal Therapy for Effectively Treating Papillary Thyroid Cancer and Inhibiting Lymphatic Metastasis.

As a traditional treatment for papillary thyroid cancer (PTC), surgical resection of diseased tissues often brings lots of inconveniences to patients, and the tumor recurrence and metastasis are difficult to avoid. Herein, we developed a gene and photothermal combined therapy nanosystem based on a polypyrrole (Ppy)-poly(ethylene imine)-siILK nanocomplex (PPR) to achieve minimally invasive ablation and lymphatic metastasis inhibition in PTC simultaneously. In this system, gelatin-stabilized Ppy mainly acted as a photothermal- and photoacoustic (PA)-responsive nanomaterial and contributed to its well-behaved photosensitivity in the near-infrared region.

Specific diagnosis of lymph node micrometastasis in breast cancer by targeting activatable near-infrared fluorescence imaging.

Axillary lymph node metastasis has always been defined as the most important prognostic factor in the treatment of early breast cancer. Ultrasound and MRI can detect only 10% of lymph node micrometastases in early breast cancer. Therefore, it is crucial to detect early breast cancer with lymph node metastasis, however, there is no current examination method for accurate diagnosis.