Developing a Validated Family-School Partnership Assessment for Child Health and Well-Being: A Multidimensional Approach.

Background: Family-school partnerships (FSPs) play an important role in supporting child health and well-being. The current study aimed to develop and validate a psychometrically sound instrument to assess FSPs within the context of child health.

Methods: The instrument was developed through a mixed-methods three-phased approach, including pilot testing with 105 parent/caregiver (n = 53) and school staff (n = 52) participants.

ENLITE PD: A Randomized Clinical Trial of Light Therapy for Impaired Sleep in Parkinson's Disease.

Background: Light therapy (LT) in Parkinson's disease improves sleep. Specific LT parameters require further study, including optimal frequency.

Objectives: We aimed to determine if once- or twice-daily bright white light therapy (BWLT) improves sleep.

Academic Practice, Hospital-medical School Environment.

Hospital-medical school practices and their training programs exist in a unique environment with a focus rooted in the medical, or maxillofacial aspects of oral and maxillofacial surgery (OMS). This environment focuses on major maxillofacial surgical cases. The teaching role of the academic oral and maxillofacial surgeon is rooted in direct OMS resident training, rotating otolaryngology and plastic surgery resident training, as well as a minor role in medical student training.

Composite arterial and venous collateral score on single-phase CTA predicts 90-day outcomes in anterior circulation large-vessel occlusion stroke.

Background: Collateral circulation influences clinical outcomes in patients with acute ischemic stroke due to anterior circulation large-vessel occlusion (LVO). While both arterial and venous collateral assessments on single-phase computed tomography angiography (CTA) have prognostic value, they have traditionally been evaluated independently.

Purpose: We developed the CTA Collateral Impairment Score (CCIS), a composite measure incorporating arterial (Tan) and venous (Cortical Venous Opacification Score (COVES)) scores, and investigated its association with 90-day functional outcomes.

Associations Between Gestational Polybrominated Diphenyl Ether (PBDE) Serum Concentrations and Child Sleep Outcomes from Ages 2 to 8 Years.

Gestational polybrominated diphenyl ethers (PBDEs) exposures have been associated with thyroid disruption in pregnant women and adverse neurobehavioral outcomes in their children, but it is unknown if they interfere with children's sleep patterns. We assessed gestational PBDE exposure (16 weeks) and child sleep patterns from ages 2 to 8 years using 410 mother-child dyads in the Health Outcomes and Measures of the Environment (HOME) Study. Gestational biomarkers of serum PBDEs include PBDE-153 (GM±GSD: 5.

Edge-centric Brain Connectome Representations Reveal Increased Brain Functional Diversity of Reward Circuit in Patients with Major Depressive Disorder.

Background: Major depressive disorder (MDD) has been increasingly understood as a disorder of network-level functional dysconnectivity. However, previous brain connectome studies have primarily relied on node-centric approaches, neglecting critical edge-edge interactions that may capture essential features of network dysfunction.

Methods: This study included resting-state functional MRI data from 838 MDD patients and 881 healthy controls (HC) across 23 sites.

Utilization of intravenous posaconazole in pediatric patients undergoing hematopoietic stem cell transplant.

Background: Pediatric patients undergoing hematopoietic stem cell transplant (HSCT) are at high risk for fungal infections including Candida, Aspergillus, and Mucorales necessitating the use of broad-spectrum antifungal agents such as posaconazole for prophylaxis and at times for treatment of invasive fungal infections. When first approved, posaconazole was limited to an immediate release oral suspension, which exhibited unreliable absorption dependent on co-administration with high fat meals. During HSCT, patients commonly have significant nausea, vomiting, and decreased enteral intake making this formulation particularly challenging.

Perturbation of the ovine placental transcriptome occurs at sub-therapeutic exposures to antenatal steroid therapy.

Introduction: Antenatal steroid (ANS) therapy accelerates preterm lung maturation. Clinical and experimental data show current regimens disrupt placental function and transport and impact fetal growth. We have previously shown that higher materno-fetal steroid exposures increase fetal glucocorticoid clearance.

The effect of particle seeding on the rheological properties of blood Analog fluid used during laser Doppler velocimetry.

BackgroundThe viscosity of (BAF) influences the hemodynamics during testing of medical devices and implants in cardiovascular systems mimicking physiologic flow conditions. BAF, typically composed of water, glycerin, and Xanthan gum, is used to simulate blood's non-Newtonian shear-thinning behavior. Additionally, BAF may include microsphere particles for flow visualization in Laser Doppler Velocimetry (LDV) experiments, though their impact on viscosity remained an under-investigated area.

DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function.

Background: Calcium (Ca) dysregulation is a hallmark of heart failure, impairing excitation-contraction coupling and contributing to pathological remodeling. The SERCA2a (sarco/endoplasmic reticulum Ca ATPase isoform 2a) mediates Ca reuptake into the sarcoplasmic reticulum (SR) during diastole, but its activity declines in failing hearts. DWORF (dwarf open reading frame), a newly identified cardiac microprotein, enhances SERCA2a activity and improves cardiomyocyte Ca cycling and contractility.

Prevention of Atopic Dermatitis in High-Risk Infants: A Review of the Role of Lipid-Based Barrier Repair Therapy.

Background/objective: Growing evidence highlights the role of physiological lipids, namely ceramides, cholesterol, and free fatty acids, in maintaining skin barrier function and preventing atopic dermatitis (AD). Current evidence on the efficacy, safety, and clinical relevance of stratum corneum (SC) lipid-based therapies to prevent AD and increase skin barrier integrity in high-risk infants was reviewed and synthesized.

Methods: Searches with key words lipid-based therapy, atopic dermatitis, infant, and prevention were conducted to identify papers using PubMed, Embase, Cochrane Library, and Scopus databases from January 2000 to June 2024.

Early Postoperative Fever in Pediatric Oncology Patients Undergoing Solid Tumor Resection.

Background: Postoperative fever is common following cancer resection and often prompts extensive, costly workups. The purpose of this study was to determine the incidence of and risk factors for postoperative fever in oncology patients, evaluate incidence of true infection, and determine the utility of fever workup.

Methods: Single institution retrospective chart review (2018-2023) identified postoperative oncology patients who developed postoperative fever (≥38.

TRACHEAL WORK OF BREATHING IN NEONATES WITH TRACHEOESOPHAGEAL FISTULA BEFORE AND AFTER SURGICAL REPAIR VIA COMPUTATIONAL FLUID DYNAMICS ASSESSMENT.

Introduction: Tracheoesophageal fistula (TEF), often occurring with esophageal atresia (EA), presents significant respiratory challenges in neonates. Neither the effect of EA/TEF, nor the effect of post-surgical complications such as tracheomalacia, on respiratory effort has been previously quantified. This study calculates the tracheal resistive component of work of breathing (TR-WOB) to quantify breathing effort pre- and post-surgical repair of EA/TEF.

Quality of Hand Hygiene Performance: A Systematic Literature Review.

Background: Hand hygiene (HH) is essential for infection prevention in healthcare, but the quality of its performance, meaning how well it is done, receives much less attention than compliance. This review examines how HH technique is assessed and can be improved among healthcare providers.

Methods: Following PRISMA guidelines, six databases were searched through May 15, 2025.

Does the addition of fentanyl premedication impact brown fat uptake in children undergoing a warming protocol for FDG PET?

Background: Fentanyl is used in some pediatric practices with a goal of suppressing 18F-fluorodeoxyglucose (18F-FDG) uptake in brown fat.

Objective: The purpose of this study was to examine the frequency, intensity, and distribution of brown fat uptake in warmed children undergoing 18F-FDG PET/CT with and without premedication with fentanyl. MATERIALS AND METHODS: This retrospective study included children (< 18 years old) who underwent 18F-FDG-PET from 2014 to 2024 at a center that routinely warms patients and uses intravenous fentanyl for brown fat suppression for most patients.

Show Me the Money: A Movement Towards Transparency in Pediatric Emergency Medicine Compensation.

Background: National studies report sustained gender-based differences in physician compensation, even after adjustment for workplace factors such as academic rank, specialty type, and work hours. This study examines differences in compensation among pediatric emergency medicine (PEM) fellows' first job after training.

Methods: Between May 2023 and June 2023, we distributed an electronic survey to all United States PEM fellowship program directors (FPDs), requesting they forward it to their graduating fellows.

Transition of headache care from childhood to adulthood: Focusing needs, barriers, and models of care. A position paper of the IHS Child and Adolescent Committee.

Headache disorders are among the most common neurological conditions in children and adolescents, often continuing into adulthood and causing substantial personal and societal burdens. Yet, the transition from childhood to adult headache care remains under-addressed, with critical clinical practice, policy, and research gaps. This narrative review synthesizes existing evidence and expert perspectives to highlight the urgent need for structured, developmentally appropriate transition models in headache care.

The impact of donor and recipient age on post-transplantation clonality in murine haematopoiesis.

The sustained production of blood and immune cells is driven by a pool of hematopoietic stem cells (HSCs) and their offspring. Due to the intrinsic heterogeneity of HSCs, the composition of emergent clones changes over time, leading to a reduced clonality in aging mice and humans. Theoretical analyses suggest that clonal conversion rates and clonal complexity depend not only on HSC heterogeneity, but also on additional stress conditions.

Literature analysis and implication of biologic therapy for children with non-systemic juvenile idiopathic arthritis in real-world settings.

Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease in children. Besides the more severe systemic form, non-systemic JIA is divided into 5 different subgroups. Polyarticular JIA (polyJIA), particularly rheumatoid factor (RF)-positive, which is defined as the disease involving five or more joints in the first 6 months of disease, has the worst prognosis.

Evidence-Based Suturing Education for Midwives.

Perineal repair is a skill that student nurse-midwives must achieve competency in before graduating and entering practice. Students and new midwives often express a lack of confidence in their ability to undertake perineal repair. This article aims to share one public university nurse-midwifery program's experience developing and implementing a suturing education program with an interprofessional approach.