Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Fentanyl is used in some pediatric practices with a goal of suppressing 18F-fluorodeoxyglucose (18F-FDG) uptake in brown fat.
Objective: The purpose of this study was to examine the frequency, intensity, and distribution of brown fat uptake in warmed children undergoing 18F-FDG PET/CT with and without premedication with fentanyl. MATERIALS AND METHODS: This retrospective study included children (< 18 years old) who underwent 18F-FDG-PET from 2014 to 2024 at a center that routinely warms patients and uses intravenous fentanyl for brown fat suppression for most patients. Three radiologists assessed the presence, intensity, and location of brown fat uptake. Chi-square test and two-sample t-test were used to compare the demographics and brown fat uptake between premedication and non-premedication groups.
Results: Among 873 18F-FDG-PETs, 595 (68%) were performed with fentanyl premedication and warming and 278 (32%) were conducted with warming alone. Brown fat uptake was observed in 46 (5.3%) FDG-PETs, 32/595 (5.4%) in the premedicated group and 14/278 (5.0%) in the non-premedicated group (P = 0.83). No differences were found in brown fat intensity or location based on premedication status. Age (14.5 vs. 8.5; P < 0.001) and BMI (20.1 vs. 17.7; P < 0.001) were significantly associated with brown fat uptake.
Conclusion: Fentanyl premedication does not significantly affect brown fat uptake frequency, intensity, or location in warmed children undergoing 18F-FDG-PET.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00247-025-06381-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Brown Rice, Meal Replacements, and Anti-Obesity Drugs on Mitochondria in Obese Rats.
Diabetes Metab Syndr Obes
September 2025
School of Medical, Indigenous and Health, University of Wollongong, Wollongong, New South Wales, Australia.
Introduction: Obesity remains a critical global health challenge, intricately linked to poor dietary quality, gut microbiota dysbiosis, and mitochondrial dysfunction.
Purpose: This study aimed to investigate the comparative effects of brown rice, meal replacements, and thiazolidinediones on mitochondrial abundance and gut microbiota composition in a rat model of diet-induced obesity.
Methods And Materials: A total of twenty male Sprague Dawley rats were randomly assigned to five groups: control, high-fat high-fructose diet, and three intervention groups receiving the same obesogenic diet supplemented with brown rice, meal replacement, or thiazolidinediones for twelve weeks.
Mitochondrial membrane remodeling during heat acclimation in Mongolian gerbils.
Mar Life Sci Technol
August 2025
School of Life Sciences, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237 China.
Unlabelled: Mongolian gerbils had high ability to endure both high and cold temperatures. To study the mechanism of high ability for thermal adaptation, gerbils were acclimated to high temperature (30 °C) for 8 weeks, and were measured for metabolic features, body composition as well as mitochondrial content and activities. Lipidomic techniques were used to measure changes in mitochondrial membrane, including potential mitochondrial membrane remodeling during acute thermoregulation in gerbils.
View Article and Find Full Text PDFMediastinal Hibernoma on Fluorine-18 Fluorodeoxyglucose (18F-FDG) Positron-Emission Tomography/Computed Tomography (PET/CT): A Case Report and Literature Review.
Cureus
August 2025
School of Medicine, University of Costa Rica, San José, CRI.
Hibernomas are infrequent brown adipose tissue tumors that can mimic various other soft tissue tumors, both malignant and benign, and multiple imaging modalities are usually used in the diagnostic approach. We present the case of a 30-year-old female patient who was initially diagnosed with a mediastinal hibernoma through complete excisional biopsy in 2022 and underwent surgical resection at that time. She required a second surgical intervention in 2024 due to recurrence and is now being evaluated for a second recurrence using fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT), reporting an extensive polylobulated mediastinal tumor intercalating normometabolic and discretely hypermetabolic zones.
View Article and Find Full Text PDFSex Differences in Ketogenic Diet Response Reveal Gonadal Hormone Interaction With FGF21 in Mice.
J Endocr Soc
October 2025
Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Although indicated as adjunctive therapy for seizure disorders, ketogenic diets (KDs) have gained popularity for weight loss and mitigating the metabolic risks associated with severe obesity. However, efficacy, durability, and long-term consequences are incompletely understood. In preclinical models, most studies have included only male mice, precluding an understanding of sex-specific responses to KD.
View Article and Find Full Text PDFThe fungicide jinggangmycin stimulates fecundity of Nilaparvata lugens Stål via ILP/Foxo signaling.
Pestic Biochem Physiol
November 2025
College of Plant Protection, Yangzhou University, Yangzhou, Jiangsu Province 225009, China; Jiangsu Province Engineering Research Center of Green Pesticides, Yangzhou University, Yangzhou 225009, China. Electronic address:
The brown planthopper (BPH), Nilaparvata lugens is a typical pesticide-induced resurgent rice pest. A previous study showed that a fungicide, jinggangmycin (JGM)-treated rice led to markedly increased sugar content and (Insulin-like Peptide 2) ILP2 in response to sugar-mediated TOR signaling and stimulated fecundity in BPH. However, the role of the other ILPs in response to types of carbohydrate compounds remained poorly understood.
View Article and Find Full Text PDF