Transition of headache care from childhood to adulthood: Focusing needs, barriers, and models of care. A position paper of the IHS Child and Adolescent Committee.

Headache disorders are among the most common neurological conditions in children and adolescents, often continuing into adulthood and causing substantial personal and societal burdens. Yet, the transition from childhood to adult headache care remains under-addressed, with critical clinical practice, policy, and research gaps. This narrative review synthesizes existing evidence and expert perspectives to highlight the urgent need for structured, developmentally appropriate transition models in headache care.

The impact of donor and recipient age on post-transplantation clonality in murine haematopoiesis.

The sustained production of blood and immune cells is driven by a pool of hematopoietic stem cells (HSCs) and their offspring. Due to the intrinsic heterogeneity of HSCs, the composition of emergent clones changes over time, leading to a reduced clonality in aging mice and humans. Theoretical analyses suggest that clonal conversion rates and clonal complexity depend not only on HSC heterogeneity, but also on additional stress conditions.

Literature analysis and implication of biologic therapy for children with non-systemic juvenile idiopathic arthritis in real-world settings.

Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease in children. Besides the more severe systemic form, non-systemic JIA is divided into 5 different subgroups. Polyarticular JIA (polyJIA), particularly rheumatoid factor (RF)-positive, which is defined as the disease involving five or more joints in the first 6 months of disease, has the worst prognosis.

Evidence-Based Suturing Education for Midwives.

Perineal repair is a skill that student nurse-midwives must achieve competency in before graduating and entering practice. Students and new midwives often express a lack of confidence in their ability to undertake perineal repair. This article aims to share one public university nurse-midwifery program's experience developing and implementing a suturing education program with an interprofessional approach.

Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies.

Attention-deficit hyperactivity disorder (ADHD) is characterized by core symptoms of inattention, hyperactivity, and impulsivity. Aberrant dopaminergic and noradrenergic neurotransmission are often implicated in the pathogenesis of these symptoms because ADHD treatments increase synaptic levels of these neurotransmitters in brain regions associated with attention and impulse control. However, some ADHD treatments also enhance serotonergic neurotransmission in these regions, which could contribute to their efficacy.

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions.

T cells recognize antigens and induce specialized gene expression programs (GEPs), enabling functions like proliferation, cytotoxicity and cytokine production. Traditionally, different T cell classes are thought to exhibit mutually exclusive responses, including T1, T2 and T17 programs. However, single-cell RNA sequencing has revealed a continuum of T cell states without clearly distinct subsets, necessitating new analytical frameworks.

Exploring the role of ionic liquids in biopolymer films for sustainable food packaging: A review.

Food packaging is essential for ensuring product safety and extending shelf-life. Traditional packaging materials, primarily made from petrochemical-derived plastics, pose significant environmental challenges due to their non-biodegradability. As a sustainable alternative, biopolymers such as biopolyesters, proteins, and polysaccharides derived from renewable resources have emerged; however, they often lack sufficient mechanical strength and can be costly to produce.

Tolerance to non-inherited maternal antigen is sustained by LysM CD11c maternal microchimeric cells.

Maternal-fetal microchimerism is increasingly linked with both inflammatory disorders and immune tolerance phenotypes. However, finding microchimeric cells in target tissues does not establish causality, which require platforms for manipulating these rare and heterogeneous cells. Here, we studied maternal microchimeric cells (MMc) that sustain non-inherited maternal antigen (NIMA) tolerance.

Dramatic multifocal osteosarcoma treatment response in the setting of POT1 tumor predisposition syndrome.

Introduction: POT1 tumor predisposition (POT1-TPD) is associated with a spectrum of malignancies due to loss of function mutations in POT1 leading to telomere elongation and genomic instability. Osteosarcoma is the most common primary malignant bone tumor and has a poor prognosis when multifocal.

Case Presentation: A 15-year-old male was found to have a primary right distal femur osteosarcoma with multiple additional bony sites of disease.

An individual-level data synthesis of Clinical Trials Network studies to examine the impact of psychosocial treatments for Black people who use cocaine and/or opioids.

Objective: Cocaine- and opioid-related overdose deaths have increased among Black people, which makes identifying effective treatments for Black people a high priority. We investigated the comparative effectiveness of behavioral treatments among Black adults who use cocaine and/or opioids.

Methods: Identified multisite randomized clinical trials (RCTs) of behavioral interventions that targeted substance use, had participants who self-identified as Black, and included cocaine use outcome measures from the National Drug Abuse Treatment Clinical Trials Network (CTN) datashare.

Variation in Intensive Pediatric Physical Therapy Practice in the United States: Results From a National Survey.

Purpose: Intensive pediatric physical therapy (PT) programs are increasingly common yet lack a clear definition. This study aimed to examine current practice patterns of intensive pediatric PT in the United States.

Methods: A survey was developed and administered using the FITT (frequency, intensity, time, type) model and Knowledge to Action Cycle for pediatric physical therapists providing intensive PT.

Cost savings of EMS administration of bronchodilators and systemic corticosteroids for pediatric asthma patients.

Background: Pediatric asthma costs the United States healthcare system $5 billion annually. A major component of those costs are hospitalizations for acute exacerbations. This brief report examines the cost savings from emergency medical services (EMS) administration of bronchodilators and systemic corticosteroids to pediatric asthma patients, as opposed to waiting for emergency department (ED) arrival.

Xanthogranulomatous Epithelial Tumor in a Pediatric Patient. A Potential Diagnostic Pitfall With Non-Langerhans Cell Histiocytic Neoplasms, Particularly Juvenile Xanthogranuloma.

Xanthogranulomatous epithelial tumor is a recently described neoplasm harboring recurrent HMGA2::NCOR2 fusions, which, owing to its extensive xanthogranulomatous appearance with abundant foamy histiocytes and frequent Touton-type giant cells, may be confused with other inflammatory and neoplastic entities. We present a case arising in the right arm subcutaneous tissues of a 10-year-old boy, which was initially interpreted as a non-Langerhans cell histiocytic neoplasm compatible with Juvenile xanthogranuloma.

Leveraging artificial intelligence in the peer review of neurosurgical research articles.

The traditional peer review process is time-consuming and can delay the dissemination of critical research. This study evaluates the effectiveness of artificial intelligence (AI) in predicting the acceptance or rejection of neurosurgical manuscripts, offering a possible solution to optimize the process. Neurosurgical preprints from Preprint.

Bioinspired Provisional Matrix Stimulates Regenerative Healing of Diabetic Wounds.

This study tested the hypothesis that diabetic wound treatment with biomimetic pro-angiogenic, proteolytically and mechanically stable RADA16-II peptide nanofibers promotes regenerative wound healing via attenuation of inflammation and stimulation of neovascularization. Two full-thickness excisional dorsal skin wounds were created on 8-10 week old female db/db mice and treated with nanofiber hydrogel or saline (control). Animals were euthanized on days 7, 14, 28, and 56 and their wounds were analysed for morphology, vascularization, strength, and inflammation.

ACR-ABS-ACNM-ARS-SIR-SNMMI Practice Parameter for Radioembolization of Liver Malignancies.

Objectives: The practice parameter was revised collaboratively by the American College of Radiology (ACR), the American Brachytherapy Society (ABS), the American College of Nuclear Medicine (ACNM), the American Radium Society (ARS), the Society of Interventional Radiology (SIR), and the Society of Nuclear Medicine and Molecular Imaging (SNMMI). This document summarizes current evidence-based guidelines for the administration of Yttrium radioembolic therapy to the liver, including training requirements, evidence-based guidelines for administration, and safe practice for administration.

Methods: This practice parameter was revised according to the process described under the heading The Process for Developing ACR Practice Parameters and Technical Standards on the ACR website (https://www.

Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice.

Background: Small artery remodeling and endothelial dysfunction are hallmarks of hypertension. Evidence supports a likely causal association between cardiovascular diseases and endothelial-to-mesenchymal transition, a cellular transdifferentiation process in which endothelial cells (ECs) partially lose their identity and acquire mesenchymal phenotypes. EC reprogramming represents an innovative strategy in regenerative medicine to prevent deleterious effects induced by cardiovascular diseases.

Data Sharing Experience, Guidance, and Resources From the Rare Diseases Clinical Research Network (RDCRN).

The Rare Diseases Clinical Research Network (RDCRN) comprises research consortia and other partners focused on the study of rare diseases. Its goals include sharing de-identified data with the scientific community and other stakeholders to advance rare disease research. The RDCRN Data Use & Data Sharing Committee and RDCRN Data Management and Coordinating Center reviewed data sharing practices across established consortia and published literature to develop guidance documents.

Long-term efficacy of migalastat in females with Fabry disease.

Background: Fabry disease is a progressive, X-linked lysosomal disorder caused by reduced or absent α-galactosidase A activity due to variants. Females with Fabry disease often experience diagnostic delays and an underappreciated disease burden owing to their variable disease presentation and progression.

Methods: We conducted a analysis of all females from the clinical studies FACETS (NCT00925301) and ATTRACT (NCT01218659) and their open-label extensions, assessing baseline characteristics and long-term efficacy of migalastat regarding cardiac and renal function and Fabry-associated clinical events (FACEs).

Validation of comprehensive genomic profiling for prognostic and potential therapeutic molecular classification of endometrial cancer.

Objective: We sought to validate the prognostic utility of comprehensive genomic profiling (CGP)-based molecular stratification for patients with endometrial carcinoma and to assess co-occurring biomarkers across subtypes.

Methods: This study included patients from a de-identified nationwide (US-based) endometrial cancer clinicogenomic database who underwent CGP testing as part of routine care. Molecular subtypes were classified as POLE mutated (POLEmut), MSI-H, TP53 mutated (TP53mut), and no specific molecular profile (NSMP).

Decrease in SinglePlex Viral PCRs Use and acyclovir utilization following implementation of The BioFire Meningitis/Encephalitis Panel at A Tertiary Care Cancer Center.

Purpose: Meningitis and encephalitis are medical emergencies requiring prompt intervention. The BioFire Meningitis/Encephalitis (M/E) panel (BioFire Diagnostics, Salt Lake City, UT) is approved by the U.S.

Dilated Cardiomyopathy - Exploring the Underlying Causes.

Cardiovascular disease is one of the world's leading causes of natural mortality, taking approximately 18 million lives each year. Dilated cardiomyopathy, a subgroup of cardiac diseases, has an annual incidence of 5 - 8 cases per 100,000 for European and North American populations. Common features of dilated cardiomyopathy include cardiac chamber enlargement, impaired systolic function, reduced ejection fraction, and arrhythmias, with an endpoint of ventricular dilation and heart failure.