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Article Abstract
Unlabelled: This study explored the associations between triglyceride glucose (TyG), TyG with body mass index (TyG-BMI), triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) and the effects of dietary acid-base load in patients with chronic kidney disease (CKD).
Methods: A total of 288 patients with CKD were included in this study. Four non-insulin-based insulin resistance (IR) markers were used to assess IR levels in patients with CKD; dietary intake - 24-h dietary recall; and diet-based acidity - potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL). Multiple linear regression analysis correlated dietary acid-base load and non-insulin-based IR markers.
Results: Spearman's correlation indicated DAL was significantly associated with TyG-BMI (r = 0.251, P < 0.001) and METS-IR (r = 0.274, P < 0.001), but weakly correlated with the TG/HDL-C ratio (r = 0.14, P = 0.018). After adjusting for sex, age, energy, hypertension (HTN), diabetes, and estimated glomerular filtration rate, multiple linear regression analysis showed that DAL was associated with TyG-BMI (β = 0.336; P = 0.008) and METS-IR (β = 0.091; P = 0.007).
Conclusions: Patients with the highest DAL scores had the highest TyG-BMI, TyG, TG/HDL-C ratio, and METS-IR. After adjusting for confounders, there was a significant positive association between DAL and TyG-BMI and METS-IR.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226242 | PMC |
| http://dx.doi.org/10.3389/fendo.2025.1589528 | DOI Listing |
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