An Open-Label, Single-Arm, Phase II Trial of Sintilimab Plus Anlotinib for Metastatic Non-Small Cell Lung Cancer After First-Line PD-(L)1 Inhibitor.

Background: Although immune checkpoint inhibitors (ICIs) have markedly improved first-line management of non-small cell lung cancer (NSCLC), many tumors eventually escape control after anti-PD-(L)1 therapy, leaving a clear therapeutic gap. Preclinical studies and preliminary clinical data suggest that coupling ICIs with anti-angiogenesis therapy can yield complementary antitumor effects. Consequently, we launched this investigation to evaluate the therapeutic benefit and tolerability of sintilimab, a PD-(L)1-blocking monoclonal antibody, together with the oral multi-target anti-angiogenesis agent anlotinib in metastatic NSCLC individuals experiencing progression after first-line PD-(L)1 inhibition.

Research on quality and safety risk identification of import and export toys based on the WOA-BP model.

Within customs risk management, the weak ability to identify quality and safety risks of import and export toys-special products with high safety sensitivity-leads to persistently high recall rates. This study constructs a "data collection-risk classification-risk identification" framework integrating LDA and WOA-BP to address this. First, 2010-2024 toy recall texts from international systems are preprocessed.

Broadband achromatic wavefront tailoring with high-efficiency reflective metadevices.

Metasurfaces have exhibited unprecedented capabilities to manipulate electromagnetic (EM) waves, but many of them suffer from frequency dispersions, which significantly degrade their performance. Although extensive efforts have been devoted to the design of achromatic metasurfaces at optical frequencies, their microwave counterparts are less studied, with a few attempts suffering from large thicknesses. Here, based on high-efficiency meta-atoms exhibiting tailored reflection phases of both resonant and geometric origins, we propose a generic scheme to design achromatic metasurfaces for controlling EM far-field wavefronts within microwave broadband.

Translocator protein facilitates neutrophil-mediated mucosal inflammation in inflammatory bowel diseases.

Background: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic gastrointestinal disorders with an increasing global prevalence and significant healthcare impact. The exact etiology of this condition remains unclear. Neutrophils play a critical role in IBD pathogenesis.

Histone deacetylases in myocardial infarction: Orchestrating programmed cell death pathways and emerging therapeutic opportunities.

Myocardial infarction (MI) remains a major global health challenge, characterized by irreversible cardiomyocyte loss primarily mediated by multiple programmed cell death (PCD) pathways - including apoptosis, necroptosis, autophagy, ferroptosis, and pyroptosis. Histone deacetylases (HDACs) have emerged as pivotal epigenetic regulators orchestrating these diverse PCD processes by modulating the acetylation status of histone and non-histone proteins, thereby significantly influencing myocardial injury, inflammation, oxidative stress, and cardiac remodeling. Individual HDAC isoforms exhibit complex, dual, and context-dependent roles, acting either as promoters or suppressors of cardiomyocyte death depending on cellular stress conditions.

Electron-Initiated Self-Growth In Situ Hydrogel Electrolyte with Gradient Protection Interface Enables Stable Zinc Metal Batteries.

In situ gelation technology holds great promise for high-performance and scalable energy storage systems, but the dynamic analysis of in situ polymerization kinetics and interface evolution mechanism has not yet been explored in aqueous zinc metal batteries (AZMBs). Herein, an electron-initiated self-growth in situ hydrogel electrolyte was developed, realizing the controllable growth of a vertically oriented gel electrolyte through interfacial chemical reconstruction. The formation mechanism has been explored in detail in which the axially aligned polymer chains formed by the self-growing behavior of the hydrogel promote the precise alignment of internal zwitterionic functional groups, creating unique zinc ion transport channels.

Distinct Role of TP53 Co-mutations in Different EGFR Subtypes Mediating the Response to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.

Background: TP53 co-mutations are closely associated with poor outcomes in patients with EGFR-mutant non-small cell lung cancer (NSCLC). Our study aimed to explore whether TP53 co-mutations affect survival and response to EGFR tyrosine kinase inhibitors (TKIs) in patients with different EGFR subtypes.

Patients And Methods: We retrospectively analyzed 240 NSCLC with EGFR mutation (MT) from the First Affiliated Hospital of Sun Yat-sen University.

Dispersion-engineered spin photonics based on folded-path metasurfaces.

Spin photonics revolutionizes photonic technology by enabling precise manipulation of photon spin states, with spin-decoupled metasurfaces emerging as pivotal in complex optical field manipulation. Here, we propose a folded-path metasurface concept that enables independent dispersion and phase control of two opposite spin states, effectively overcoming the limitations of spin photonics in achieving broadband decoupling and higher integration levels. This advanced dispersion engineering is achieved by modifying the equivalent length of a folded path, generated by a virtual reflective surface, in contrast to previous methods that depended on effective refractive index control by altering structural geometries.

Prediction of HPLC chromatograms under linear and curved gradient elution by linear gradient trials with initial hold time.

It is demonstrated that initial hold time (t) before gradient elution may be taken as an extension of dwell time (t) of the chromatograph. On the basis of this property, we deduce the expressions for retention time (t) and band compression factor (G) under linear gradient with t which is also called scouting gradient in this work. In the case of linear solvent strength model (LSSM) and when the analyte is eluted from the column after the end of linear gradient, an algebraic expression for G is deduced.

Scaled transverse translation by planar optical elements for sub-pixel sampling and remote super-resolution imaging.

High resolution imaging represents a relentless pursuit within the field of optical system. Multi-frame super-resolution (SR) is an effective method for enhancing sampling density, while it heavily relies on sub-pixel scale displacement of a bulky camera. Based on the symmetric transformation of quadratic-phase metasurface, we propose scaled transverse translation (STT) utilizing planar optical elements (POEs) to facilitate sub-pixel sampling and remote super-resolution imaging.

Nanometre-resolution three-dimensional tomographic and vectorial near-field imaging in dielectric optical resonators.

All-dielectric optical nano-resonators have emerged as low-loss, versatile and highly adaptable components in nanophotonic structures for manipulating electromagnetic waves and enhancing light-matter interactions. However, achieving full three-dimensional characterization of near fields within dielectric nano-resonators poses great experimental challenges. Here we develop a technique to image near-field wave patterns inside dielectric optical nano-resonators using high-order sideband generation.

Abnormal beam steering with kirigami reconfigurable metasurfaces.

Dynamically controlling electromagnetic waves at will is highly desired in many applications, but most previously realized mechanically reconfigurable metasurfaces are of restricted wave-control capabilities due to the limited tuning ranges of structural properties (e.g., lattice constant or meta-atoms).

Electromagnetic Wavefront Engineering by Switchable and Multifunctional Kirigami Metasurfaces.

Developing switchable and multifunctional metasurfaces is essential for high-integration photonics. However, most previous studies encountered challenges such as limited degrees of freedom, simple tuning of predefined functionality, and complicated control systems. Here, we develop a general strategy to construct switchable and multifunctional metasurfaces.

Quantitative Ultrasound Parameters as Predictors of Chemotherapy Toxicity in Lymphoma: A Novel Approach to Assessing Muscle Mass and Quality Based on Ultrasound Radiofrequency Signals.

Objectives: The aim of this study was to use quantitative ultrasound (QUS) parameters to assess the muscle mass and quality in patients with lymphoma. Additionally, the study aimed to investigate the relationship between these QUS parameters and post-chemotherapy myelosuppression.

Methods: The study cohort comprised 202 patients diagnosed with lymphoma (105 males, 97 females; mean age 57.

Electrochemically and chemically in-situ interfacial protection layers towards stable and reversible Zn anodes.

Aqueous zinc metal batteries (AZMBs) have received widespread attention for large-scale sustainable energy storage due to their low toxicity, safety, cost-effectiveness. However, the technology and industrialization of AZMBs are greatly plagued by issues of Zn anode such as persistent dendrites and parasitic side reactions, resulting in rapid capacity degradation or battery failure. Electrochemically or chemically in-situ interfacial protection layers have very good self-adaption features for stability and reversibility of Zn anodes, which can also be well matched to current battery manufacturing.

A low-voltage-driven MEMS ultrasonic phased-array transducer for fast 3D volumetric imaging.

Wearable ultrasound imaging technology has become an emerging modality for the continuous monitoring of deep-tissue physiology, providing crucial health and disease information. Fast volumetric imaging that can provide a full spatiotemporal view of intrinsic 3D targets is desirable for interpreting internal organ dynamics. However, existing 1D ultrasound transducer arrays provide 2D images, making it challenging to overcome the trade-off between the temporal resolution and volumetric coverage.

Monocular Metasurface for Structured Light Generation and 3D Imaging with a Large Field-of-View.

Structured light three-dimensional (3D) imaging technology captures the geometric information on 3D objects by recording waves reflected from the objects' surface. The projection angle and point number of the laser dots directly determine the field-of-view (FOV) and the resolution of the reconstructed image. Conventionally, diffractive optical elements with micrometer-scale pixel size have been used to generate laser dot arrays, leading to limited FOV and point number within the projection optical path.

Circulating tumor cells with increasing aneuploidy predict inferior prognosis and therapeutic resistance in small cell lung cancer.

Aims: Treatment resistance commonly emerges in small cell lung cancer (SCLC), necessitating the development of novel and effective biomarkers to dynamically assess therapeutic efficacy. This study aims to evaluate the clinical utility of aneuploid circulating tumor cells (CTCs) for risk stratification and treatment response monitoring.

Methods: A total of 126 SCLC patients (two cohorts) from two independent cancer centers were recruited as the study subjects.