Ivermectin Identified Using a High-Throughput Screening System Exhibits Anti- Activity in Rats.

Clonorchiasis, caused by the parasite , remains a public health concern in East Asian countries. In this study, high-throughput screening was used to analyze 320 compounds for potential inhibitory activity against . To ensure the selection of high-confidence hits, a stringent inhibition threshold of 80% was applied, leading to the identification of three active compounds: moxifloxacin, hexachlorophene, and ivermectin (IVM).

Therapeutic application of canine adipose tissue-derived mesenchymal stromal cells in a dog with refractory immune-mediated thrombocytopenia, with diabetic ketoacidosis, and gastrointestinal bleeding induced by immunosuppressive treatment.

Refractory immune-mediated thrombocytopenia (ITP) in dogs is a condition with a poor prognosis due to the poor response to immunosuppressive therapy and the adverse effects of long-term drug administration. This case report describes the successful management of refractory ITP using stem cell therapy in a dog that experienced severe side effects from immunosuppressive treatment. The patient experienced recurrent relapses when prednisolone (PDS) tapering was attempted during conventional immunosuppressive therapy, necessitating prolonged use of PDS; this led to complications, such as diabetic ketoacidosis and chronic gastrointestinal bleeding.

Optimal Interval of Screening Endoscopy for Reducing Gastric Cancer Mortality: A Nationwide Cohort Study.

Background And Aims: The optimal endoscopic screening interval for gastric cancer (GC) has not yet been established. We compared survival outcomes in patients with GC based on their history of endoscopic screening prior to diagnosis.

Methods: Using the Korean national insurance claims data, we identified all patients newly diagnosed with GC in 2010.

Risks of cataract surgery in solid and hematologic cancer survivors.

In this nationwide retrospective cohort study, we investigated the risk of cataract surgery among cancer survivors compared to propensity score (PS)-matched non-cancer controls. This study included 4.5 million adults in the National Health Insurance Service database who underwent health screenings between year 2011 and 2014.

Chaperone-Mediated Responses and Mitochondrial-Endoplasmic Reticulum Coupling: Emerging Insight into Alzheimer's Disease.

Alzheimer's disease (AD) is increasingly recognized as a multifactorial disorder driven by a combination of disruptions in proteostasis and organelle communication. The 2020 Lancet commission reported that approximately 10 million people worldwide were affected by AD in the mid-20th century. AD is the most prevalent cause of dementia.

Contrast-Enhanced Computed Tomography Imaging Features of Primary Hepatic Neuroendocrine Carcinoma in a 4-Year-Old French Bulldog.

A 4-year-old female-spayed French bulldog presented with symptoms of anorexia, lethargy and vomiting. Abdominal ultrasonography revealed multiple coalescing hyperechoic nodules in the liver. Single-phase contrast-enhanced computed tomography (CT) scan showed heterogeneous liver lobes with hyperattenuating parenchyma and multiple hypoattenuating lesions in the post-contrast phase.

Risk of Depression in Persistent Blue Light Deprivation after Cataract Surgery: APopulation-BasedCohort Study.

Purpose: To identify the risk of depression in individuals exposed to persistent blue light deprivation through blue light-filtering (BLF) intraocular lenses (IOLs) based on previous studies that found blue light to promote affective arousal and modulate emotional responses.

Design: Population-based cohort analysis.

Participants: Individuals who underwent cataract removal and IOL implantation in both eyes within 1 year between January 2012 and December 2018.

Expression of Free Radicals and Reactive Oxygen Species in Endometriosis: Current Knowledge and Its Implications.

This review explores the dual role of reactive oxygen species (ROS) and free radicals in the pathogenesis of endometriosis, aiming to deepen our understanding of these processes through a systematic literature review. To assess the induction and involvement of ROS in endometriosis, we conducted a comprehensive literature review using Cochrane Libraries, EMBASE, Google Scholar, PubMed, and SCOPUS databases. Of 30 qualifying papers ultimately reviewed, 28 reported a significant contribution of ROS to the pathogenesis of endometriosis, while two found no association.

Exudative AMD Risk Following Blue Light-Filtering IOL Implantation: A Population-Based Study According to Non-Exudative AMD Status.

Purpose: To evaluate whether blue light-filtering (BLF) intraocular lenses (IOLs) reduce the risk of exudative age-related macular degeneration (AMD).

Design: A nationwide, population-based cohort study using data from the Korean National Health Insurance Sharing Service (NHISS) database.

Participants: Individuals who underwent cataract surgery and received the same type of IOL (BLF or clear) in both eyes within one year between January 2012 and December 2018.

Complete mitochondrial genome of Oberthür, 1879 (Lepidoptera: Limacodidae).

The phylogenetic relationships within Limacodidae remain unresolved, highlighting the need for expanded genomic resources. This study presents the first complete mitochondrial genome of , 15,354 bp in length and comprising 13 protein-coding genes, 22 tRNAs, two rRNAs, and an A+T rich region. The gene arrangement follows the typical Lepidopteran pattern.

Efficacy and safety of low-dose rosuvastatin/ezetimibe for dyslipidemia in patients with rheumatoid arthritis or osteoarthritis.

Background: Dyslipidemia is an important condition in patients with rheumatoid arthritis (RA). This study compared the effectiveness and safety of a low-dose rosuvastatin/ezetimibe formulation for dyslipidemia in RA and osteoarthritis (OA).

Methods: This multicenter, open-label, clinical trial enrolled patients >19 years of age with RA and or hand/knee OA who met the prescribing indications for rosuvastatin/ezetimibe in primary hypercholesterolemia or mixed dyslipidemia, and the Korean insurance criteria.

Predicting the therapeutic effect of photodynamic therapy on circumscribed choroidal haemangioma: a retrospective cohort study.

Background/aims: Circumscribed choroidal haemangioma (CCH) can cause visual impairment, primarily managed with photodynamic therapy (PDT). This study aimed to identify predictive factors of therapeutic response in patients with CCH treated with PDT and to analyse serial anatomical outcomes, focusing on visual acuity, tumour characteristics, and inner retinal microstructures.

Methods: This retrospective study included patients diagnosed with CCH at Severance Eye Hospital, Yonsei University, from January 2005 to December 2022.

Optic disc pit maculopathy-like retinoschisis without a clinically visible optic disc pit.

Purpose: This study aimed to describe the structural and clinical characteristics of optic disc pit maculopathy-like retinoschisis without a clinically visible optic disc pit and discuss possible pathogenesis and treatment.

Methods: This retrospective observational case series reviewed 20 eyes in 19 patients diagnosed with peripapillary retinoschisis (PPRS) without a visible optic disc pit. Patients were divided into three groups according to management method: observation, intraocular pressure (IOP) control, and vitrectomy.

Generating Solar Steam Using Waste Cellulose Fabric: Harnessing Synthetic Yet Plentiful and Cost-Effective Resources.

Numerous studies have been conducted into the reuse of such waste fabric; however, diversity in fiber type and the dyes used limits their potential applications. Therefore, innovative methods for recycling waste fiber need to be developed. This study explores the use of waste fabric as the primary raw material for the development of solar steam generators (SSGs) by harnessing abundant and affordable artificial 3D structures to deliver an efficient and cost-effective steam-generation solution.

Short-term effects of PCSK-9 inhibitors on percutaneous coronary intervention in patients with acute coronary syndrome.

Background/aims: Proprotein-converting enzyme subtilisin-kexin type 9 (PCSK9) inhibitors act more promptly and efficiently than statins and reduce the risk of cardiovascular events in patients with acute coronary syndrome (ACS). This study aimed to assess the short-term effects of perioperative administration of a single-dose PCSK9 inhibitor in patients with ACS.

Methods: This study included 789 consecutive patients undergoing percutaneous coronary intervention (PCI) for ACS.

An updated list of the genus Schrank (Lepidoptera, Erebidae) from Korea with five additional records to the fauna.

Background: The paper provides the updated checklist of the genus Schrank from Korea. This genus is one of the largest genera within the Noctuoidea comprising more than 680 species worldwide and the genus is the monophyletic group based on the morphological characters. The external examination along with the genitalia examination and DNA barcoding could reveal the diversity of the genus in Korea.

Production and Role of Free Radicals and Reactive Oxygen Species After Facial Nerve Injury.

Facial nerve injury (FNI) induces complex molecular and cellular responses, with reactive oxygen species (ROS) and free radicals (FRs) playing pivotal roles in nerve degeneration and regeneration. However, to date, no systematic review has specifically investigated the involvement of ROS and FRs in FNI. To address this unmet need, we reviewed the literature on the subject, comprehensively searching SCOPUS, PubMed, Cochrane Library, EMBASE, and Google Scholar to identify studies that assessed the roles of FRs and ROS in FNI and summarize their findings.

Influenza A hemagglutinin virus-like particles confer protection against influenza B virus infection.

Influenza A hemagglutinin (HA), neuraminidase, and/or M2e-containing virus-like particles (VLPs) induce immune responses that contribute to protection against multiple influenza A virus subtypes. In this study, we investigated the protective efficacy of influenza A/H1H3 VLPs against influenza B virus infections (B/Colorado/06/2017 and B/Malaysia/2506/2004, Victoria lineage) in mice. A/H1H3 VLP immunization elicited protection against lethal challenge infections with both B/Colorado and B/Malaysia, significantly reducing lung viral loads and ensuring 100% survival of immunized mice.

Production and Role of Nitric Oxide in Endometrial Cancer.

Endometrial cancer ranks as the fourth most common cancer among women in the United States. While early-stage treatment is generally effective with a cure rate of approximately 90%, the five-year survival rate dramatically decreases to 10-15% for advanced-stage diagnoses. Consequently, ongoing research seeks to improve treatment outcomes for endometrial cancer.

Induction of Nitric Oxide and Its Role in Otitis Media.

Although many studies have investigated the expression and role of nitric oxide (NO) in various diseases, it remains unclear whether NO has a beneficial or detrimental impact on otitis media. This review examines the literature on the expression and role of NO in different forms of otitis media, including acute otitis media, otitis media with effusion, chronic otitis media, and cholesteatomatous otitis media. Of the 22 studies reviewed, 18 reported that NO induces or exacerbates otitis media, whereas two studies suggested that NO may aid in its treatment.

A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis.

Nitric oxide (NO) is a key signaling molecule involved in cellular communication and plays a critical role in various biological processes. Given its dual role in the pathogenesis of endometriosis, we conducted a systematic literature review to explore its mechanisms further. Numerous studies have investigated the expression and role of NO in various diseases, including those in the field of gynecology.

Impact of csDMARDs vs. b/tsDMARDs on the Prognosis of Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Multicenter, Retrospective Study.

: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) significantly affects disease prognosis and patient survival. The impact of conventional synthetic DMARDs (csDMARDs) and biologic/targeted synthetic DMARDs (b/tsDMARDs) on RA-ILD prognoses remains unclear. This study aimed to investigate the effects of csDMARDs and b/tsDMARDs on RA-ILD progression and prognosis based on pulmonary function tests (PFTs), high-resolution computed tomography (HRCT), and symptom changes.

Hsp70: A Multifunctional Chaperone in Maintaining Proteostasis and Its Implications in Human Disease.

Hsp70, a 70 kDa molecular chaperone, plays a crucial role in maintaining protein homeostasis. It interacts with the DnaJ family of co-chaperones to modulate the functions of client proteins involved in various cellular processes, including transmembrane transport, extracellular vesicle trafficking, complex formation, and proteasomal degradation. Its presence in multiple cellular organelles enables it to mediate stress responses, apoptosis, and inflammation, highlighting its significance in disease progression.