Correction: Decoding tissue complexity: multiscale mapping of chemistry-structure-function relationships through advanced visualization technologies.

Correction for 'Decoding tissue complexity: multiscale mapping of chemistry-structure-function relationships through advanced visualization technologies' by Zhiyuan Zhao , , 2025, , 7897-7918, https://doi.org/10.1039/D5TB00744E.

Immune-related hepatitis and hypophysitis are associated with superior survival in melanoma patients treated with combined ipilimumab and nivolumab.

Combination CTLA-4 (ipilimumab) and PD-1 (nivolumab) checkpoint inhibition (dual-ICI) improves survival in patients with advanced melanoma. However, many patients also experience immune-related adverse events (irAE) that require systemic treatment with corticosteroids. Corticosteroids dampen the anti-tumoral response and may impair survival.

InO Nanoribbon-Based Field-Effect Transistor Biosensors for Ultrasensitive Detection of Exosomal Circulating microRNA with Peptide Nucleic Acid Probes.

The expression of distinct microRNA (miRNA) species is associated with many major diseases, and thus, stable and reliable detection at low concentrations is crucial for early diagnosis and treatment. Field-effect transistor (FET)-based biosensors have shown significant progress in miRNA detection, but detection at ultralow concentrations remains challenging due to weak signal generation from small, low-charge miRNA molecules. Here, we report an InO nanoribbon-based FET biosensor platform capable of detecting miRNAs at attomolar (aM) concentrations.

Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers.

Immunomodulatory drugs (IMiDs) are widely utilized therapies in multiple hematological cancers; however, their clinical application is frequently constrained by drug resistance. Here, though screening of diverse cereblon (CRBN) binders, comprehensive structure-activity relationships (SAR) analyses and systematic degradation profiling, , a potent IKZF1/2/3 degrader featuring a phthalazinone scaffold, demonstrated nanomolar-range IC potencies across diverse multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL) cancer cells and overcame acquired resistance to pomalidomide. selectively induced robust degradation of IKZF1/2/3 in a Cullin-CRBN pathway-dependent manner, with nanomolar DC potency.

Magnetically induced magnetosome chain (MAGiC): A biogenic magnetic-particle-imaging tracer with high performance and navigability.

Magnetic particle imaging (MPI) enables real-time, sensitive, and quantitative visualization of tracer distribution, augmenting the capability of in vivo imaging technologies. Previous MPI tracer research has predominantly focused on superparamagnetic nanoparticles, whose suboptimal sigmoidal magnetization curves limit their spatial resolution. Here, we introduce the magnetically induced magnetosome chain (MAGiC), a superferromagnetic MPI tracer, demonstrating a 25-fold improvement in resolution in the excitation direction and an order of magnitude improvement in signal intensity compared to the commercial tracer VivoTrax+.

Novel Highly Potent c-Met Degraders against a Broad Range of Cancers.

The cellular-mesenchymal epithelial transition factor (c-Met) is an attractive target in multiple cancers. Despite various c-Met inhibitors having been developed, the acquired drug resistance hampers their clinical application. In this study, through elaborately rational optimization, c-Met degraders, namely, , , and , were developed to exhibit single-digit nanomolar cell growth inhibition IC values, picomolar c-Met degradation DC values, and >99% of maximum degradation in cancer cells with alterations via a Cullin-CRBN-dependent pathway.

Understanding the Retention of Microplastics in Wastewater Treatment Plants: Insights from Tracer Tests and Numerical Modeling.

This study integrates full-scale tracer-test experiments and microplastics (MPs) tracer transport modeling to determine the role of flow patterns in the retention of MPs within wastewater treatment plants (WWTPs). Unlike previous studies that determined MP content through discrete sampling without controlling their entrance, this study tracked nile red-stained acrylic fiber tracer-MPs across a disinfection tank in a WWTP. The full-scale tracer test showed that ∼70% of the input tracers was retained in the disinfection tank 20 minutes after the minimum Hydraulic Retention Time (HRT, 30 minutes) (total duration: 50 minutes), but dropped to 39% 4 hours after the minimum HRT (total duration: 4.

Decoding tissue complexity: multiscale mapping of chemistry-structure-function relationships through advanced visualization technologies.

Comprehensively acquiring biological tissue information is pivotal for advancing our understanding of biological systems, elucidating disease mechanisms, and developing innovative clinical strategies. Biological tissues, as nature's archetypal biomaterials, exhibit multiscale structural and functional complexity that provides critical principles for synthetic biomaterials. Tissues/organs integrate molecular, biomechanical, and hierarchical architectural features across scales, offering a blueprint for engineering functional materials capable of mimicking or interfacing with living systems.

Strain-Insensitive, Air-Stable Stretchable Carbon Nanotube-Based Synaptic Transistors Array via Direct Microfabrication for Neuromorphic Computing.

Stretchable synaptic transistors show great promise in mimicking brain activities in soft robotics and skin electronics applications. However, the fabrication of such device arrays on elastic substrates with high stability, throughput, and yield remains challenging. Here, we have developed an approach to fabricate stretchable synaptic transistors directly on elastic substrates, in which carbon nanotubes and SU-8 are used as channel and dielectric, respectively.

Determining the Role of OsAGP6P in Anther Development Within the Arabinogalactan Peptide Family of Rice ().

Arabinogalactan proteins (AGPs) are complex proteoglycans present in plant cell walls across the kingdom. They play crucial roles in biological functions throughout the plant life cycle. In this study, we identified 43 gene members of the AG peptide (an AGP subfamily) within the rice genome, detailing their structure, protein-conserved domains, and motif compositions for the first time.

A Semantic Conditional Diffusion Model for Enhanced Personal Privacy Preservation in Medical Images.

Deep learning has significantly advanced medical image processing, yet the inherent inclusion of personally identifiable information (PII) within medical images-such as facial features, distinctive anatomical structures, rare lesions, or specific textural patterns-poses a critical risk to patient privacy during data transmission. To mitigate this risk, we introduce the Medical Semantic Diffusion Model (MSDM), a novel framework designed to synthesize medical images guided by semantic information, synthesis images with the same distribution as the original data, which effectively removes the PPI of the original data to ensure robust privacy protection. Unlike conventional techniques that combine semantic and noisy images for denoising, MSDM integrates Adaptive Batch Normalization (AdaBN) to encode semantic information into high-dimensional latent space, embedding it directly within the denoising neural network.

Printing Multi-Layered Functional Devices Using One Stamp with Programmable Surface Energy.

Beyond its role in cultural communication, printing technology has emerged as one of the most important approaches to distributing and patterning functional materials for advanced manufacturing. In a printing process, a stamp is employed to transfer functional inks to a target surface, generating a specific pattern that exactly replicates the stamp. Through precise manipulation of different inkdrops, herein, a "one stamp, diverse patterns" printing strategy is developed and achieves deposition of varied patterns utilizing a single stamp.

Distinct Fermi Resonance Patterns of Weak Coupling in 2D-IR Spectra of 5-Cyanoindole Revealed by Isotope Labeling.

Fermi resonance is a common phenomenon, and a hidden caveat exists in the applications of infrared probes, causing spectral complication and shorter vibrational lifetime. In this work, using the cyanotryptophan (CNTrp) side chain model compound 5-cyanoindole (CN-5CNI), we performed Fourier transform infrared spectroscopy (FTIR) and two-dimensional infrared (2D-IR) spectroscopy on unlabeled CN-5CNI and its isotopically labeled substituents (CN-5CNI, CN-5CNI, CN-5CNI) and demonstrated the existence of Fermi resonance in 5CNI. By constructing the Hamiltonian and simulating 2D-IR spectra, we show that the distinct Fermi resonance 2D-IR patterns in various isotope substituents are determined by the quantum mixing consequences at the = 1 state, as well as the = 2 state, where the Fermi coupling and anharmonicity play a crucial role.

Oxyglutamate Carrier Alleviates Cerebral Ischaemia-Reperfusion Injury by Regulating Mitochondrial Function.

Mitochondrial dysfunction has been reported to participate in the pathophysiological processes of cerebral ischaemia-reperfusion injury, which include reduced energy homeostasis, increased generation of oxidative stress species (ROS) and the release of apoptotic factors. Oxyglutamate carrier (OGC) is an important carrier protein on the inner mitochondrial membrane that can transport metabolites from the cytoplasm to the mitochondria. The role of OGC in cerebral ischaemia-reperfusion injury (I/R) remains unknown.

Optimal repetitive readout of single solid-state spins determined by Fisher information.

Quantum systems, including superconducting circuits, trapped ions, quantum dots, solid-state defects, etc., have achieved considerable advancements in readout fidelity. However, the widely used threshold method disregards the importance of temporal characteristics of the signal during continuous measurements, leading to information loss.

Continuous Monitoring of Lithium Ions in Lithium-Rich Brine Using Ion Selective Electrode Sensors Modified with Polyelectrolyte Multilayers of Poly(allylamine hydrochloride)/Poly(sodium 4-styrenesulfonate).

Monitoring lithium ions (Li) in lithium-rich brine (LrB) is critical for metal recovery, yet challenges such as high ionic strength and gypsum-induced surface deterioration hinder the performance of potentiometric ion-selective electrode (ISE) sensors. This study advances the functionality of Li ISE sensors and enables continuous monitoring of Li concentration in LrB by introducing apolyelectrolyte multilayer (PEM) of poly(allylamine hydrochloride)/poly(sodium 4-styrenesulfonate) (PAH/PSS) that serves as an antigypsum scaling material to minimize nucleation on the sensor surface. With 5.

Diffusion limited synthesis of wafer-scale covalent organic framework films for adaptative visual device.

Synthesizing high-crystalline covalent organic framework films is highly desired to advance their applications in two-dimensional optoelectronics, but it remains a great challenge. Here, we report a diffusion-limited synthesis strategy for wafer-scale uniform covalent organic framework films, in which pre-deposited 4,4',4″,4‴-(1,3,6,8-Tetrakis(4-aminophenyl) pyrene is encapsulated on substrate surface with a layer of covalent organic framework prepolymer. The polymer not only prevents the dissolution of precursor, but limits the reaction with terephthalaldehyde dissolved in solution, thereby regulating the polymerization process.

Advances in Biointegrated Wearable and Implantable Optoelectronic Devices for Cardiac Healthcare.

With the prevalence of cardiovascular disease, it is imperative that medical monitoring and treatment become more instantaneous and comfortable for patients. Recently, wearable and implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological monitoring and treatment in an imperceptible and spatiotemporally unconstrained manner, opening countless possibilities for the intelligent healthcare paradigm. To achieve biointegrated cardiac healthcare, researchers have focused on novel strategies for the construction of flexible/stretchable optoelectronic devices and systems.

Molecular-Scale Geometric Design: Zigzag-Structured Intrinsically Stretchable Polymer Semiconductors.

Orienting intelligence and multifunction, stretchable semiconductors are of great significance in constructing next-generation human-friendly wearable electronic devices. Nevertheless, rendering semiconducting polymers mechanical stretchability without compromising intrinsic electrical performance remains a major challenge. Combining geometry-innovated inorganic systems and structure-tailored organic semiconductors, a molecular-scale geometric design strategy is proposed to obtain high-performance intrinsically stretchable polymer semiconductors.

Enantio- and Diastereoselective Desymmetrization of 1,1'-Biaryl-2,6-Dicarbaldehydes by Copper-Catalyzed 1,2-Addition of Silicon Nucleophiles.

A desymmetrizing 1,2-addition of silicon nucleophiles to biaryl derivatives containing an 2,6-dicarbaldehyde-1-yl unit is reported. The reaction is catalyzed by copper with a triazolium-ion-derived N-heterocyclic carbene as the chiral ligand and makes use of an Si-B reagent as the silicon pronucleophile. The practical methodology furnishes axially chiral aromatic carbaldehydes decorated with a centrally chiral α-hydroxysilane moiety in moderate to good yields and with high enantio- as well as excellent diastereoselectivities.

Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.

Background: Targeted protein degradation of neosubstrates plays a crucial role in hematological cancer treatment involving immunomodulatory imide drugs (IMiDs) therapy. Nevertheless, the persistence of inevitable drug resistance and hematological toxicities represents a significant obstacle to their clinical effectiveness.

Methods: Phenotypic profiling of a small molecule compounds library in multiple hematological cancer cell lines was conducted to screen for hit degraders.

In Vitro Characterization and Identification of Potential Probiotic Yeasts Isolated from Zaopocu, a Traditional Fermented Dregs Vinegar from Hainan Island.

Recently, there has been an increasing interest in researching fermented food-derived yeasts as probiotics because they offer a natural and diverse source of potential strains with unique functional properties and health benefits. In this study, 13 yeast strains isolated from Zaopocu (ZPC), a traditional fermented dregs vinegar on Hainan Island, China, were evaluated for their probiotic characteristics in vitro. Yeast identification was conducted through 5.

CYP17A1 Pathogenic Variants in 26 Chinese Patients With 17α-Hydroxylase Deficiency by Targeted Long-Read Sequencing.

Background: 17α-hydroxylase/17,20-lyase deficiency (17-OHD) is a rare subtype of congenital adrenal hyperplasia caused by homozygous or compound heterozygous pathogenic variants in the CYP17A1 gene.

Purpose: This study aimed to identify and characterize pathogenic variants in individuals with 17-OHD and to classify and validate the pathogenicity of novel variants.

Methods: Variants were identified via targeted long-read sequencing (TLRS) of the entire CYP17A1 gene in enrolled 17-OHD patients.