InO Nanoribbon-Based Field-Effect Transistor Biosensors for Ultrasensitive Detection of Exosomal Circulating microRNA with Peptide Nucleic Acid Probes.

The expression of distinct microRNA (miRNA) species is associated with many major diseases, and thus, stable and reliable detection at low concentrations is crucial for early diagnosis and treatment. Field-effect transistor (FET)-based biosensors have shown significant progress in miRNA detection, but detection at ultralow concentrations remains challenging due to weak signal generation from small, low-charge miRNA molecules. Here, we report an InO nanoribbon-based FET biosensor platform capable of detecting miRNAs at attomolar (aM) concentrations.