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Accurate forecasts can enable more effective public health responses during seasonal influenza epidemics. For the 2021-22 and 2022-23 influenza seasons, 26 forecasting teams provided national and jurisdiction-specific probabilistic predictions of weekly confirmed influenza hospital admissions for one-to-four weeks ahead. Forecast skill is evaluated using the Weighted Interval Score (WIS), relative WIS, and coverage. Six out of 23 models outperform the baseline model across forecast weeks and locations in 2021-22 and 12 out of 18 models in 2022-23. Averaging across all forecast targets, the FluSight ensemble is the 2 most accurate model measured by WIS in 2021-22 and the 5 most accurate in the 2022-23 season. Forecast skill and 95% coverage for the FluSight ensemble and most component models degrade over longer forecast horizons. In this work we demonstrate that while the FluSight ensemble was a robust predictor, even ensembles face challenges during periods of rapid change.
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http://dx.doi.org/10.1038/s41467-024-50601-9 | DOI Listing |
Epidemics
June 2025
Department of Biostatistics and Health Data Science, College of Health, Lehigh University, Bethlehem, Pennsylvania, United States of America. Electronic address:
Seasonal influenza causes on average 425,000 hospitalizations and 32,000 deaths per year in the United States. Forecasts of influenza-like illness (ILI) - a surrogate for the proportion of patients infected with influenza - support public health decision making. The goal of an ensemble forecast of ILI is to increase accuracy and calibration compared to individual forecasts and to provide a single, cohesive prediction of future influenza.
View Article and Find Full Text PDFEpidemics
March 2025
Machine Intelligence Group for the betterment of Health and the Environment, Network Science Institute, Northeastern University, Boston, MA, USA; Department of Physics, Northeastern University, Boston, MA, USA; Center for Communicable Disease Dynamics, Harvard T.H. Chan School of Public Health, Bost
Accurate, real-time forecasts of influenza hospitalizations would facilitate prospective resource allocation and public health preparedness. State-of-the-art machine learning methods are a promising approach to produce such forecasts, but they require extensive historical data to be properly trained. Unfortunately, data on influenza hospitalizations, for the 50 states in the United States, are only available since the beginning of 2020.
View Article and Find Full Text PDFCombining predictions from multiple models into an ensemble is a widely used practice across many fields with demonstrated performance benefits. Popularized through domains such as weather forecasting and climate modeling, multi-model ensembles are becoming increasingly common in public health and biological applications. For example, multi-model outbreak forecasting provides more accurate and reliable information about the timing and burden of infectious disease outbreaks to public health officials and medical practitioners.
View Article and Find Full Text PDFmedRxiv
December 2023
Centers for Disease Control and Prevention, Atlanta, Georgia, 30329, USA.
Accurate forecasts can enable more effective public health responses during seasonal influenza epidemics. Forecasting teams were asked to provide national and jurisdiction-specific probabilistic predictions of weekly confirmed influenza hospital admissions for one through four weeks ahead for the 2021-22 and 2022-23 influenza seasons. Across both seasons, 26 teams submitted forecasts, with the submitting teams varying between seasons.
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